Protein: DIF
Dorsal-related immunity factor Dif

Gene: DIF
Organism: Drosophila melanogaster
Interactions: 120
UniProt ID: P98149

Gene Ontology (top 5):
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific
GO:0002225 - positive regulation of antimicrobial peptide production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1022286

CACT
NF-kappa-B inhibitor cactus

5

19

Small-scale

0.924

High

1022321

NFKB1
Nuclear factor NF-kappa-B p110 subunit

4

20

Small-scale

0.878

High

1022326

Q9V481
Forkhead domain 102C

2

11

High-throughput

0.767

High

899776

PNT
ETS-like protein pointed

1

12

High-throughput

0.637

High

583360

DORS
Embryonic polarity protein dorsal

1

19

Small-scale

0.618

High

1022284

DIF
Dorsal-related immunity factor Dif

1

18

Small-scale

0.618

High

355759

O96378
RE17884p

2

3

High-throughput

0.594

High

357033

O97183
DNA-directed RNA polymerase II subunit RPB3

2

1

High-throughput

0.594

High

458091

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

2

2

High-throughput

0.594

High

662820

DISC
Protein disconnected

2

1

High-throughput

0.594

High

1022294

Q5U1B0
Beta hydroxy acid dehydrogenase 2

2

4

High-throughput

0.594

High

1022308

Q8IHH3
AT01055p

2

1

High-throughput

0.594

High

1022317

Q8SZ13
RE24163p

2

3

High-throughput

0.594

High

1022320

Q8T972
N-terminal E2 ubiquitin-conjugating enzyme

2

9

High-throughput

0.594

High

1022341

Q9VHH0
MIP25022p1

2

1

High-throughput

0.594

High

1022342

ARL8
ADP-ribosylation factor-like protein 8

2

1

High-throughput

0.594

High

1022348

AURKB
Aurora kinase B

2

10

High-throughput

0.594

High

1022350

Q9VL10
Acylglycerol kinase, mitochondrial

2

2

High-throughput

0.594

High

1022364

Q9VTW6
U6 snRNA-associated Sm-like protein LSm2

2

2

High-throughput

0.594

High

1022366

Q9VWL9
LD25711p

2

6

High-throughput

0.594

High

1022374

Q9W526
LD24704p

2

4

High-throughput

0.594

High

1022376

MB21L
Protein mab-21-like

2

1

High-throughput

0.594

High

1022337

MED17
Mediator of RNA polymerase II transcription subunit 17

2

2

Small-scale

0.584

High

1022297

NTM1
Alpha N-terminal protein methyltransferase 1

2

0

High-throughput

0.569

High

1022299

Q7K049
AT10229p

2

0

High-throughput

0.569

High

1022322

FAXC
Failed axon connections

2

0

High-throughput

0.569

High

1022338

TRM71
tRNA

2

0

High-throughput

0.569

High

1022340

Q9VHG6
Insulator binding factor 2

2

0

High-throughput

0.569

High

1022368

ENY2
Enhancer of yellow 2 transcription factor

2

0

High-throughput

0.569

High

631757

T23O
Tryptophan 2,3-dioxygenase

2

1

High-throughput

0.542

High

1014771

H4
Histone H4

2

1

High-throughput

0.542

High

1022290

Q4V3S6
trypsin

2

2

High-throughput

0.542

High

1022300

CC130
Coiled-coil domain-containing protein 130 homolog

2

1

High-throughput

0.542

High

1022301

Q7K0S6
LD36817p

2

3

High-throughput

0.542

High

1022329

MTH3
Probable G-protein coupled receptor Mth-like 3

2

1

High-throughput

0.542

High

1022335

Q9VDJ7
GH21518p

2

1

High-throughput

0.542

High

1022349

Q9VKW8
U6 snRNA-associated Sm-like protein LSm4

2

2

High-throughput

0.542

High

1022356

Q9VPR0
LP14662p

2

1

High-throughput

0.542

High

1022360

Q9VSN9
Signal recognition particle receptor subunit beta

2

1

High-throughput

0.542

High

1022363

Q9VTN7
Spliceosome-associated protein CWC27 homolog

2

1

High-throughput

0.542

High

1022371

Q9W260
GH03113p

2

1

High-throughput

0.542

High

1022373

Q9W4B1
MIP10861p

2

1

High-throughput

0.542

High

197686

PITX
Pituitary homeobox homolog Ptx1

1

1

High-throughput

0.541

High

652143

TIN
Muscle-specific homeobox protein tinman

1

11

High-throughput

0.541

High

662107

POXM
Paired box pox-meso protein

1

6

High-throughput

0.541

High

114293

G7H806
Survival of motor neuron-related-splicing factor 30

1

1

High-throughput

0.494

High

1022355

Q9VNC0
GH11824p

1

2

High-throughput

0.494

High

1022367

Q9VYD9
alanine transaminase

1

1

High-throughput

0.494

High

1022303

Q7KV27
alanine transaminase

1

1

High-throughput

0.481

High

1022312

Q8IPQ6
Polymerase

1

2

High-throughput

0.481

High

1022323

Q95RI7
Survival of motor neuron-related-splicing factor 30

1

1

High-throughput

0.481

High

1022307

MED31
Mediator of RNA polymerase II transcription subunit 31

1

3

Small-scale

0.479

High

1022362

CDK8
Cyclin-dependent kinase 8

1

5

Small-scale

0.479

High

1022375

MED21
Mediator of RNA polymerase II transcription subunit 21

1

1

Small-scale

0.479

High

4802

A0A1B2AKX6
GEO11081p1

1

1

High-throughput

0.451

High

50182

A1A6Q1
IP16890p

1

1

High-throughput

0.451

High

74955

B3DN13
IP21380p

1

4

High-throughput

0.451

High

75106

B3DNJ1
IP21419p

1

12

High-throughput

0.451

High

91261

C6SUT9
IP11002p

1

1

High-throughput

0.451

High

91399

C6TP31
IP21143p

1

3

High-throughput

0.451

High

1022287

Q0E8F2
FI05451p

1

8

High-throughput

0.451

High

1022291

Q4V4E0
glutaminyl-peptide cyclotransferase

1

2

High-throughput

0.451

High

1022293

Q5BIB5
RE15376p

1

1

High-throughput

0.451

High

1022304

Q7KVA8
FI02073p

1

1

High-throughput

0.451

High

1022311

Q8IPA8
Uncharacterized protein, isoform E

1

1

High-throughput

0.451

High

1022314

Q8MR18
LD39537p

1

1

High-throughput

0.451

High

1022316

Q8SY94
RH16768p

1

2

High-throughput

0.451

High

56702

A1ZAG9
Peptidase S1 domain-containing protein

1

3

High-throughput

0.439

High

68620

A8JNQ7
Uncharacterized protein

1

1

High-throughput

0.439

High

121129

M9PF04
Short Calcium-binding mitochondrial carrier, isoform D

1

9

High-throughput

0.439

High

121889

M9PGV2
Uncharacterized protein, isoform E

1

1

High-throughput

0.439

High

1022288

Q3HKQ0
BG642163, isoform A

1

12

High-throughput

0.439

High

1022295

Q6IGL1
HDC06006

1

1

High-throughput

0.439

High

1022302

Q7KSK1
Serine-peptidase 212

1

4

High-throughput

0.439

High

1022306

Q8I936
glutaminyl-peptide cyclotransferase

1

2

High-throughput

0.439

High

1022310

Q8IPA6
RE15759p

1

1

High-throughput

0.439

High

1022313

Q8IRN0
FI06485p

1

2

High-throughput

0.439

High

1022339

Q9VEV6
Uncharacterized protein, isoform A

1

2

High-throughput

0.439

High

1022346

Q9VJP0
GEO02132p1

1

1

High-throughput

0.439

High

1022361

Q9VST1
Uncharacterized protein, isoform A

1

1

High-throughput

0.439

High

1022377

X2J600
Uncharacterized protein, isoform D

1

1

High-throughput

0.439

High

1022285

UMPS
Uridine 5'-monophosphate synthase

1

2

High-throughput

0.407

High

1022324

NUP88
Nuclear pore complex protein Nup88

1

1

High-throughput

0.381

High

68311

A8DYG7
Uncharacterized protein, isoform A

2

0

High-throughput

0.310

High

264477

O62531
Adaptor protein complex 1, mu subunit

2

0

High-throughput

0.310

High

357213

U184
UPF0184 protein CG14818

2

0

High-throughput

0.310

High

1022289

Q4QPW4
GEO12050p1

2

0

High-throughput

0.310

High

1022292

Q4V4Q7
IP04270p

2

0

High-throughput

0.310

High

1022296

Q6IGN6
HDC05827

2

0

High-throughput

0.310

High

1022298

Q7JRQ4
AT16918p

2

0

High-throughput

0.310

High

1022305

Q86BH3
2'-phosphotransferase

2

0

High-throughput

0.310

High

1022309

Q8IP17
GEO12041p1

2

0

High-throughput

0.310

High

1022315

Q8MYX8
RE56208p

2

0

High-throughput

0.310

High

1022318

Q8SZ38
RE18076p

2

0

High-throughput

0.310

High

1022319

Q8T4H6
AT08210p

2

0

High-throughput

0.310

High

1022325

Q9V3L0
Bc10

2

0

High-throughput

0.310

High

1022327

S61G1
Protein transport protein Sec61 gamma-1 subunit

2

0

High-throughput

0.310

High

1022328

SAM50
SAM50-like protein CG7639

2

0

High-throughput

0.310

High

1022330

OB57C
General odorant-binding protein 57c

2

0

High-throughput

0.310

High

1022331

DIM1
Probable dimethyladenosine transferase

2

0

High-throughput

0.310

High

1022332

Q9VBS0
CHK domain ov2

2

0

High-throughput

0.310

High

1022333

RT24
Small ribosomal subunit protein uS3m

2

0

High-throughput

0.310

High

1022334

Q9VD00
FI07666p

2

0

High-throughput

0.310

High

1022336

Q9VDK9
GH12359p

2

0

High-throughput

0.310

High

1022343

Q9VII2
IP07785p

2

0

High-throughput

0.310

High

1022344

Q9VJB2
GEO12089p1

2

0

High-throughput

0.310

High

1022345

EFTS
Elongation factor Ts, mitochondrial

2

0

High-throughput

0.310

High

1022347

Q9VJS1
RE15191p

2

0

High-throughput

0.310

High

1022351

Q9VLX3
AT30011p

2

0

High-throughput

0.310

High

1022352

Q9VMI3
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

2

0

High-throughput

0.310

High

1022353

Q9VMS1
Cyclope, isoform A

2

0

High-throughput

0.310

High

1022354

Y1161
Uncharacterized protein CG1161

2

0

High-throughput

0.310

High

1022357

TGT
Queuine tRNA-ribosyltransferase catalytic subunit

2

0

High-throughput

0.310

High

1022358

Q9VR00
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2

2

0

High-throughput

0.310

High

1022359

Q9VRE4
LD23009p

2

0

High-throughput

0.310

High

1022365

Q9VU69
Enkurin domain-containing protein

2

0

High-throughput

0.310

High

1022369

Q9W194
RE08772p

2

0

High-throughput

0.310

High

1022370

Q9W1Z1
Putative inorganic phosphate cotransporter

2

0

High-throughput

0.310

High

1022372

Q9W3A6
RE29909p

1

0

High-throughput

0.257

Low


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Last updated: 11Aug2025