Protein: NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2 (NF-ATc2) (NFATc2) (NFAT pre-existing subunit) (NF-ATp) (T-cell transcription factor NFAT1)

Gene: NFAC2, NFATC2
Organism: Homo sapiens
Interactions: 198
UniProt ID: Q13469

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

401950

JUN
Transcription factor Jun

3

20

Small-scale

0.865

High

1035228

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

3

17

Small-scale

0.857

High

317964

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

3

18

Small-scale

0.827

High

556859

CREB1
Cyclic AMP-responsive element-binding protein 1

2

3

High-throughput

0.789

High

575423

EGR1
Early growth response protein 1

3

5

Small-scale

0.640

High

1035249

I2BP2
Interferon regulatory factor 2-binding protein 2

2

1

Small-scale

0.631

High

345421

FOS
Protein c-Fos

1

20

High-throughput

0.618

High

566755

JUNB
Transcription factor JunB

1

20

High-throughput

0.618

High

568092

JUND
Transcription factor JunD

1

20

High-throughput

0.618

High

568261

ATF7
Cyclic AMP-dependent transcription factor ATF-7

1

18

High-throughput

0.618

High

692132

ELF1
ETS-related transcription factor Elf-1

1

14

Small-scale

0.618

High

781627

ETV6
Transcription factor ETV6

1

12

High-throughput

0.618

High

952806

FOXK1
Forkhead box protein K1

1

8

High-throughput

0.618

High

1035238

CEBPE
CCAAT/enhancer-binding protein epsilon

1

13

High-throughput

0.618

High

1035264

CBP
CREB-binding protein

2

17

Small-scale

0.602

High

1035237

IRF4
Interferon regulatory factor 4

2

20

Small-scale

0.601

High

1035251

VRK2
Serine/threonine-protein kinase VRK2

1

12

Small-scale

0.598

High

352606

TNFA
Tumor necrosis factor

2

15

Small-scale

0.584

High

800884

MK09
Mitogen-activated protein kinase 9

2

10

Small-scale

0.584

High

891387

IL2
Interleukin-2

2

6

Small-scale

0.584

High

998662

EP300
Histone acetyltransferase p300

2

20

Small-scale

0.584

High

369545

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

983827

KPCZ
Protein kinase C zeta type

1

9

Small-scale

0.561

High

1035234

MEF2D
Myocyte-specific enhancer factor 2D

1

1

Small-scale

0.561

High

443495

VIME
Vimentin

1

6

High-throughput

0.541

High

1035299

MED31
Mediator of RNA polymerase II transcription subunit 31

1

2

High-throughput

0.541

High

994078

PP2BA
Protein phosphatase 3 catalytic subunit alpha

1

10

Small-scale

0.536

High

672109

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

5

Small-scale

0.536

High

809295

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

3

Small-scale

0.536

High

874501

XPO2
Exportin-2

1

2

Small-scale

0.536

High

1035268

TNPO1
Transportin-1

1

5

Small-scale

0.536

High

1035243

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

Small-scale

0.530

High

1035295

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

1

Small-scale

0.515

High

147418

SOCS3
Suppressor of cytokine signaling 3

1

11

Small-scale

0.501

High

1035229

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

Small-scale

0.501

High

1035239

TAF9
Transcription initiation factor TFIID subunit 9

1

1

Small-scale

0.501

High

123931

SPT5H
Transcription elongation factor SPT5

1

12

High-throughput

0.479

High

146212

ARI1A
AT-rich interactive domain-containing protein 1A

1

11

High-throughput

0.479

High

154179

CHK1
Serine/threonine-protein kinase Chk1

1

3

High-throughput

0.479

High

163603

BTAF1
TATA-binding protein-associated factor 172

1

12

High-throughput

0.479

High

169842

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

2

High-throughput

0.479

High

181926

MAFG
Transcription factor MafG

1

3

High-throughput

0.479

High

201789

RIPK2
Receptor-interacting serine/threonine-protein kinase 2

1

2

High-throughput

0.479

High

203678

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

Small-scale

0.479

High

215981

IDH3B
Isocitrate dehydrogenase [NAD] subunit beta, mitochondrial

1

1

High-throughput

0.479

High

229390

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

10

High-throughput

0.479

High

232147

KDM1A
Lysine-specific histone demethylase 1A

1

6

High-throughput

0.479

High

238458

MAFK
Transcription factor MafK

1

3

High-throughput

0.479

High

246569

MCE1
mRNA-capping enzyme

1

1

High-throughput

0.479

High

260875

H2AY
Core histone macro-H2A.1

1

4

High-throughput

0.479

High

271561

ERAL1
GTPase Era, mitochondrial

1

1

High-throughput

0.479

High

296014

MTA2
Metastasis-associated protein MTA2

1

3

High-throughput

0.479

High

309306

KIF4A
Chromosome-associated kinesin KIF4A

1

1

High-throughput

0.479

High

310624

VAPB
Vesicle-associated membrane protein-associated protein B/C

1

6

High-throughput

0.479

High

325160

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

3

High-throughput

0.479

High

328548

MBD3
Methyl-CpG-binding domain protein 3

1

1

High-throughput

0.479

High

331506

ACL6A
Actin-like protein 6A

1

9

High-throughput

0.479

High

453336

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

Small-scale

0.479

High

455402

PARP1
Poly [ADP-ribose] polymerase 1

1

7

High-throughput

0.479

High

502063

BIP
Endoplasmic reticulum chaperone BiP

1

20

High-throughput

0.479

High

504030

HSP7C
Heat shock cognate 71 kDa protein

1

20

High-throughput

0.479

High

523730

XRCC6
X-ray repair cross-complementing protein 6

1

4

High-throughput

0.479

High

524913

XRCC5
X-ray repair cross-complementing protein 5

1

4

High-throughput

0.479

High

531139

EF2
Elongation factor 2

1

3

High-throughput

0.479

High

552654

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

573247

TCPA
T-complex protein 1 subunit alpha

1

7

High-throughput

0.479

High

584591

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

7

High-throughput

0.479

High

610850

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

4

High-throughput

0.479

High

627429

NFYB
Nuclear transcription factor Y subunit beta

1

1

High-throughput

0.479

High

646869

1433T
14-3-3 protein theta

1

18

High-throughput

0.479

High

651128

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

653250

PYR1
Multifunctional protein CAD

1

6

High-throughput

0.479

High

681432

DNJA1
DnaJ homolog subfamily A member 1

1

6

High-throughput

0.479

High

683321

1433B
14-3-3 protein beta/alpha

1

18

High-throughput

0.479

High

721980

RFC4
Replication factor C subunit 4

1

6

High-throughput

0.479

High

722101

RFC2
Replication factor C subunit 2

1

6

High-throughput

0.479

High

751613

GRP75
Stress-70 protein, mitochondrial

1

20

High-throughput

0.479

High

777851

RFC5
Replication factor C subunit 5

1

6

High-throughput

0.479

High

777979

RFC3
Replication factor C subunit 3

1

6

High-throughput

0.479

High

778134

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

4

High-throughput

0.479

High

799098

NKX21
Homeobox protein Nkx-2.1

1

8

High-throughput

0.479

High

800369

CBX5
Chromobox protein homolog 5

1

5

High-throughput

0.479

High

800773

MK08
Mitogen-activated protein kinase 8

1

10

Small-scale

0.479

High

822255

KC1D
Casein kinase I isoform delta

1

8

High-throughput

0.479

High

827367

EFTU
Elongation factor Tu, mitochondrial

1

8

High-throughput

0.479

High

832432

MCM2
DNA replication licensing factor MCM2

1

2

High-throughput

0.479

High

834735

RBP2
E3 SUMO-protein ligase RanBP2

1

2

High-throughput

0.479

High

835726

GSK3B
Glycogen synthase kinase-3 beta

1

8

High-throughput

0.479

High

836722

DNLI3
DNA ligase 3

1

1

High-throughput

0.479

High

837726

IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

838811

EMD
Emerin

1

1

High-throughput

0.479

High

846960

SMCA4
Transcription activator BRG1

1

10

High-throughput

0.479

High

855906

ZN131
Zinc finger protein 131

1

2

High-throughput

0.479

High

861736

PLK1
Serine/threonine-protein kinase PLK1

1

7

High-throughput

0.479

High

867866

HIRA
Protein HIRA

1

2

High-throughput

0.479

High

883288

PRD15
PR domain zinc finger protein 15

1

1

High-throughput

0.479

High

902903

DCAF7
DDB1- and CUL4-associated factor 7

1

3

High-throughput

0.479

High

904526

1433G
14-3-3 protein gamma

1

18

High-throughput

0.479

High

905877

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

3

High-throughput

0.479

High

909525

1433E
14-3-3 protein epsilon

1

1

High-throughput

0.479

High

919382

RL23
Large ribosomal subunit protein uL14

1

1

High-throughput

0.479

High

927009

1433Z
14-3-3 protein zeta/delta

1

18

High-throughput

0.479

High

944226

PRKDC
DNA-dependent protein kinase catalytic subunit

1

6

High-throughput

0.479

High

949776

CBX1
Chromobox protein homolog 1

1

5

High-throughput

0.479

High

958896

TFAM
Transcription factor A, mitochondrial

1

11

High-throughput

0.479

High

964321

RUNX1
Runt-related transcription factor 1

1

1

High-throughput

0.479

High

966973

SATB1
DNA-binding protein SATB1

1

1

High-throughput

0.479

High

981231

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

1

High-throughput

0.479

High

982991

CSTF1
Cleavage stimulation factor subunit 1

1

5

High-throughput

0.479

High

983530

EGR4
Early growth response protein 4

1

7

Small-scale

0.479

High

996652

SSRP1
FACT complex subunit SSRP1

1

11

High-throughput

0.479

High

997709

RBBP4
Histone-binding protein RBBP4

1

1

High-throughput

0.479

High

1018944

TP53B
TP53-binding protein 1

1

3

High-throughput

0.479

High

1024541

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.479

High

1026978

CBX3
Chromobox protein homolog 3

1

5

High-throughput

0.479

High

1031847

MTA1
Metastasis-associated protein MTA1

1

3

High-throughput

0.479

High

1032386

CTBP1
C-terminal-binding protein 1

1

8

High-throughput

0.479

High

1033631

IKZF1
DNA-binding protein Ikaros

1

5

High-throughput

0.479

High

1035230

HDAC1
Histone deacetylase 1

1

20

High-throughput

0.479

High

1035231

TF2H2
General transcription factor IIH subunit 2

1

1

High-throughput

0.479

High

1035232

NFYC
Nuclear transcription factor Y subunit gamma

1

3

High-throughput

0.479

High

1035233

HLTF
Helicase-like transcription factor

1

14

High-throughput

0.479

High

1035235

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

4

High-throughput

0.479

High

1035236

IMB1
Importin subunit beta-1

1

4

Small-scale

0.479

High

1035240

IF16
Gamma-interferon-inducible protein 16

1

1

High-throughput

0.479

High

1035241

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

7

High-throughput

0.479

High

1035242

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

3

High-throughput

0.479

High

1035244

BEND3
BEN domain-containing protein 3

1

1

High-throughput

0.479

High

1035245

T2H2L
General transcription factor IIH subunit 2-like protein

1

1

High-throughput

0.479

High

1035246

TBA1A
Tubulin alpha-1A chain

1

17

Small-scale

0.479

High

1035248

POGZ
Pogo transposable element with ZNF domain

1

2

High-throughput

0.479

High

1035250

TLK2
Serine/threonine-protein kinase tousled-like 2

1

8

High-throughput

0.479

High

1035252

P66A
Transcriptional repressor p66-alpha

1

2

High-throughput

0.479

High

1035253

I2BP1
Interferon regulatory factor 2-binding protein 1

1

1

High-throughput

0.479

High

1035254

ABC3F
DNA dC->dU-editing enzyme APOBEC-3F

1

1

Small-scale

0.479

High

1035255

RPTOR
Regulatory-associated protein of mTOR

1

7

High-throughput

0.479

High

1035257

SCAI
Protein SCAI

1

1

High-throughput

0.479

High

1035258

WDR48
WD repeat-containing protein 48

1

9

High-throughput

0.479

High

1035259

SMRC2
SWI/SNF complex subunit SMARCC2

1

17

High-throughput

0.479

High

1035261

P66B
Transcriptional repressor p66-beta

1

2

High-throughput

0.479

High

1035262

HS105
Heat shock protein 105 kDa

1

20

High-throughput

0.479

High

1035263

REQU
Zinc finger protein ubi-d4

1

18

High-throughput

0.479

High

1035265

RAD50
DNA repair protein RAD50

1

6

High-throughput

0.479

High

1035266

SMRC1
SWI/SNF complex subunit SMARCC1

1

16

High-throughput

0.479

High

1035267

SMRD2
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 2

1

8

High-throughput

0.479

High

1035269

IRF7
Interferon regulatory factor 7

1

20

Small-scale

0.479

High

1035270

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

9

High-throughput

0.479

High

1035272

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

6

High-throughput

0.479

High

1035273

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

12

High-throughput

0.479

High

1035274

CIC
Protein capicua homolog

1

13

High-throughput

0.479

High

1035275

RANB9
Ran-binding protein 9

1

10

High-throughput

0.479

High

1035276

UHRF1
E3 ubiquitin-protein ligase UHRF1

1

9

High-throughput

0.479

High

1035277

HTF4
Transcription factor 12

1

1

High-throughput

0.479

High

1035278

KIF2C
Kinesin-like protein KIF2C

1

4

High-throughput

0.479

High

1035279

BC11B
B-cell lymphoma/leukemia 11B

1

1

High-throughput

0.479

High

1035280

ADNP
Activity-dependent neuroprotector homeobox protein

1

1

High-throughput

0.479

High

1035281

WDR26
WD repeat-containing protein 26

1

9

High-throughput

0.479

High

1035285

VAPA
Vesicle-associated membrane protein-associated protein A

1

6

High-throughput

0.479

High

1035287

ZMYM2
Zinc finger MYM-type protein 2

1

2

High-throughput

0.479

High

1035288

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1035289

HERC5
E3 ISG15--protein ligase HERC5

1

3

Small-scale

0.479

High

1035290

LEF1
Lymphoid enhancer-binding factor 1

1

9

High-throughput

0.479

High

1035291

TLK1
Serine/threonine-protein kinase tousled-like 1

1

5

High-throughput

0.479

High

1035292

RCOR1
REST corepressor 1

1

7

High-throughput

0.479

High

1035294

IKZF2
Zinc finger protein Helios

1

4

High-throughput

0.479

High

1035296

ZN148
Zinc finger protein 148

1

1

High-throughput

0.479

High

1035297

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

1035298

PDIP2
Polymerase delta-interacting protein 2

1

2

High-throughput

0.479

High

1035300

TRRAP
Transformation/transcription domain-associated protein

1

6

High-throughput

0.479

High

1035302

CABIN
Calcineurin-binding protein cabin-1

1

11

High-throughput

0.479

High

669883

CD40L
CD40 ligand

1

15

Small-scale

0.470

High

260377

ZN217
Zinc finger protein 217

1

0

High-throughput

0.458

High

414271

RB
Retinoblastoma-associated protein

1

0

High-throughput

0.458

High

451894

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.458

High

563600

ZNF24
Zinc finger protein 24

1

0

High-throughput

0.458

High

579700

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.458

High

720390

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

727372

DEK
Protein DEK

1

0

High-throughput

0.458

High

837007

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.458

High

867328

DPOG1
DNA polymerase subunit gamma-1

1

0

High-throughput

0.458

High

921554

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

0

Small-scale

0.458

High

966236

TFAP4
Transcription factor AP-4

1

0

Small-scale

0.458

High

1035247

SPT6H
Transcription elongation factor SPT6

1

0

High-throughput

0.458

High

1035260

ZN384
Zinc finger protein 384

1

0

High-throughput

0.458

High

1035271

MCRS1
Microspherule protein 1

1

0

High-throughput

0.458

High

1035282

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

1035293

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.458

High

1035301

TF3C5
General transcription factor 3C polypeptide 5

1

0

High-throughput

0.458

High

264902

MPPB
Mitochondrial-processing peptidase subunit beta

1

5

High-throughput

0.437

High

534301

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

1

3

High-throughput

0.437

High

825306

CX3C1
CX3C chemokine receptor 1

1

8

Small-scale

0.437

High

873409

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

1

High-throughput

0.437

High

1035256

LRC47
Leucine-rich repeat-containing protein 47

1

2

High-throughput

0.437

High

677953

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.249

Low

1035283

RM17
Large ribosomal subunit protein bL17m

1

0

High-throughput

0.249

Low

1035284

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.249

Low

1035286

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024