Protein: ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (E-NPP 1) (Membrane component chromosome 6 surface marker 1) (Phosphodiesterase I/nucleotide pyrophosphatase 1) (Plasma-cell membrane glycoprotein PC-1) [Cleaved into: Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, secreted form] [Includes: Alkaline phosphodiesterase I (EC 3.1.4.1); Nucleotide pyrophosphatase (NPPase) (EC 3.6.1.9) (Nucleotide diphosphatase)]

Gene: ENPP1
Organism: Homo sapiens
Interactions: 50
UniProt ID: P22413

Gene Ontology (top 5):
GO:0003676 - nucleic acid binding
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004527 - exonuclease activity
GO:0004528 - phosphodiesterase I activity
GO:0004551 - dinucleotide phosphatase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

607761

PTC1
Protein patched homolog 1

3

2

High-throughput

0.667

High

607751

FNTB
Protein farnesyltransferase subunit beta

3

0

High-throughput

0.638

High

607766

5MP2
eIF5-mimic protein 2

3

0

High-throughput

0.638

High

411295

INSR
Insulin receptor

2

1

Small-scale

0.624

High

607756

CD81
CD81 antigen

2

2

Small-scale

0.601

High

607758

VA0D1
V-type proton ATPase subunit d 1

2

0

High-throughput

0.585

High

607762

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.585

High

607783

ABCG2
Broad substrate specificity ATP-binding cassette transporter ABCG2

1

0

Small-scale

0.554

High

161017

CLGN
Calmegin

1

6

High-throughput

0.536

High

449189

LEG1
Galectin-1

1

4

High-throughput

0.536

High

607749

CALX
Calnexin

1

6

High-throughput

0.536

High

607752

EI2BB
Translation initiation factor eIF2B subunit beta

1

1

High-throughput

0.536

High

607760

SQSTM
Sequestosome-1

1

1

High-throughput

0.536

High

607768

T106A
Transmembrane protein 106A

1

4

High-throughput

0.536

High

321273

TBCD8
TBC1 domain family member 8

1

0

High-throughput

0.513

High

557032

PGFRA
Platelet-derived growth factor receptor alpha

1

0

High-throughput

0.513

High

607753

GPC3
Glypican-3

1

0

High-throughput

0.513

High

607755

DEF1
Neutrophil defensin 1

1

0

High-throughput

0.513

High

607763

INSC
Protein inscuteable homolog

1

0

High-throughput

0.513

High

607778

STK36
Serine/threonine-protein kinase 36

1

0

High-throughput

0.513

High

271033

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

1

Small-scale

0.501

High

362453

C1QA
Complement C1q subcomponent subunit A

1

1

High-throughput

0.489

High

607764

CL12B
C-type lectin domain family 12 member B

1

4

High-throughput

0.489

High

607770

SAAL1
Protein SAAL1

1

1

High-throughput

0.489

High

607773

C1QT7
Complement C1q tumor necrosis factor-related protein 7

1

1

High-throughput

0.489

High

607782

FBX2
F-box only protein 2

1

4

High-throughput

0.489

High

119167

LEG9
Galectin-9

1

4

High-throughput

0.479

High

205046

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.479

High

241446

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

607754

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.479

High

607757

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

607769

LRC59
Leucine-rich repeat-containing protein 59

1

3

High-throughput

0.479

High

607774

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

607779

T106B
Transmembrane protein 106B

1

4

High-throughput

0.479

High

121932

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

0

Small-scale

0.458

High

319719

HERC2
E3 ubiquitin-protein ligase HERC2

1

0

High-throughput

0.458

High

503203

PPAL
Lysosomal acid phosphatase

1

0

High-throughput

0.458

High

607781

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

607767

H2B1H
Histone H2B type 1-H

1

2

High-throughput

0.437

High

607772

CALR3
Calreticulin-3

1

6

High-throughput

0.437

High

607777

FBX6
F-box only protein 6

1

4

High-throughput

0.437

High

607776

FANCE
Fanconi anemia group E protein

2

0

High-throughput

0.328

High

607759

LCN6
Epididymal-specific lipocalin-6

1

0

High-throughput

0.279

Low

607765

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.279

Low

607771

LCFC1
Sperm-egg fusion protein LLCFC1

1

0

High-throughput

0.279

Low

607775

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

0

High-throughput

0.279

Low

594445

PSB1
Proteasome subunit beta type-1

1

0

Small-scale

0.249

Low

607748

PSA1
Proteasome subunit alpha type-1

1

0

Small-scale

0.249

Low

607750

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

607780

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024