Protein: SLK
STE20-like serine/threonine-protein kinase (STE20-like kinase) (hSLK) (EC 2.7.11.1) (CTCL tumor antigen se20-9) (STE20-related serine/threonine-protein kinase) (STE20-related kinase) (Serine/threonine-protein kinase 2)

Gene: SLK
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q9H2G2

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

915964

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1329362

SLK
STE20-like serine/threonine-protein kinase

1

18

Small-scale

0.716

High

120634

RHOD
Rho-related GTP-binding protein RhoD

1

20

High-throughput

0.691

High

201828

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

7

High-throughput

0.691

High

278874

DNJC8
DnaJ homolog subfamily C member 8

1

5

High-throughput

0.691

High

686741

CCR1
C-C chemokine receptor type 1

1

1

High-throughput

0.691

High

972251

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

20

High-throughput

0.691

High

1083227

KCC4
Calcium/calmodulin-dependent protein kinase type IV

1

19

High-throughput

0.691

High

1329373

DAPK2
Death-associated protein kinase 2

1

20

High-throughput

0.691

High

1049328

KEAP1
Kelch-like ECH-associated protein 1

3

4

Small-scale

0.650

High

361922

FIBB
Fibrinogen beta chain [Cleaved into: Fibrinopeptide B; Fibrinogen beta chain]

2

5

High-throughput

0.628

High

1121801

ANR39
Ankyrin repeat domain-containing protein 39

1

16

High-throughput

0.618

High

1235644

ZBTB2
Zinc finger and BTB domain-containing protein 2

1

9

High-throughput

0.618

High

1329369

RBM28
RNA-binding protein 28

1

8

High-throughput

0.618

High

1329371

ZIM2
Zinc finger imprinted 2

1

11

High-throughput

0.618

High

166488

MCF2L
Guanine nucleotide exchange factor DBS

1

20

High-throughput

0.618

High

228670

PRKN
E3 ubiquitin-protein ligase parkin

1

17

High-throughput

0.618

High

232978

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

11

High-throughput

0.618

High

296419

STK10
Serine/threonine-protein kinase 10

1

17

High-throughput

0.618

High

385503

NTRK1
High affinity nerve growth factor receptor

1

20

High-throughput

0.618

High

436499

RHOC
Rho-related GTP-binding protein RhoC

1

20

High-throughput

0.618

High

780086

CCNF
Cyclin-F

1

5

High-throughput

0.618

High

900884

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

1036895

SQSTM
Sequestosome-1

1

8

High-throughput

0.618

High

1050265

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

20

High-throughput

0.618

High

1171672

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.618

High

1329364

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.618

High

504746

HSP7C
Heat shock cognate 71 kDa protein

2

18

High-throughput

0.611

High

808919

YAP1
Transcriptional coactivator YAP1

2

20

High-throughput

0.611

High

664127

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

751824

GRP75
Stress-70 protein, mitochondrial

2

20

High-throughput

0.601

High

323122

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

12

High-throughput

0.584

High

1239232

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.578

High

1130576

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

15

High-throughput

0.575

High

1329366

RAB18
Ras-related protein Rab-18

1

13

High-throughput

0.575

High

1261495

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

2

High-throughput

0.574

High

127865

SAP18
Histone deacetylase complex subunit SAP18

1

1

High-throughput

0.536

High

324028

BAG2
BAG family molecular chaperone regulator 2

1

5

High-throughput

0.536

High

591412

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

2

High-throughput

0.536

High

675228

CLIP1
CAP-Gly domain-containing linker protein 1

1

20

High-throughput

0.536

High

871777

HSP72
Heat shock-related 70 kDa protein 2

1

18

High-throughput

0.536

High

1046334

EXOS2
Exosome complex component RRP4

1

2

High-throughput

0.536

High

1046953

BYST
Bystin

1

2

High-throughput

0.536

High

1185499

MOB1B
MOB kinase activator 1B

1

18

High-throughput

0.536

High

1244841

BBS1
Bardet-Biedl syndrome 1 protein

1

4

High-throughput

0.536

High

1274136

VPP1
V-type proton ATPase 116 kDa subunit a 1

1

1

High-throughput

0.536

High

1292655

DDX27
Probable ATP-dependent RNA helicase DDX27

1

18

High-throughput

0.536

High

1303740

CDC5L
Cell division cycle 5-like protein

1

11

High-throughput

0.536

High

1329363

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

11

High-throughput

0.536

High

1329374

RUVB2
RuvB-like 2

1

4

High-throughput

0.536

High

1329375

RUVB1
RuvB-like 1

1

4

High-throughput

0.536

High

1132922

NHRF3
Na(+)/H(+) exchange regulatory cofactor NHE-RF3

1

20

Small-scale

0.527

High

325390

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

1

High-throughput

0.515

High

213745

ENSA
Alpha-endosulfine

1

0

High-throughput

0.513

High

533730

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.513

High

679635

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.513

High

809871

GLYG
Glycogenin-1

1

0

High-throughput

0.513

High

867256

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.513

High

1329376

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.513

High

623367

AT5F1
ATP synthase F(0) complex subunit B1, mitochondrial

1

1

High-throughput

0.489

High

1170418

TBCD9
TBC1 domain family member 9

1

5

High-throughput

0.489

High

1192021

MILR1
Allergin-1

1

10

High-throughput

0.489

High

1242397

MISSL
MAPK-interacting and spindle-stabilizing protein-like

1

9

High-throughput

0.489

High

1289796

KBP
KIF-binding protein

1

2

High-throughput

0.489

High

1291142

BORC8
BLOC-1-related complex subunit 8

1

1

High-throughput

0.489

High

1327732

NSRP1
Nuclear speckle splicing regulatory protein 1

1

3

High-throughput

0.489

High

1329365

SUV92
Histone-lysine N-methyltransferase SUV39H2

1

6

High-throughput

0.489

High

1329368

MED17
Mediator of RNA polymerase II transcription subunit 17

1

3

High-throughput

0.489

High

522185

CADH1
Cadherin-1

1

7

High-throughput

0.479

High

575846

VINC
Vinculin

1

6

High-throughput

0.479

High

900265

RL37A
Large ribosomal subunit protein eL43

1

2

High-throughput

0.479

High

909106

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

11

High-throughput

0.479

High

923518

RL8
Large ribosomal subunit protein uL2

1

1

High-throughput

0.479

High

999084

EP300
Histone acetyltransferase p300

1

16

High-throughput

0.479

High

1024411

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

3

High-throughput

0.479

High

1033099

MYO7A
Unconventional myosin-VIIa

1

20

High-throughput

0.479

High

1059866

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

10

High-throughput

0.479

High

1064707

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1068662

PLEC
Plectin

1

20

High-throughput

0.479

High

1129134

CYTSB
Cytospin-B

1

20

High-throughput

0.479

High

1163849

RICTR
Rapamycin-insensitive companion of mTOR

1

5

High-throughput

0.479

High

1200655

NAA40
N-alpha-acetyltransferase 40

1

4

High-throughput

0.479

High

1256045

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.479

High

1266551

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

5

High-throughput

0.479

High

1267156

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

4

High-throughput

0.479

High

1272604

CSN5
COP9 signalosome complex subunit 5

1

9

High-throughput

0.479

High

1313161

DDX23
Probable ATP-dependent RNA helicase DDX23

1

16

High-throughput

0.479

High

1326735

WWTR1
WW domain-containing transcription regulator protein 1

1

20

High-throughput

0.479

High

1329370

ARGL1
Arginine and glutamate-rich protein 1

1

11

High-throughput

0.479

High

1329372

ZRAN1
Ubiquitin thioesterase ZRANB1

1

15

High-throughput

0.479

High

302436

CSTN1
Calsyntenin-1

1

10

Small-scale

0.464

High

264743

VP26A
Vacuolar protein sorting-associated protein 26A

1

0

High-throughput

0.458

High

620202

PAX7
Paired box protein Pax-7

1

8

High-throughput

0.457

High

799004

GATA4
Transcription factor GATA-4

1

3

High-throughput

0.457

High

306314

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

17

High-throughput

0.445

High

1295593

NEUL4
Neuralized-like protein 4

1

3

High-throughput

0.445

High

518203

ADT1
ADP/ATP translocase 1

1

5

High-throughput

0.437

High

553684

RFA2
Replication protein A 32 kDa subunit

1

10

High-throughput

0.437

High

652221

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

8

High-throughput

0.437

High

721415

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.437

High

1146177

DCA15
DDB1- and CUL4-associated factor 15

1

1

High-throughput

0.437

High

1162117

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.437

High

1188850

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.437

High

1318845

ZDHC5
Palmitoyltransferase ZDHHC5

1

3

High-throughput

0.407

High

1238193

RM43
Large ribosomal subunit protein mL43

3

0

High-throughput

0.347

High

1295794

CH076
Uncharacterized protein C8orf76

1

0

High-throughput

0.279

Low

1329367

MED4
Mediator of RNA polymerase II transcription subunit 4

1

0

High-throughput

0.249

Low

1302836

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024