Protein: HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3)

Gene: HEM6, CPOX
Organism: Homo sapiens
Interactions: 43
UniProt ID: P36551

Gene Ontology (top 5):
GO:0004109 - coproporphyrinogen oxidase activity
GO:0005212 - structural constituent of eye lens
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005758 - mitochondrial intermembrane space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

325066

AIFM1
Apoptosis-inducing factor 1, mitochondrial

2

0

High-throughput

0.559

High

525442

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

736191

SFXN1
Sideroflexin-1

2

0

High-throughput

0.559

High

736171

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

0

High-throughput

0.518

High

736175

CUL3
Cullin-3

1

0

High-throughput

0.513

High

736179

STYX
Serine/threonine/tyrosine-interacting protein

1

0

Small-scale

0.513

High

226698

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

736174

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

736183

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.479

High

736188

S2551
Mitochondrial nicotinamide adenine dinucleotide transporter SLC25A51

1

1

High-throughput

0.479

High

736195

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.479

High

119217

LEG9
Galectin-9

1

0

High-throughput

0.458

High

203886

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.458

High

274500

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

276796

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

294459

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

318584

EYA4
Eyes absent homolog 4

1

0

High-throughput

0.458

High

503562

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

736167

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

736168

TCPZ
T-complex protein 1 subunit zeta

1

0

High-throughput

0.458

High

736169

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

736170

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

736172

LACTB
Serine beta-lactamase-like protein LACTB, mitochondrial

1

0

High-throughput

0.458

High

736173

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

736176

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

736178

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

736181

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.458

High

736182

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

736185

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

0

High-throughput

0.458

High

736186

PHB2
Prohibitin-2

1

0

High-throughput

0.458

High

736187

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.458

High

736189

PARL
Presenilin-associated rhomboid-like protein, mitochondrial

1

0

High-throughput

0.458

High

736190

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

736193

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

High-throughput

0.458

High

736194

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

736184

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.437

High

330885

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

736177

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

736196

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

0

High-throughput

0.426

High

551081

ITF2
Transcription factor 4

1

0

High-throughput

0.279

Low

736180

ATOH1
Transcription factor ATOH1

1

0

Small-scale

0.249

Low

736192

PLRKT
Plasminogen receptor

1

0

High-throughput

0.249

Low

401534

JUN
Transcription factor Jun

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024