Protein: IGHG1
Immunoglobulin heavy constant gamma 1 (Ig gamma-1 chain C region) (Ig gamma-1 chain C region EU) (Ig gamma-1 chain C region KOL) (Ig gamma-1 chain C region NIE)

Gene: IGHG1
Organism: Homo sapiens
Interactions: 177
UniProt ID: P01857

Gene Ontology (top 5):
GO:0001788 - antibody-dependent cellular cytotoxicity
GO:0002250 - adaptive immune response
GO:0003823 - antigen binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

353480

IGKC
Immunoglobulin kappa constant

3

16

Small-scale

0.834

High

353621

IGLC1
Immunoglobulin lambda constant 1

2

16

Small-scale

0.755

High

353626

FCGR1
High affinity immunoglobulin gamma Fc receptor I

1

8

Small-scale

0.692

High

353642

FCG2B
Low affinity immunoglobulin gamma Fc region receptor II-b

1

7

Small-scale

0.692

High

353208

LV208
Immunoglobulin lambda variable 2-8

1

19

Small-scale

0.647

High

353595

IGHG1
Immunoglobulin heavy constant gamma 1

1

15

Small-scale

0.647

High

353644

CAH8
Carbonic anhydrase-related protein

2

4

High-throughput

0.637

High

60268

POTEF
POTE ankyrin domain family member F

1

5

High-throughput

0.575

High

126324

MATN2
Matrilin-2

1

11

High-throughput

0.575

High

198338

KLK10
Kallikrein-10

1

9

High-throughput

0.575

High

353203

LV147
Immunoglobulin lambda variable 1-47

1

19

High-throughput

0.575

High

353347

HV323
Immunoglobulin heavy variable 3-23

1

15

High-throughput

0.575

High

353350

HV307
Immunoglobulin heavy variable 3-7

1

15

High-throughput

0.575

High

353596

IGHG2
Immunoglobulin heavy constant gamma 2

1

16

High-throughput

0.575

High

353597

IGHG3
Immunoglobulin heavy constant gamma 3

1

17

High-throughput

0.575

High

353598

IGHG4
Immunoglobulin heavy constant gamma 4

1

16

High-throughput

0.575

High

353604

FINC
Fibronectin

1

9

High-throughput

0.575

High

353606

ALBU
Albumin

1

5

High-throughput

0.575

High

353613

HEP2
Heparin cofactor 2

1

1

High-throughput

0.575

High

353615

KLK3
Prostate-specific antigen

1

9

High-throughput

0.575

High

353624

FGFR1
Fibroblast growth factor receptor 1

1

12

High-throughput

0.575

High

353631

IGLL1
Immunoglobulin lambda-like polypeptide 1

1

16

High-throughput

0.575

High

353634

VCAM1
Vascular cell adhesion protein 1

1

6

High-throughput

0.575

High

353638

ZA2G
Zinc-alpha-2-glycoprotein

1

4

High-throughput

0.575

High

353651

SC6A9
Sodium- and chloride-dependent glycine transporter 1

1

1

High-throughput

0.575

High

353676

FNDC1
Fibronectin type III domain-containing protein 1

1

15

High-throughput

0.575

High

353698

Q8N355
IGL@ protein

1

19

High-throughput

0.575

High

353702

FNDC5
Fibronectin type III domain-containing protein 5

1

6

High-throughput

0.575

High

353707

TITIN
Titin

1

17

High-throughput

0.575

High

353727

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

8

High-throughput

0.575

High

353639

1433T
14-3-3 protein theta

2

9

High-throughput

0.552

High

353717

SUSD3
Sushi domain-containing protein 3

2

2

High-throughput

0.552

High

353609

IFNA4
Interferon alpha-4

1

0

High-throughput

0.546

High

353677

LRC10
Leucine-rich repeat-containing protein 10

1

3

High-throughput

0.514

High

353637

CP3A5
Cytochrome P450 3A5

2

1

High-throughput

0.504

High

353701

ASCC1
Activating signal cointegrator 1 complex subunit 1

2

4

High-throughput

0.504

High

353719

CDK15
Cyclin-dependent kinase 15

2

6

High-throughput

0.504

High

353731

DDX31
ATP-dependent DNA helicase DDX31

2

9

High-throughput

0.504

High

353710

H2B1H
Histone H2B type 1-H

1

10

High-throughput

0.479

High

125954

UPK1A
Uroplakin-1a

1

10

High-throughput

0.445

High

182068

PDPK1
3-phosphoinositide-dependent protein kinase 1

1

5

High-throughput

0.445

High

182997

P2RX6
P2X purinoceptor 6

1

4

High-throughput

0.445

High

239687

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

6

High-throughput

0.445

High

260115

VPS4B
Vacuolar protein sorting-associated protein 4B

1

1

High-throughput

0.445

High

328080

SG1D1
Secretoglobin family 1D member 1

1

6

High-throughput

0.445

High

353599

K1C14
Keratin, type I cytoskeletal 14

1

10

High-throughput

0.445

High

353600

K2C6A
Keratin, type II cytoskeletal 6A

1

7

High-throughput

0.445

High

353601

APOA1
Apolipoprotein A-I

1

3

High-throughput

0.445

High

353602

APOC1
Apolipoprotein C-I

1

2

High-throughput

0.445

High

353603

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

5

High-throughput

0.445

High

353605

TTHY
Transthyretin

1

1

High-throughput

0.445

High

353607

TRFE
Serotransferrin

1

3

High-throughput

0.445

High

353608

K2C1
Keratin, type II cytoskeletal 1

1

6

High-throughput

0.445

High

353611

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

6

High-throughput

0.445

High

353612

F13B
Coagulation factor XIII B chain

1

5

Small-scale

0.445

High

353616

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

12

High-throughput

0.445

High

353618

K2C7
Keratin, type II cytoskeletal 7

1

3

High-throughput

0.445

High

353619

K1C16
Keratin, type I cytoskeletal 16

1

10

High-throughput

0.445

High

353622

CLUS
Clusterin

1

1

High-throughput

0.445

High

353623

BIP
Endoplasmic reticulum chaperone BiP

1

10

High-throughput

0.445

High

353627

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

353628

K1C10
Keratin, type I cytoskeletal 10

1

12

High-throughput

0.445

High

353629

K2C5
Keratin, type II cytoskeletal 5

1

4

High-throughput

0.445

High

353630

ELN
Elastin

1

2

High-throughput

0.445

High

353633

AATC
Aspartate aminotransferase, cytoplasmic

1

7

High-throughput

0.445

High

353641

AL3A1
Aldehyde dehydrogenase, dimeric NADP-preferring

1

11

High-throughput

0.445

High

353643

CCR1
C-C chemokine receptor type 1

1

12

High-throughput

0.445

High

353645

ADA1B
Alpha-1B adrenergic receptor

1

2

High-throughput

0.445

High

353646

K1C9
Keratin, type I cytoskeletal 9

1

11

High-throughput

0.445

High

353649

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

4

High-throughput

0.445

High

353653

TGM4
Protein-glutamine gamma-glutamyltransferase 4

1

1

High-throughput

0.445

High

353655

CAD12
Cadherin-12

1

3

High-throughput

0.445

High

353656

STX17
Syntaxin-17

1

4

High-throughput

0.445

High

353658

1433G
14-3-3 protein gamma

1

9

High-throughput

0.445

High

353663

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

3

Small-scale

0.445

High

353666

PAPP1
Pappalysin-1

1

6

High-throughput

0.445

High

353667

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

7

High-throughput

0.445

High

353668

ICAM4
Intercellular adhesion molecule 4

1

1

High-throughput

0.445

High

353686

GP141
Probable G-protein coupled receptor 141

1

13

High-throughput

0.445

High

353692

FRAS1
Extracellular matrix organizing protein FRAS1

1

6

High-throughput

0.445

High

353696

RTKN2
Rhotekin-2

1

1

High-throughput

0.445

High

353697

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

10

High-throughput

0.445

High

353704

ARI1B
AT-rich interactive domain-containing protein 1B

1

2

High-throughput

0.445

High

353706

ITLN2
Intelectin-2

1

6

High-throughput

0.445

High

353712

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

5

High-throughput

0.445

High

353721

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.445

High

353723

EGFL8
Epidermal growth factor-like protein 8

1

14

High-throughput

0.445

High

353728

OR8D2
Olfactory receptor 8D2

1

2

High-throughput

0.445

High

353741

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

8

High-throughput

0.445

High

353743

DD19B
ATP-dependent RNA helicase DDX19B

1

5

High-throughput

0.445

High

260432

PITX3
Pituitary homeobox 3

1

4

Small-scale

0.437

High

353665

TRAF1
TNF receptor-associated factor 1

1

1

High-throughput

0.437

High

353747

NEMO
NF-kappa-B essential modulator

1

8

High-throughput

0.437

High

336751

CERU
Ceruloplasmin

1

0

High-throughput

0.426

High

353610

APOD
Apolipoprotein D

1

0

High-throughput

0.426

High

353617

CO4A2

1

0

High-throughput

0.426

High

353640

AOAH
Acyloxyacyl hydrolase

1

0

High-throughput

0.426

High

353647

SAA4
Serum amyloid A-4 protein

1

0

High-throughput

0.426

High

353654

FAS
Fatty acid synthase

1

0

High-throughput

0.426

High

353671

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.426

High

353682

HRG1
Heme transporter HRG1

1

0

High-throughput

0.426

High

353729

ADNP
Activity-dependent neuroprotector homeobox protein

1

0

High-throughput

0.426

High

152478

ENC1
Ectoderm-neural cortex protein 1

1

4

High-throughput

0.407

High

217696

PDE6D
Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta

1

2

High-throughput

0.407

High

265578

E2F6
Transcription factor E2F6

1

1

High-throughput

0.407

High

266295

TAD2A
Transcriptional adapter 2-alpha

1

1

High-throughput

0.407

High

303619

OR2A4
Olfactory receptor 2A4

1

7

High-throughput

0.407

High

305332

ZFPL1
Zinc finger protein-like 1

1

3

High-throughput

0.407

High

353614

NFM
Neurofilament medium polypeptide

1

6

High-throughput

0.407

High

353625

ADT3
ADP/ATP translocase 3

1

4

High-throughput

0.407

High

353632

ZSC20
Zinc finger and SCAN domain-containing protein 20

1

2

High-throughput

0.407

High

353635

CSK22
Casein kinase II subunit alpha'

1

5

High-throughput

0.407

High

353636

CCNA2
Cyclin-A2

1

2

High-throughput

0.407

High

353648

NU214
Nuclear pore complex protein Nup214

1

2

High-throughput

0.407

High

353650

KI67
Proliferation marker protein Ki-67

1

5

High-throughput

0.407

High

353652

PTSS1
Phosphatidylserine synthase 1

1

4

High-throughput

0.407

High

353657

DSCR6
Protein ripply3

1

3

High-throughput

0.407

High

353659

SSBP2
Single-stranded DNA-binding protein 2

1

5

High-throughput

0.407

High

353660

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

9

High-throughput

0.407

High

353661

EF1A2
Elongation factor 1-alpha 2

1

3

High-throughput

0.407

High

353662

GABPA
GA-binding protein alpha chain

1

2

High-throughput

0.407

High

353664

TRAF2
TNF receptor-associated factor 2

1

3

High-throughput

0.407

High

353670

ABRX2
BRISC complex subunit Abraxas 2

1

1

High-throughput

0.407

High

353672

KAT1
Kynurenine--oxoglutarate transaminase 1

1

3

High-throughput

0.407

High

353673

UPP1
Uridine phosphorylase 1

1

3

High-throughput

0.407

High

353674

RFX7
DNA-binding protein RFX7

1

2

High-throughput

0.407

High

353675

CR021
UPF0711 protein C18orf21

1

7

High-throughput

0.407

High

353678

EMC4
ER membrane protein complex subunit 4

1

3

High-throughput

0.407

High

353679

MYOME
Myomegalin

1

5

High-throughput

0.407

High

353680

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

9

High-throughput

0.407

High

353683

SFXN4
Sideroflexin-4

1

6

High-throughput

0.407

High

353684

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

High-throughput

0.407

High

353687

PCGF5
Polycomb group RING finger protein 5

1

8

High-throughput

0.407

High

353688

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

3

High-throughput

0.407

High

353690

CIR1
Corepressor interacting with RBPJ 1

1

7

High-throughput

0.407

High

353691

MICU3
Calcium uptake protein 3, mitochondrial

1

1

High-throughput

0.407

High

353693

Z354C
Zinc finger protein 354C

1

1

High-throughput

0.407

High

353694

CERS3
Ceramide synthase 3

1

7

High-throughput

0.407

High

353695

NRSN1
Neurensin-1

1

6

High-throughput

0.407

High

353699

RYBP
RING1 and YY1-binding protein

1

2

High-throughput

0.407

High

353700

GDPD1
Lysophospholipase D GDPD1

1

3

High-throughput

0.407

High

353705

RHBL4
Rhomboid-related protein 4

1

8

High-throughput

0.407

High

353708

TFG
Protein TFG

1

3

High-throughput

0.407

High

353709

TANK
TRAF family member-associated NF-kappa-B activator

1

2

High-throughput

0.407

High

353711

PIGT
GPI transamidase component PIG-T

1

6

High-throughput

0.407

High

353713

SARAF
Store-operated calcium entry-associated regulatory factor

1

3

High-throughput

0.407

High

353714

F120B
Constitutive coactivator of peroxisome proliferator-activated receptor gamma

1

1

High-throughput

0.407

High

353715

EDC3
Enhancer of mRNA-decapping protein 3

1

1

High-throughput

0.407

High

353716

SMIM8
Small integral membrane protein 8

1

1

High-throughput

0.407

High

353718

SNX27
Sorting nexin-27

1

10

High-throughput

0.407

High

353720

SETB2
Histone-lysine N-methyltransferase SETDB2

1

1

High-throughput

0.407

High

353722

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

11

High-throughput

0.407

High

353724

FUND2
FUN14 domain-containing protein 2

1

2

High-throughput

0.407

High

353725

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

9

High-throughput

0.407

High

353726

SRRT
Serrate RNA effector molecule homolog

1

2

High-throughput

0.407

High

353730

SFR19
Splicing factor, arginine/serine-rich 19

1

3

High-throughput

0.407

High

353732

QTRT2
Queuine tRNA-ribosyltransferase accessory subunit 2

1

1

High-throughput

0.407

High

353733

COE2
Transcription factor COE2

1

6

High-throughput

0.407

High

353734

UD110
UDP-glucuronosyltransferase 1A10

1

1

High-throughput

0.407

High

353735

MET14
N6-adenosine-methyltransferase non-catalytic subunit

1

3

High-throughput

0.407

High

353736

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

1

High-throughput

0.407

High

353737

MBNL1
Muscleblind-like protein 1

1

4

High-throughput

0.407

High

353738

TB22B
TBC1 domain family member 22B

1

3

High-throughput

0.407

High

353739

MO4L1
Mortality factor 4-like protein 1

1

2

High-throughput

0.407

High

353740

PHF11
PHD finger protein 11

1

11

High-throughput

0.407

High

353742

PNMA2
Paraneoplastic antigen Ma2

1

1

High-throughput

0.407

High

353744

SSUH2
Protein SSUH2 homolog

1

4

High-throughput

0.407

High

353745

AR2BP
ADP-ribosylation factor-like protein 2-binding protein

1

2

High-throughput

0.407

High

353746

RN115
E3 ubiquitin-protein ligase RNF115

1

4

High-throughput

0.407

High

297217

DDHD2
Phospholipase DDHD2

1

0

High-throughput

0.232

Low

353620

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.232

Low

353669

FL2D
Pre-mRNA-splicing regulator WTAP

1

0

High-throughput

0.232

Low

353681

TENS3
Tensin-3

1

0

High-throughput

0.232

Low

353685

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

0

High-throughput

0.232

Low

353689

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.232

Low

353703

ARMC2
Armadillo repeat-containing protein 2

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024