Protein: FADS1
Acyl-CoA (8-3)-desaturase (EC 1.14.19.44) (Delta(5) fatty acid desaturase) (D5D) (Delta(5) desaturase) (Delta-5 desaturase) (Fatty acid desaturase 1)

Gene: FADS1
Organism: Homo sapiens
Interactions: 81
UniProt ID: O60427

Gene Ontology (top 5):
GO:0000248 - C-5 sterol desaturase activity
GO:0005739 - mitochondrion
GO:0005789 - endoplasmic reticulum membrane
GO:0006355 - regulation of DNA-templated transcription
GO:0006629 - lipid metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

234127

SIR2
NAD-dependent protein deacetylase sirtuin-2

3

0

High-throughput

0.638

High

234106

VMAT1
Chromaffin granule amine transporter

2

5

High-throughput

0.628

High

234100

CD80
T-lymphocyte activation antigen CD80

1

2

High-throughput

0.618

High

234119

TMCO3
Transmembrane and coiled-coil domain-containing protein 3

2

0

High-throughput

0.602

High

234153

UQCC1
Ubiquinol-cytochrome c reductase complex assembly factor 1

2

0

High-throughput

0.602

High

234096

NK1R
Substance-P receptor

2

4

High-throughput

0.574

High

234097

5HT2C
5-hydroxytryptamine receptor 2C

2

1

High-throughput

0.574

High

234099

GRPR
Gastrin-releasing peptide receptor

2

4

High-throughput

0.574

High

234118

S39AC
Zinc transporter ZIP12

2

1

High-throughput

0.574

High

234139

GPR21
Probable G-protein coupled receptor 21

2

1

High-throughput

0.574

High

234113

PTH1R
Parathyroid hormone/parathyroid hormone-related peptide receptor

2

1

High-throughput

0.558

High

171896

GP182
G-protein coupled receptor 182

1

8

High-throughput

0.536

High

173253

S22A2
Solute carrier family 22 member 2

1

1

High-throughput

0.536

High

234088

TSN15
Tetraspanin-15

1

4

High-throughput

0.536

High

234090

CD63
CD63 antigen

1

4

High-throughput

0.536

High

234095

FPR1
fMet-Leu-Phe receptor

1

6

High-throughput

0.536

High

234098

V2R
Vasopressin V2 receptor

1

2

High-throughput

0.536

High

234102

GLR
Glucagon receptor

1

1

High-throughput

0.536

High

234104

PSN1
Presenilin-1

1

1

High-throughput

0.536

High

234116

PTHD3
Patched domain-containing protein 3

1

2

High-throughput

0.536

High

234130

ABCA6
ATP-binding cassette sub-family A member 6

1

1

High-throughput

0.536

High

234140

CML1
Chemerin-like receptor 1

1

6

High-throughput

0.536

High

234145

S22A4
Solute carrier family 22 member 4

1

1

High-throughput

0.536

High

234150

AT133
Polyamine-transporting ATPase 13A3

1

4

High-throughput

0.536

High

234159

SC5A6
Sodium-dependent multivitamin transporter

1

1

High-throughput

0.536

High

234103

SYHM
Histidine--tRNA ligase, mitochondrial

1

1

High-throughput

0.515

High

234157

DHCR7
7-dehydrocholesterol reductase

1

1

High-throughput

0.515

High

234094

KCNA2
Potassium voltage-gated channel subfamily A member 2

1

0

High-throughput

0.513

High

234135

BSCL2
Seipin

1

0

High-throughput

0.513

High

234136

VMP1
Vacuole membrane protein 1

1

0

High-throughput

0.513

High

234137

ZDH12
Palmitoyltransferase ZDHHC12

1

0

High-throughput

0.513

High

234143

ASPC1
Tether containing UBX domain for GLUT4

1

0

High-throughput

0.513

High

234147

TTYH1
Protein tweety homolog 1

1

0

High-throughput

0.513

High

234160

B3GT5
Beta-1,3-galactosyltransferase 5

1

0

High-throughput

0.513

High

234161

BACE2
Beta-secretase 2

1

0

High-throughput

0.513

High

208445

OX2R
Orexin receptor type 2

1

3

High-throughput

0.489

High

234101

OPRX
Nociceptin receptor

1

3

High-throughput

0.489

High

234108

CXCR4
C-X-C chemokine receptor type 4

1

5

High-throughput

0.489

High

234114

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

5

High-throughput

0.489

High

234121

VSTM1
V-set and transmembrane domain-containing protein 1

1

1

High-throughput

0.489

High

234123

SV2A
Synaptic vesicle glycoprotein 2A

1

2

High-throughput

0.489

High

234134

NPL4
Nuclear protein localization protein 4 homolog

1

1

High-throughput

0.489

High

234154

SC5A4
Probable glucose sensor protein SLC5A4

1

1

High-throughput

0.489

High

225991

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

234091

PARP1
Poly [ADP-ribose] polymerase 1

1

1

High-throughput

0.479

High

234093

RAC2
Ras-related C3 botulinum toxin substrate 2

1

10

High-throughput

0.479

High

234107

CDC42
Cell division control protein 42 homolog

1

12

High-throughput

0.479

High

234109

RHOA
Transforming protein RhoA

1

11

High-throughput

0.479

High

234115

RHOH
Rho-related GTP-binding protein RhoH

1

11

High-throughput

0.479

High

234125

TAXB1
Tax1-binding protein 1

1

2

High-throughput

0.479

High

234141

PAAF1
Proteasomal ATPase-associated factor 1

1

1

High-throughput

0.470

High

234129

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.460

High

234110

H4
Histone H4

1

0

High-throughput

0.458

High

234120

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

234126

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.458

High

234144

MLP3B
Microtubule-associated proteins 1A/1B light chain 3B

1

0

High-throughput

0.458

High

234092

FGFR1
Fibroblast growth factor receptor 1

1

1

High-throughput

0.445

High

120228

RHOD
Rho-related GTP-binding protein RhoD

1

13

High-throughput

0.437

High

234089

MYC
Myc proto-oncogene protein

1

1

High-throughput

0.437

High

234105

RND2
Rho-related GTP-binding protein RhoN

1

11

High-throughput

0.437

High

234111

RNF4
E3 ubiquitin-protein ligase RNF4

1

5

High-throughput

0.437

High

234122

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

234124

RHOU
Rho-related GTP-binding protein RhoU

1

14

High-throughput

0.437

High

234138

RHOV
Rho-related GTP-binding protein RhoV

1

13

High-throughput

0.437

High

234142

RHBT2
Rho-related BTB domain-containing protein 2

1

10

High-throughput

0.437

High

234148

RHOJ
Rho-related GTP-binding protein RhoJ

1

11

High-throughput

0.437

High

234149

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

234151

RHOF
Rho-related GTP-binding protein RhoF

1

12

High-throughput

0.437

High

234112

GBRE
Gamma-aminobutyric acid receptor subunit epsilon

3

0

High-throughput

0.347

High

234132

I17RC
Interleukin-17 receptor C

2

0

High-throughput

0.328

High

234155

RN181
E3 ubiquitin-protein ligase RNF181

2

0

High-throughput

0.328

High

234086

CCD22
Coiled-coil domain-containing protein 22

1

0

High-throughput

0.279

Low

234087

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

High-throughput

0.279

Low

234117

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.279

Low

234131

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

234133

OR2M7
Olfactory receptor 2M7

1

0

High-throughput

0.279

Low

234152

NCKX3
Sodium/potassium/calcium exchanger 3

1

0

High-throughput

0.279

Low

234156

CSC1
Calcium permeable stress-gated cation channel 1

1

0

High-throughput

0.279

Low

234158

LAT2
Large neutral amino acids transporter small subunit 2

1

0

High-throughput

0.279

Low

234128

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.249

Low

234146

TOLIP
Toll-interacting protein

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024