Protein: PNKP
Bifunctional polynucleotide phosphatase/kinase (DNA 5'-kinase/3'-phosphatase) (Polynucleotide kinase-3'-phosphatase) [Includes: Polynucleotide 3'-phosphatase (EC 3.1.3.32) (2'(3')-polynucleotidase); Polynucleotide 5'-hydroxyl-kinase (EC 2.7.1.78)]

Gene: PNKP
Organism: Homo sapiens
Interactions: 132
UniProt ID: Q96T60

Gene Ontology (top 5):
GO:0003684 - damaged DNA binding
GO:0003690 - double-stranded DNA binding
GO:0004519 - endonuclease activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

579732

XRCC1
DNA repair protein XRCC1

9

2

Small-scale

0.755

High

1033971

XRCC4
DNA repair protein XRCC4

8

1

Small-scale

0.755

High

417837

DPOLB
DNA polymerase beta

4

1

Small-scale

0.702

High

836767

DNLI3
DNA ligase 3

4

3

Small-scale

0.701

High

1064060

TNIP1
TNFAIP3-interacting protein 1

3

1

High-throughput

0.675

High

1302955

ZN639
Zinc finger protein 639

3

1

High-throughput

0.675

High

215921

ZBT14
Zinc finger and BTB domain-containing protein 14

3

0

High-throughput

0.646

High

1033716

IKZF1
DNA-binding protein Ikaros

3

0

High-throughput

0.646

High

1298227

CCD43
Coiled-coil domain-containing protein 43

4

1

High-throughput

0.634

High

936070

HBA
Hemoglobin subunit alpha

2

1

High-throughput

0.628

High

455785

PARP1
Poly [ADP-ribose] polymerase 1

2

3

Small-scale

0.611

High

996850

SSRP1
FACT complex subunit SSRP1

2

1

Small-scale

0.611

High

301988

TRI37
E3 ubiquitin-protein ligase TRIM37

3

3

High-throughput

0.609

High

213154

SNG1
Synaptogyrin-1

2

1

High-throughput

0.606

High

213276

SNG3
Synaptogyrin-3

2

1

High-throughput

0.606

High

1038917

KCC2B
Calcium/calmodulin-dependent protein kinase type II subunit beta

2

1

High-throughput

0.606

High

627335

MCM3
DNA replication licensing factor MCM3

2

1

Small-scale

0.601

High

836869

DNLI4
DNA ligase 4

2

3

Small-scale

0.601

High

944384

PRKDC
DNA-dependent protein kinase catalytic subunit

2

1

Small-scale

0.595

High

962301

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

0

Small-scale

0.586

High

244828

BRD4
Bromodomain-containing protein 4

2

1

High-throughput

0.584

High

917793

H4
Histone H4

2

1

High-throughput

0.584

High

207827

PPIP1
Proline-serine-threonine phosphatase-interacting protein 1

2

0

High-throughput

0.580

High

240434

SNX2
Sorting nexin-2

2

0

High-throughput

0.580

High

617640

CRCM
Colorectal mutant cancer protein

2

0

High-throughput

0.580

High

970898

SP4
Transcription factor Sp4

2

0

High-throughput

0.580

High

1075627

TRBP2
RISC-loading complex subunit TARBP2

2

0

High-throughput

0.580

High

1198506

TBCD1
TBC1 domain family member 1

2

0

High-throughput

0.580

High

1234700

CISD2
CDGSH iron-sulfur domain-containing protein 2

2

0

High-throughput

0.580

High

1238379

FADS6
Fatty acid desaturase 6

2

0

High-throughput

0.580

High

1241981

MSD4
Myb/SANT-like DNA-binding domain-containing protein 4

2

0

High-throughput

0.580

High

1260983

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.580

High

1262234

TM239
Transmembrane protein 239

2

0

High-throughput

0.580

High

1302943

MGST2
Microsomal glutathione S-transferase 2

2

0

High-throughput

0.580

High

1302951

RPRM
Protein reprimo

2

0

High-throughput

0.580

High

1302952

THAP1
THAP domain-containing protein 1

2

0

High-throughput

0.580

High

935820

HBB
Hemoglobin subunit beta

2

1

High-throughput

0.574

High

370264

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

868302

ATX3
Ataxin-3

2

0

Small-scale

0.561

High

206852

FOXO3
Forkhead box protein O3

1

1

High-throughput

0.554

High

1230165

CNTRB
Centrobin

2

1

High-throughput

0.553

High

1299822

PNMA5
Paraneoplastic antigen-like protein 5

2

2

High-throughput

0.553

High

1302950

PICK1
PRKCA-binding protein

2

1

High-throughput

0.553

High

1087357

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1302960

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

1

High-throughput

0.536

High

796336

MAGAB
Melanoma-associated antigen 11

1

0

High-throughput

0.518

High

1302948

MYOZ1
Myozenin-1

1

0

High-throughput

0.518

High

647213

1433T
14-3-3 protein theta

1

1

High-throughput

0.515

High

609494

FGFR3
Fibroblast growth factor receptor 3

1

1

High-throughput

0.515

High

1151196

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

536547

IRF2
Interferon regulatory factor 2

1

0

High-throughput

0.513

High

915486

ACTA
Actin, aortic smooth muscle

1

0

High-throughput

0.513

High

980996

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

1031591

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.501

High

246308

NOL3
Nucleolar protein 3

1

0

High-throughput

0.493

High

274606

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.493

High

1230802

NUP93
Nuclear pore complex protein Nup93

1

0

High-throughput

0.493

High

1302954

DDX20
Probable ATP-dependent RNA helicase DDX20

1

0

High-throughput

0.493

High

1302962

LAS1L
Ribosomal biogenesis protein LAS1L

1

0

High-throughput

0.493

High

657973

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.493

High

1302957

UBQL1
Ubiquilin-1

1

0

High-throughput

0.493

High

203772

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.486

High

232451

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.486

High

1302942

SMAD5
Mothers against decapentaplegic homolog 5

1

0

High-throughput

0.486

High

838221

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

175131

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

395552

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

385390

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

523957

XRCC6
X-ray repair cross-complementing protein 6

1

1

Small-scale

0.479

High

525029

XRCC5
X-ray repair cross-complementing protein 5

1

1

Small-scale

0.479

High

707720

H2B1B
Histone H2B type 1-B

1

2

High-throughput

0.479

High

799139

NKX21
Homeobox protein Nkx-2.1

1

2

High-throughput

0.479

High

877845

FOXA1
Hepatocyte nuclear factor 3-alpha

1

1

High-throughput

0.479

High

927440

1433Z
14-3-3 protein zeta/delta

1

1

High-throughput

0.479

High

1067108

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1270769

CBP
CREB-binding protein

1

1

Small-scale

0.479

High

1203601

Q86WV7
Coiled-coil domain-containing protein 43

1

1

High-throughput

0.470

High

360319

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.460

High

1302949

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

123697

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.458

High

124249

TAF4
Transcription initiation factor TFIID subunit 4

1

0

Small-scale

0.458

High

149197

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

228447

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

233599

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

268239

EED
Polycomb protein EED

1

0

High-throughput

0.458

High

391855

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.458

High

497475

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.458

High

524584

LYL1
Protein lyl-1

1

0

High-throughput

0.458

High

553509

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

569984

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

596808

CD11B
Cyclin-dependent kinase 11B

1

0

Small-scale

0.458

High

625012

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.458

High

652038

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

708738

MCM5
DNA replication licensing factor MCM5

1

0

Small-scale

0.458

High

719592

MERL
Merlin

1

0

High-throughput

0.458

High

721236

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

742483

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

791894

HD
Huntingtin

1

0

Small-scale

0.458

High

825862

NASP
Nuclear autoantigenic sperm protein

1

0

Small-scale

0.458

High

869407

HAP1
Huntingtin-associated protein 1

1

0

Small-scale

0.458

High

884060

GEMI4
Gem-associated protein 4

1

0

Small-scale

0.458

High

986975

SUH
Recombining binding protein suppressor of hairless

1

0

High-throughput

0.458

High

1019358

TRI26
Tripartite motif-containing protein 26

1

0

Small-scale

0.458

High

1034112

TCOF
Treacle protein

1

0

Small-scale

0.458

High

1036834

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1061047

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

0

Small-scale

0.458

High

1125219

NOM1
Nucleolar MIF4G domain-containing protein 1

1

0

High-throughput

0.458

High

1135300

ATD3B
ATPase family AAA domain-containing protein 3B

1

0

High-throughput

0.458

High

1281821

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1284224

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.458

High

1284930

ARK2N
Protein ARK2N

1

0

Small-scale

0.458

High

1302946

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

Small-scale

0.458

High

1302958

PPIE
Peptidyl-prolyl cis-trans isomerase E

1

0

High-throughput

0.458

High

1302959

CBPC1
Cytosolic carboxypeptidase 1

1

0

Small-scale

0.458

High

1302961

DCAF1
DDB1- and CUL4-associated factor 1

1

0

Small-scale

0.458

High

1302963

SP16H
FACT complex subunit SPT16

1

0

Small-scale

0.458

High

1171358

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

330125

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.316

High

439165

SYPH
Synaptophysin

2

0

High-throughput

0.316

High

1115663

CCD14
Coiled-coil domain-containing protein 14

2

0

High-throughput

0.316

High

1120806

KLH12
Kelch-like protein 12

2

0

High-throughput

0.316

High

1144757

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

0

High-throughput

0.316

High

1273615

DVL3
Segment polarity protein dishevelled homolog DVL-3

2

0

High-throughput

0.316

High

1302945

CAR10
Caspase recruitment domain-containing protein 10

2

0

High-throughput

0.316

High

1302953

FLOWR
Calcium channel flower homolog

2

0

High-throughput

0.316

High

1302956

COHA1
Collagen alpha-1(XVII) chain

2

0

High-throughput

0.316

High

836358

GRAK
Granzyme K

1

0

High-throughput

0.282

High

1302944

KR412
Keratin-associated protein 4-12

1

0

High-throughput

0.282

High

1302947

CF062
Uncharacterized protein C6orf62

1

0

High-throughput

0.279

Low

1205273

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.269

Low

1139864

OBI1
ORC ubiquitin ligase 1

1

0

High-throughput

0.251

Low

216089

NRDC
Nardilysin

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024