Protein: AKAP8
A-kinase anchor protein 8 (AKAP-8) (A-kinase anchor protein 95 kDa) (AKAP 95)

Gene: AKAP8
Organism: Homo sapiens
Interactions: 174
UniProt ID: O43823

Gene Ontology (top 5):
GO:0000278 - mitotic cell cycle
GO:0000793 - condensed chromosome
GO:0001939 - female pronucleus
GO:0003690 - double-stranded DNA binding
GO:0003723 - RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

215562

MYC
Myc proto-oncogene protein

4

5

High-throughput

0.694

High

215563

ESR1
Estrogen receptor

4

10

High-throughput

0.683

High

215571

ROA1
Heterogeneous nuclear ribonucleoprotein A1

3

3

Small-scale

0.656

High

215575

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

3

0

Small-scale

0.646

High

215595

FUS
RNA-binding protein FUS

2

6

High-throughput

0.611

High

215599

MATR3
Matrin-3

2

3

High-throughput

0.611

High

215624

CUL3
Cullin-3

2

4

High-throughput

0.611

High

215587

CCND1
G1/S-specific cyclin-D1

2

4

Small-scale

0.601

High

215712

CLC11
C-type lectin domain family 11 member A

2

0

High-throughput

0.585

High

215614

EWS
RNA-binding protein EWS

2

5

High-throughput

0.584

High

215622

TIF1B
Transcription intermediary factor 1-beta

2

5

High-throughput

0.584

High

215676

MYCBP
c-Myc-binding protein

2

0

Small-scale

0.580

High

215666

ESR2
Estrogen receptor beta

2

10

High-throughput

0.571

High

215601

MCM2
DNA replication licensing factor MCM2

1

0

Small-scale

0.561

High

215590

CCND3
G1/S-specific cyclin-D3

1

4

Small-scale

0.552

High

215612

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.545

High

126414

FOXE1
Forkhead box protein E1

1

6

High-throughput

0.536

High

156581

PPE1
Serine/threonine-protein phosphatase with EF-hands 1

1

3

High-throughput

0.536

High

177138

HDAC3
Histone deacetylase 3

1

3

Small-scale

0.536

High

208876

FOXS1
Forkhead box protein S1

1

5

High-throughput

0.536

High

215569

SNRPA
U1 small nuclear ribonucleoprotein A

1

4

High-throughput

0.536

High

215570

RU1C
U1 small nuclear ribonucleoprotein C

1

2

High-throughput

0.536

High

215574

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

215576

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

215579

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

3

High-throughput

0.536

High

215591

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.536

High

215592

1433B
14-3-3 protein beta/alpha

1

5

High-throughput

0.536

High

215602

FOXG1
Forkhead box protein G1

1

5

High-throughput

0.536

High

215603

FOXA3
Hepatocyte nuclear factor 3-gamma

1

6

High-throughput

0.536

High

215605

WDR5
WD repeat-containing protein 5

1

2

Small-scale

0.536

High

215606

1433G
14-3-3 protein gamma

1

5

High-throughput

0.536

High

215610

1433Z
14-3-3 protein zeta/delta

1

5

High-throughput

0.536

High

215617

1433F
14-3-3 protein eta

1

5

High-throughput

0.536

High

215618

SSRP1
FACT complex subunit SSRP1

1

8

High-throughput

0.536

High

215623

ILK
Integrin-linked protein kinase

1

1

High-throughput

0.536

High

215632

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

215635

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

1

High-throughput

0.536

High

215651

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

3

High-throughput

0.536

High

215652

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.536

High

215657

HIPK4
Homeodomain-interacting protein kinase 4

1

3

High-throughput

0.536

High

215672

HDA11
Histone deacetylase 11

1

6

High-throughput

0.536

High

215674

RBM14
RNA-binding protein 14

1

3

High-throughput

0.536

High

215681

FOXC2
Forkhead box protein C2

1

5

High-throughput

0.536

High

215684

FOXP3
Forkhead box protein P3

1

6

High-throughput

0.536

High

215695

DDX21
Nucleolar RNA helicase 2

1

4

High-throughput

0.536

High

215698

FOXJ2
Forkhead box protein J2

1

5

High-throughput

0.536

High

215700

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

2

Small-scale

0.536

High

215714

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

1

High-throughput

0.536

High

215581

DDX5
Probable ATP-dependent RNA helicase DDX5

1

1

Small-scale

0.527

High

215566

HG2A
HLA class II histocompatibility antigen gamma chain

1

0

High-throughput

0.513

High

215604

RHOA
Transforming protein RhoA

1

0

High-throughput

0.513

High

215608

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.513

High

215626

TFDP1
Transcription factor Dp-1

1

0

High-throughput

0.513

High

215640

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

Small-scale

0.513

High

215667

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.513

High

215669

PIGT
GPI transamidase component PIG-T

1

0

High-throughput

0.513

High

215675

PASK
PAS domain-containing serine/threonine-protein kinase

1

0

High-throughput

0.513

High

215677

CDC5L
Cell division cycle 5-like protein

1

0

High-throughput

0.513

High

215686

DPY30
Protein dpy-30 homolog

1

0

Small-scale

0.513

High

215707

NAGK
N-acetyl-D-glucosamine kinase

1

0

High-throughput

0.513

High

215558

KLF8
Krueppel-like factor 8

1

7

High-throughput

0.500

High

215683

KLF16
Krueppel-like factor 16

1

6

High-throughput

0.500

High

215706

KLF15
Krueppel-like factor 15

1

6

High-throughput

0.500

High

215598

CASP3
Caspase-3

1

0

Small-scale

0.493

High

215621

FLII
Protein flightless-1 homolog

1

0

High-throughput

0.493

High

215633

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.493

High

122387

MEN1
Menin

1

2

High-throughput

0.479

High

160272

AURKA
Aurora kinase A

1

5

High-throughput

0.479

High

164331

TRI66
Tripartite motif-containing protein 66

1

7

High-throughput

0.479

High

209508

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

215552

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

215554

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.479

High

215555

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

215556

TRI37
E3 ubiquitin-protein ligase TRIM37

1

6

High-throughput

0.479

High

215557

KI20A
Kinesin-like protein KIF20A

1

6

High-throughput

0.479

High

215559

BRD1
Bromodomain-containing protein 1

1

6

High-throughput

0.479

High

215560

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

215564

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

4

High-throughput

0.479

High

215565

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

215567

HSPB1
Heat shock protein beta-1

1

2

Small-scale

0.479

High

215568

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

6

High-throughput

0.479

High

215578

GATA1
Erythroid transcription factor

1

2

High-throughput

0.479

High

215580

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

215582

KAPCB
cAMP-dependent protein kinase catalytic subunit beta

1

3

Small-scale

0.479

High

215583

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

9

Small-scale

0.479

High

215585

SP100
Nuclear autoantigen Sp-100

1

7

High-throughput

0.479

High

215586

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

2

High-throughput

0.479

High

215588

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

215589

CCND2
G1/S-specific cyclin-D2

1

4

Small-scale

0.479

High

215593

BMI1
Polycomb complex protein BMI-1

1

6

High-throughput

0.479

High

215594

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

215596

BRCA1
Breast cancer type 1 susceptibility protein

1

6

High-throughput

0.479

High

215597

CCNF
Cyclin-F

1

1

High-throughput

0.479

High

215607

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.479

High

215609

H4
Histone H4

1

1

High-throughput

0.479

High

215613

VIGLN
Vigilin

1

3

High-throughput

0.479

High

215615

MECOM
Histone-lysine N-methyltransferase MECOM

1

2

High-throughput

0.479

High

215616

TLE3
Transducin-like enhancer protein 3

1

5

High-throughput

0.479

High

215619

EP300
Histone acetyltransferase p300

1

4

High-throughput

0.479

High

215620

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

5

High-throughput

0.479

High

215627

RBM39
RNA-binding protein 39

1

3

High-throughput

0.479

High

215628

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

5

High-throughput

0.479

High

215629

KIF14
Kinesin-like protein KIF14

1

2

High-throughput

0.479

High

215630

ZMY11
Zinc finger MYND domain-containing protein 11

1

10

Small-scale

0.479

High

215631

KS6A1
Ribosomal protein S6 kinase alpha-1

1

5

Small-scale

0.479

High

215634

E2F4
Transcription factor E2F4

1

2

High-throughput

0.479

High

215643

IFIX
Pyrin and HIN domain-containing protein 1

1

1

High-throughput

0.479

High

215647

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

215648

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

215653

DHX40
Probable ATP-dependent RNA helicase DHX40

1

2

High-throughput

0.479

High

215656

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

215658

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

215660

DNJB8
DnaJ homolog subfamily B member 8

1

1

High-throughput

0.479

High

215662

SP7
Transcription factor Sp7

1

6

High-throughput

0.479

High

215663

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

2

High-throughput

0.479

High

215664

DCAF4
DDB1- and CUL4-associated factor 4

1

1

High-throughput

0.479

High

215665

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

215671

ARMC5
Armadillo repeat-containing protein 5

1

2

High-throughput

0.479

High

215673

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

2

High-throughput

0.479

High

215678

RING2
E3 ubiquitin-protein ligase RING2

1

10

High-throughput

0.479

High

215679

BARD1
BRCA1-associated RING domain protein 1

1

4

High-throughput

0.479

High

215680

ANM1
Protein arginine N-methyltransferase 1

1

4

High-throughput

0.479

High

215682

CECR2
Chromatin remodeling regulator CECR2

1

5

High-throughput

0.479

High

215685

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.479

High

215688

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

215689

PKHA4
Pleckstrin homology domain-containing family A member 4

1

3

High-throughput

0.479

High

215691

PRD16
Histone-lysine N-methyltransferase PRDM16

1

2

High-throughput

0.479

High

215692

RC3H2
Roquin-2

1

5

High-throughput

0.479

High

215693

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

215694

ANLN
Anillin

1

1

High-throughput

0.479

High

215696

DJC11
DnaJ homolog subfamily C member 11

1

2

High-throughput

0.479

High

215702

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

215704

ABC3B
DNA dC->dU-editing enzyme APOBEC-3B

1

3

Small-scale

0.479

High

215708

FBW1B
F-box/WD repeat-containing protein 11

1

4

High-throughput

0.479

High

215709

BRPF3
Bromodomain and PHD finger-containing protein 3

1

6

High-throughput

0.479

High

215711

FZR1
Fizzy-related protein homolog

1

4

High-throughput

0.479

High

215713

FBW1A
F-box/WD repeat-containing protein 1A

1

4

High-throughput

0.479

High

165799

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.458

High

215572

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.458

High

215577

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

215584

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

215600

ARL4D
ADP-ribosylation factor-like protein 4D

1

0

High-throughput

0.458

High

215636

PTN21
Tyrosine-protein phosphatase non-receptor type 21

1

0

High-throughput

0.458

High

215637

PDS5A
Sister chromatid cohesion protein PDS5 homolog A

1

0

High-throughput

0.458

High

215639

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

215642

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

215644

NIPBL
Nipped-B-like protein

1

0

High-throughput

0.458

High

215645

LMBRL
Protein LMBR1L

1

0

High-throughput

0.458

High

215649

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

0

High-throughput

0.458

High

215650

DTX2
Probable E3 ubiquitin-protein ligase DTX2

1

0

High-throughput

0.458

High

215654

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.458

High

215655

STAG2
Cohesin subunit SA-2

1

0

High-throughput

0.458

High

215659

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.458

High

215668

FGF11
Fibroblast growth factor 11

1

0

High-throughput

0.458

High

215670

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

215687

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

215697

ARL8B
ADP-ribosylation factor-like protein 8B

1

0

High-throughput

0.458

High

215701

LRWD1
Leucine-rich repeat and WD repeat-containing protein 1

1

0

Small-scale

0.458

High

215703

TES
Testin

1

0

High-throughput

0.458

High

215705

MKRN1
E3 ubiquitin-protein ligase makorin-1

1

0

Small-scale

0.458

High

215715

SCC4
MAU2 chromatid cohesion factor homolog

1

0

High-throughput

0.458

High

135187

E2F3
Transcription factor E2F3

1

2

Small-scale

0.445

High

215553

NCOR1
Nuclear receptor corepressor 1

1

3

Small-scale

0.445

High

215561

PAK4
Serine/threonine-protein kinase PAK 4

1

1

High-throughput

0.445

High

215611

YBOX1
Y-box-binding protein 1

1

3

Small-scale

0.445

High

215625

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.445

High

215646

NBEL2
Neurobeachin-like protein 2

1

3

High-throughput

0.445

High

215690

LN28A
Protein lin-28 homolog A

1

3

High-throughput

0.445

High

215699

WRP73
WD repeat-containing protein WRAP73

1

3

Small-scale

0.445

High

215573

ARAF
Serine/threonine-protein kinase A-Raf

1

4

High-throughput

0.437

High

215641

RNF43
E3 ubiquitin-protein ligase RNF43

1

1

High-throughput

0.437

High

215661

TIP
T-cell immunomodulatory protein

1

1

High-throughput

0.437

High

215710

HECD1
E3 ubiquitin-protein ligase HECTD1

1

6

High-throughput

0.437

High

215638

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024