Protein: NIPBL
Nipped-B-like protein (Delangin) (SCC2 homolog)

Gene: NIPBL
Organism: Homo sapiens
Interactions: 176
UniProt ID: Q6KC79

Gene Ontology (top 5):
GO:0000070 - mitotic sister chromatid segregation
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0001656 - metanephros development
GO:0003007 - heart morphogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1057289

SMC1A
Structural maintenance of chromosomes protein 1A

3

11

Small-scale

0.847

High

1154087

SMC3
Structural maintenance of chromosomes protein 3

3

9

Small-scale

0.827

High

1154096

SCC4
MAU2 chromatid cohesion factor homolog

6

1

Small-scale

0.736

High

1027054

CBX3
Chromobox protein homolog 3

4

8

Small-scale

0.680

High

800421

CBX5
Chromobox protein homolog 5

2

8

Small-scale

0.636

High

1154053

ARFG1
ADP-ribosylation factor GTPase-activating protein 1

2

2

High-throughput

0.628

High

1154049

SMC5
Structural maintenance of chromosomes protein 5

1

14

High-throughput

0.618

High

1154052

STAG2
Cohesin subunit SA-2

2

4

High-throughput

0.611

High

244571

BRD4
Bromodomain-containing protein 4

2

17

High-throughput

0.584

High

552957

RFA2
Replication protein A 32 kDa subunit

2

8

High-throughput

0.584

High

651461

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

8

High-throughput

0.584

High

720703

RFA3
Replication protein A 14 kDa subunit

2

7

High-throughput

0.584

High

818155

SOX2
Transcription factor SOX-2

2

20

Small-scale

0.584

High

934881

H31
Histone H3.1

2

20

High-throughput

0.584

High

369815

ESR1
Estrogen receptor

2

20

High-throughput

0.571

High

960195

CDK6
Cyclin-dependent kinase 6

1

5

Small-scale

0.569

High

517312

PCNA
Proliferating cell nuclear antigen

1

4

Small-scale

0.561

High

317281

PCNT
Pericentrin

1

10

High-throughput

0.541

High

168647

IMA6
Importin subunit alpha-6

1

4

High-throughput

0.536

High

508571

TOP1
DNA topoisomerase 1

1

2

High-throughput

0.536

High

595271

LMNB1
Lamin-B1

1

8

High-throughput

0.536

High

649558

RL10
Large ribosomal subunit protein uL16

1

2

High-throughput

0.536

High

801197

KI67
Proliferation marker protein Ki-67

1

19

High-throughput

0.536

High

813547

CAPZB
F-actin-capping protein subunit beta

1

3

High-throughput

0.536

High

853625

IMA5
Importin subunit alpha-5

1

4

High-throughput

0.536

High

948806

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

1

High-throughput

0.536

High

949814

CBX1
Chromobox protein homolog 1

1

8

High-throughput

0.536

High

994211

DHX9
ATP-dependent RNA helicase A

1

3

High-throughput

0.536

High

996715

SSRP1
FACT complex subunit SSRP1

1

20

High-throughput

0.536

High

1087196

H2B2E
Histone H2B type 2-E

1

20

High-throughput

0.536

High

1154060

TFG
Protein TFG

1

13

High-throughput

0.536

High

1154066

CDC5L
Cell division cycle 5-like protein

1

5

High-throughput

0.536

High

487522

ANDR
Androgen receptor

1

20

High-throughput

0.534

High

304544

PRS23
Serine protease 23

1

0

High-throughput

0.518

High

1067006

BRD3
Bromodomain-containing protein 3

1

20

High-throughput

0.515

High

617319

SP100
Nuclear autoantigen Sp-100

1

14

Small-scale

0.501

High

902632

SUMO2
Small ubiquitin-related modifier 2

1

5

High-throughput

0.501

High

1154071

MLP3C
Microtubule-associated proteins 1A/1B light chain 3C

1

20

High-throughput

0.501

High

1154047

LDHD
Probable D-lactate dehydrogenase, mitochondrial

1

1

High-throughput

0.489

High

1154085

AT7L1
Ataxin-7-like protein 1

1

11

High-throughput

0.489

High

1154068

HINFP
Histone H4 transcription factor

1

2

Small-scale

0.481

High

123982

SPT5H
Transcription elongation factor SPT5

1

12

High-throughput

0.479

High

148941

CTRO
Citron Rho-interacting kinase

1

9

High-throughput

0.479

High

153705

ANM5
Protein arginine N-methyltransferase 5

1

2

High-throughput

0.479

High

165860

KDM6B
Lysine-specific demethylase 6B

1

20

Small-scale

0.479

High

171039

TBXT
T-box transcription factor T

1

7

High-throughput

0.479

High

179684

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

9

High-throughput

0.479

High

197733

CRX
Cone-rod homeobox protein

1

18

High-throughput

0.479

High

211883

TLX3
T-cell leukemia homeobox protein 3

1

12

High-throughput

0.479

High

213344

TLX2
T-cell leukemia homeobox protein 2

1

10

High-throughput

0.479

High

255864

OBSL1
Obscurin-like protein 1

1

12

High-throughput

0.479

High

268143

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

268759

SF3B1
Splicing factor 3B subunit 1

1

6

High-throughput

0.479

High

272175

U520
U5 small nuclear ribonucleoprotein 200 kDa helicase

1

8

High-throughput

0.479

High

316915

KLF8
Krueppel-like factor 8

1

18

High-throughput

0.479

High

317982

NFAC1
Nuclear factor of activated T-cells, cytoplasmic 1

1

7

High-throughput

0.479

High

322759

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

18

High-throughput

0.479

High

347056

MYC
Myc proto-oncogene protein

1

15

High-throughput

0.479

High

360045

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

9

High-throughput

0.479

High

377401

GCR
Glucocorticoid receptor

1

20

High-throughput

0.479

High

382031

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

3

High-throughput

0.479

High

427585

ANXA2
Annexin A2

1

1

High-throughput

0.479

High

431958

HS90A
Heat shock protein HSP 90-alpha

1

8

High-throughput

0.479

High

455559

PARP1
Poly [ADP-ribose] polymerase 1

1

15

High-throughput

0.479

High

486800

MYB
Transcriptional activator Myb

1

5

High-throughput

0.479

High

504250

HSP7C
Heat shock cognate 71 kDa protein

1

9

High-throughput

0.479

High

505235

EGR2
E3 SUMO-protein ligase EGR2

1

3

High-throughput

0.479

High

507447

ERG
Transcriptional regulator ERG

1

11

High-throughput

0.479

High

545984

MYOD1
Myoblast determination protein 1

1

4

High-throughput

0.479

High

555503

H2AX
Histone H2AX

1

10

High-throughput

0.479

High

598171

FLNA
Filamin-A

1

15

High-throughput

0.479

High

614354

PPIB
Peptidyl-prolyl cis-trans isomerase B

1

8

High-throughput

0.479

High

620367

GATA2
Endothelial transcription factor GATA-2

1

6

High-throughput

0.479

High

641445

PAX6
Paired box protein Pax-6

1

12

High-throughput

0.479

High

652889

APEX1
DNA repair nuclease/redox regulator APEX1

1

1

High-throughput

0.479

High

658517

TEAD1
Transcriptional enhancer factor TEF-1

1

2

High-throughput

0.479

High

679119

TLX1
T-cell leukemia homeobox protein 1

1

13

High-throughput

0.479

High

682851

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

13

High-throughput

0.479

High

727537

HNF1B
Hepatocyte nuclear factor 1-beta

1

18

High-throughput

0.479

High

749592

BRCA1
Breast cancer type 1 susceptibility protein

1

7

High-throughput

0.479

High

782571

HNF4A
Hepatocyte nuclear factor 4-alpha

1

20

High-throughput

0.479

High

788041

AF9
Protein AF-9

1

5

Small-scale

0.479

High

824108

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

9

High-throughput

0.479

High

828271

CENPA
Histone H3-like centromeric protein A

1

20

High-throughput

0.479

High

831421

CEBPA
CCAAT/enhancer-binding protein alpha

1

11

High-throughput

0.479

High

877298

DSRAD
Double-stranded RNA-specific adenosine deaminase

1

18

High-throughput

0.479

High

878419

PAX9
Paired box protein Pax-9

1

12

High-throughput

0.479

High

884184

KLF3
Krueppel-like factor 3

1

19

High-throughput

0.479

High

902935

DCAF7
DDB1- and CUL4-associated factor 7

1

18

High-throughput

0.479

High

903992

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

13

High-throughput

0.479

High

917444

H4
Histone H4

1

8

High-throughput

0.479

High

918442

H2B1C
Histone H2B type 1-C/E/F/G/I

1

20

High-throughput

0.479

High

932749

EF1A1
Elongation factor 1-alpha 1

1

6

High-throughput

0.479

High

952407

H33
Histone H3.3

1

20

High-throughput

0.479

High

958057

RBM10
RNA-binding protein 10

1

9

High-throughput

0.479

High

967233

EWS
RNA-binding protein EWS

1

9

High-throughput

0.479

High

980782

TLE3
Transducin-like enhancer protein 3

1

18

High-throughput

0.479

High

985223

HME1
Homeobox protein engrailed-1

1

6

High-throughput

0.479

High

985676

CTSL2
CTD small phosphatase-like protein 2

1

4

Small-scale

0.479

High

988771

PAX8
Paired box protein Pax-8

1

12

High-throughput

0.479

High

1029535

TIF1B
Transcription intermediary factor 1-beta

1

10

High-throughput

0.479

High

1036663

SQSTM
Sequestosome-1

1

8

High-throughput

0.479

High

1037259

TBB3
Tubulin beta-3 chain

1

4

High-throughput

0.479

High

1039630

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.479

High

1046699

KLF5
Krueppel-like factor 5

1

17

High-throughput

0.479

High

1047752

CKAP5
Cytoskeleton-associated protein 5

1

4

High-throughput

0.479

High

1060305

NFIX
Nuclear factor 1 X-type

1

18

High-throughput

0.479

High

1064403

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

5

High-throughput

0.479

High

1069616

STK38
Serine/threonine-protein kinase 38

1

6

High-throughput

0.479

High

1069707

NONO
Non-POU domain-containing octamer-binding protein

1

14

High-throughput

0.479

High

1071043

IRF4
Interferon regulatory factor 4

1

4

High-throughput

0.479

High

1072114

PCBP2
Poly(rC)-binding protein 2

1

12

High-throughput

0.479

High

1073022

SF3B3
Splicing factor 3B subunit 3

1

5

High-throughput

0.479

High

1085126

NFIL3
Nuclear factor interleukin-3-regulated protein

1

9

High-throughput

0.479

High

1114099

TBB8
Tubulin beta-8 chain

1

4

High-throughput

0.479

High

1153660

ANO7
Anoctamin-7

1

1

Small-scale

0.479

High

1154038

NIPBL
Nipped-B-like protein

1

17

High-throughput

0.479

High

1154041

MD13L
Mediator of RNA polymerase II transcription subunit 13-like

1

1

High-throughput

0.479

High

1154042

SETX
Probable helicase senataxin

1

2

High-throughput

0.479

High

1154043

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

12

High-throughput

0.479

High

1154045

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

5

Small-scale

0.479

High

1154046

NAA40
N-alpha-acetyltransferase 40

1

6

High-throughput

0.479

High

1154048

MGAP
MAX gene-associated protein

1

7

High-throughput

0.479

High

1154050

SLX4
Structure-specific endonuclease subunit SLX4

1

18

High-throughput

0.479

High

1154054

NUP43
Nucleoporin Nup43

1

20

High-throughput

0.479

High

1154055

SNIP1
Smad nuclear-interacting protein 1

1

1

High-throughput

0.479

High

1154056

SP7
Transcription factor Sp7

1

15

High-throughput

0.479

High

1154057

STAG1
Cohesin subunit SA-1

1

4

High-throughput

0.479

High

1154059

ESR2
Estrogen receptor beta

1

20

High-throughput

0.479

High

1154061

DDX17
Probable ATP-dependent RNA helicase DDX17

1

1

High-throughput

0.479

High

1154062

FUBP2
Far upstream element-binding protein 2

1

12

High-throughput

0.479

High

1154063

MED12
Mediator of RNA polymerase II transcription subunit 12

1

17

High-throughput

0.479

High

1154064

DCPS
m7GpppX diphosphatase

1

2

High-throughput

0.479

High

1154067

FEV
Protein FEV

1

10

High-throughput

0.479

High

1154070

KLF16
Krueppel-like factor 16

1

14

High-throughput

0.479

High

1154072

FACD2
Fanconi anemia group D2 protein

1

6

High-throughput

0.479

High

1154073

PDIP3
Polymerase delta-interacting protein 3

1

4

High-throughput

0.479

High

1154074

DDX47
Probable ATP-dependent RNA helicase DDX47

1

9

High-throughput

0.479

High

1154075

CCDC8
Coiled-coil domain-containing protein 8

1

1

High-throughput

0.479

High

1154078

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

9

High-throughput

0.479

High

1154079

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

5

High-throughput

0.479

High

1154080

LHX3
LIM/homeobox protein Lhx3

1

12

High-throughput

0.479

High

1154082

ZRAN1
Ubiquitin thioesterase ZRANB1

1

11

High-throughput

0.479

High

1154083

MED13
Mediator of RNA polymerase II transcription subunit 13

1

1

High-throughput

0.479

High

1154084

KLF15
Krueppel-like factor 15

1

16

High-throughput

0.479

High

1154086

MED23
Mediator of RNA polymerase II transcription subunit 23

1

2

Small-scale

0.479

High

1154088

RUVB2
RuvB-like 2

1

1

High-throughput

0.479

High

1154089

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

1154090

ST38L
Serine/threonine-protein kinase 38-like

1

6

High-throughput

0.479

High

1154091

TR150
Thyroid hormone receptor-associated protein 3

1

17

High-throughput

0.479

High

1154093

PKP3
Plakophilin-3

1

12

High-throughput

0.479

High

1154095

SNX9
Sorting nexin-9

1

1

High-throughput

0.479

High

215644

AKAP8
A-kinase anchor protein 8

1

0

High-throughput

0.458

High

629140

ZA2G
Zinc-alpha-2-glycoprotein

1

0

High-throughput

0.458

High

750311

COIL
Coilin

1

0

High-throughput

0.458

High

1134336

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.458

High

1154039

TET2
Methylcytosine dioxygenase TET2

1

0

High-throughput

0.458

High

1154044

WAPL
Wings apart-like protein homolog

1

0

High-throughput

0.458

High

1154058

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.458

High

1154069

SPNDC
Spindlin interactor and repressor of chromatin-binding protein

1

0

High-throughput

0.458

High

1154092

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

1154065

CEP63
Centrosomal protein of 63 kDa

1

15

High-throughput

0.457

High

826294

CDK8
Cyclin-dependent kinase 8

1

10

Small-scale

0.445

High

738228

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

8

High-throughput

0.437

High

1154040

TRI67
Tripartite motif-containing protein 67

1

14

High-throughput

0.437

High

1154076

PKHA4
Pleckstrin homology domain-containing family A member 4

1

18

High-throughput

0.437

High

886296

DSCR9
Down syndrome critical region protein 9

1

1

High-throughput

0.417

High

1084975

DREB
Drebrin

1

9

High-throughput

0.417

High

445946

NMB
Neuromedin-B [Cleaved into: Neuromedin-B-32; Neuromedin-B]

1

0

High-throughput

0.279

Low

1136810

FAXC
Failed axon connections homolog

1

0

High-throughput

0.279

Low

1150655

IL31
Interleukin-31

1

0

High-throughput

0.279

Low

1154081

SUCO
SUN domain-containing ossification factor

1

0

High-throughput

0.279

Low

1154094

GPSM3
G-protein-signaling modulator 3

1

0

High-throughput

0.279

Low

1154051

IQCK
IQ domain-containing protein K

1

0

High-throughput

0.249

Low

1154077

ZDBF2
DBF4-type zinc finger-containing protein 2

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024