Protein: TIMP2
Metalloproteinase inhibitor 2 (CSC-21K) (Tissue inhibitor of metalloproteinases 2) (TIMP-2)

Gene: TIMP2
Organism: Homo sapiens
Interactions: 47
UniProt ID: P16035

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0008191 - metalloendopeptidase inhibitor activity
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439223

MMP2
72 kDa type IV collagenase

10

20

Small-scale

0.976

High

554808

MMP14
Matrix metalloproteinase-14

6

20

Small-scale

0.950

High

554805

TIMP3
Metalloproteinase inhibitor 3

3

1

High-throughput

0.667

High

372726

MMP1
Interstitial collagenase

1

20

Small-scale

0.647

High

439263

MMP3
Stromelysin-1

1

20

Small-scale

0.647

High

540409

MMP9
Matrix metalloproteinase-9

1

20

Small-scale

0.647

High

554809

MMP15
Matrix metalloproteinase-15

1

20

Small-scale

0.647

High

554810

MMP16
Matrix metalloproteinase-16

1

20

Small-scale

0.647

High

321966

ZMYM6
Zinc finger MYM-type protein 6

3

0

High-throughput

0.638

High

319508

LY86
Lymphocyte antigen 86

1

1

High-throughput

0.536

High

532889

PRG2
Bone marrow proteoglycan

1

1

High-throughput

0.536

High

554811

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

1

High-throughput

0.536

High

554814

WNT3A
Protein Wnt-3a

1

1

High-throughput

0.536

High

554822

ESPB1
Epididymal sperm-binding protein 1

1

7

High-throughput

0.536

High

554823

WN10A
Protein Wnt-10a

1

1

High-throughput

0.536

High

554821

LPD6B
Ly6/PLAUR domain-containing protein 6B

1

0

High-throughput

0.513

High

443029

ITA5
Integrin alpha-5

1

1

Small-scale

0.512

High

554813

ITA1
Integrin alpha-1

1

2

Small-scale

0.512

High

403768

ITB1
Integrin beta-1

1

1

Small-scale

0.501

High

344933

CYTN
Cystatin-SN

1

2

Small-scale

0.479

High

156213

PSA7
Proteasome subunit alpha type-7

1

1

High-throughput

0.470

High

123485

PGRC1
Membrane-associated progesterone receptor component 1

1

0

High-throughput

0.458

High

554799

EGR1
Early growth response protein 1

1

0

Small-scale

0.458

High

554812

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.458

High

181051

INSI1
Insulin-induced gene 1 protein

1

1

High-throughput

0.437

High

345844

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

554804

ECHM
Enoyl-CoA hydratase, mitochondrial

1

1

High-throughput

0.437

High

554815

PSA6
Proteasome subunit alpha type-6

1

1

High-throughput

0.437

High

554826

INSI2
Insulin-induced gene 2 protein

1

1

High-throughput

0.437

High

554803

HEMH
Ferrochelatase, mitochondrial

3

0

High-throughput

0.347

High

554824

UBQL2
Ubiquilin-2

2

0

High-throughput

0.316

High

554820

PTPRN
Receptor-type tyrosine-protein phosphatase-like N

1

0

High-throughput

0.279

Low

282762

SYUG
Gamma-synuclein

1

0

High-throughput

0.269

Low

320808

HS74L
Heat shock 70 kDa protein 4L

1

0

High-throughput

0.249

Low

324212

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.249

Low

330153

APCL
Adenomatous polyposis coli protein 2

1

0

High-throughput

0.249

Low

554800

RAB3A
Ras-related protein Rab-3A

1

0

High-throughput

0.249

Low

554801

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.249

Low

554802

PUR6
Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase

1

0

High-throughput

0.249

Low

554806

RANG
Ran-specific GTPase-activating protein

1

0

High-throughput

0.249

Low

554807

RL29
Large ribosomal subunit protein eL29

1

0

High-throughput

0.249

Low

554816

PSME3
Proteasome activator complex subunit 3

1

0

High-throughput

0.249

Low

554818

CUL3
Cullin-3

1

0

High-throughput

0.249

Low

554819

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.249

Low

554825

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.249

Low

554827

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.249

Low

554817

UBE3A
Ubiquitin-protein ligase E3A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024