Protein: UBP5
Ubiquitin carboxyl-terminal hydrolase 5 (EC 3.4.19.12) (Deubiquitinating enzyme 5) (Isopeptidase T) (Ubiquitin thioesterase 5) (Ubiquitin-specific-processing protease 5)

Gene: UBP5, USP5
Organism: Homo sapiens
Interactions: 128
UniProt ID: P45974

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005764 - lysosome
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

475461

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

34

20

Small-scale

0.994

High

800610

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

2

16

Small-scale

0.776

High

474951

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

20

High-throughput

0.776

High

800621

STK33
Serine/threonine-protein kinase 33

1

6

Small-scale

0.724

High

800568

RD23B
UV excision repair protein RAD23 homolog B

1

20

Small-scale

0.665

High

397832

ISG15
Ubiquitin-like protein ISG15

1

20

Small-scale

0.647

High

800589

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

8

Small-scale

0.647

High

800620

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

14

High-throughput

0.647

High

800630

SMUF1
E3 ubiquitin-protein ligase SMURF1

3

20

Small-scale

0.646

High

265122

MAF
Transcription factor Maf

3

5

Small-scale

0.640

High

800603

UBTD2
Ubiquitin domain-containing protein 2

1

0

Small-scale

0.633

High

496512

TAU
Microtubule-associated protein tau

2

10

High-throughput

0.628

High

346171

MYC
Myc proto-oncogene protein

2

19

Small-scale

0.624

High

158426

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

10

Small-scale

0.618

High

160433

AURKA
Aurora kinase A

1

16

Small-scale

0.618

High

226777

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

800567

RD23A
UV excision repair protein RAD23 homolog A

1

19

Small-scale

0.618

High

800570

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

8

High-throughput

0.618

High

800571

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

20

High-throughput

0.618

High

800583

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

6

High-throughput

0.618

High

800591

A16L1
Autophagy-related protein 16-1

1

11

High-throughput

0.618

High

800599

SPART
Spartin

2

3

High-throughput

0.606

High

800626

TRIM8
E3 ubiquitin-protein ligase TRIM8

2

20

High-throughput

0.606

High

800637

RN216
E3 ubiquitin-protein ligase RNF216

2

6

High-throughput

0.606

High

306608

CAC1H
Voltage-dependent T-type calcium channel subunit alpha-1H

3

2

Small-scale

0.601

High

800645

RNF11
RING finger protein 11

2

10

Small-scale

0.600

High

125223

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

20

Small-scale

0.595

High

800647

TRAF6
TNF receptor-associated factor 6

2

20

Small-scale

0.595

High

622393

CCND1
G1/S-specific cyclin-D1

2

8

Small-scale

0.584

High

800576

FOXM1
Forkhead box protein M1

2

7

Small-scale

0.584

High

267632

TADA3
Transcriptional adapter 3

1

4

High-throughput

0.582

High

800580

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

8

High-throughput

0.575

High

800584

DAZP2
DAZ-associated protein 2

1

1

High-throughput

0.573

High

213498

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

1

13

Small-scale

0.561

High

800596

MTA70
N6-adenosine-methyltransferase catalytic subunit

1

1

Small-scale

0.561

High

800600

TRIML
Probable E3 ubiquitin-protein ligase TRIML1

1

17

Small-scale

0.561

High

150900

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

5

High-throughput

0.541

High

800585

TCAL1
Transcription elongation factor A protein-like 1

1

1

High-throughput

0.536

High

800625

B2L14
Apoptosis facilitator Bcl-2-like protein 14

1

1

High-throughput

0.536

High

800628

TXNIP
Thioredoxin-interacting protein

1

5

High-throughput

0.536

High

800639

PD1L1
Programmed cell death 1 ligand 1

1

8

Small-scale

0.528

High

800574

CAV1
Caveolin-1

2

1

High-throughput

0.521

High

455190

PARP1
Poly [ADP-ribose] polymerase 1

1

9

High-throughput

0.515

High

154596

TPP1
Tripeptidyl-peptidase 1

1

1

High-throughput

0.515

High

800597

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

394296

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

800569

SUMO2
Small ubiquitin-related modifier 2

1

4

High-throughput

0.501

High

800601

PJA1
E3 ubiquitin-protein ligase Praja-1

1

11

High-throughput

0.501

High

800606

RFFL
E3 ubiquitin-protein ligase rififylin

1

12

High-throughput

0.501

High

800611

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

800622

TRI54
Tripartite motif-containing protein 54

1

20

High-throughput

0.501

High

800623

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.501

High

800590

TMM31
Transmembrane protein 31

1

1

High-throughput

0.489

High

800578

TRI26
Tripartite motif-containing protein 26

1

20

High-throughput

0.481

High

800627

TRIM5
Tripartite motif-containing protein 5

1

20

High-throughput

0.481

High

800631

TRI39
E3 ubiquitin-protein ligase TRIM39

1

20

High-throughput

0.481

High

204122

KLF4
Krueppel-like factor 4

1

13

Small-scale

0.479

High

208771

SNAI2
Zinc finger protein SNAI2

1

12

Small-scale

0.479

High

209748

PRC1
Protein regulator of cytokinesis 1

1

3

High-throughput

0.479

High

244074

BRD4
Bromodomain-containing protein 4

1

18

High-throughput

0.479

High

379106

MYCN
N-myc proto-oncogene protein

1

19

Small-scale

0.479

High

386269

P53
Cellular tumor antigen p53

1

8

High-throughput

0.479

High

453205

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

1

Small-scale

0.479

High

487213

ANDR
Androgen receptor

1

19

High-throughput

0.479

High

532418

TCTP
Translationally-controlled tumor protein

1

2

High-throughput

0.479

High

545252

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.479

High

569349

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

607018

UBA1
Ubiquitin-like modifier-activating enzyme 1

1

1

Small-scale

0.479

High

607792

USF1
Upstream stimulatory factor 1

1

18

Small-scale

0.479

High

632211

TNR6
Tumor necrosis factor receptor superfamily member 6

1

2

High-throughput

0.479

High

637802

PSA3
Proteasome subunit alpha type-3

1

2

Small-scale

0.479

High

668499

PML
Protein PML

1

20

High-throughput

0.479

High

684488

STIP1
Stress-induced-phosphoprotein 1

1

7

High-throughput

0.479

High

800566

PMS1
PMS1 protein homolog 1

1

2

High-throughput

0.479

High

800572

HSF1
Heat shock factor protein 1

1

4

High-throughput

0.479

High

800573

KIF23
Kinesin-like protein KIF23

1

8

High-throughput

0.479

High

800577

EP300
Histone acetyltransferase p300

1

16

High-throughput

0.479

High

800579

G3BP1
Ras GTPase-activating protein-binding protein 1

1

3

High-throughput

0.479

High

800581

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

High-throughput

0.479

High

800582

CUL7
Cullin-7

1

3

High-throughput

0.479

High

800586

ELAV1
ELAV-like protein 1

1

4

Small-scale

0.479

High

800594

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.479

High

800595

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

5

High-throughput

0.479

High

800598

SLX4
Structure-specific endonuclease subunit SLX4

1

10

High-throughput

0.479

High

800607

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

11

High-throughput

0.479

High

800608

HDAC2
Histone deacetylase 2

1

11

Small-scale

0.479

High

800609

CSN5
COP9 signalosome complex subunit 5

1

8

High-throughput

0.479

High

800612

OTUL
Ubiquitin thioesterase otulin

1

2

Small-scale

0.479

High

800613

ARMC5
Armadillo repeat-containing protein 5

1

13

High-throughput

0.479

High

800615

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

20

High-throughput

0.479

High

800616

SNX27
Sorting nexin-27

1

9

High-throughput

0.479

High

800619

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

4

Small-scale

0.479

High

800632

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

10

High-throughput

0.479

High

800633

METL5
rRNA N6-adenosine-methyltransferase METTL5

1

2

Small-scale

0.479

High

800634

DUS22
Dual specificity protein phosphatase 22

1

6

High-throughput

0.479

High

800635

RAD18
E3 ubiquitin-protein ligase RAD18

1

3

Small-scale

0.479

High

800638

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

800641

ZRAN1
Ubiquitin thioesterase ZRANB1

1

8

High-throughput

0.479

High

800642

SRRM2
Serine/arginine repetitive matrix protein 2

1

9

High-throughput

0.479

High

800648

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

11

Small-scale

0.479

High

800649

MAFB
Transcription factor MafB

1

12

Small-scale

0.479

High

800565

EFTU
Elongation factor Tu, mitochondrial

1

0

Small-scale

0.458

High

800624

OSBL8
Oxysterol-binding protein-related protein 8

1

0

Small-scale

0.458

High

800646

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

537562

PA2GA
Phospholipase A2, membrane associated

1

4

Small-scale

0.457

High

800575

FMR1
Fragile X messenger ribonucleoprotein 1

1

6

High-throughput

0.457

High

800592

PKHA7
Pleckstrin homology domain-containing family A member 7

1

20

High-throughput

0.445

High

800618

CEP63
Centrosomal protein of 63 kDa

1

11

High-throughput

0.445

High

123532

PGRC1
Membrane-associated progesterone receptor component 1

1

2

Small-scale

0.437

High

205150

TGON2
Trans-Golgi network integral membrane protein 2

1

3

High-throughput

0.437

High

329472

AGR2
Anterior gradient protein 2 homolog

1

1

High-throughput

0.437

High

384448

NTRK1
High affinity nerve growth factor receptor

1

14

High-throughput

0.437

High

672947

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

1

Small-scale

0.437

High

719899

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

800588

E2F4
Transcription factor E2F4

1

5

High-throughput

0.437

High

800593

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

800602

DUS19
Dual specificity protein phosphatase 19

1

6

High-throughput

0.437

High

800604

DEP1B
DEP domain-containing protein 1B

1

4

Small-scale

0.437

High

800614

PP14B
Protein phosphatase 1 regulatory subunit 14B

1

2

Small-scale

0.437

High

800629

PKHA4
Pleckstrin homology domain-containing family A member 4

1

16

High-throughput

0.437

High

800636

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

10

High-throughput

0.437

High

800640

TR10D
Tumor necrosis factor receptor superfamily member 10D

1

2

High-throughput

0.437

High

800587

EREP1
Endosomal transmembrane epsin interactor 1

1

1

Small-scale

0.417

High

800643

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.407

High

800605

TM239
Transmembrane protein 239

3

0

High-throughput

0.352

High

800617

CEP19
Centrosomal protein of 19 kDa

1

0

High-throughput

0.249

Low

800644

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

382342

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024