Protein: PTC
Protein patched (Hedgehog receptor ptc)

Gene: PTC
Organism: Drosophila melanogaster
Interactions: 122
UniProt ID: P18502

Gene Ontology (top 5):
GO:0001746 - Bolwig's organ morphogenesis
GO:0005119 - smoothened binding
GO:0005886 - plasma membrane
GO:0005929 - cilium
GO:0007346 - regulation of mitotic cell cycle

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

615044

PTC
Protein patched

4

11

Small-scale

0.696

High

615120

NEDD4
E3 ubiquitin-protein ligase Nedd-4

4

14

Small-scale

0.677

High

615055

HH
Protein hedgehog

4

3

Small-scale

0.667

High

615093

SMUF1
E3 ubiquitin-protein ligase Smurf1

2

14

Small-scale

0.620

High

615139

SUDX
E3 ubiquitin-protein ligase Su(dx)

2

14

Small-scale

0.586

High

615053

SMO
Protein smoothened

2

5

Small-scale

0.584

High

615109

IHOG
Interference hedgehog

2

4

Small-scale

0.584

High

615063

DJTID
DnaJ homolog l(2)tid, mitochondrial

1

0

Small-scale

0.549

High

615092

APLP
Apolipophorins

1

0

Small-scale

0.513

High

473339

BTKL
Tyrosine-protein kinase Btk

1

1

High-throughput

0.508

High

615121

FRIZ2
Frizzled-2

1

4

High-throughput

0.508

High

615056

SAS
Putative epidermal cell surface receptor

1

0

High-throughput

0.486

High

615062

NETB
Netrin-B

1

3

High-throughput

0.484

High

52872

A1Z7C4
LDL receptor protein 1, isoform G

1

2

High-throughput

0.481

High

56694

A1ZAF5
Semaphorin-2A

1

8

High-throughput

0.481

High

69125

A8JTM7
Megalin, isoform A

1

2

High-throughput

0.481

High

117936

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

5

High-throughput

0.481

High

232062

ITA3
Integrin alpha-PS3

1

5

High-throughput

0.481

High

547529

ITBX
Integrin beta-PS

1

1

High-throughput

0.481

High

610215

KCNAB
Potassium voltage-gated channel protein Shab

1

1

High-throughput

0.481

High

615050

ECR
Ecdysone receptor

1

1

High-throughput

0.481

High

615054

LAMA
Laminin subunit alpha

1

6

High-throughput

0.481

High

615057

DGK2
Eye-specific diacylglycerol kinase

1

1

High-throughput

0.481

High

615067

Q7K4M9
LD31969p

1

2

High-throughput

0.481

High

615076

Q7YU60
receptor protein serine/threonine kinase

1

2

High-throughput

0.481

High

615095

NPL4
Nuclear protein localization protein 4 homolog

1

1

High-throughput

0.481

High

615098

FLNA
Filamin-A

1

2

High-throughput

0.481

High

615099

Q9VGK8
Tyrosine-protein kinase

1

1

High-throughput

0.481

High

615102

Q9VJ37
Insulin gene enhancer protein ISL-1

1

2

High-throughput

0.481

High

615103

Q9VJJ9
FI20237p1

1

4

High-throughput

0.481

High

615130

Q9W0Y0
RE57840p

1

1

High-throughput

0.481

High

615140

X2JE09
Terribly reduced optic lobes, isoform AV

1

6

High-throughput

0.481

High

615046

CI
Transcriptional activator cubitus interruptus

1

1

Small-scale

0.479

High

615074

Q7KUL1
Dally-like, isoform C

1

1

Small-scale

0.479

High

615091

Q9V3X2
Tetraspanin

1

2

Small-scale

0.479

High

615137

Q9W4Y6
Brother of ihog, isoform B

1

4

Small-scale

0.479

High

615048

SINA
E3 ubiquitin-protein ligase sina

1

2

High-throughput

0.464

High

615049

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.464

High

615052

RL22
Large ribosomal subunit protein eL22

1

1

High-throughput

0.464

High

615059

ABRU
Protein abrupt

1

1

High-throughput

0.464

High

615061

MLP2
Muscle LIM protein Mlp84B

1

3

High-throughput

0.464

High

615124

Q9VX41
LD29081p

1

6

High-throughput

0.464

High

615127

CYHR1
Zinc finger TRAF-type-containing protein 1 homolog

1

2

High-throughput

0.464

High

52994

A1Z7J1
Sticks and stones, isoform A

1

0

High-throughput

0.460

High

117992

M9MRS9
Formin homology 2 domain containing, isoform E

1

0

High-throughput

0.460

High

120520

M9PD94
Crooked legs, isoform F

1

0

High-throughput

0.460

High

122140

M9PHS8
Uncharacterized protein, isoform C

1

0

High-throughput

0.460

High

615051

MOEH
Moesin/ezrin/radixin homolog 1

1

0

High-throughput

0.460

High

615060

LACH
Lachesin

1

0

High-throughput

0.460

High

615072

CHD1
Chromodomain-helicase-DNA-binding protein 1

1

0

High-throughput

0.460

High

615088

HIW
E3 ubiquitin-protein ligase highwire

1

0

High-throughput

0.460

High

615090

Q9TVI0
FI23915p1

1

0

High-throughput

0.460

High

615135

Q9W3R6
Downstream of kinase

1

0

High-throughput

0.460

High

195755

COS
Kinesin-like protein costa

1

0

Small-scale

0.458

High

553471

KAPC1
cAMP-dependent protein kinase catalytic subunit 1

1

0

Small-scale

0.458

High

615065

Q3YMU0
Protein disulfide-isomerase

1

6

High-throughput

0.439

High

615066

GALT6
N-acetylgalactosaminyltransferase 6

1

7

High-throughput

0.439

High

615073

Q7KUB3
Ecdysone-inducible gene E1, isoform A

1

4

High-throughput

0.439

High

615078

PPN
Papilin

1

1

High-throughput

0.439

High

615079

Q8IMK1
WD repeat-containing protein 44

1

3

High-throughput

0.439

High

615080

Q8INQ9
LIM domain-containing protein

1

2

High-throughput

0.439

High

615082

Q8SXN9
polynucleotide adenylyltransferase

1

1

High-throughput

0.439

High

615085

HRD1
E3 ubiquitin-protein ligase HRD1

1

10

High-throughput

0.439

High

615087

Q961D1
Cyclin-K

1

1

High-throughput

0.439

High

615089

CEG1A
Centaurin-gamma-1A

1

1

High-throughput

0.439

High

615097

Q9VEH3
Uncharacterized protein, isoform A

1

1

High-throughput

0.439

High

615100

Q9VHJ3
Enhancer of variegation 3-9

1

2

High-throughput

0.439

High

615101

GZL
E3 ubiquitin-protein ligase Godzilla

1

13

High-throughput

0.439

High

615106

Q9VL21
LD11652p

1

1

High-throughput

0.439

High

615115

Q9VQ95
Testis EndoG-Like 3

1

1

High-throughput

0.439

High

615116

Q9VRQ4
LD47944p

1

1

High-throughput

0.439

High

615117

Q9VRV4
D19B

1

1

High-throughput

0.439

High

615123

RG190
Rho GTPase-activating protein 190

1

1

High-throughput

0.439

High

615125

Q9VXR3
HECT-type E3 ubiquitin transferase

1

14

High-throughput

0.439

High

615133

Q9W3F1
RE21057p

1

3

High-throughput

0.439

High

615045

SXL
Protein sex-lethal

1

1

Small-scale

0.437

High

52750

A1Z743
polynucleotide adenylyltransferase

1

1

High-throughput

0.417

High

464732

SNAI
Protein snail

1

0

High-throughput

0.265

Low

615047

NCD
Protein claret segregational

1

0

High-throughput

0.265

Low

615094

ZN330
Zinc finger protein 330 homolog

1

0

High-throughput

0.265

Low

615131

POF
Protein painting of fourth

1

0

High-throughput

0.265

Low

52748

A1Z739
Acyltransferase

1

0

High-throughput

0.251

Low

85010

B7Z143
Protein interacting with Ttk69 and Sin3A, isoform D

1

0

High-throughput

0.251

Low

118513

M9NES5
Histone gene-specific epigenetic repressor in late S phase, isoform H

1

0

High-throughput

0.251

Low

120458

M9PD73
TEP1-F

1

0

High-throughput

0.251

Low

121136

M9PF26
Zizimin, isoform B

1

0

High-throughput

0.251

Low

234823

O46070
EG:25E8.4 protein

1

0

High-throughput

0.251

Low

235067

LIP3
Lipase 3

1

0

High-throughput

0.251

Low

615058

Q0E8J0
MOG interacting and ectopic P-granules protein 1

1

0

High-throughput

0.251

Low

615064

RAD51
DNA repair protein Rad51 homolog

1

0

High-throughput

0.251

Low

615068

Q7KLX3
Translocon-associated protein subunit delta

1

0

High-throughput

0.251

Low

615069

Q7KMH9
BcDNA.LD26050

1

0

High-throughput

0.251

Low

615070

Q7KN75
Dodeca-satellite-binding protein 1, isoform A

1

0

High-throughput

0.251

Low

615071

Q7KNM2
Dorsal interacting protein 4

1

0

High-throughput

0.251

Low

615075

DCLK
Serine/threonine-protein kinase CG17528

1

0

High-throughput

0.251

Low

615077

Q7Z2C5
Uncharacterized protein

1

0

High-throughput

0.251

Low

615081

Q8SXL5
RE09177p

1

0

High-throughput

0.251

Low

615083

Q8SXV4
RH68528p

1

0

High-throughput

0.251

Low

615084

Q8T092
LD21421p

1

0

High-throughput

0.251

Low

615086

Q95U38
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.251

Low

615096

Q9VED4
Bard

1

0

High-throughput

0.251

Low

615104

NU160
Nuclear pore complex protein Nup160 homolog

1

0

High-throughput

0.251

Low

615105

Q9VKQ7
LD46233p

1

0

High-throughput

0.251

Low

615107

Q9VL77
Cysteine-rich PDZ-binding protein

1

0

High-throughput

0.251

Low

615108

Q9VL91
LD23102p

1

0

High-throughput

0.251

Low

615110

Q9VMP7
Uncharacterized protein

1

0

High-throughput

0.251

Low

615111

Q9VNE0
PHD and RING finger domain-containing protein 1

1

0

High-throughput

0.251

Low

615112

Q9VP16
Kazal-like domain-containing protein

1

0

High-throughput

0.251

Low

615113

Q9VPX3
NOL1/NOP2/Sun domain family member 4

1

0

High-throughput

0.251

Low

615114

Q9VPX6
Adenylyl cyclase-associated protein

1

0

High-throughput

0.251

Low

615118

TONSL
Tonsoku-like protein

1

0

High-throughput

0.251

Low

615119

Q9VUD3
GH07353p

1

0

High-throughput

0.251

Low

615122

Q9VW34
FI03450p

1

0

High-throughput

0.251

Low

615126

Q9VZJ4
Uncharacterized protein, isoform B

1

0

High-throughput

0.251

Low

615128

Q9W0C4
Gamma-glutamyl carboxylase, isoform A

1

0

High-throughput

0.251

Low

615129

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.251

Low

615132

Q9W219
GEO12575p1

1

0

High-throughput

0.251

Low

615134

Q9W3J0
FI23536p1

1

0

High-throughput

0.251

Low

615136

Q9W3V3
E3 ubiquitin-protein ligase ZNRF1

1

0

High-throughput

0.251

Low

615138

Q9XZ29
EG:BACR25B3.9 protein

1

0

High-throughput

0.251

Low

615141

X2JG79
Supervillin, isoform W

1

0

High-throughput

0.251

Low


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Last updated: 11Aug2025