Protein: PTPRA
Receptor-type tyrosine-protein phosphatase alpha (Protein-tyrosine phosphatase alpha) (R-PTP-alpha) (EC 3.1.3.48)

Gene: PTPRA
Organism: Homo sapiens
Interactions: 134
UniProt ID: P18433

Gene Ontology (top 5):
GO:0004725 - protein tyrosine phosphatase activity
GO:0005001 - transmembrane receptor protein tyrosine phosphatase activity
GO:0005886 - plasma membrane
GO:0005925 - focal adhesion
GO:0007229 - integrin-mediated signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

577009

GRB2
Growth factor receptor-bound protein 2

15

20

Small-scale

0.988

High

576983

PTPRE
Receptor-type tyrosine-protein phosphatase epsilon

6

17

High-throughput

0.943

High

522756

SRC
Proto-oncogene tyrosine-protein kinase Src

4

20

Small-scale

0.903

High

337909

EGFR
Epidermal growth factor receptor

3

20

High-throughput

0.865

High

576980

PTPRA
Receptor-type tyrosine-protein phosphatase alpha

3

17

Small-scale

0.858

High

383597

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

20

High-throughput

0.754

High

434133

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

20

High-throughput

0.724

High

576991

RYK
Tyrosine-protein kinase RYK

1

20

High-throughput

0.691

High

121103

LEG8
Galectin-8

3

20

High-throughput

0.667

High

134518

FCN1
Ficolin-1

3

4

High-throughput

0.667

High

449184

LEG1
Galectin-1

2

20

High-throughput

0.628

High

411997

FYN
Tyrosine-protein kinase Fyn

1

20

Small-scale

0.618

High

576984

PTPRG
Receptor-type tyrosine-protein phosphatase gamma

1

17

Small-scale

0.618

High

576988

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

8

High-throughput

0.618

High

576990

TYK2
Non-receptor tyrosine-protein kinase TYK2

1

20

High-throughput

0.618

High

576998

CRK
Adapter molecule crk

1

17

High-throughput

0.618

High

577013

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.618

High

577018

PTN13
Tyrosine-protein phosphatase non-receptor type 13

1

18

High-throughput

0.618

High

577024

SHB
SH2 domain-containing adapter protein B

1

20

High-throughput

0.618

High

577000

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

0

High-throughput

0.602

High

576989

SHC1
SHC-transforming protein 1

1

20

High-throughput

0.590

High

576993

MERL
Merlin

2

7

High-throughput

0.584

High

577005

XPO2
Exportin-2

2

11

High-throughput

0.584

High

577020

GAB1
GRB2-associated-binding protein 1

2

8

High-throughput

0.584

High

577027

GRDN
Girdin

2

3

High-throughput

0.584

High

577032

GRIN3
G protein-regulated inducer of neurite outgrowth 3

2

2

High-throughput

0.584

High

577033

RAPH1
Ras-associated and pleckstrin homology domains-containing protein 1

2

1

High-throughput

0.584

High

577077

BAIP2
BAR/IMD domain-containing adapter protein 2

2

2

High-throughput

0.584

High

577014

SP4
Transcription factor Sp4

2

2

High-throughput

0.574

High

577037

MYCPP
C-myc promoter-binding protein

2

1

High-throughput

0.574

High

577039

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

2

1

High-throughput

0.574

High

577044

TPC2
Two pore channel protein 2

2

10

High-throughput

0.574

High

577069

ASND1
Asparagine synthetase domain-containing protein 1

2

1

High-throughput

0.574

High

558707

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

2

Small-scale

0.561

High

577011

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

4

Small-scale

0.561

High

577012

BASP1
Brain acid soluble protein 1

2

0

High-throughput

0.559

High

208991

NCK2
Cytoplasmic protein NCK2

1

20

High-throughput

0.553

High

388216

HSPB1
Heat shock protein beta-1

1

1

High-throughput

0.541

High

576994

PE2R4
Prostaglandin E2 receptor EP4 subtype

1

4

High-throughput

0.541

High

572277

LEG3
Galectin-3

1

20

High-throughput

0.536

High

576995

ARL2
ADP-ribosylation factor-like protein 2

1

5

High-throughput

0.536

High

577010

1433Z
14-3-3 protein zeta/delta

1

14

High-throughput

0.536

High

577017

KCMA1
Calcium-activated potassium channel subunit alpha-1

1

4

High-throughput

0.536

High

577043

RN149
E3 ubiquitin-protein ligase RNF149

1

10

High-throughput

0.536

High

577045

MARH1
E3 ubiquitin-protein ligase MARCHF1

1

7

High-throughput

0.536

High

577059

ATX2
Ataxin-2

1

2

High-throughput

0.536

High

577080

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

2

High-throughput

0.536

High

576996

GDNF
Glial cell line-derived neurotrophic factor

2

1

High-throughput

0.521

High

576982

LMNB1
Lamin-B1

1

3

High-throughput

0.515

High

577060

VPS25
Vacuolar protein-sorting-associated protein 25

1

0

High-throughput

0.513

High

577061

CCG6
Voltage-dependent calcium channel gamma-6 subunit

1

0

High-throughput

0.513

High

577075

HCST
Hematopoietic cell signal transducer

1

0

High-throughput

0.513

High

577079

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.513

High

577007

HUNK
Hormonally up-regulated neu tumor-associated kinase

1

5

High-throughput

0.494

High

519120

KCRB
Creatine kinase B-type

1

0

High-throughput

0.493

High

119150

LEG9
Galectin-9

1

20

High-throughput

0.489

High

127630

EF2K
Eukaryotic elongation factor 2 kinase

1

2

High-throughput

0.489

High

577026

LEG9B
Galectin-9B

1

20

High-throughput

0.489

High

577052

LEG12
Galectin-12

1

20

High-throughput

0.489

High

577071

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

7

High-throughput

0.489

High

362057

MBP
Myelin basic protein

1

0

Small-scale

0.480

High

577003

GAS1
Growth arrest-specific protein 1

1

0

Small-scale

0.480

High

127181

IPO5
Importin-5

1

5

High-throughput

0.479

High

131993

NCHL1
Neural cell adhesion molecule L1-like protein

1

7

Small-scale

0.479

High

199865

SPIT2
Kunitz-type protease inhibitor 2

1

1

High-throughput

0.479

High

225515

PCDH7
Protocadherin-7

1

18

High-throughput

0.479

High

239047

CTND1
Catenin delta-1

1

20

High-throughput

0.479

High

306904

UNC5C
Netrin receptor UNC5C

1

7

High-throughput

0.479

High

349111

RASH
GTPase HRas

1

10

High-throughput

0.479

High

576981

CADH2
Cadherin-2

1

20

High-throughput

0.479

High

576986

MARK3
MAP/microtubule affinity-regulating kinase 3

1

2

High-throughput

0.479

High

576987

CALX
Calnexin

1

8

High-throughput

0.479

High

576992

CTNB1
Catenin beta-1

1

20

High-throughput

0.479

High

576997

MUC18
Cell surface glycoprotein MUC18

1

16

High-throughput

0.479

High

576999

BAG6
Large proline-rich protein BAG6

1

2

High-throughput

0.479

High

577001

NUMB
Protein numb homolog

1

4

High-throughput

0.479

High

577006

TERA
Transitional endoplasmic reticulum ATPase

1

5

High-throughput

0.479

High

577015

NOTC2
Neurogenic locus notch homolog protein 2

1

3

High-throughput

0.479

High

577019

ANK3
Ankyrin-3

1

1

High-throughput

0.479

High

577022

PDIA6
Protein disulfide-isomerase A6

1

13

High-throughput

0.479

High

577034

MARK2
Serine/threonine-protein kinase MARK2

1

2

High-throughput

0.479

High

577035

CYFP1
Cytoplasmic FMR1-interacting protein 1

1

2

High-throughput

0.479

High

577036

GRIN1
G protein-regulated inducer of neurite outgrowth 1

1

6

High-throughput

0.479

High

577038

TM11B
Transmembrane protease serine 11B

1

7

High-throughput

0.479

High

577041

UNC5B
Netrin receptor UNC5B

1

7

High-throughput

0.479

High

577042

TXND5
Thioredoxin domain-containing protein 5

1

13

High-throughput

0.479

High

577047

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

5

High-throughput

0.479

High

577048

GCN1
Stalled ribosome sensor GCN1

1

10

High-throughput

0.479

High

577049

KCNB2
Potassium voltage-gated channel subfamily B member 2

1

4

High-throughput

0.479

High

577050

TNPO1
Transportin-1

1

10

High-throughput

0.479

High

577054

CERS2
Ceramide synthase 2

1

4

High-throughput

0.479

High

577058

NIBA2
Protein Niban 2

1

1

High-throughput

0.479

High

577062

PAR6B
Partitioning defective 6 homolog beta

1

2

High-throughput

0.479

High

577065

E41L1
Band 4.1-like protein 1

1

7

High-throughput

0.479

High

577066

PEAK1
Inactive tyrosine-protein kinase PEAK1

1

5

High-throughput

0.479

High

577073

ATX10
Ataxin-10

1

1

High-throughput

0.479

High

577076

AMFR
E3 ubiquitin-protein ligase AMFR

1

13

High-throughput

0.479

High

577025

SMN
Survival motor neuron protein

1

1

High-throughput

0.470

High

206458

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.458

High

262366

TULP3
Tubby-related protein 3

1

0

High-throughput

0.458

High

335773

COX2
Cytochrome c oxidase subunit 2

1

0

High-throughput

0.458

High

533783

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

0

High-throughput

0.458

High

576985

AKAP5
A-kinase anchor protein 5

1

0

High-throughput

0.458

High

577023

L2GL1
Lethal(2) giant larvae protein homolog 1

1

0

High-throughput

0.458

High

577046

FRS2
Fibroblast growth factor receptor substrate 2

1

0

High-throughput

0.458

High

577051

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.458

High

577056

XPO6
Exportin-6

1

0

High-throughput

0.458

High

577057

ERBIN
Erbin

1

0

High-throughput

0.458

High

577064

S6A15
Sodium-dependent neutral amino acid transporter B(0)AT2

1

0

High-throughput

0.458

High

577068

TMM51
Transmembrane protein 51

1

0

High-throughput

0.458

High

577074

NCDN
Neurochondrin

1

0

High-throughput

0.458

High

239764

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

5

High-throughput

0.445

High

577021

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

8

High-throughput

0.445

High

577029

Q5VWH6
Protein tyrosine phosphatase receptor type E

1

14

High-throughput

0.445

High

130733

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.437

High

207885

XPOT
Exportin-T

1

13

High-throughput

0.437

High

577004

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

2

High-throughput

0.437

High

577028

NHSL1
NHS-like protein 1

1

7

High-throughput

0.437

High

577031

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.437

High

577053

SAAL1
Protein SAAL1

1

1

High-throughput

0.437

High

577063

XPO4
Exportin-4

1

6

High-throughput

0.437

High

577067

XPO5
Exportin-5

1

13

High-throughput

0.437

High

577070

PSD3
PH and SEC7 domain-containing protein 3

1

2

High-throughput

0.437

High

577078

TNPO3
Transportin-3

1

15

High-throughput

0.437

High

577081

NUMBL
Numb-like protein

1

4

High-throughput

0.437

High

237938

EXOC3
Exocyst complex component 3

2

0

High-throughput

0.305

High

577055

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

577016

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.279

Low

577030

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

1

0

High-throughput

0.279

Low

577072

UVRAG
UV radiation resistance-associated gene protein

1

0

High-throughput

0.279

Low

577008

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

High-throughput

0.265

Low

577002

RD23B
UV excision repair protein RAD23 homolog B

1

0

High-throughput

0.249

Low

577040

PHAR4
Phosphatase and actin regulator 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024