Protein: ZCHC8
Zinc finger CCHC domain-containing protein 8 (TRAMP-like complex RNA-binding factor ZCCHC8)

Gene: ZCHC8, ZCCHC8
Organism: Homo sapiens
Interactions: 125
UniProt ID: Q6NZY4

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1157920

RBM7
RNA-binding protein 7

8

2

Small-scale

0.975

High

882927

RBM11
Splicing regulator RBM11

4

2

High-throughput

0.905

High

1157896

RBM4B
RNA-binding protein 4B

3

0

High-throughput

0.816

High

853926

NCBP2
Nuclear cap-binding protein subunit 2

3

0

High-throughput

0.787

High

726884

FUS
RNA-binding protein FUS

2

2

High-throughput

0.737

High

1063728

EXOS7
Exosome complex component RRP42

4

3

High-throughput

0.694

High

1157890

EXOS8
Exosome complex component RRP43

4

3

High-throughput

0.694

High

446673

SNRPA
U1 small nuclear ribonucleoprotein A

1

1

High-throughput

0.691

High

541046

HNRPL
Heterogeneous nuclear ribonucleoprotein L

1

1

High-throughput

0.691

High

682853

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

1

High-throughput

0.691

High

855100

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

1

High-throughput

0.691

High

1084304

SRSF7
Serine/arginine-rich splicing factor 7

1

2

High-throughput

0.691

High

1157908

EXOS3
Exosome complex component RRP40

4

0

High-throughput

0.670

High

1157918

EXOS1
Exosome complex component CSL4

3

1

High-throughput

0.667

High

1084492

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

0

High-throughput

0.656

High

1157893

PABP5
Polyadenylate-binding protein 5

1

0

High-throughput

0.656

High

786970

MTREX
Exosome RNA helicase MTR4

4

0

Small-scale

0.651

High

672174

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

3

0

High-throughput

0.649

High

833902

CLK2
Dual specificity protein kinase CLK2

3

0

High-throughput

0.646

High

1157881

ZCH18
Zinc finger CCCH domain-containing protein 18

3

0

High-throughput

0.646

High

1146337

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

4

3

High-throughput

0.645

High

347069

MYC
Myc proto-oncogene protein

3

1

High-throughput

0.640

High

1157907

EXOS5
Exosome complex component RRP46

2

4

High-throughput

0.628

High

442242

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

3

High-throughput

0.618

High

967236

EWS
RNA-binding protein EWS

1

2

High-throughput

0.618

High

1157889

RBP56
TATA-binding protein-associated factor 2N

1

2

High-throughput

0.618

High

1157900

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

1

High-throughput

0.618

High

958706

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

3

3

High-throughput

0.616

High

1157905

EXOS4
Exosome complex component RRP41

2

4

High-throughput

0.611

High

448704

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.602

High

1047023

C1D
Nuclear nucleic acid-binding protein C1D

2

0

High-throughput

0.602

High

1048108

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

Small-scale

0.586

High

1046293

EXOS2
Exosome complex component RRP4

2

0

High-throughput

0.585

High

1157895

MPH6
M-phase phosphoprotein 6

2

0

High-throughput

0.585

High

1059678

CHD4
Chromodomain-helicase-DNA-binding protein 4

2

1

High-throughput

0.584

High

369825

ESR1
Estrogen receptor

2

2

High-throughput

0.571

High

552965

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.559

High

651468

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

720712

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

966423

EXOSX
Exosome complex component 10

2

0

High-throughput

0.559

High

1157917

2ABG
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform

2

3

High-throughput

0.558

High

927834

2ABA
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B alpha isoform

1

3

High-throughput

0.554

High

1157903

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.546

High

818159

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.536

High

996716

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

1076051

OASL
2'-5'-oligoadenylate synthase-like protein

1

1

High-throughput

0.536

High

1092841

HNRL2
Heterogeneous nuclear ribonucleoprotein U-like protein 2

1

1

High-throughput

0.536

High

982146

1433F
14-3-3 protein eta

2

2

High-throughput

0.521

High

717939

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.515

High

508573

TOP1
DNA topoisomerase 1

1

0

High-throughput

0.513

High

539011

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

0

High-throughput

0.513

High

742353

SYUA
Alpha-synuclein

1

0

High-throughput

0.513

High

801199

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

853626

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.513

High

934247

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.513

High

994213

DHX9
ATP-dependent RNA helicase A

1

0

High-throughput

0.513

High

1029257

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1041817

CUL3
Cullin-3

1

0

High-throughput

0.513

High

1157909

DDX21
Nucleolar RNA helicase 2

1

0

High-throughput

0.513

High

749598

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.512

High

434217

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

1

High-throughput

0.489

High

683449

1433B
14-3-3 protein beta/alpha

1

2

High-throughput

0.489

High

263683

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.486

High

162876

XPO1
Exportin-1

1

1

High-throughput

0.479

High

227789

PRKN
E3 ubiquitin-protein ligase parkin

1

1

High-throughput

0.479

High

379508

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

386933

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

487525

ANDR
Androgen receptor

1

2

High-throughput

0.479

High

794006

MATR3
Matrin-3

1

1

High-throughput

0.479

High

986685

EXOS9
Exosome complex component RRP45

1

3

High-throughput

0.479

High

1018536

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

1

High-throughput

0.479

High

1130026

EXOS6
Exosome complex component MTR3

1

5

High-throughput

0.479

High

1157883

DHX40
Probable ATP-dependent RNA helicase DHX40

1

1

High-throughput

0.479

High

1157888

ESR2
Estrogen receptor beta

1

2

High-throughput

0.479

High

1157892

PF21A
PHD finger protein 21A

1

3

High-throughput

0.479

High

1157894

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

1157913

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

1

High-throughput

0.479

High

122828

MEN1
Menin

1

0

High-throughput

0.458

High

170396

TIF1A
Transcription intermediary factor 1-alpha

1

0

High-throughput

0.458

High

1157914

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

179687

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

232250

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.458

High

237237

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

High-throughput

0.458

High

525538

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

583502

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

615763

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

917450

H4
Histone H4

1

0

High-throughput

0.458

High

974591

MECOM
Histone-lysine N-methyltransferase MECOM

1

0

High-throughput

0.458

High

1038469

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1080040

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1153848

IFIX
Pyrin and HIN domain-containing protein 1

1

0

High-throughput

0.458

High

1157877

GGYF2
GRB10-interacting GYF protein 2

1

0

High-throughput

0.458

High

1157878

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1157879

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1157880

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1157882

MIB1
E3 ubiquitin-protein ligase MIB1

1

0

High-throughput

0.458

High

1157886

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

1157887

DI3L1
DIS3-like exonuclease 1

1

0

High-throughput

0.458

High

1157897

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

1157898

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1157899

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

1157904

RC3H2
Roquin-2

1

0

High-throughput

0.458

High

1157910

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

1157911

RNC
Ribonuclease 3

1

0

High-throughput

0.458

High

1157912

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1157916

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

385010

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.437

High

1146511

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

998091

NCBP1
Nuclear cap-binding protein subunit 1

1

0

High-throughput

0.426

High

375756

GBA1
Lysosomal acid glucosylceramidase

1

0

High-throughput

0.279

Low

1157884

KCTD6
BTB/POZ domain-containing protein KCTD6

1

0

High-throughput

0.279

Low

1157891

ARRD3
Arrestin domain-containing protein 3

1

0

High-throughput

0.279

Low

1157915

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

394951

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.261

Low

129780

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low

373393

CATA
Catalase

1

0

High-throughput

0.249

Low

514696

CP2C9
Cytochrome P450 2C9

1

0

High-throughput

0.249

Low

932212

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.249

Low

1157876

FBX42
F-box only protein 42

1

0

High-throughput

0.249

Low

1157885

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1157902

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1157906

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

High-throughput

0.249

Low

1157919

HBS1L
HBS1-like protein

1

0

High-throughput

0.249

Low

301094

FBX21
F-box only protein 21

1

0

Small-scale

0.232

Low

1157901

MLP3A
Microtubule-associated proteins 1A/1B light chain 3A

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024