Protein: ZEB2
Zinc finger E-box-binding homeobox 2 (Smad-interacting protein 1) (SMADIP1) (Zinc finger homeobox protein 1b)

Gene: ZEB2
Organism: Homo sapiens
Interactions: 85
UniProt ID: O60315

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

231235

CTBP1
C-terminal-binding protein 1

9

8

Small-scale

0.755

High

231220

KLF3
Krueppel-like factor 3

2

20

High-throughput

0.754

High

231236

HDAC1
Histone deacetylase 1

5

10

Small-scale

0.712

High

231203

CSK22
Casein kinase II subunit alpha'

1

3

High-throughput

0.691

High

231224

CSK21
Casein kinase II subunit alpha

1

4

High-throughput

0.691

High

231251

HDAC2
Histone deacetylase 2

4

10

Small-scale

0.687

High

231234

MTA1
Metastasis-associated protein MTA1

3

5

Small-scale

0.684

High

231230

RBBP4
Histone-binding protein RBBP4

4

4

Small-scale

0.683

High

231188

MTA2
Metastasis-associated protein MTA2

3

5

Small-scale

0.667

High

231193

A4
Amyloid-beta precursor protein

3

14

High-throughput

0.658

High

204097

KLF4
Krueppel-like factor 4

1

17

High-throughput

0.618

High

231191

KLF8
Krueppel-like factor 8

1

19

High-throughput

0.618

High

231197

EGR2
E3 SUMO-protein ligase EGR2

1

19

High-throughput

0.618

High

231249

SP7
Transcription factor Sp7

1

19

High-throughput

0.618

High

231259

KLF16
Krueppel-like factor 16

1

19

High-throughput

0.618

High

231263

KLF12
Krueppel-like factor 12

1

20

High-throughput

0.618

High

231226

SMAD3
Mothers against decapentaplegic homolog 3

2

15

Small-scale

0.600

High

231242

SMAD1
Mothers against decapentaplegic homolog 1

2

15

Small-scale

0.600

High

231215

CEBPA
CCAAT/enhancer-binding protein alpha

2

8

Small-scale

0.584

High

123143

CBX4
E3 SUMO-protein ligase CBX4

1

20

Small-scale

0.578

High

231250

ZN516
Zinc finger protein 516

1

19

Small-scale

0.575

High

231256

EHMT2
Histone-lysine N-methyltransferase EHMT2

1

7

Small-scale

0.568

High

231192

MBD3
Methyl-CpG-binding domain protein 3

2

0

Small-scale

0.563

High

231244

DDB1
DNA damage-binding protein 1

1

3

Small-scale

0.561

High

231214

SOX2
Transcription factor SOX-2

1

15

High-throughput

0.536

High

231218

CTBP2
C-terminal-binding protein 2

1

8

High-throughput

0.536

High

231240

TEAD2
Transcriptional enhancer factor TEF-4

1

2

High-throughput

0.536

High

231247

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.518

High

171345

SMAD9
Mothers against decapentaplegic homolog 9

1

15

High-throughput

0.508

High

231241

SMAD2
Mothers against decapentaplegic homolog 2

1

15

High-throughput

0.508

High

231222

UBC9
SUMO-conjugating enzyme UBC9

1

1

Small-scale

0.501

High

123794

SPT5H
Transcription elongation factor SPT5

1

2

High-throughput

0.479

High

170995

TBXT
T-box transcription factor T

1

3

High-throughput

0.479

High

177142

HDAC3
Histone deacetylase 3

1

10

Small-scale

0.479

High

179481

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

197631

CRX
Cone-rod homeobox protein

1

11

High-throughput

0.479

High

231187

KDM1A
Lysine-specific histone demethylase 1A

1

8

High-throughput

0.479

High

231189

TRI37
E3 ubiquitin-protein ligase TRIM37

1

20

High-throughput

0.479

High

231190

KI20A
Kinesin-like protein KIF20A

1

4

High-throughput

0.479

High

231194

NFIC
Nuclear factor 1 C-type

1

7

High-throughput

0.479

High

231196

MYB
Transcriptional activator Myb

1

2

High-throughput

0.479

High

231199

HXB2
Homeobox protein Hox-B2

1

11

High-throughput

0.479

High

231200

MYOD1
Myoblast determination protein 1

1

5

High-throughput

0.479

High

231201

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

231202

CEBPB
CCAAT/enhancer-binding protein beta

1

8

High-throughput

0.479

High

231204

GATA2
Endothelial transcription factor GATA-2

1

3

High-throughput

0.479

High

231206

PAX6
Paired box protein Pax-6

1

7

High-throughput

0.479

High

231207

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

231208

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

231209

TLX1
T-cell leukemia homeobox protein 1

1

7

High-throughput

0.479

High

231210

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

231211

HNF1B
Hepatocyte nuclear factor 1-beta

1

13

High-throughput

0.479

High

231212

HNF4A
Hepatocyte nuclear factor 4-alpha

1

6

High-throughput

0.479

High

231213

ELK3
ETS domain-containing protein Elk-3

1

5

High-throughput

0.479

High

231216

LHX2
LIM/homeobox protein Lhx2

1

7

High-throughput

0.479

High

231217

HDAC4
Histone deacetylase 4

1

11

Small-scale

0.479

High

231219

GSC
Homeobox protein goosecoid

1

7

High-throughput

0.479

High

231223

CSK2B
Casein kinase II subunit beta

1

1

High-throughput

0.479

High

231225

H31
Histone H3.1

1

14

High-throughput

0.479

High

231227

H33
Histone H3.3

1

14

High-throughput

0.479

High

231228

HME1
Homeobox protein engrailed-1

1

5

High-throughput

0.479

High

231229

PAX8
Paired box protein Pax-8

1

8

High-throughput

0.479

High

231231

EP300
Histone acetyltransferase p300

1

7

Small-scale

0.479

High

231233

FOXL1
Forkhead box protein L1

1

1

High-throughput

0.479

High

231237

CUL4A
Cullin-4A

1

20

High-throughput

0.479

High

231238

CUL4B
Cullin-4B

1

20

Small-scale

0.479

High

231239

NFIX
Nuclear factor 1 X-type

1

9

High-throughput

0.479

High

231243

EZH2
Histone-lysine N-methyltransferase EZH2

1

6

High-throughput

0.479

High

231245

RBBP7
Histone-binding protein RBBP7

1

3

Small-scale

0.479

High

231246

FBX38
F-box only protein 38

1

1

High-throughput

0.479

High

231248

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

231252

FBXW7
F-box/WD repeat-containing protein 7

1

3

Small-scale

0.479

High

231253

PF21A
PHD finger protein 21A

1

19

High-throughput

0.479

High

231257

FEV
Protein FEV

1

5

High-throughput

0.479

High

231258

SOX7
Transcription factor SOX-7

1

11

High-throughput

0.479

High

231260

VSX1
Visual system homeobox 1

1

9

High-throughput

0.479

High

231261

LHX3
LIM/homeobox protein Lhx3

1

7

High-throughput

0.479

High

231262

RCOR1
REST corepressor 1

1

7

High-throughput

0.479

High

231221

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

231205

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

3

Small-scale

0.445

High

231232

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

4

Small-scale

0.445

High

231254

MBD6
Methyl-CpG-binding domain protein 6

1

2

Small-scale

0.445

High

231198

CADH1
Cadherin-1

1

2

Small-scale

0.437

High

231255

MTBP
Mdm2-binding protein

1

0

Small-scale

0.426

High

231195

SCHI1
Schwannomin-interacting protein 1

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024