Protein: MFN2
Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2)

Gene: MFN2
Organism: Homo sapiens
Interactions: 138
UniProt ID: O95140

Gene Ontology (top 5):
GO:0001825 - blastocyst formation
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

304850

MFN1
Mitofusin-1

5

3

Small-scale

0.925

High

304772

MFN2
Mitofusin-2

3

3

Small-scale

0.834

High

226123

PRKN
E3 ubiquitin-protein ligase parkin

10

5

Small-scale

0.754

High

304886

MARH5
E3 ubiquitin-protein ligase MARCHF5

8

3

Small-scale

0.751

High

304860

AKAP1
A-kinase anchor protein 1, mitochondrial

3

2

High-throughput

0.656

High

304845

MAVS
Mitochondrial antiviral-signaling protein

3

3

Small-scale

0.650

High

304809

TERA
Transitional endoplasmic reticulum ATPase

3

1

Small-scale

0.646

High

304876

GHITM
Growth hormone-inducible transmembrane protein

2

1

High-throughput

0.628

High

128381

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.618

High

304827

SQSTM
Sequestosome-1

2

1

High-throughput

0.584

High

304835

BAK
Bcl-2 homologous antagonist/killer

2

3

Small-scale

0.584

High

304862

S2546
Mitochondrial outer membrane protein SLC25A46

2

1

Small-scale

0.584

High

304873

TCHP
Trichoplein keratin filament-binding protein

2

2

Small-scale

0.584

High

304897

SAM50
Sorting and assembly machinery component 50 homolog

2

1

Small-scale

0.584

High

304846

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

0

Small-scale

0.559

High

230484

TRAK2
Trafficking kinesin-binding protein 2

1

1

High-throughput

0.536

High

304837

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

Small-scale

0.515

High

304775

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

304851

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

304875

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

Small-scale

0.500

High

118660

AIP
AH receptor-interacting protein

1

2

High-throughput

0.479

High

121651

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

High-throughput

0.479

High

156187

PSA7
Proteasome subunit alpha type-7

1

4

High-throughput

0.479

High

202568

TXNL1
Thioredoxin-like protein 1

1

2

High-throughput

0.479

High

259399

NIPS2
Protein NipSnap homolog 2

1

1

High-throughput

0.479

High

304773

TTC4
Tetratricopeptide repeat protein 4

1

3

High-throughput

0.479

High

304778

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.479

High

304779

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

304781

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

High-throughput

0.479

High

304783

PRS6A
26S proteasome regulatory subunit 6A

1

5

High-throughput

0.479

High

304784

PSB1
Proteasome subunit beta type-1

1

6

High-throughput

0.479

High

304785

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.479

High

304786

PSA2
Proteasome subunit alpha type-2

1

4

High-throughput

0.479

High

304787

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.479

High

304789

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.479

High

304790

PSB4
Proteasome subunit beta type-4

1

7

High-throughput

0.479

High

304791

PSB6
Proteasome subunit beta type-6

1

4

High-throughput

0.479

High

304792

PSB5
Proteasome subunit beta type-5

1

4

High-throughput

0.479

High

304794

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

High-throughput

0.479

High

304795

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

304798

PRS7
26S proteasome regulatory subunit 7

1

4

High-throughput

0.479

High

304800

PRS6B
26S proteasome regulatory subunit 6B

1

4

High-throughput

0.479

High

304803

PSB3
Proteasome subunit beta type-3

1

5

High-throughput

0.479

High

304804

F10A1
Hsc70-interacting protein

1

2

High-throughput

0.479

High

304810

PSA6
Proteasome subunit alpha type-6

1

4

High-throughput

0.479

High

304812

PRS4
26S proteasome regulatory subunit 4

1

4

High-throughput

0.479

High

304813

PRS8
26S proteasome regulatory subunit 8

1

5

High-throughput

0.479

High

304815

PRS10
26S proteasome regulatory subunit 10B

1

5

High-throughput

0.479

High

304817

TPM4
Tropomyosin alpha-4 chain

1

1

High-throughput

0.479

High

304822

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

High-throughput

0.479

High

304823

GOGA3
Golgin subfamily A member 3

1

1

High-throughput

0.479

High

304825

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

304828

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

High-throughput

0.479

High

304831

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.479

High

304832

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

304842

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

304852

MIRO2
Mitochondrial Rho GTPase 2

1

1

High-throughput

0.479

High

304858

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

304859

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.479

High

304863

S2538
Mitochondrial glycine transporter

1

1

Small-scale

0.479

High

304866

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.479

High

304869

PSB7
Proteasome subunit beta type-7

1

3

High-throughput

0.479

High

304870

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

304871

TTC1
Tetratricopeptide repeat protein 1

1

2

High-throughput

0.479

High

304872

NIPS1
Protein NipSnap homolog 1

1

1

High-throughput

0.479

High

304874

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

1

High-throughput

0.479

High

304887

MTCH1
Mitochondrial carrier homolog 1

1

1

High-throughput

0.479

High

304895

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

304896

TDRKH
Tudor and KH domain-containing protein

1

2

High-throughput

0.479

High

127144

IPO5
Importin-5

1

0

High-throughput

0.458

High

180774

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

304774

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

304780

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

304782

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

304793

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

304797

MYH10
Myosin-10

1

0

High-throughput

0.458

High

304799

KPCI
Protein kinase C iota type

1

0

High-throughput

0.458

High

304801

MK09
Mitogen-activated protein kinase 9

1

0

Small-scale

0.458

High

304802

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

304805

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

304806

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.458

High

304807

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

304808

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.458

High

304811

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

Small-scale

0.458

High

304814

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

304816

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

304819

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

304821

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.458

High

304824

FADD
FAS-associated death domain protein

1

0

High-throughput

0.458

High

304829

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

304830

DIP2A
Disco-interacting protein 2 homolog A

1

0

High-throughput

0.458

High

304833

SMAD2
Mothers against decapentaplegic homolog 2

1

0

Small-scale

0.458

High

304834

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

304839

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.458

High

304844

LARP4
La-related protein 4

1

0

High-throughput

0.458

High

304856

CIP2A
Protein CIP2A

1

0

High-throughput

0.458

High

304861

GLMN
Glomulin

1

0

High-throughput

0.458

High

304864

KBP
KIF-binding protein

1

0

High-throughput

0.458

High

304868

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

304879

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

304881

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

304882

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

304890

HDAC6
Histone deacetylase 6

1

0

Small-scale

0.458

High

304891

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

304893

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.458

High

304894

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.458

High

304777

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

304818

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

304849

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.437

High

304854

NNRE
NAD(P)H-hydrate epimerase

1

1

Small-scale

0.437

High

304877

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

304888

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

1

High-throughput

0.407

High

304820

REEP5
Receptor expression-enhancing protein 5

2

0

High-throughput

0.328

High

304847

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

0

High-throughput

0.328

High

304776

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.279

Low

304796

CP2CJ
Cytochrome P450 2C19

1

0

High-throughput

0.279

Low

304892

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

195664

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

0

High-throughput

0.249

Low

304788

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

304826

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.249

Low

304836

ACTBL
Beta-actin-like protein 2

1

0

High-throughput

0.249

Low

304838

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

304840

VP13D
Intermembrane lipid transfer protein VPS13D

1

0

High-throughput

0.249

Low

304841

CRBG3
Very large A-kinase anchor protein

1

0

High-throughput

0.249

Low

304843

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.249

Low

304848

LRC49
Leucine-rich repeat-containing protein 49

1

0

High-throughput

0.249

Low

304853

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

304855

DIK2A
Divergent protein kinase domain 2A

1

0

Small-scale

0.249

Low

304857

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.249

Low

304865

CFA36
Cilia- and flagella-associated protein 36

1

0

High-throughput

0.249

Low

304867

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.249

Low

304878

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.249

Low

304880

WDR41
WD repeat-containing protein 41

1

0

High-throughput

0.249

Low

304883

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

304884

TM160
Transmembrane protein 160

1

0

High-throughput

0.249

Low

304885

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.249

Low

304889

IBTK
Inhibitor of Bruton tyrosine kinase

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024