Protein: M4K2
Mitogen-activated protein kinase kinase kinase kinase 2 (EC 2.7.11.1) (B lymphocyte serine/threonine-protein kinase) (Germinal center kinase) (GC kinase) (MAPK/ERK kinase kinase kinase 2) (MEK kinase kinase 2) (MEKKK 2) (Rab8-interacting protein)

Gene: M4K2, MAP4K2
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q12851

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006468 - protein phosphorylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1018152

M3K1
Mitogen-activated protein kinase kinase kinase 1

2

20

Small-scale

0.789

High

325708

LATS1
Serine/threonine-protein kinase LATS1

2

20

Small-scale

0.778

High

894728

RAB8A
Ras-related protein Rab-8A

1

8

Small-scale

0.713

High

1018151

STK3
Serine/threonine-protein kinase 3

1

16

High-throughput

0.691

High

1018159

CDC37
Hsp90 co-chaperone Cdc37

1

9

High-throughput

0.691

High

1018180

CDKL2
Cyclin-dependent kinase-like 2

1

11

High-throughput

0.691

High

1018183

SRPK1
SRSF protein kinase 1

1

17

High-throughput

0.691

High

1018161

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

11

Small-scale

0.665

High

609828

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

9

High-throughput

0.656

High

800977

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

19

Small-scale

0.647

High

431786

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

438112

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

958178

RBM3
RNA-binding protein 3

1

4

High-throughput

0.618

High

992740

SRSF1
Serine/arginine-rich splicing factor 1

1

6

High-throughput

0.618

High

1017869

GRSF1
G-rich sequence factor 1

1

7

High-throughput

0.618

High

1018153

SRSF9
Serine/arginine-rich splicing factor 9

1

9

High-throughput

0.618

High

1018154

G3BP1
Ras GTPase-activating protein-binding protein 1

1

9

High-throughput

0.618

High

1018156

CIRBP
Cold-inducible RNA-binding protein

1

7

High-throughput

0.618

High

1018158

RNPS1
RNA-binding protein with serine-rich domain 1

1

4

High-throughput

0.618

High

1018162

RA1L2
Heterogeneous nuclear ribonucleoprotein A1-like 2

1

11

High-throughput

0.618

High

1018170

M4K3
Mitogen-activated protein kinase kinase kinase kinase 3

1

15

High-throughput

0.618

High

1018182

AURKB
Aurora kinase B

1

17

High-throughput

0.618

High

1018207

M4K5
Mitogen-activated protein kinase kinase kinase kinase 5

1

17

High-throughput

0.618

High

1018160

U1SBP
U11/U12 small nuclear ribonucleoprotein 35 kDa protein

1

3

High-throughput

0.587

High

306141

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

16

High-throughput

0.561

High

891114

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

16

High-throughput

0.561

High

1018149

TRAF2
TNF receptor-associated factor 2

1

20

Small-scale

0.561

High

441270

RU2B
U2 small nuclear ribonucleoprotein B''

1

8

High-throughput

0.553

High

963974

SRSF2
Serine/arginine-rich splicing factor 2

1

3

High-throughput

0.553

High

1018185

RBM4B
RNA-binding protein 4B

1

4

High-throughput

0.553

High

1018193

PKHA5
Pleckstrin homology domain-containing family A member 5

1

20

High-throughput

0.553

High

1018204

SF3B6
Splicing factor 3B subunit 6

1

9

High-throughput

0.553

High

1018157

NAA30
N-alpha-acetyltransferase 30

1

2

High-throughput

0.536

High

1018189

GBRL1
Gamma-aminobutyric acid receptor-associated protein-like 1

1

16

High-throughput

0.512

High

166505

NACAD
NAC-alpha domain-containing protein 1

1

5

High-throughput

0.508

High

523702

XRCC6
X-ray repair cross-complementing protein 6

1

2

High-throughput

0.508

High

1018195

STRN4
Striatin-4

1

20

High-throughput

0.501

High

147327

DPYL4
Dihydropyrimidinase-related protein 4

1

6

High-throughput

0.489

High

887753

DEFB1
Beta-defensin 1

1

0

High-throughput

0.486

High

269710

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

7

High-throughput

0.479

High

603153

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

3

High-throughput

0.479

High

846687

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2

1

2

High-throughput

0.479

High

922813

RL32
Large ribosomal subunit protein eL32

1

3

High-throughput

0.479

High

1018163

PDZ11
PDZ domain-containing protein 11

1

14

High-throughput

0.479

High

1018167

LN28B
Protein lin-28 homolog B

1

6

High-throughput

0.479

High

1018168

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

12

High-throughput

0.479

High

1018169

LUZP1
Leucine zipper protein 1

1

20

High-throughput

0.479

High

1018184

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

5

High-throughput

0.479

High

1018187

PYM1
Partner of Y14 and mago

1

1

High-throughput

0.479

High

1018190

DDX47
Probable ATP-dependent RNA helicase DDX47

1

9

High-throughput

0.479

High

1018200

DDX41
Probable ATP-dependent RNA helicase DDX41

1

6

High-throughput

0.479

High

1018202

RTRAF
RNA transcription, translation and transport factor protein

1

1

High-throughput

0.479

High

1018206

RL36
Large ribosomal subunit protein eL36

1

2

High-throughput

0.479

High

669250

KAIN
Kallistatin

1

2

High-throughput

0.464

High

1018150

PRDX4
Peroxiredoxin-4

1

5

High-throughput

0.464

High

243058

KIN17
DNA/RNA-binding protein KIN17

1

0

High-throughput

0.458

High

1018164

CI114
Putative methyltransferase C9orf114

1

0

High-throughput

0.458

High

1018175

CHSTE
Carbohydrate sulfotransferase 14

1

0

High-throughput

0.458

High

1018181

ZN622
Cytoplasmic 60S subunit biogenesis factor ZNF622

1

0

High-throughput

0.458

High

119820

SMAP
Small acidic protein

1

2

High-throughput

0.437

High

119954

AP3B1
AP-3 complex subunit beta-1

1

5

High-throughput

0.437

High

197010

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

10

High-throughput

0.437

High

259581

HMMR
Hyaluronan mediated motility receptor

1

20

High-throughput

0.437

High

453803

RU2A
U2 small nuclear ribonucleoprotein A'

1

9

High-throughput

0.437

High

583470

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.437

High

958892

TFAM
Transcription factor A, mitochondrial

1

4

High-throughput

0.437

High

1018155

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.437

High

1018166

RM14
Large ribosomal subunit protein uL14m

1

1

High-throughput

0.437

High

1018171

PHF6
PHD finger protein 6

1

5

High-throughput

0.437

High

1018177

TFB1M
Dimethyladenosine transferase 1, mitochondrial

1

1

High-throughput

0.437

High

1018178

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

2

High-throughput

0.437

High

1018186

CG050
Uncharacterized protein C7orf50

1

1

High-throughput

0.437

High

1018188

MMTA2
Multiple myeloma tumor-associated protein 2

1

1

High-throughput

0.437

High

1018191

CH033
UPF0488 protein C8orf33

1

1

High-throughput

0.437

High

1018192

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

4

High-throughput

0.437

High

1018197

NHP2
H/ACA ribonucleoprotein complex subunit 2

1

3

High-throughput

0.437

High

1018198

RCC2
Protein RCC2

1

6

High-throughput

0.437

High

1018199

TRM6
tRNA

1

1

High-throughput

0.437

High

1018201

DIM1
Probable dimethyladenosine transferase

1

1

High-throughput

0.437

High

1018203

AP3M1
AP-3 complex subunit mu-1

1

2

High-throughput

0.437

High

1018205

RM11
Large ribosomal subunit protein uL11m

1

1

High-throughput

0.437

High

401910

JUN
Transcription factor Jun

1

3

High-throughput

0.407

High

1018196

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.296

High

426628

H10
Histone H1.0

1

0

High-throughput

0.249

Low

602089

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

0

High-throughput

0.249

Low

603474

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.249

Low

666387

3MG
DNA-3-methyladenine glycosylase

1

0

High-throughput

0.249

Low

854297

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.249

Low

912437

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.249

Low

1018165

RM54
Large ribosomal subunit protein mL54

1

0

High-throughput

0.249

Low

1018172

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.249

Low

1018173

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.249

Low

1018174

RP25L
Ribonuclease P protein subunit p25-like protein

1

0

High-throughput

0.249

Low

1018176

BRX1
Ribosome biogenesis protein BRX1 homolog

1

0

High-throughput

0.249

Low

1018179

RTF1
RNA polymerase-associated protein RTF1 homolog

1

0

High-throughput

0.249

Low

1018194

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024