Protein: PUR2
Trifunctional purine biosynthetic protein adenosine-3 [Includes: Phosphoribosylamine--glycine ligase (EC 6.3.4.13) (Glycinamide ribonucleotide synthetase) (GARS) (Phosphoribosylglycinamide synthetase); Phosphoribosylformylglycinamidine cyclo-ligase (EC 6.3.3.1) (AIR synthase) (AIRS) (Phosphoribosyl-aminoimidazole synthetase); Phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) (5'-phosphoribosylglycinamide transformylase) (GAR transformylase) (GART)]

Gene: PUR2, GART
Organism: Homo sapiens
Interactions: 136
UniProt ID: P22102

Gene Ontology (top 5):
GO:0003360 - brainstem development
GO:0004637 - phosphoribosylamine-glycine ligase activity
GO:0004641 - phosphoribosylformylglycinamidine cyclo-ligase activity
GO:0004644 - phosphoribosylglycinamide formyltransferase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

604191

INP5K
Inositol polyphosphate 5-phosphatase K

3

0

High-throughput

0.646

High

226522

PRKN
E3 ubiquitin-protein ligase parkin

3

2

High-throughput

0.640

High

604155

CUL3
Cullin-3

2

1

High-throughput

0.611

High

604160

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

604167

ARHGI
Rho guanine nucleotide exchange factor 18

2

0

High-throughput

0.559

High

498207

KAP0
cAMP-dependent protein kinase type I-alpha regulatory subunit

2

0

High-throughput

0.547

High

604176

SH2D3
SH2 domain-containing protein 3C

2

0

High-throughput

0.547

High

496301

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.536

High

604126

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

604134

LIMK1
LIM domain kinase 1

1

1

High-throughput

0.536

High

604180

CUL5
Cullin-5

1

1

High-throughput

0.536

High

604188

DNJC7
DnaJ homolog subfamily C member 7

1

2

High-throughput

0.536

High

604218

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

604129

PAXI
Paxillin

1

0

High-throughput

0.518

High

604142

ARF6
ADP-ribosylation factor 6

1

1

High-throughput

0.515

High

604173

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

3

High-throughput

0.515

High

201214

M3K7
Mitogen-activated protein kinase kinase kinase 7

1

0

High-throughput

0.513

High

362816

FINC
Fibronectin

1

0

High-throughput

0.513

High

604143

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.513

High

604148

KPCZ
Protein kinase C zeta type

1

0

High-throughput

0.513

High

604149

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.513

High

604169

COX15
Heme A synthase COX15

1

0

High-throughput

0.513

High

604185

MYO19
Unconventional myosin-XIX

1

0

High-throughput

0.513

High

604203

RTN4
Reticulon-4

1

0

High-throughput

0.513

High

604212

NRBP
Nuclear receptor-binding protein

1

0

High-throughput

0.513

High

174620

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

604139

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.501

High

604217

TRAF6
TNF receptor-associated factor 6

1

0

Small-scale

0.480

High

325036

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.479

High

381799

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

2

High-throughput

0.479

High

604121

STIP1
Stress-induced-phosphoprotein 1

1

2

High-throughput

0.479

High

604123

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

604137

HDAC4
Histone deacetylase 4

1

1

High-throughput

0.479

High

604141

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

604144

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

1

High-throughput

0.479

High

604150

EP300
Histone acetyltransferase p300

1

1

High-throughput

0.479

High

604151

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

1

High-throughput

0.479

High

604157

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

604158

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

604172

Z3H7A
Zinc finger CCCH domain-containing protein 7A

1

3

High-throughput

0.479

High

604179

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

604182

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

604183

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

604189

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

604193

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

604195

KPCD2
Serine/threonine-protein kinase D2

1

1

High-throughput

0.479

High

604198

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

604200

Q9H4D1
Protein kinase

1

1

High-throughput

0.479

High

604204

ANLN
Anillin

1

1

High-throughput

0.479

High

604205

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

3

High-throughput

0.479

High

604210

HDAC6
Histone deacetylase 6

1

1

High-throughput

0.479

High

604211

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

329357

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.470

High

604133

IMA1
Importin subunit alpha-1

1

0

High-throughput

0.460

High

119164

LEG9
Galectin-9

1

0

High-throughput

0.458

High

148398

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

165813

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.458

High

255505

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

294364

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298152

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

322183

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

326437

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

375879

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

384262

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

386093

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

417153

ENOA
Alpha-enolase

1

0

High-throughput

0.458

High

503432

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

530830

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

1

0

High-throughput

0.458

High

542997

GLNA
Glutamine synthetase

1

0

High-throughput

0.458

High

604119

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

604131

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

604132

GSK3B
Glycogen synthase kinase-3 beta

1

0

High-throughput

0.458

High

604135

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

604136

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.458

High

604140

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

604145

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

604146

RON
Macrophage-stimulating protein receptor

1

0

High-throughput

0.458

High

604147

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.458

High

604152

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

604153

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

604154

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

604156

CUL7
Cullin-7

1

0

High-throughput

0.458

High

604159

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

604162

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

604163

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

604164

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

604166

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

604171

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

604174

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

604181

FBXW7
F-box/WD repeat-containing protein 7

1

0

High-throughput

0.458

High

604187

NECD
Necdin

1

0

High-throughput

0.458

High

604197

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

604202

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

604206

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

604208

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

604209

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

604213

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

604219

NEMO
NF-kappa-B essential modulator

1

0

High-throughput

0.458

High

604120

GRN
Progranulin

1

1

High-throughput

0.445

High

604138

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

604196

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

1

High-throughput

0.445

High

604199

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

1

High-throughput

0.445

High

604168

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

604201

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

528547

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

581426

VCAM1
Vascular cell adhesion protein 1

1

0

High-throughput

0.426

High

604184

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

401418

JUN
Transcription factor Jun

1

1

High-throughput

0.407

High

604190

SH3G3
Endophilin-A3

2

0

High-throughput

0.298

High

452624

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

604122

CNR2
Cannabinoid receptor 2

1

0

Small-scale

0.279

Low

604125

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

604128

NEST
Nestin

1

0

High-throughput

0.279

Low

604161

DREB
Drebrin

1

0

High-throughput

0.279

Low

604165

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

604194

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

233221

NUPR1
Nuclear protein 1

1

0

High-throughput

0.249

Low

241966

PAGE4
P antigen family member 4

1

0

High-throughput

0.249

Low

243932

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.249

Low

345928

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.249

Low

351255

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.249

Low

551945

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

569184

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.249

Low

604124

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

604127

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.249

Low

604130

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

604170

KCTD9
BTB/POZ domain-containing protein KCTD9

1

0

High-throughput

0.249

Low

604175

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

604177

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

604186

CIC
Protein capicua homolog

1

0

High-throughput

0.249

Low

604192

DERL1
Derlin-1

1

0

Small-scale

0.249

Low

604207

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

604214

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

High-throughput

0.249

Low

604215

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

604216

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.249

Low

604178

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024