HitPredict

Interactor 1: LEG8 (O00214)
Galectin-8 (Gal-8) (Po66 carbohydrate-binding protein) (Po66-CBP) (Prostate carcinoma tumor antigen 1) (PCTA-1)
Gene: LGALS8

Interactor 2: ITA3 (P26006)
Integrin alpha-3 (CD49 antigen-like family member C) (FRP-2) (Galactoprotein B3) (GAPB3) (VLA-3 subunit alpha) (CD antigen CD49c) [Cleaved into: Integrin alpha-3 heavy chain; Integrin alpha-3 light chain]
Gene: ITGA3

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	0.60	0.736

Property	Details
Experiments	26186194, 28514442, 33961781, 10852818, 18849583, 16368432
Identification Methods	affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005178 - integrin binding
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 317 Hs			1 1051
+	Hs
		121107 LEG8_HUMAN (1-317): 8.73e-135: 386: 100.00		ITA6_HUMAN (11-1043): 0: 1027: 35.75
+	Hs
		121150 LEG8_HUMAN (1-317): 8.73e-135: 386: 100.00		ITA7_HUMAN (1-1043): 0: 1001: 33.85
+	Hs
		121095 LEG8_HUMAN (1-317): 8.73e-135: 386: 100.00		ITA4_HUMAN (3-1050): 0: 898: 22.77
+	Hs
		121078 LEG8_HUMAN (1-317): 8.73e-135: 386: 100.00		ITAV_HUMAN (30-1021): 0: 854: 25.26
+	Hs
		119131 LEG9_HUMAN (3-316): 1.06e-111: 329: 30.83		ITA4_HUMAN (3-1050): 0: 898: 22.77
+	Hs
		121084 LEG8_HUMAN (1-317): 8.73e-135: 386: 100.00		ITA5_HUMAN (7-1038): 0: 819: 25.67
+	Hs
		119100 LEG9_HUMAN (3-316): 1.06e-111: 329: 30.83		ITA5_HUMAN (7-1038): 0: 819: 25.67
+	Mm
		139224 LEG9_MOUSE (3-316): 6.48e-117: 342: 34.08		ITA2B_MOUSE (19-1026): 0: 786: 25.72
+	Hs
		449172 LEG1_HUMAN (192-314): 3.25e-38: 133: 31.50		ITA4_HUMAN (3-1050): 0: 898: 22.77
+	Hs
		419138 LEG1_HUMAN (192-314): 3.25e-38: 133: 31.50		ITAV_HUMAN (30-1021): 0: 854: 25.26
+	Hs
		443032 LEG3_HUMAN (16-153): 2.84e-45: 155: 39.72		ITA5_HUMAN (7-1038): 0: 819: 25.67
+	Hs
		443022 LEG1_HUMAN (192-314): 3.25e-38: 133: 31.50		ITA5_HUMAN (7-1038): 0: 819: 25.67
+	Hs
		121135 LEG8_HUMAN (1-317): 8.73e-135: 386: 100.00		ITA1_HUMAN (1-171): 1.12e-34: 146: 23.56
+	Hs
		121102 LEG8_HUMAN (1-317): 8.73e-135: 386: 100.00		ITA2_HUMAN (4-187): 2.16e-34: 145: 25.81
+	Hs
		121106 LEG8_HUMAN (1-317): 8.73e-135: 386: 100.00		ITAL_HUMAN (11-190): 1.16e-29: 129: 22.22
+	Hs
		119160 LEG9_HUMAN (3-316): 1.06e-111: 329: 30.83		ITAL_HUMAN (11-190): 1.16e-29: 129: 22.22
+	Hs
		572330 LEG3_HUMAN (16-153): 2.84e-45: 155: 39.72		ITA1_HUMAN (1-171): 1.12e-34: 146: 23.56
+	Hs
		566849 LEG3_HUMAN (16-153): 2.84e-45: 155: 39.72		ITA2_HUMAN (4-187): 2.16e-34: 145: 25.81
+	Hs
		449180 LEG1_HUMAN (192-314): 3.25e-38: 133: 31.50		ITA2_HUMAN (4-187): 2.16e-34: 145: 25.81
+	Hs
		506097 LEG3_HUMAN (16-153): 2.84e-45: 155: 39.72		ITAM_HUMAN (17-183): 7.99e-27: 120: 20.59