Protein: UBP39
Ubiquitin carboxyl-terminal hydrolase 39 (EC 3.4.19.12) (SAD1 homolog) (U4/U6.U5 tri-snRNP-associated 65 kDa protein)

Gene: UBP39, USP39
Organism: Homo sapiens
Interactions: 162
UniProt ID: Q53GS9

Gene Ontology (top 5):
GO:0000245 - spliceosomal complex assembly
GO:0000398 - mRNA splicing, via spliceosome
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1121184

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

4

10

High-throughput

0.900

High

1064376

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

4

8

Small-scale

0.892

High

1121159

PRP8
Pre-mRNA-processing-splicing factor 8

4

2

High-throughput

0.892

High

197036

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

2

13

High-throughput

0.802

High

227649

PRKN
E3 ubiquitin-protein ligase parkin

2

20

High-throughput

0.754

High

1074131

SF3A1
Splicing factor 3A subunit 1

1

10

High-throughput

0.691

High

313295

CD2B2
CD2 antigen cytoplasmic tail-binding protein 2

5

0

High-throughput

0.688

High

1121187

SRPK1
SRSF protein kinase 1

3

19

Small-scale

0.676

High

1037813

PRP4K
Serine/threonine-protein kinase PRP4 homolog

3

11

High-throughput

0.671

High

259287

UBP12
Ubiquitin carboxyl-terminal hydrolase 12

1

16

High-throughput

0.665

High

1121192

DDX23
Probable ATP-dependent RNA helicase DDX23

3

16

Small-scale

0.650

High

435112

SP1
Transcription factor Sp1

2

6

Small-scale

0.624

High

942699

SRPK2
SRSF protein kinase 2

2

15

High-throughput

0.619

High

1058220

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

18

Small-scale

0.618

High

1121193

FACD2
Fanconi anemia group D2 protein

1

5

High-throughput

0.618

High

1121216

FZR1
Fizzy-related protein homolog

1

11

High-throughput

0.618

High

1054366

RBM39
RNA-binding protein 39

2

4

High-throughput

0.611

High

199763

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

2

2

Small-scale

0.601

High

202459

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

2

1

Small-scale

0.601

High

300172

PRP6
Pre-mRNA-processing factor 6

2

4

Small-scale

0.601

High

1121177

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

4

Small-scale

0.601

High

1019313

TRI26
Tripartite motif-containing protein 26

2

20

Small-scale

0.586

High

244532

BRD4
Bromodomain-containing protein 4

2

20

High-throughput

0.584

High

934837

H31
Histone H3.1

2

8

High-throughput

0.584

High

331301

CHK2
Serine/threonine-protein kinase Chk2

1

6

Small-scale

0.578

High

1121206

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

Small-scale

0.578

High

639759

IKBA
NF-kappa-B inhibitor alpha

1

4

Small-scale

0.561

High

717141

CTNB1
Catenin beta-1

1

16

Small-scale

0.561

High

993317

FOXM1
Forkhead box protein M1

1

9

Small-scale

0.561

High

1121157

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

8

High-throughput

0.549

High

268747

SF3B1
Splicing factor 3B subunit 1

1

6

High-throughput

0.536

High

441305

RU2B
U2 small nuclear ribonucleoprotein B''

1

9

High-throughput

0.536

High

446663

SNRPA
U1 small nuclear ribonucleoprotein A

1

6

High-throughput

0.536

High

508559

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

726868

FUS
RNA-binding protein FUS

1

7

High-throughput

0.536

High

801183

KI67
Proliferation marker protein Ki-67

1

11

High-throughput

0.536

High

911860

RUXF
Small nuclear ribonucleoprotein F

1

4

High-throughput

0.536

High

996699

SSRP1
FACT complex subunit SSRP1

1

11

High-throughput

0.536

High

1073671

SF3A2
Splicing factor 3A subunit 2

1

2

High-throughput

0.536

High

1084476

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

7

High-throughput

0.536

High

1121167

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

6

High-throughput

0.536

High

1121189

CDC5L
Cell division cycle 5-like protein

1

2

High-throughput

0.536

High

1121191

RBM42
RNA-binding protein 42

1

6

High-throughput

0.536

High

1121205

DDX21
Nucleolar RNA helicase 2

1

17

High-throughput

0.536

High

1121209

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.536

High

1121215

LSM7
U6 snRNA-associated Sm-like protein LSm7

1

5

High-throughput

0.536

High

1121217

SRPK3
SRSF protein kinase 3

1

16

High-throughput

0.536

High

1121161

RHG36
Rho GTPase-activating protein 36

2

7

High-throughput

0.521

High

196107

RRP8
Ribosomal RNA-processing protein 8

1

1

High-throughput

0.515

High

272166

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

18

High-throughput

0.515

High

321407

LSM8
U6 snRNA-associated Sm-like protein LSm8

1

5

High-throughput

0.515

High

386856

P53
Cellular tumor antigen p53

1

9

High-throughput

0.515

High

1121175

NOC3L
Nucleolar complex protein 3 homolog

1

3

High-throughput

0.515

High

1121180

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

12

High-throughput

0.515

High

1121182

H2B1H
Histone H2B type 1-H

1

20

High-throughput

0.515

High

1121208

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

2

High-throughput

0.515

High

1121218

PA2G4
Proliferation-associated protein 2G4

1

2

High-throughput

0.515

High

448688

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

538995

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

911663

RUXE
Small nuclear ribonucleoprotein E

1

0

High-throughput

0.513

High

912478

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.513

High

571727

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

4

Small-scale

0.512

High

1121211

SAE1
SUMO-activating enzyme subunit 1

1

2

Small-scale

0.501

High

307819

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

1

0

High-throughput

0.493

High

949639

TXN4A
Thioredoxin-like protein 4A

1

0

High-throughput

0.493

High

1121163

TM10C
tRNA methyltransferase 10 homolog C

1

0

High-throughput

0.493

High

1121176

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.493

High

1121183

TSR2
Pre-rRNA-processing protein TSR2 homolog

1

0

High-throughput

0.493

High

1121203

COPRS
Coordinator of PRMT5 and differentiation stimulator

1

0

High-throughput

0.493

High

363199

FINC
Fibronectin

1

5

High-throughput

0.489

High

506599

BCR
Breakpoint cluster region protein

1

7

High-throughput

0.489

High

845928

RB27A
Ras-related protein Rab-27A

1

3

High-throughput

0.489

High

949021

HTRA4
Serine protease HTRA4

1

2

High-throughput

0.489

High

1121219

MAST1
Microtubule-associated serine/threonine-protein kinase 1

1

13

High-throughput

0.489

High

844092

FXR2
RNA-binding protein FXR2

1

5

High-throughput

0.481

High

1052677

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

High-throughput

0.481

High

1121194

TRIM8
E3 ubiquitin-protein ligase TRIM8

1

20

High-throughput

0.481

High

1121195

TRIM5
Tripartite motif-containing protein 5

1

20

High-throughput

0.481

High

1121201

TRI39
E3 ubiquitin-protein ligase TRIM39

1

20

High-throughput

0.481

High

1121220

TRAF6
TNF receptor-associated factor 6

1

20

High-throughput

0.481

High

167694

LSM1
U6 snRNA-associated Sm-like protein LSm1

1

5

High-throughput

0.479

High

210047

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

233492

NUPR1
Nuclear protein 1

1

1

High-throughput

0.479

High

326668

SNAI1
Zinc finger protein SNAI1

1

12

Small-scale

0.479

High

346960

MYC
Myc proto-oncogene protein

1

17

High-throughput

0.479

High

377377

GCR
Glucocorticoid receptor

1

17

High-throughput

0.479

High

379471

MYCN
N-myc proto-oncogene protein

1

17

High-throughput

0.479

High

442212

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

552879

RFA2
Replication protein A 32 kDa subunit

1

5

High-throughput

0.479

High

582326

NUCL
Nucleolin

1

5

High-throughput

0.479

High

631453

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

651371

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

684784

STIP1
Stress-induced-phosphoprotein 1

1

5

High-throughput

0.479

High

718913

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

720622

RFA3
Replication protein A 14 kDa subunit

1

6

High-throughput

0.479

High

772000

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.479

High

780969

ID1
DNA-binding protein inhibitor ID-1

1

2

Small-scale

0.479

High

786365

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

7

Small-scale

0.479

High

890693

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

8

Small-scale

0.479

High

908651

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

6

High-throughput

0.479

High

917383

H4
Histone H4

1

5

High-throughput

0.479

High

918411

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

952377

H33
Histone H3.3

1

8

High-throughput

0.479

High

962130

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

14

Small-scale

0.479

High

992801

SRSF1
Serine/arginine-rich splicing factor 1

1

8

Small-scale

0.479

High

1018519

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

8

High-throughput

0.479

High

1022112

NFX1
Transcriptional repressor NF-X1

1

7

High-throughput

0.479

High

1059658

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

8

High-throughput

0.479

High

1062156

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

1063218

SART3
Squamous cell carcinoma antigen recognized by T-cells 3

1

13

High-throughput

0.479

High

1066990

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.479

High

1080008

EZH2
Histone-lysine N-methyltransferase EZH2

1

7

Small-scale

0.479

High

1085756

IF16
Gamma-interferon-inducible protein 16

1

6

High-throughput

0.479

High

1121162

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

1121164

MEPCE
7SK snRNA methylphosphate capping enzyme

1

1

High-throughput

0.479

High

1121171

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

3

Small-scale

0.479

High

1121173

FBX22
F-box only protein 22

1

1

High-throughput

0.479

High

1121179

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

12

High-throughput

0.479

High

1121181

ESR2
Estrogen receptor beta

1

16

High-throughput

0.479

High

1121185

AURKB
Aurora kinase B

1

16

High-throughput

0.479

High

1121190

EPAS1
Endothelial PAS domain-containing protein 1

1

11

Small-scale

0.479

High

1121197

CCDC8
Coiled-coil domain-containing protein 8

1

4

High-throughput

0.479

High

1121198

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

4

Small-scale

0.479

High

1121199

KAT8
Histone acetyltransferase KAT8

1

3

Small-scale

0.479

High

1121202

BRD7
Bromodomain-containing protein 7

1

20

High-throughput

0.479

High

1121204

ANLN
Anillin

1

2

High-throughput

0.479

High

1121207

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

High-throughput

0.479

High

1121212

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1121221

ARI1
E3 ubiquitin-protein ligase ARIH1

1

13

High-throughput

0.479

High

1121222

LSM4
U6 snRNA-associated Sm-like protein LSm4

1

3

High-throughput

0.479

High

1121223

Q9Y654
Heterochromatin-specific nonhistone protein

1

13

High-throughput

0.479

High

1121160

RL22L
Ribosomal protein eL22-like

1

1

High-throughput

0.470

High

1121196

DDX24
ATP-dependent RNA helicase DDX24

1

20

High-throughput

0.470

High

1121200

MRM3
rRNA methyltransferase 3, mitochondrial

1

1

High-throughput

0.470

High

122804

MEN1
Menin

1

0

High-throughput

0.458

High

964351

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1121156

EAPP
E2F-associated phosphoprotein

1

0

High-throughput

0.458

High

1121165

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

1121169

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

1121174

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1121178

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1121188

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

1121210

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

394853

A4
Amyloid-beta precursor protein

1

6

High-throughput

0.457

High

402110

JUN
Transcription factor Jun

1

10

High-throughput

0.445

High

708940

MCM7
DNA replication licensing factor MCM7

1

9

Small-scale

0.445

High

717896

BMI1
Polycomb complex protein BMI-1

1

20

High-throughput

0.445

High

1121214

DDX41
Probable ATP-dependent RNA helicase DDX41

1

13

High-throughput

0.445

High

148895

CTRO
Citron Rho-interacting kinase

1

4

High-throughput

0.437

High

255841

OBSL1
Obscurin-like protein 1

1

5

High-throughput

0.437

High

322717

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

13

High-throughput

0.437

High

384951

NTRK1
High affinity nerve growth factor receptor

1

12

High-throughput

0.437

High

1061450

CUL7
Cullin-7

1

4

High-throughput

0.437

High

1121158

RN123
E3 ubiquitin-protein ligase RNF123

1

13

High-throughput

0.437

High

1121166

ZCH18
Zinc finger CCCH domain-containing protein 18

1

13

High-throughput

0.437

High

1121170

RHG24
Rho GTPase-activating protein 24

1

3

High-throughput

0.437

High

1121186

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

1039613

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.426

High

1121172

POC5
Centrosomal protein POC5

1

0

Small-scale

0.426

High

831392

CEBPA
CCAAT/enhancer-binding protein alpha

1

5

High-throughput

0.408

High

1121168

DAAF5
Dynein axonemal assembly factor 5

1

0

Small-scale

0.261

Low

1121213

ZNHI2
Zinc finger HIT domain-containing protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024