Protein: MCE1
mRNA-capping enzyme (HCAP1) (HCE) [Includes: mRNA 5'-triphosphate monophosphatase (EC 3.6.1.74) (mRNA 5'-phosphatase); mRNA guanylyltransferase (EC 2.7.7.50) (GTP--RNA guanylyltransferase) (GTase)]

Gene: MCE1, RNGTT
Organism: Homo sapiens
Interactions: 124
UniProt ID: O60942

Gene Ontology (top 5):
GO:0004484 - mRNA guanylyltransferase activity
GO:0004651 - polynucleotide 5'-phosphatase activity
GO:0005524 - ATP binding
GO:0005525 - GTP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

181367

RPB4
DNA-directed RNA polymerase II subunit RPB4

4

1

High-throughput

0.694

High

246620

NUP50
Nuclear pore complex protein Nup50

4

2

High-throughput

0.694

High

123802

SPT5H
Transcription elongation factor SPT5

4

3

High-throughput

0.686

High

246533

RPB3
DNA-directed RNA polymerase II subunit RPB3

4

2

High-throughput

0.686

High

246552

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.656

High

246534

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

2

High-throughput

0.656

High

246538

RPB2
DNA-directed RNA polymerase II subunit RPB2

3

5

High-throughput

0.656

High

246559

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

3

4

High-throughput

0.656

High

246562

RPB7
DNA-directed RNA polymerase II subunit RPB7

3

1

High-throughput

0.656

High

246579

P4R3A
Serine/threonine-protein phosphatase 4 regulatory subunit 3A

3

1

High-throughput

0.656

High

246542

RPB9
DNA-directed RNA polymerase II subunit RPB9

3

2

High-throughput

0.650

High

246618

PP4R2
Serine/threonine-protein phosphatase 4 regulatory subunit 2

3

0

High-throughput

0.628

High

246512

MCE1
mRNA-capping enzyme

1

17

High-throughput

0.618

High

246535

CSK22
Casein kinase II subunit alpha'

1

13

High-throughput

0.618

High

246566

CSK21
Casein kinase II subunit alpha

1

12

High-throughput

0.618

High

246574

DUS28
Dual specificity phosphatase 28

1

7

High-throughput

0.618

High

246595

STYX
Serine/threonine/tyrosine-interacting protein

1

7

High-throughput

0.618

High

246607

BARD1
BRCA1-associated RING domain protein 1

1

9

High-throughput

0.618

High

246586

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

3

0

High-throughput

0.613

High

246536

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

7

High-throughput

0.611

High

246575

P4R3B
Serine/threonine-protein phosphatase 4 regulatory subunit 3B

2

1

High-throughput

0.611

High

246598

APBP2
Amyloid protein-binding protein 2

2

1

High-throughput

0.606

High

246537

EF1D
Elongation factor 1-delta

2

0

High-throughput

0.602

High

246518

RECQ5
ATP-dependent DNA helicase Q5

2

3

High-throughput

0.584

High

246564

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

2

High-throughput

0.584

High

246565

SPT4H
Transcription elongation factor SPT4

2

1

High-throughput

0.584

High

246525

ESR1
Estrogen receptor

2

5

High-throughput

0.571

High

246581

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.553

High

246591

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.553

High

246622

HECD1
E3 ubiquitin-protein ligase HECTD1

1

13

High-throughput

0.553

High

134811

IMA3
Importin subunit alpha-3

1

4

High-throughput

0.536

High

168604

IMA6
Importin subunit alpha-6

1

4

High-throughput

0.536

High

246523

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.536

High

246546

KI67
Proliferation marker protein Ki-67

1

9

High-throughput

0.536

High

246549

SOX2
Transcription factor SOX-2

1

6

High-throughput

0.536

High

246554

IMA5
Importin subunit alpha-5

1

4

High-throughput

0.536

High

246563

RAN
GTP-binding nuclear protein Ran

1

3

High-throughput

0.536

High

246571

IMB1
Importin subunit beta-1

1

12

High-throughput

0.536

High

246573

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

High-throughput

0.536

High

246601

EFMT3
EEF1A lysine methyltransferase 3

1

4

High-throughput

0.536

High

246625

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

3

High-throughput

0.536

High

246550

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.527

High

246609

SH3G3
Endophilin-A3

2

2

High-throughput

0.521

High

246553

IMA1
Importin subunit alpha-1

1

4

High-throughput

0.515

High

195614

MCES
mRNA cap guanine-N7 methyltransferase

1

1

Small-scale

0.501

High

246524

CRYAA
Alpha-crystallin A chain

1

0

High-throughput

0.480

High

179486

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

2

High-throughput

0.479

High

226023

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.479

High

230689

AQR
RNA helicase aquarius

1

3

High-throughput

0.479

High

246513

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

5

High-throughput

0.479

High

246517

RECQ4
ATP-dependent DNA helicase Q4

1

5

High-throughput

0.479

High

246519

PCF11
Pre-mRNA cleavage complex 2 protein Pcf11

1

2

High-throughput

0.479

High

246520

SCAF4
SR-related and CTD-associated factor 4

1

2

High-throughput

0.479

High

246522

HERC2
E3 ubiquitin-protein ligase HERC2

1

13

High-throughput

0.479

High

246526

MYCN
N-myc proto-oncogene protein

1

5

High-throughput

0.479

High

246527

NTRK1
High affinity nerve growth factor receptor

1

9

High-throughput

0.479

High

246528

P53
Cellular tumor antigen p53

1

4

High-throughput

0.479

High

246531

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

246532

NCK1
SH2/SH3 adapter protein NCK1

1

7

Small-scale

0.479

High

246539

HNRH3
Heterogeneous nuclear ribonucleoprotein H3

1

2

High-throughput

0.479

High

246540

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

246543

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

246544

CCNF
Cyclin-F

1

4

High-throughput

0.479

High

246545

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

7

High-throughput

0.479

High

246547

CRK
Adapter molecule crk

1

6

High-throughput

0.479

High

246551

MCM2
DNA replication licensing factor MCM2

1

9

High-throughput

0.479

High

246555

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

2

High-throughput

0.479

High

246556

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

1

2

High-throughput

0.479

High

246557

BLM
RecQ-like DNA helicase BLM

1

5

High-throughput

0.479

High

246567

NOP14
Nucleolar protein 14

1

1

High-throughput

0.479

High

246568

TP53B
TP53-binding protein 1

1

4

High-throughput

0.479

High

246569

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

1

High-throughput

0.479

High

246576

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

3

High-throughput

0.479

High

246583

SPT6H
Transcription elongation factor SPT6

1

4

High-throughput

0.479

High

246584

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

2

High-throughput

0.479

High

246585

AROS
Active regulator of SIRT1

1

3

High-throughput

0.479

High

246588

ARL14
ADP-ribosylation factor-like protein 14

1

3

High-throughput

0.479

High

246589

SIR6
NAD-dependent protein deacylase sirtuin-6

1

5

High-throughput

0.479

High

246590

ARL10
ADP-ribosylation factor-like protein 10

1

4

High-throughput

0.479

High

246593

G45IP
Large ribosomal subunit protein mL64

1

3

High-throughput

0.479

High

246597

RTF1
RNA polymerase-associated protein RTF1 homolog

1

1

High-throughput

0.479

High

246599

ESR2
Estrogen receptor beta

1

5

High-throughput

0.479

High

246600

RL36L
Ribosomal protein eL42-like

1

3

High-throughput

0.479

High

246602

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.479

High

246605

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

3

High-throughput

0.479

High

246611

SETD2
Histone-lysine N-methyltransferase SETD2

1

7

High-throughput

0.479

High

246616

SFR19
Splicing factor, arginine/serine-rich 19

1

4

High-throughput

0.479

High

246623

FZR1
Fizzy-related protein homolog

1

10

High-throughput

0.479

High

246624

SRRM2
Serine/arginine repetitive matrix protein 2

1

5

High-throughput

0.479

High

246516

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.458

High

246521

MED26
Mediator of RNA polymerase II transcription subunit 26

1

0

High-throughput

0.458

High

246560

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

246561

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

246580

CDC73
Parafibromin

1

0

High-throughput

0.458

High

246587

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

246610

MED10
Mediator of RNA polymerase II transcription subunit 10

1

0

High-throughput

0.458

High

246613

MED28
Mediator of RNA polymerase II transcription subunit 28

1

0

High-throughput

0.458

High

246614

NELFA
Negative elongation factor A

1

0

High-throughput

0.458

High

246617

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.458

High

246529

JUN
Transcription factor Jun

1

2

High-throughput

0.445

High

246541

FUS
RNA-binding protein FUS

1

2

High-throughput

0.445

High

246514

CLU
Clustered mitochondria protein homolog

1

4

High-throughput

0.437

High

246558

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

2

High-throughput

0.437

High

246577

RN123
E3 ubiquitin-protein ligase RNF123

1

5

High-throughput

0.437

High

246592

LY65B
Lymphocyte antigen 6 complex locus protein G5b

1

1

High-throughput

0.437

High

246594

BRX1
Ribosome biogenesis protein BRX1 homolog

1

2

High-throughput

0.437

High

246596

POF1B
Protein POF1B

1

2

High-throughput

0.437

High

246603

RNF31
E3 ubiquitin-protein ligase RNF31

1

6

High-throughput

0.437

High

246604

DDRGK
DDRGK domain-containing protein 1

1

1

High-throughput

0.437

High

246606

SNX18
Sorting nexin-18

1

4

High-throughput

0.437

High

246615

PKHA4
Pleckstrin homology domain-containing family A member 4

1

8

High-throughput

0.437

High

246619

PHRF1
PHD and RING finger domain-containing protein 1

1

5

High-throughput

0.437

High

246626

SNX9
Sorting nexin-9

1

3

High-throughput

0.437

High

246548

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.279

Low

246621

INTU
Protein inturned

1

0

High-throughput

0.279

Low

246515

SG2A1
Mammaglobin-B

1

0

High-throughput

0.249

Low

246570

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.249

Low

246572

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.249

Low

246578

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

1

0

High-throughput

0.249

Low

246582

NOL8
Nucleolar protein 8

1

0

High-throughput

0.249

Low

246608

PROL1
Opiorphin prepropeptide

1

0

High-throughput

0.249

Low

246612

LACRT
Extracellular glycoprotein lacritin

1

0

High-throughput

0.249

Low

246530

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024