Protein: UBE4B
Ubiquitin conjugation factor E4 B (EC 2.3.2.27) (Homozygously deleted in neuroblastoma 1) (RING-type E3 ubiquitin transferase E4 B) (Ubiquitin fusion degradation protein 2)

Gene: UBE4B
Organism: Homo sapiens
Interactions: 72
UniProt ID: O95155

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0000209 - protein polyubiquitination
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006511 - ubiquitin-dependent protein catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

305165

UB2D2
Ubiquitin-conjugating enzyme E2 D2

6

20

Small-scale

0.949

High

305164

UB2D3
Ubiquitin-conjugating enzyme E2 D3

5

20

Small-scale

0.937

High

305139

UBE4B
Ubiquitin conjugation factor E4 B

4

14

Small-scale

0.888

High

305162

TERA
Transitional endoplasmic reticulum ATPase

11

10

Small-scale

0.757

High

305146

P53
Cellular tumor antigen p53

4

7

Small-scale

0.705

High

305191

UBL7
Ubiquitin-like protein 7

3

0

High-throughput

0.638

High

305161

RD23B
UV excision repair protein RAD23 homolog B

2

9

High-throughput

0.628

High

305167

MDM2
E3 ubiquitin-protein ligase Mdm2

2

1

Small-scale

0.624

High

305159

ATX3
Ataxin-3

2

5

Small-scale

0.602

High

305154

MPIP1
M-phase inducer phosphatase 1

2

0

High-throughput

0.602

High

305202

FBW1B
F-box/WD repeat-containing protein 11

2

3

Small-scale

0.584

High

305143

ESR1
Estrogen receptor

1

10

High-throughput

0.541

High

305174

TRA2A
Transformer-2 protein homolog alpha

1

0

Small-scale

0.537

High

305193

FEZ1
Fasciculation and elongation protein zeta-1

1

0

Small-scale

0.537

High

305170

UBXN1
UBX domain-containing protein 1

1

3

High-throughput

0.536

High

305184

NAL10
NACHT, LRR and PYD domains-containing protein 10

1

3

High-throughput

0.536

High

305204

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.536

High

305157

CDN2A
Cyclin-dependent kinase inhibitor 2A

1

5

Small-scale

0.516

High

305196

DUS16
Dual specificity protein phosphatase 16

1

0

High-throughput

0.513

High

305158

VAV2
Guanine nucleotide exchange factor VAV2

1

1

High-throughput

0.508

High

305148

GRAB
Granzyme B

1

2

Small-scale

0.501

High

305152

MK03
Mitogen-activated protein kinase 3

1

3

Small-scale

0.501

High

305160

RD23A
UV excision repair protein RAD23 homolog A

1

10

Small-scale

0.501

High

305171

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

1

Small-scale

0.501

High

305175

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

2

Small-scale

0.501

High

305194

ANM1
Protein arginine N-methyltransferase 1

1

2

Small-scale

0.501

High

305192

EYA3
Eyes absent homolog 3

1

0

High-throughput

0.493

High

305181

LRC73
Leucine-rich repeat-containing protein 73

1

3

High-throughput

0.489

High

305198

Q9H4D1
Protein kinase

1

6

High-throughput

0.481

High

305142

RASH
GTPase HRas

1

0

Small-scale

0.480

High

175801

P73
Tumor protein p73

1

7

Small-scale

0.479

High

209553

PRC1
Protein regulator of cytokinesis 1

1

1

High-throughput

0.479

High

305141

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

305147

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.479

High

305149

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

305150

EGR1
Early growth response protein 1

1

6

High-throughput

0.479

High

305153

CDC27
Cell division cycle protein 27 homolog

1

1

Small-scale

0.479

High

305155

TTK
Dual specificity protein kinase TTK

1

7

Small-scale

0.479

High

305166

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.479

High

305168

XPC
DNA repair protein complementing XP-C cells

1

1

Small-scale

0.479

High

305172

TIF1B
Transcription intermediary factor 1-beta

1

2

High-throughput

0.479

High

305173

SMAD4
Mothers against decapentaplegic homolog 4

1

7

High-throughput

0.479

High

305177

SF3B4
Splicing factor 3B subunit 4

1

1

Small-scale

0.479

High

305183

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.479

High

305185

RPTOR
Regulatory-associated protein of mTOR

1

1

High-throughput

0.479

High

305186

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.479

High

305195

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

8

High-throughput

0.479

High

305197

P63
Tumor protein 63

1

7

Small-scale

0.479

High

305199

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

305201

HERC5
E3 ISG15--protein ligase HERC5

1

2

Small-scale

0.479

High

305203

FBW1A
F-box/WD repeat-containing protein 1A

1

3

Small-scale

0.479

High

305176

PTPA
Serine/threonine-protein phosphatase 2A activator

1

0

Small-scale

0.458

High

305180

KLH22
Kelch-like protein 22

1

0

Small-scale

0.458

High

305200

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

159820

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

1

Small-scale

0.457

High

305189

OTUB1
Ubiquitin thioesterase OTUB1

1

1

Small-scale

0.457

High

305163

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

5

High-throughput

0.457

High

305140

EGFR
Epidermal growth factor receptor

1

12

High-throughput

0.445

High

305144

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

7

High-throughput

0.445

High

305145

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.437

High

305156

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

305187

STAM1
Signal transducing adapter molecule 1

1

1

Small-scale

0.437

High

305151

CBL
E3 ubiquitin-protein ligase CBL

1

0

Small-scale

0.426

High

305169

CNTN2
Contactin-2

1

0

Small-scale

0.292

High

305188

P5CR2
Pyrroline-5-carboxylate reductase 2

1

0

Small-scale

0.292

High

305178

OR7A5
Olfactory receptor 7A5

1

0

High-throughput

0.279

Low

305179

AMZ1
Archaemetzincin-1

1

0

High-throughput

0.279

Low

305205

PCDA8
Protocadherin alpha-8

1

0

High-throughput

0.279

Low

305190

PGAM5
Serine/threonine-protein phosphatase PGAM5, mitochondrial

1

0

Small-scale

0.261

Low

123445

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.249

Low

305182

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024