Protein: PHC2
Polyhomeotic-like protein 2 (hPH2) (Early development regulatory protein 2)

Gene: PHC2
Organism: Homo sapiens
Interactions: 144
UniProt ID: Q8IXK0

Gene Ontology (top 5):
GO:0000792 - heterochromatin
GO:0003677 - DNA binding
GO:0003682 - chromatin binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

943073

PHC1
Polyhomeotic-like protein 1

8

18

Small-scale

0.971

High

1220848

PHC2
Polyhomeotic-like protein 2

4

18

Small-scale

0.895

High

1220873

SCMH1
Polycomb protein SCMH1

3

19

High-throughput

0.864

High

1220902

SMBT1
Scm-like with four MBT domains protein 1

2

19

High-throughput

0.834

High

1220856

PHC3
Polyhomeotic-like protein 3

3

19

Small-scale

0.827

High

1220874

LMBL3
Lethal(3)malignant brain tumor-like protein 3

2

19

High-throughput

0.826

High

824653

MAPK2
MAP kinase-activated protein kinase 2

2

4

Small-scale

0.800

High

1220903

SCML1
Sex comb on midleg-like protein 1

2

18

High-throughput

0.789

High

717999

BMI1
Polycomb complex protein BMI-1

14

20

Small-scale

0.763

High

718408

PCGF2
Polycomb group RING finger protein 2

10

20

Small-scale

0.758

High

1220905

SCML2
Sex comb on midleg-like protein 2

2

19

Small-scale

0.754

High

1220894

CBX8
Chromobox protein homolog 8

8

20

Small-scale

0.754

High

327853

CBX7
Chromobox protein homolog 7

7

20

Small-scale

0.750

High

1220877

RING2
E3 ubiquitin-protein ligase RING2

8

20

Small-scale

0.750

High

861836

PLK1
Serine/threonine-protein kinase PLK1

1

2

High-throughput

0.740

High

132935

SDCB1
Syntenin-1

1

4

High-throughput

0.740

High

1025166

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

2

High-throughput

0.740

High

123280

CBX4
E3 SUMO-protein ligase CBX4

6

20

Small-scale

0.735

High

1059170

CBX2
Chromobox protein homolog 2

6

20

Small-scale

0.732

High

316088

CBX6
Chromobox protein homolog 6

5

20

High-throughput

0.722

High

987988

RING1
E3 ubiquitin-protein ligase RING1

5

20

Small-scale

0.718

High

1085117

MAPK3
MAP kinase-activated protein kinase 3

1

4

Small-scale

0.713

High

1216659

SIAH1
E3 ubiquitin-protein ligase SIAH1

4

5

Small-scale

0.707

High

1085430

MK06
Mitogen-activated protein kinase 6

1

4

High-throughput

0.656

High

950217

SMAD3
Mothers against decapentaplegic homolog 3

2

1

High-throughput

0.654

High

1220865

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

1

High-throughput

0.654

High

575101

RL7
Large ribosomal subunit protein uL30

3

0

High-throughput

0.649

High

638339

RBTN2
Rhombotin-2

2

4

High-throughput

0.640

High

1046881

BYST
Bystin

2

1

High-throughput

0.640

High

1220906

DRG1
Developmentally-regulated GTP-binding protein 1

2

1

High-throughput

0.640

High

638536

RBTN1
Rhombotin-1

2

4

High-throughput

0.633

High

1220864

KBTB7
Kelch repeat and BTB domain-containing protein 7

2

2

High-throughput

0.633

High

1108515

PCGF3
Polycomb group RING finger protein 3

2

20

High-throughput

0.631

High

1197568

PCGF5
Polycomb group RING finger protein 5

2

20

High-throughput

0.631

High

1220876

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

2

5

High-throughput

0.628

High

1082590

MK14
Mitogen-activated protein kinase 14

1

4

Small-scale

0.621

High

851581

NEK4
Serine/threonine-protein kinase Nek4

1

3

High-throughput

0.618

High

374511

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.618

High

586843

CSK22
Casein kinase II subunit alpha'

1

11

Small-scale

0.618

High

934291

CSK21
Casein kinase II subunit alpha

1

11

Small-scale

0.618

High

802651

CRK
Adapter molecule crk

2

15

High-throughput

0.594

High

931720

CSK2B
Casein kinase II subunit beta

2

1

Small-scale

0.586

High

244646

BRD4
Bromodomain-containing protein 4

2

11

High-throughput

0.584

High

918505

H2B1C
Histone H2B type 1-C/E/F/G/I

2

15

High-throughput

0.584

High

1220881

PCGF1
Polycomb group RING finger protein 1

2

20

High-throughput

0.584

High

514419

PSPC
Surfactant protein C

2

2

High-throughput

0.574

High

875670

MFAP1
Microfibrillar-associated protein 1

1

2

High-throughput

0.573

High

921136

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

1

High-throughput

0.573

High

1054423

RBM39
RNA-binding protein 39

1

1

High-throughput

0.573

High

1063013

MO4L2
Mortality factor 4-like protein 2

1

2

High-throughput

0.573

High

1220854

MAGB6
Melanoma-associated antigen B6

1

3

High-throughput

0.573

High

1220863

TRI41
E3 ubiquitin-protein ligase TRIM41

1

4

High-throughput

0.573

High

369962

ESR1
Estrogen receptor

2

16

High-throughput

0.571

High

1220871

MCRS1
Microspherule protein 1

1

0

High-throughput

0.558

High

738236

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

3

High-throughput

0.553

High

196633

ZBT24
Zinc finger and BTB domain-containing protein 24

1

0

High-throughput

0.549

High

202479

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

0

High-throughput

0.549

High

1220852

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

0

High-throughput

0.549

High

1220860

ZN417
Zinc finger protein 417

1

0

High-throughput

0.549

High

1220861

AEN
Apoptosis-enhancing nuclease

1

0

High-throughput

0.549

High

1220867

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.549

High

1220875

ZMAT2
Zinc finger matrin-type protein 2

1

0

High-throughput

0.549

High

1220882

THAP7
THAP domain-containing protein 7

1

0

High-throughput

0.549

High

1220888

SPC1L
Speriolin-like protein

1

0

High-throughput

0.549

High

1220898

AIRIM
AFG2-interacting ribosome maturation factor

1

0

High-throughput

0.549

High

1220907

ADIP
Afadin- and alpha-actinin-binding protein

1

0

High-throughput

0.549

High

641246

DNMT1
DNA

1

4

High-throughput

0.541

High

843785

FXR1
RNA-binding protein FXR1

1

8

High-throughput

0.541

High

844141

FXR2
RNA-binding protein FXR2

1

8

High-throughput

0.541

High

1044645

FHL3
Four and a half LIM domains protein 3

1

5

High-throughput

0.541

High

1220859

LMO3
LIM domain only protein 3

1

4

High-throughput

0.541

High

1220869

TRI63
E3 ubiquitin-protein ligase TRIM63

1

6

High-throughput

0.541

High

1220887

TRI55
Tripartite motif-containing protein 55

1

9

High-throughput

0.541

High

1220908

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

1

High-throughput

0.541

High

235943

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

2

High-throughput

0.536

High

818230

SOX2
Transcription factor SOX-2

1

11

High-throughput

0.536

High

1087245

H2B2E
Histone H2B type 2-E

1

15

High-throughput

0.536

High

1138768

ZN691
Zinc finger protein 691

1

1

High-throughput

0.536

High

1220880

TBA1C
Tubulin alpha-1C chain

1

5

High-throughput

0.536

High

1220855

MB213
Protein mab-21-like 3

1

3

High-throughput

0.523

High

1220884

KIFC3
Kinesin-like protein KIFC3

1

1

High-throughput

0.523

High

1220885

AP1M1
AP-1 complex subunit mu-1

1

2

High-throughput

0.523

High

1220890

CARD9
Caspase recruitment domain-containing protein 9

1

1

High-throughput

0.523

High

832572

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.518

High

157955

KLF11
Krueppel-like factor 11

1

8

High-throughput

0.515

High

736572

RL4
Large ribosomal subunit protein uL4

1

0

High-throughput

0.513

High

232307

KDM1A
Lysine-specific histone demethylase 1A

1

17

High-throughput

0.508

High

1138061

GFI1B
Zinc finger protein Gfi-1b

1

1

High-throughput

0.508

High

435136

SP1
Transcription factor Sp1

1

7

Small-scale

0.506

High

1220853

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

High-throughput

0.489

High

1220891

CPVL
Probable serine carboxypeptidase CPVL

1

3

High-throughput

0.489

High

1220900

FBLN5
Fibulin-5

1

2

High-throughput

0.489

High

557735

NCK1
SH2/SH3 adapter protein NCK1

1

15

High-throughput

0.481

High

802869

CRKL
Crk-like protein

1

14

High-throughput

0.481

High

862624

FOSB
Protein FosB

1

4

High-throughput

0.481

High

876608

AF17
Protein AF-17

1

6

High-throughput

0.481

High

924689

GRB2
Growth factor receptor-bound protein 2

1

14

High-throughput

0.481

High

1220862

HDAC7
Histone deacetylase 7

1

12

High-throughput

0.481

High

1220904

PLAL2
Zinc finger protein PLAGL2

1

3

High-throughput

0.481

High

203732

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

High-throughput

0.479

High

268164

EED
Polycomb protein EED

1

12

High-throughput

0.479

High

347272

MYC
Myc proto-oncogene protein

1

7

High-throughput

0.479

High

391783

H2A1B
Histone H2A type 1-B/E

1

8

High-throughput

0.479

High

828293

CENPA
Histone H3-like centromeric protein A

1

17

High-throughput

0.479

High

917562

H4
Histone H4

1

8

High-throughput

0.479

High

959530

VIGLN
Vigilin

1

3

High-throughput

0.479

High

1067040

BRD3
Bromodomain-containing protein 3

1

16

High-throughput

0.479

High

1125885

BCORL
BCL-6 corepressor-like protein 1

1

16

High-throughput

0.479

High

1167265

BCOR
BCL-6 corepressor

1

14

High-throughput

0.479

High

1220849

YAF2
YY1-associated factor 2

1

7

High-throughput

0.479

High

1220850

PELP1
Proline-, glutamic acid- and leucine-rich protein 1

1

8

Small-scale

0.479

High

1220851

RYBP
RING1 and YY1-binding protein

1

7

High-throughput

0.479

High

1220858

KDM2B
Lysine-specific demethylase 2B

1

4

High-throughput

0.479

High

1220866

HDAC2
Histone deacetylase 2

1

12

High-throughput

0.479

High

1220868

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

5

Small-scale

0.479

High

1220879

TBX5
T-box transcription factor TBX5

1

3

High-throughput

0.479

High

1220886

PCGF6
Polycomb group RING finger protein 6

1

20

High-throughput

0.479

High

1220895

ANLN
Anillin

1

2

High-throughput

0.479

High

1220896

MDN1
Midasin

1

6

Small-scale

0.479

High

1220901

ZRAN1
Ubiquitin thioesterase ZRANB1

1

3

High-throughput

0.479

High

1129967

F74A1
Protein FAM74A1

1

1

High-throughput

0.470

High

1137120

FAM74
Protein FAM74A4/A6

1

1

High-throughput

0.470

High

1220870

COQA1
Collagen alpha-1(XXVI) chain

1

3

High-throughput

0.470

High

1220909

R4GMX3
Polycomb complex protein BMI-1

1

20

High-throughput

0.457

High

1071259

K1H1
Keratin, type I cuticular Ha1

1

3

High-throughput

0.439

High

1220872

KLD7B
Kelch domain-containing protein 7B

1

3

High-throughput

0.439

High

1220883

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.438

High

882418

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

11

High-throughput

0.437

High

1220892

PKHA4
Pleckstrin homology domain-containing family A member 4

1

10

High-throughput

0.437

High

1220893

FBRS
Probable fibrosin-1

1

3

High-throughput

0.437

High

1220899

HECW2
E3 ubiquitin-protein ligase HECW2

1

7

High-throughput

0.437

High

1086210

H31T
Histone H3.1t

1

17

High-throughput

0.408

High

1220889

ENKD1
Enkurin domain-containing protein 1

2

0

High-throughput

0.334

High

883251

RWD2B
RWD domain-containing protein 2B

1

0

High-throughput

0.299

High

1089401

SYT16
Synaptotagmin-16

1

0

High-throughput

0.299

High

1107893

F161A
Protein FAM161A

1

0

High-throughput

0.299

High

1200939

F124A
Protein FAM124A

1

0

High-throughput

0.299

High

1220857

FA13C
Protein FAM13C

1

0

High-throughput

0.299

High

1220897

BSDC1
BSD domain-containing protein 1

1

0

High-throughput

0.282

High

172615

KMO
Kynurenine 3-monooxygenase

1

0

High-throughput

0.279

Low

1220878

SORT
Sortilin

1

0

High-throughput

0.279

Low

1077904

TAB1
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1

1

0

High-throughput

0.265

Low

129793

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024