Protein: SPCS2
Signal peptidase complex subunit 2 (Microsomal signal peptidase 25 kDa subunit) (SPase 25 kDa subunit)

Gene: SPCS2
Organism: Homo sapiens
Interactions: 130
UniProt ID: Q15005

Gene Ontology (top 5):
GO:0005787 - signal peptidase complex
GO:0005789 - endoplasmic reticulum membrane
GO:0006465 - signal peptide processing
GO:0045047 - protein targeting to ER

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1062478

SC11C
Signal peptidase complex catalytic subunit SEC11C

3

2

High-throughput

0.667

High

1062472

TECT2
Tectonic-2

3

1

High-throughput

0.609

High

654344

CALX
Calnexin

2

0

High-throughput

0.585

High

1062445

TGO1
Transport and Golgi organization protein 1 homolog

2

0

High-throughput

0.585

High

1062511

SPCS1
Signal peptidase complex subunit 1

2

0

High-throughput

0.585

High

266554

GPC4
Glypican-4

2

2

High-throughput

0.574

High

714843

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

2

2

High-throughput

0.574

High

1062505

TSP50
Probable threonine protease PRSS50

2

3

High-throughput

0.558

High

338447

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.551

High

207558

RNF13
E3 ubiquitin-protein ligase RNF13

1

3

High-throughput

0.536

High

931523

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

2

High-throughput

0.536

High

1062507

AMFR
E3 ubiquitin-protein ligase AMFR

1

1

High-throughput

0.536

High

502111

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.513

High

558728

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

0

High-throughput

0.513

High

894851

SPCS3
Signal peptidase complex subunit 3

1

0

High-throughput

0.513

High

1062468

NCLN
BOS complex subunit NCLN

1

0

High-throughput

0.513

High

1062470

CCD47
PAT complex subunit CCDC47

1

0

High-throughput

0.513

High

1062485

LMA1L
Protein ERGIC-53-like

1

0

High-throughput

0.513

High

1062498

VAPA
Vesicle-associated membrane protein-associated protein A

1

0

High-throughput

0.513

High

1062488

AT132
Polyamine-transporting ATPase 13A2

1

1

Small-scale

0.494

High

621783

PRTN3
Myeloblastin

1

3

High-throughput

0.489

High

941844

GPC5
Glypican-5 [Cleaved into: Secreted glypican-5]

1

2

High-throughput

0.489

High

348669

RASN
GTPase NRas

1

1

High-throughput

0.479

High

350178

RASK
GTPase KRas

1

1

High-throughput

0.479

High

436307

RHOC
Rho-related GTP-binding protein RhoC

1

3

High-throughput

0.479

High

545385

RAC2
Ras-related C3 botulinum toxin substrate 2

1

3

High-throughput

0.479

High

900484

RHOA
Transforming protein RhoA

1

3

High-throughput

0.479

High

951002

RHOG
Rho-related GTP-binding protein RhoG

1

3

High-throughput

0.479

High

1062454

SYVN1
E3 ubiquitin-protein ligase synoviolin

1

3

High-throughput

0.479

High

1062503

CLN8
Protein CLN8

1

0

Small-scale

0.460

High

163809

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

0

High-throughput

0.458

High

390240

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

390894

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

795135

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

847474

BAP31
B-cell receptor-associated protein 31

1

0

High-throughput

0.458

High

890155

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

976214

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.458

High

990450

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1062441

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.458

High

1062444

MKS3
Meckelin

1

0

High-throughput

0.458

High

1062450

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

1062461

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.458

High

1062469

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

0

High-throughput

0.458

High

1062471

LRC59
Leucine-rich repeat-containing protein 59

1

0

High-throughput

0.458

High

1062475

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1062477

DERL1
Derlin-1

1

0

High-throughput

0.458

High

1062480

LNP
Endoplasmic reticulum junction formation protein lunapark

1

0

High-throughput

0.458

High

1062482

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

0

High-throughput

0.458

High

1062495

ELOV5
Very long chain fatty acid elongase 5

1

0

High-throughput

0.458

High

1062501

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

507025

LAMP1
Lysosome-associated membrane glycoprotein 1

1

1

High-throughput

0.437

High

595234

LMNB1
Lamin-B1

1

1

High-throughput

0.437

High

1062448

TECT3
Tectonic-3

1

1

High-throughput

0.437

High

1062453

TM11B
Transmembrane protease serine 11B

1

1

High-throughput

0.437

High

1062457

GOLI
E3 ubiquitin-protein ligase RNF130

1

4

High-throughput

0.437

High

1062463

RN149
E3 ubiquitin-protein ligase RNF149

1

4

High-throughput

0.437

High

1062491

TMPS4
Transmembrane protease serine 4

1

1

High-throughput

0.437

High

1062497

PD1L1
Programmed cell death 1 ligand 1

1

1

High-throughput

0.437

High

1062509

LAMP3
Lysosome-associated membrane glycoprotein 3

1

1

High-throughput

0.437

High

1062446

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

824922

DNSL1
Deoxyribonuclease-1-like 1

3

0

High-throughput

0.347

High

1062447

PVRIG
Transmembrane protein PVRIG

3

0

High-throughput

0.347

High

1062476

TM2D3
TM2 domain-containing protein 3

3

0

High-throughput

0.347

High

315887

VNN2
Pantetheine hydrolase VNN2

2

0

High-throughput

0.328

High

398467

PPBT
Alkaline phosphatase, tissue-nonspecific isozyme

2

0

High-throughput

0.328

High

1062460

FXL14
F-box/LRR-repeat protein 14

2

0

High-throughput

0.328

High

1062502

MGT4C
Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C

2

0

High-throughput

0.328

High

1062506

ADA30
Disintegrin and metalloproteinase domain-containing protein 30

2

0

High-throughput

0.328

High

905513

TSN5
Tetraspanin-5

2

0

High-throughput

0.318

High

941857

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

2

0

High-throughput

0.318

High

123599

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.279

Low

571133

EGLN
Endoglin

1

0

High-throughput

0.279

Low

682608

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

0

High-throughput

0.279

Low

856381

EFNA4
Ephrin-A4

1

0

High-throughput

0.279

Low

1023045

STK4
Serine/threonine-protein kinase 4

1

0

High-throughput

0.279

Low

1062442

AMHR2
Anti-Muellerian hormone type-2 receptor

1

0

High-throughput

0.279

Low

1062449

ARSK
Arylsulfatase K

1

0

High-throughput

0.279

Low

1062458

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.279

Low

1062465

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.279

Low

1062479

RTN4R
Reticulon-4 receptor

1

0

High-throughput

0.279

Low

1062483

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.279

Low

1062486

TREM1
Triggering receptor expressed on myeloid cells 1

1

0

High-throughput

0.279

Low

1062487

NRN1
Neuritin

1

0

High-throughput

0.279

Low

1062490

FBX6
F-box only protein 6

1

0

High-throughput

0.279

Low

1062492

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.279

Low

1062510

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.279

Low

1062512

WNT6
Protein Wnt-6

1

0

High-throughput

0.279

Low

119382

LEG9
Galectin-9

1

0

High-throughput

0.249

Low

160571

AURKA
Aurora kinase A

1

0

High-throughput

0.249

Low

167920

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.249

Low

205406

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

227482

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.249

Low

344980

CYTN
Cystatin-SN

1

0

Small-scale

0.249

Low

386751

P53
Cellular tumor antigen p53

1

0

High-throughput

0.249

Low

402024

JUN
Transcription factor Jun

1

0

High-throughput

0.249

Low

552752

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

651232

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

720493

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

779431

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

781021

OPRD
Delta-type opioid receptor

1

0

Small-scale

0.249

Low

801883

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.249

Low

832470

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.249

Low

844527

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.249

Low

917290

H4
Histone H4

1

0

High-throughput

0.249

Low

940915

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.249

Low

1062443

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.249

Low

1062451

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1062452

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1062455

LBN
Limbin

1

0

High-throughput

0.249

Low

1062456

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1062459

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

1062462

DHB11
Estradiol 17-beta-dehydrogenase 11

1

0

High-throughput

0.249

Low

1062464

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.249

Low

1062466

PTPR2
Receptor-type tyrosine-protein phosphatase N2

1

0

High-throughput

0.249

Low

1062467

TNR14
Tumor necrosis factor receptor superfamily member 14

1

0

High-throughput

0.249

Low

1062481

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low

1062484

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1062489

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1062493

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1062494

DDX56
Probable ATP-dependent RNA helicase DDX56

1

0

High-throughput

0.249

Low

1062499

TM216
Transmembrane protein 216

1

0

High-throughput

0.249

Low

1062500

SIRPG
Signal-regulatory protein gamma

1

0

High-throughput

0.249

Low

1062504

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1062508

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.249

Low

416429

S10A9
Protein S100-A9

1

0

Small-scale

0.238

Low

1062474

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.238

Low

1062496

STMN3
Stathmin-3

1

0

High-throughput

0.238

Low

497035

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.232

Low

789274

CNDD3
Condensin-2 complex subunit D3

1

0

High-throughput

0.232

Low

1062473

BT2A3
Putative butyrophilin subfamily 2 member A3

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024