Protein: SPI1
Transcription factor PU.1 (31 kDa-transforming protein)

Gene: SPI1
Organism: Homo sapiens
Interactions: 77
UniProt ID: P17947

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

506098

ITAM
Integrin alpha-M

5

2

Small-scale

0.706

High

572557

IRF8
Interferon regulatory factor 8

4

10

Small-scale

0.699

High

572538

GATA2
Endothelial transcription factor GATA-2

3

14

Small-scale

0.690

High

352981

IL1B
Interleukin-1 beta

4

3

Small-scale

0.676

High

572566

IRF4
Interferon regulatory factor 4

3

10

Small-scale

0.650

High

541977

ETS1
Protein C-ets-1

1

18

Small-scale

0.647

High

542731

ETS2
Protein C-ets-2

1

17

Small-scale

0.647

High

572551

ETV1
ETS translocation variant 1

1

19

Small-scale

0.647

High

572556

SPIB
Transcription factor Spi-B

1

17

Small-scale

0.647

High

401381

JUN
Transcription factor Jun

3

20

Small-scale

0.646

High

554403

GATA1
Erythroid transcription factor

3

14

Small-scale

0.646

High

572562

HDAC1
Histone deacetylase 1

3

10

Small-scale

0.646

High

500987

IRF1
Interferon regulatory factor 1

2

10

Small-scale

0.646

High

572533

TBP
TATA-box-binding protein

2

5

Small-scale

0.634

High

572552

MECP2
Methyl-CpG-binding protein 2

2

3

Small-scale

0.629

High

507362

ERG
Transcriptional regulator ERG

1

17

Small-scale

0.618

High

572548

CEBPA
CCAAT/enhancer-binding protein alpha

2

15

Small-scale

0.595

High

572544

FUS
RNA-binding protein FUS

1

7

Small-scale

0.586

High

426984

CSF1R
Macrophage colony-stimulating factor 1 receptor

2

2

Small-scale

0.584

High

572542

C2TA
MHC class II transactivator

2

2

Small-scale

0.584

High

414160

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.578

High

572573

GFI1
Zinc finger protein Gfi-1

1

4

Small-scale

0.578

High

521213

SKI
Ski oncogene

1

1

Small-scale

0.561

High

572545

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.561

High

572550

GSK3B
Glycogen synthase kinase-3 beta

1

4

Small-scale

0.561

High

572565

NONO
Non-POU domain-containing octamer-binding protein

1

5

Small-scale

0.561

High

572568

FBXW7
F-box/WD repeat-containing protein 7

1

3

Small-scale

0.561

High

572572

SIN3A
Paired amphipathic helix protein Sin3a

1

5

Small-scale

0.561

High

572575

DNM3B
DNA

1

2

Small-scale

0.561

High

572579

DNM3A
DNA

1

2

Small-scale

0.561

High

572554

PRKDC
DNA-dependent protein kinase catalytic subunit

1

8

Small-scale

0.550

High

389774

CY24B
Cytochrome b-245 heavy chain

2

1

Small-scale

0.549

High

572564

Q15156
PML-RAR protein

1

14

Small-scale

0.536

High

572541

HXA10
Homeobox protein Hox-A10

1

14

Small-scale

0.534

High

572549

CEBPD
CCAAT/enhancer-binding protein delta

1

20

Small-scale

0.515

High

252901

MITF
Microphthalmia-associated transcription factor

1

3

Small-scale

0.501

High

345315

FOS
Protein c-Fos

1

19

Small-scale

0.501

High

536469

IRF2
Interferon regulatory factor 2

1

10

Small-scale

0.501

High

569147

CEBPB
CCAAT/enhancer-binding protein beta

1

15

Small-scale

0.501

High

572532

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

10

Small-scale

0.501

High

572537

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.501

High

572539

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

14

Small-scale

0.501

High

572547

MK08
Mitogen-activated protein kinase 8

1

16

Small-scale

0.501

High

572553

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

572555

RUNX1
Runt-related transcription factor 1

1

5

Small-scale

0.501

High

572558

CREM
cAMP-responsive element modulator

1

8

Small-scale

0.501

High

572574

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.494

High

572570

YTDC1
YTH domain-containing protein 1

1

0

High-throughput

0.493

High

120132

TLR4
Toll-like receptor 4

1

6

Small-scale

0.479

High

160371

AURKA
Aurora kinase A

1

2

High-throughput

0.479

High

177187

HDAC3
Histone deacetylase 3

1

10

Small-scale

0.479

High

397764

ISG15
Ubiquitin-like protein ISG15

1

2

Small-scale

0.479

High

487898

RARA
Retinoic acid receptor alpha

1

10

Small-scale

0.479

High

572535

NF1
Neurofibromin

1

1

Small-scale

0.479

High

572536

IL10
Interleukin-10

1

2

Small-scale

0.479

High

572540

PML
Protein PML

1

18

Small-scale

0.479

High

572546

CATK
Cathepsin K

1

2

Small-scale

0.479

High

572559

KPCD
Protein kinase C delta type

1

2

Small-scale

0.479

High

572561

FOXC1
Forkhead box protein C1

1

13

High-throughput

0.479

High

572567

CEBPE
CCAAT/enhancer-binding protein epsilon

1

16

Small-scale

0.479

High

572576

LIMD1
LIM domain-containing protein 1

1

6

Small-scale

0.479

High

572578

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

1

Small-scale

0.479

High

548631

VAV
Proto-oncogene vav

1

2

Small-scale

0.470

High

572543

CD68
Macrosialin

1

3

Small-scale

0.470

High

515695

CD20
B-lymphocyte antigen CD20

1

0

Small-scale

0.458

High

572569

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

572571

ZN300
Zinc finger protein 300

1

0

Small-scale

0.458

High

455072

PARP1
Poly [ADP-ribose] polymerase 1

1

4

Small-scale

0.445

High

523507

XRCC6
X-ray repair cross-complementing protein 6

1

11

Small-scale

0.445

High

524786

XRCC5
X-ray repair cross-complementing protein 5

1

11

Small-scale

0.445

High

426944

FES
Tyrosine-protein kinase Fes/Fps

1

4

Small-scale

0.437

High

572534

ITAX
Integrin alpha-X

1

2

Small-scale

0.437

High

572563

AGRE1
Adhesion G protein-coupled receptor E1

1

1

Small-scale

0.437

High

572560

SSRP1
FACT complex subunit SSRP1

1

20

Small-scale

0.381

High

532892

PRG2
Bone marrow proteoglycan

1

0

Small-scale

0.249

Low

572577

EVL
Ena/VASP-like protein

1

0

Small-scale

0.249

Low

572580

LY96
Lymphocyte antigen 96

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024