Protein: INSI1
Insulin-induced gene 1 protein (INSIG-1)

Gene: INSI1, INSIG1
Organism: Homo sapiens
Interactions: 124
UniProt ID: O15503

Gene Ontology (top 5):
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0006641 - triglyceride metabolic process
GO:0006695 - cholesterol biosynthetic process
GO:0008142 - oxysterol binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181098

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

11

3

Small-scale

0.972

High

181030

HMDH
3-hydroxy-3-methylglutaryl-coenzyme A reductase

6

3

Small-scale

0.931

High

181127

AMFR
E3 ubiquitin-protein ligase AMFR

6

5

Small-scale

0.726

High

181023

ERLN2
Erlin-2

4

1

Small-scale

0.686

High

181080

TERA
Transitional endoplasmic reticulum ATPase

3

1

Small-scale

0.646

High

181118

FAF2
FAS-associated factor 2

3

1

Small-scale

0.646

High

181114

RN139
E3 ubiquitin-protein ligase RNF139

3

5

Small-scale

0.640

High

181016

INSI1
Insulin-induced gene 1 protein

1

2

Small-scale

0.618

High

181131

INSI2
Insulin-induced gene 2 protein

1

2

Small-scale

0.618

High

181099

SRBP2
Sterol regulatory element-binding protein 2

2

2

Small-scale

0.584

High

181068

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

1

High-throughput

0.578

High

123429

PGRC1
Membrane-associated progesterone receptor component 1

2

0

Small-scale

0.569

High

181102

AQP6
Aquaporin-6

2

2

High-throughput

0.553

High

181120

TM237
Transmembrane protein 237

2

1

High-throughput

0.553

High

181076

BKRB1
B1 bradykinin receptor

1

0

High-throughput

0.518

High

181025

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

1

Small-scale

0.515

High

181126

VAPA
Vesicle-associated membrane protein-associated protein A

1

1

Small-scale

0.515

High

181019

ERLN1
Erlin-1

1

1

Small-scale

0.479

High

181024

CSTN1
Calsyntenin-1

1

1

High-throughput

0.479

High

181029

VTNC
Vitronectin

1

1

High-throughput

0.479

High

181036

PDIA1
Protein disulfide-isomerase

1

1

High-throughput

0.479

High

181041

TSP1
Thrombospondin-1

1

1

High-throughput

0.479

High

181043

INHBA
Inhibin beta A chain

1

1

High-throughput

0.479

High

181060

CALX
Calnexin

1

1

High-throughput

0.479

High

181063

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.479

High

181070

SRBP1
Sterol regulatory element-binding protein 1

1

3

Small-scale

0.479

High

181074

VDAC2
Voltage-dependent anion-selective channel protein 2

1

1

High-throughput

0.479

High

181079

COPA
Coatomer subunit alpha

1

2

High-throughput

0.479

High

181089

YBOX1
Y-box-binding protein 1

1

1

High-throughput

0.479

High

181105

VAS1
V-type proton ATPase subunit S1

1

1

High-throughput

0.479

High

181117

PXDN
Peroxidasin homolog

1

1

High-throughput

0.479

High

181119

RN145
RING finger protein 145

1

5

Small-scale

0.479

High

129868

PLOD2
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2

1

0

High-throughput

0.458

High

181021

SOAT2
Sterol O-acyltransferase 2

1

0

Small-scale

0.458

High

181032

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

181033

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.458

High

181052

NCPR
NADPH--cytochrome P450 reductase

1

0

Small-scale

0.458

High

181082

SC61B
Protein transport protein Sec61 subunit beta

1

0

High-throughput

0.458

High

181085

1433E
14-3-3 protein epsilon

1

0

High-throughput

0.458

High

181101

AAPK1
5'-AMP-activated protein kinase catalytic subunit alpha-1

1

0

Small-scale

0.458

High

181124

FLRT1
Leucine-rich repeat transmembrane protein FLRT1

1

0

High-throughput

0.458

High

181132

COPG1
Coatomer subunit gamma-1

1

0

High-throughput

0.458

High

156171

PSA7
Proteasome subunit alpha type-7

1

2

Small-scale

0.457

High

181054

PRS6A
26S proteasome regulatory subunit 6A

1

4

Small-scale

0.457

High

134562

CCN1
CCN family member 1

1

2

High-throughput

0.437

High

153495

ANM5
Protein arginine N-methyltransferase 5

1

1

High-throughput

0.437

High

181017

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.437

High

181018

FLNB
Filamin-B

1

6

High-throughput

0.437

High

181020

WDHD1
WD repeat and HMG-box DNA-binding protein 1

1

3

High-throughput

0.437

High

181022

PHF14
PHD finger protein 14

1

1

High-throughput

0.437

High

181026

K1C14
Keratin, type I cytoskeletal 14

1

3

High-throughput

0.437

High

181027

FINC
Fibronectin

1

1

High-throughput

0.437

High

181028

TFR1
Transferrin receptor protein 1

1

1

High-throughput

0.437

High

181031

K2C1
Keratin, type II cytoskeletal 1

1

6

High-throughput

0.437

High

181034

K2C8
Keratin, type II cytoskeletal 8

1

5

High-throughput

0.437

High

181035

TPM3
Tropomyosin alpha-3 chain

1

4

High-throughput

0.437

High

181037

ANXA2
Annexin A2

1

1

High-throughput

0.437

High

181038

APT
Adenine phosphoribosyltransferase

1

1

High-throughput

0.437

High

181039

LAMB1
Laminin subunit beta-1

1

3

High-throughput

0.437

High

181040

TPM2
Tropomyosin beta chain

1

5

High-throughput

0.437

High

181042

HS90B
Heat shock protein HSP 90-beta

1

1

High-throughput

0.437

High

181044

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

High-throughput

0.437

High

181045

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.437

High

181046

LAMC1
Laminin subunit gamma-1

1

3

High-throughput

0.437

High

181047

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.437

High

181048

ACTN1
Alpha-actinin-1

1

2

High-throughput

0.437

High

181050

K2C5
Keratin, type II cytoskeletal 5

1

6

High-throughput

0.437

High

181051

TIMP2
Metalloproteinase inhibitor 2

1

1

High-throughput

0.437

High

181055

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.437

High

181057

FLNA
Filamin-A

1

6

High-throughput

0.437

High

181058

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

3

High-throughput

0.437

High

181059

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.437

High

181061

CCN2
CCN family member 2

1

2

High-throughput

0.437

High

181065

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.437

High

181066

HSP74
Heat shock 70 kDa protein 4

1

4

High-throughput

0.437

High

181071

GRP75
Stress-70 protein, mitochondrial

1

5

High-throughput

0.437

High

181073

RANG
Ran-specific GTPase-activating protein

1

1

High-throughput

0.437

High

181075

NSF
Vesicle-fusing ATPase

1

2

High-throughput

0.437

High

181077

FAS
Fatty acid synthase

1

1

High-throughput

0.437

High

181078

KC1E
Casein kinase I isoform epsilon

1

1

High-throughput

0.437

High

181084

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

1

High-throughput

0.437

High

181087

RACK1
Small ribosomal subunit protein RACK1

1

1

High-throughput

0.437

High

181088

ACTG
Actin, cytoplasmic 2

1

1

High-throughput

0.437

High

181090

EF1A1
Elongation factor 1-alpha 1

1

1

High-throughput

0.437

High

181091

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.437

High

181095

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

1

High-throughput

0.437

High

181096

K22O
Keratin, type II cytoskeletal 2 oral

1

6

High-throughput

0.437

High

181097

PRDX1
Peroxiredoxin-1

1

1

High-throughput

0.437

High

181106

ARI4B
AT-rich interactive domain-containing protein 4B

1

1

High-throughput

0.437

High

181108

ZN772
Zinc finger protein 772

1

1

High-throughput

0.437

High

181109

H2AV
Histone H2A.V

1

1

High-throughput

0.437

High

181112

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

1

High-throughput

0.437

High

181113

LS14A
Protein LSM14 homolog A

1

1

High-throughput

0.437

High

181115

CKAP2
Cytoskeleton-associated protein 2

1

1

High-throughput

0.437

High

181116

ATX2L
Ataxin-2-like protein

1

1

High-throughput

0.437

High

181121

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

4

High-throughput

0.437

High

181129

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.437

High

181130

RUVB2
RuvB-like 2

1

1

High-throughput

0.437

High

181133

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.437

High

181081

CAD13
Cadherin-13

2

0

High-throughput

0.328

High

181072

5HT2B
5-hydroxytryptamine receptor 2B

1

0

High-throughput

0.282

High

181094

MAP1A
Microtubule-associated protein 1A

1

0

High-throughput

0.279

Low

181107

FOCAD
Focadhesin

1

0

High-throughput

0.279

Low

181123

MTMR4
Myotubularin-related protein 4

1

0

High-throughput

0.279

Low

181128

PACN2
Protein kinase C and casein kinase substrate in neurons protein 2

1

0

High-throughput

0.279

Low

181049

EF2
Elongation factor 2

1

0

High-throughput

0.249

Low

181053

KCRS
Creatine kinase S-type, mitochondrial

1

0

High-throughput

0.249

Low

181056

PRPS3
Ribose-phosphate pyrophosphokinase 3

1

0

High-throughput

0.249

Low

181062

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.249

Low

181064

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

0

High-throughput

0.249

Low

181067

CTNA1
Catenin alpha-1

1

0

High-throughput

0.249

Low

181069

MYH9
Myosin-9

1

0

High-throughput

0.249

Low

181083

MYL6
Myosin light polypeptide 6

1

0

High-throughput

0.249

Low

181086

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.249

Low

181092

TBB4B
Tubulin beta-4B chain

1

0

High-throughput

0.249

Low

181093

TCPB
T-complex protein 1 subunit beta

1

0

High-throughput

0.249

Low

181100

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.249

Low

181103

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

1

0

High-throughput

0.249

Low

181104

AAAT
Neutral amino acid transporter B(0)

1

0

High-throughput

0.249

Low

181110

ZCCHV
Zinc finger CCCH-type antiviral protein 1

1

0

High-throughput

0.249

Low

181111

CAPS2
Calcium-dependent secretion activator 2

1

0

High-throughput

0.249

Low

181122

ASB6
Ankyrin repeat and SOCS box protein 6

1

0

Small-scale

0.249

Low

181125

KCMF1
E3 ubiquitin-protein ligase KCMF1

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024