Protein: MAT1
CDK-activating kinase assembly factor MAT1 (CDK7/cyclin-H assembly factor) (Cyclin-G1-interacting protein) (Menage a trois) (RING finger protein 66) (RING finger protein MAT1) (p35) (p36)

Gene: MAT1, MNAT1
Organism: Homo sapiens
Interactions: 112
UniProt ID: P51948

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000439 - transcription factor TFIIH core complex
GO:0005654 - nucleoplasm
GO:0005675 - transcription factor TFIIH holo complex
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

841101

CDK7
Cyclin-dependent kinase 7

19

7

Small-scale

0.988

High

584571

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

7

1

Small-scale

0.963

High

574141

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

6

3

Small-scale

0.950

High

851193

CCNH
Cyclin-H

7

5

Small-scale

0.746

High

125866

CDC7
Cell division cycle 7-related protein kinase

1

1

High-throughput

0.691

High

625252

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.691

High

697728

TF2H1
General transcription factor IIH subunit 1

3

2

Small-scale

0.670

High

851247

TF2H2
General transcription factor IIH subunit 2

3

1

Small-scale

0.660

High

369220

ESR1
Estrogen receptor

3

0

Small-scale

0.632

High

386354

P53
Cellular tumor antigen p53

2

0

Small-scale

0.619

High

826246

CDK8
Cyclin-dependent kinase 8

1

3

High-throughput

0.618

High

749255

BRCA1
Breast cancer type 1 susceptibility protein

2

7

Small-scale

0.614

High

624820

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

0

Small-scale

0.577

High

851294

CILK1
Serine/threonine-protein kinase ICK

1

3

Small-scale

0.553

High

708846

MCM7
DNA replication licensing factor MCM7

1

0

Small-scale

0.549

High

851245

MTA1
Metastasis-associated protein MTA1

1

0

Small-scale

0.549

High

584908

RO52
E3 ubiquitin-protein ligase TRIM21

1

6

High-throughput

0.541

High

851242

TRI26
Tripartite motif-containing protein 26

1

7

High-throughput

0.541

High

851279

TRI34
E3 ubiquitin-protein ligase TRIM34

1

6

High-throughput

0.541

High

851280

TRI31
E3 ubiquitin-protein ligase TRIM31

1

8

High-throughput

0.541

High

851281

TRIM9
E3 ubiquitin-protein ligase TRIM9

1

8

High-throughput

0.541

High

851282

TRIM5
Tripartite motif-containing protein 5

1

7

High-throughput

0.541

High

851283

TRIM2
Tripartite motif-containing protein 2

1

4

High-throughput

0.541

High

851286

RNF41
E3 ubiquitin-protein ligase NRDP1

1

7

High-throughput

0.541

High

851289

TRI39
E3 ubiquitin-protein ligase TRIM39

1

6

High-throughput

0.541

High

851293

RBX2
RING-box protein 2

1

1

High-throughput

0.541

High

851296

TRI17
E3 ubiquitin-protein ligase TRIM17

1

5

High-throughput

0.541

High

851285

FOXP1
Forkhead box protein P1

1

0

High-throughput

0.536

High

851240

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

851250

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

851272

TF2H4
General transcription factor IIH subunit 4

1

2

High-throughput

0.536

High

851256

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.529

High

851290

DMAP1
DNA methyltransferase 1-associated protein 1

1

0

Small-scale

0.529

High

540812

PO2F1
POU domain, class 2, transcription factor 1

1

2

Small-scale

0.527

High

169260

MDM4
Protein Mdm4

1

0

High-throughput

0.518

High

507387

ERG
Transcriptional regulator ERG

1

0

High-throughput

0.518

High

851252

RBM48
RNA-binding protein 48

1

0

High-throughput

0.518

High

851260

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.518

High

226920

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.515

High

134857

IMA3
Importin subunit alpha-3

1

0

High-throughput

0.513

High

245674

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

312847

GDF11
Growth/differentiation factor 11

1

0

High-throughput

0.513

High

538501

CCNB1
G2/mitotic-specific cyclin-B1

1

0

High-throughput

0.513

High

538753

HXB1
Homeobox protein Hox-B1

1

0

High-throughput

0.513

High

589811

TBP
TATA-box-binding protein

1

0

High-throughput

0.513

High

659914

ERCC5
DNA excision repair protein ERCC-5

1

0

High-throughput

0.513

High

781530

CETN2
Centrin-2

1

0

High-throughput

0.513

High

851232

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

851249

ZN174
Zinc finger protein 174

1

0

High-throughput

0.513

High

851259

TF2H5
General transcription factor IIH subunit 5

1

0

High-throughput

0.513

High

851265

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

851266

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.513

High

851287

CAPAM
mRNA

1

0

High-throughput

0.513

High

447472

PO2F2
POU domain, class 2, transcription factor 2

1

2

Small-scale

0.501

High

475503

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

851237

PO5F1
POU domain, class 5, transcription factor 1

1

2

Small-scale

0.501

High

851269

TRIML
Probable E3 ubiquitin-protein ligase TRIML1

1

5

High-throughput

0.494

High

791397

HD
Huntingtin

1

0

High-throughput

0.493

High

851244

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.493

High

851295

RNF11
RING finger protein 11

1

0

High-throughput

0.493

High

610202

CCNO
Cyclin-O

1

1

High-throughput

0.489

High

851297

GMPPB
Mannose-1-phosphate guanyltransferase beta

1

1

High-throughput

0.489

High

449613

HMGB1
High mobility group protein B1

1

1

Small-scale

0.481

High

851248

TRI14
Tripartite motif-containing protein 14

1

5

High-throughput

0.481

High

851292

MAGC2
Melanoma-associated antigen C2

1

1

Small-scale

0.481

High

123881

SPT5H
Transcription elongation factor SPT5

1

0

Small-scale

0.480

High

414219

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.480

High

851233

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

851234

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.479

High

851258

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.479

High

271060

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

0

High-throughput

0.460

High

851253

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.460

High

851276

NKX31
Homeobox protein Nkx-3.1

1

0

Small-scale

0.460

High

244146

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

346281

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

435018

SP1
Transcription factor Sp1

1

0

Small-scale

0.458

High

552285

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

569426

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

650726

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

720023

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

851241

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

851246

CUL3
Cullin-3

1

0

High-throughput

0.458

High

851273

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

851274

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

851278

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

851288

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

851291

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

851270

MAGE2
Melanoma-associated antigen E2

1

1

Small-scale

0.439

High

851254

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

234489

DSCAM
Cell adhesion molecule DSCAM

1

0

High-throughput

0.282

High

851235

EF1A1
Elongation factor 1-alpha 1

1

0

High-throughput

0.282

High

851239

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.282

High

851243

MKRN3
Probable E3 ubiquitin-protein ligase makorin-3

1

0

High-throughput

0.282

High

851263

HPS6
BLOC-2 complex member HPS6

1

0

High-throughput

0.282

High

851284

RNF32
RING finger protein 32

1

0

High-throughput

0.282

High

211356

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

257334

CNOT3
CCR4-NOT transcription complex subunit 3

1

0

High-throughput

0.279

Low

300994

ABLM3
Actin-binding LIM protein 3

1

0

High-throughput

0.279

Low

675587

GNA15
Guanine nucleotide-binding protein subunit alpha-15

1

0

High-throughput

0.279

Low

851238

LMNB2
Lamin-B2

1

0

High-throughput

0.279

Low

851255

CK071
Uncharacterized protein C11orf71

1

0

High-throughput

0.279

Low

851262

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

851267

CJ053
UPF0728 protein C10orf53

1

0

High-throughput

0.279

Low

851277

ZN747
Zinc finger protein 747

1

0

High-throughput

0.279

Low

851264

CAD26
Cadherin-like protein 26

1

0

High-throughput

0.269

Low

851236

BEX3
Protein BEX3

1

0

High-throughput

0.251

Low

851261

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

851275

YI001
Uncharacterized protein FLJ30774

1

0

High-throughput

0.249

Low

851271

TSC1
Hamartin

1

0

Small-scale

0.238

Low

851251

NSN5B
Putative NOL1/NOP2/Sun domain family member 5B

1

0

High-throughput

0.232

Low

851257

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low

851268

CI163
Uncharacterized protein C9orf163

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024