Protein: SPT6H
Transcription elongation factor SPT6 (hSPT6) (Histone chaperone suppressor of Ty6) (Tat-cotransactivator 2 protein) (Tat-CT2 protein)

Gene: SPT6H, SUPT6H
Organism: Homo sapiens
Interactions: 199
UniProt ID: Q7KZ85

Gene Ontology (top 5):
GO:0001825 - blastocyst formation
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0006368 - transcription elongation by RNA polymerase II

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

123995

SPT5H
Transcription elongation factor SPT5

3

4

High-throughput

0.861

High

934272

CSK21
Casein kinase II subunit alpha

1

7

High-throughput

0.735

High

181431

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

1

High-throughput

0.691

High

676925

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

High-throughput

0.691

High

942747

SRPK2
SRSF protein kinase 2

1

2

High-throughput

0.691

High

1079094

STK11
Serine/threonine-protein kinase STK11

1

2

High-throughput

0.691

High

583738

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

3

2

High-throughput

0.675

High

1182958

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

3

4

High-throughput

0.667

High

1182965

PIHD1
PIH1 domain-containing protein 1

4

0

High-throughput

0.664

High

681914

AKT1
RAC-alpha serine/threonine-protein kinase

1

1

Small-scale

0.647

High

624945

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

5

Small-scale

0.646

High

897549

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

3

0

High-throughput

0.638

High

369886

ESR1
Estrogen receptor

3

7

Small-scale

0.633

High

555518

H2AX
Histone H2AX

2

7

High-throughput

0.628

High

996728

SSRP1
FACT complex subunit SSRP1

2

8

High-throughput

0.628

High

1182950

IWS1
Protein IWS1 homolog

2

5

Small-scale

0.624

High

583511

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

4

Small-scale

0.611

High

854438

RPB11
DNA-directed RNA polymerase II subunit RPB11-a

2

1

High-throughput

0.611

High

905985

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

2

5

High-throughput

0.611

High

921132

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

2

1

High-throughput

0.611

High

1182920

SKAP1
Src kinase-associated phosphoprotein 1

2

4

High-throughput

0.611

High

1182937

DDB2
DNA damage-binding protein 2

2

7

High-throughput

0.611

High

383863

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

3

High-throughput

0.602

High

638321

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

1182971

UXT
Protein UXT

2

0

High-throughput

0.602

High

612991

TCEA1
Transcription elongation factor A protein 1

2

3

Small-scale

0.595

High

864958

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

2

0

High-throughput

0.585

High

386981

P53
Cellular tumor antigen p53

2

2

High-throughput

0.584

High

934915

H31
Histone H3.1

2

10

High-throughput

0.584

High

1182973

ZRAN1
Ubiquitin thioesterase ZRANB1

2

4

High-throughput

0.584

High

1182939

ESR2
Estrogen receptor beta

2

7

High-throughput

0.571

High

125539

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

2

4

High-throughput

0.558

High

148976

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.553

High

312938

SLU7
Pre-mRNA-splicing factor SLU7

1

2

High-throughput

0.536

High

317129

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

5

High-throughput

0.536

High

446685

SNRPA
U1 small nuclear ribonucleoprotein A

1

2

High-throughput

0.536

High

448715

RU1C
U1 small nuclear ribonucleoprotein C

1

1

High-throughput

0.536

High

449757

HMGB1
High mobility group protein B1

1

7

High-throughput

0.536

High

508585

TOP1
DNA topoisomerase 1

1

3

High-throughput

0.536

High

539025

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

1

High-throughput

0.536

High

639002

S100P
Protein S100-P

1

1

High-throughput

0.536

High

726897

FUS
RNA-binding protein FUS

1

1

High-throughput

0.536

High

828808

SRP09
Signal recognition particle 9 kDa protein

1

1

High-throughput

0.536

High

854321

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

1

High-throughput

0.536

High

911880

RUXF
Small nuclear ribonucleoprotein F

1

1

High-throughput

0.536

High

952430

H33
Histone H3.3

1

10

High-throughput

0.536

High

1037979

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

1

High-throughput

0.536

High

1070525

RNPS1
RNA-binding protein with serine-rich domain 1

1

3

High-throughput

0.536

High

1084504

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

2

High-throughput

0.536

High

1087216

H2B2E
Histone H2B type 2-E

1

5

High-throughput

0.536

High

1160932

CTR9
RNA polymerase-associated protein CTR9 homolog

1

4

High-throughput

0.536

High

1182925

SPB1
pre-rRNA 2'-O-ribose RNA methyltransferase FTSJ3

1

7

High-throughput

0.536

High

1182929

ZBT44
Zinc finger and BTB domain-containing protein 44

1

3

High-throughput

0.536

High

1182945

DCAF5
DDB1- and CUL4-associated factor 5

1

5

High-throughput

0.536

High

1182948

RPR1A
Regulation of nuclear pre-mRNA domain-containing protein 1A

1

4

High-throughput

0.536

High

1182962

MED17
Mediator of RNA polymerase II transcription subunit 17

1

1

High-throughput

0.536

High

1182978

RUVB2
RuvB-like 2

1

8

High-throughput

0.536

High

1182979

RUVB1
RuvB-like 1

1

8

High-throughput

0.536

High

1182980

STRAP
Serine-threonine kinase receptor-associated protein

1

5

High-throughput

0.536

High

473910

GRL1A
DNA-directed RNA polymerase II subunit GRINL1A

2

0

High-throughput

0.528

High

258084

DNJB6
DnaJ homolog subfamily B member 6

1

0

High-throughput

0.518

High

1182933

WDR48
WD repeat-containing protein 48

1

5

High-throughput

0.515

High

1130241

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.514

High

267169

GEMI
Geminin

1

0

High-throughput

0.513

High

785979

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.513

High

1125661

SGO1
Shugoshin 1

1

0

High-throughput

0.513

High

1182932

CTCFL
Transcriptional repressor CTCFL

1

0

High-throughput

0.513

High

1182944

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.513

High

1182963

RPC5
DNA-directed RNA polymerase III subunit RPC5

1

0

High-throughput

0.513

High

538288

ENPL
Endoplasmin

1

2

Small-scale

0.501

High

751697

GRP75
Stress-70 protein, mitochondrial

1

6

Small-scale

0.501

High

976472

ERCC6
DNA excision repair protein ERCC-6

1

9

High-throughput

0.501

High

152969

RIOK3
Serine/threonine-protein kinase RIO3

1

2

High-throughput

0.489

High

323856

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.489

High

885045

FBXW4
F-box/WD repeat-containing protein 4

1

6

High-throughput

0.489

High

921625

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

5

High-throughput

0.489

High

1172606

K0408
Uncharacterized protein KIAA0408

1

1

High-throughput

0.489

High

1182922

CCD71
Coiled-coil domain-containing protein 71

1

1

High-throughput

0.489

High

1182954

RPAP3
RNA polymerase II-associated protein 3

1

8

High-throughput

0.489

High

1182968

WSB2
WD repeat and SOCS box-containing protein 2

1

5

High-throughput

0.489

High

499865

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.480

High

130962

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

2

High-throughput

0.479

High

170407

TIF1A
Transcription intermediary factor 1-alpha

1

4

Small-scale

0.479

High

179698

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

3

High-throughput

0.479

High

203723

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

3

High-throughput

0.479

High

244597

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

246583

MCE1
mRNA-capping enzyme

1

4

High-throughput

0.479

High

256295

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

3

Small-scale

0.479

High

260916

H2AY
Core histone macro-H2A.1

1

7

High-throughput

0.479

High

268148

EED
Polycomb protein EED

1

6

High-throughput

0.479

High

295537

RECQ5
ATP-dependent DNA helicase Q5

1

1

High-throughput

0.479

High

295642

RMP
Unconventional prefoldin RPB5 interactor 1

1

1

Small-scale

0.479

High

296319

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

2

Small-scale

0.479

High

304634

SCAF4
SR-related and CTD-associated factor 4

1

2

High-throughput

0.479

High

345473

FOS
Protein c-Fos

1

2

High-throughput

0.479

High

347146

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.479

High

391758

H2A1B
Histone H2A type 1-B/E

1

6

High-throughput

0.479

High

455587

PARP1
Poly [ADP-ribose] polymerase 1

1

6

High-throughput

0.479

High

553023

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

651527

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

669410

EF1D
Elongation factor 1-delta

1

2

High-throughput

0.479

High

684833

STIP1
Stress-induced-phosphoprotein 1

1

4

High-throughput

0.479

High

717958

BMI1
Polycomb complex protein BMI-1

1

3

High-throughput

0.479

High

720768

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

737890

PP1G
Serine/threonine-protein phosphatase PP1-gamma catalytic subunit

1

5

High-throughput

0.479

High

749613

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.479

High

750324

COIL
Coilin

1

2

High-throughput

0.479

High

875057

TERA
Transitional endoplasmic reticulum ATPase

1

2

High-throughput

0.479

High

887533

ELOF1
Transcription elongation factor 1 homolog

1

2

Small-scale

0.479

High

917489

H4
Histone H4

1

7

High-throughput

0.479

High

927213

1433Z
14-3-3 protein zeta/delta

1

2

High-throughput

0.479

High

998833

EP300
Histone acetyltransferase p300

1

6

High-throughput

0.479

High

1018547

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

13

High-throughput

0.479

High

1035841

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

High-throughput

0.479

High

1051970

ELOA1
Elongin-A

1

4

Small-scale

0.479

High

1056874

MDC1
Mediator of DNA damage checkpoint protein 1

1

3

High-throughput

0.479

High

1059691

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

13

High-throughput

0.479

High

1080064

EZH2
Histone-lysine N-methyltransferase EZH2

1

5

High-throughput

0.479

High

1137926

RPRD2
Regulation of nuclear pre-mRNA domain-containing protein 2

1

4

High-throughput

0.479

High

1138181

BRE1A
E3 ubiquitin-protein ligase BRE1A

1

3

Small-scale

0.479

High

1153854

IFIX
Pyrin and HIN domain-containing protein 1

1

2

High-throughput

0.479

High

1182926

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

1182927

SIR6
NAD-dependent protein deacylase sirtuin-6

1

4

High-throughput

0.479

High

1182931

NUP43
Nucleoporin Nup43

1

7

High-throughput

0.479

High

1182941

DCPS
m7GpppX diphosphatase

1

1

High-throughput

0.479

High

1182943

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

4

High-throughput

0.479

High

1182952

DDX23
Probable ATP-dependent RNA helicase DDX23

1

2

High-throughput

0.479

High

1182955

SFR19
Splicing factor, arginine/serine-rich 19

1

6

High-throughput

0.479

High

1182956

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

1

High-throughput

0.479

High

1182960

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

4

High-throughput

0.479

High

1182961

RAD18
E3 ubiquitin-protein ligase RAD18

1

1

High-throughput

0.479

High

1182967

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1182969

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.479

High

1182976

BAZ1B
Tyrosine-protein kinase BAZ1B

1

10

Small-scale

0.479

High

1182981

ZN330
Zinc finger protein 330

1

2

High-throughput

0.479

High

1182982

SCC4
MAU2 chromatid cohesion factor homolog

1

1

High-throughput

0.479

High

502259

BIP
Endoplasmic reticulum chaperone BiP

1

4

High-throughput

0.470

High

564103

HSP76
Heat shock 70 kDa protein 6

1

3

High-throughput

0.470

High

1182946

H2A1H
Histone H2A type 1-H

1

6

High-throughput

0.470

High

1182930

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

308822

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

531882

PDIA4
Protein disulfide-isomerase A4

1

0

High-throughput

0.458

High

758270

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.458

High

838927

EMD
Emerin

1

0

High-throughput

0.458

High

922234

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

961171

HSF1
Heat shock factor protein 1

1

0

High-throughput

0.458

High

1035247

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

1078576

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.458

High

1182923

DHX40
Probable ATP-dependent RNA helicase DHX40

1

0

High-throughput

0.458

High

1182924

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1182940

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1182949

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

1182972

NXF1
Nuclear RNA export factor 1

1

0

High-throughput

0.458

High

1182977

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

338609

EGFR
Epidermal growth factor receptor

1

4

High-throughput

0.457

High

835075

TSC2
Tuberin

1

2

Small-scale

0.457

High

382464

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

High-throughput

0.445

High

800436

CBX5
Chromobox protein homolog 5

1

6

Small-scale

0.445

High

1182957

LN28A
Protein lin-28 homolog A

1

1

High-throughput

0.445

High

227861

PRKN
E3 ubiquitin-protein ligase parkin

1

5

High-throughput

0.437

High

255883

OBSL1
Obscurin-like protein 1

1

1

High-throughput

0.437

High

614064

TBG1
Tubulin gamma-1 chain

1

2

High-throughput

0.437

High

779634

CCNF
Cyclin-F

1

2

High-throughput

0.437

High

882386

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

5

High-throughput

0.437

High

893808

S10AA
Protein S100-A10

1

1

Small-scale

0.437

High

1061476

CUL7
Cullin-7

1

2

High-throughput

0.437

High

1170536

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.437

High

1182919

PHLB2
Pleckstrin homology-like domain family B member 2

1

8

High-throughput

0.437

High

1182951

PAAF1
Proteasomal ATPase-associated factor 1

1

6

Small-scale

0.437

High

1182953

CP250
Centrosome-associated protein CEP250

1

5

High-throughput

0.437

High

1182970

PHRF1
PHD and RING finger domain-containing protein 1

1

7

High-throughput

0.437

High

473866

MYZAP
Myocardial zonula adherens protein

1

2

High-throughput

0.407

High

1150666

GL1AD
DNA-directed RNA polymerase II subunit GRINL1A, isoforms 4/5

4

0

High-throughput

0.353

High

1150412

PVRIG
Transmembrane protein PVRIG

3

0

High-throughput

0.347

High

1182928

TTC29
Tetratricopeptide repeat protein 29

3

0

High-throughput

0.347

High

1182936

TB22A
TBC1 domain family member 22A

3

0

High-throughput

0.347

High

901692

PFD3
Prefoldin subunit 3

2

0

High-throughput

0.328

High

1182974

PFD2
Prefoldin subunit 2

2

0

High-throughput

0.328

High

941698

SHPS1
Tyrosine-protein phosphatase non-receptor type substrate 1

1

0

Small-scale

0.292

High

1035385

GAB1
GRB2-associated-binding protein 1

1

0

High-throughput

0.279

Low

211376

PI15
Peptidase inhibitor 15

1

0

High-throughput

0.279

Low

473136

OST4
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 4

1

0

High-throughput

0.279

Low

763023

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.279

Low

991106

PIGF
Phosphatidylinositol-glycan biosynthesis class F protein

1

0

High-throughput

0.279

Low

1101859

S35G1
Solute carrier family 35 member G1

1

0

High-throughput

0.279

Low

1110245

KR133
Keratin-associated protein 13-3

1

0

High-throughput

0.279

Low

1121404

P5CR3
Pyrroline-5-carboxylate reductase 3

1

0

High-throughput

0.279

Low

1150134

ATLA3
Atlastin-3

1

0

High-throughput

0.279

Low

1182935

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.279

Low

1182938

F168A
Protein FAM168A

1

0

High-throughput

0.279

Low

1182947

RN145
RING finger protein 145

1

0

High-throughput

0.279

Low

1182959

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.279

Low

1182975

GPN3
GPN-loop GTPase 3

1

0

High-throughput

0.279

Low

168266

DEGS1
Sphingolipid delta(4)-desaturase DES1

1

0

High-throughput

0.249

Low

1182921

CEP57
Centrosomal protein of 57 kDa

1

0

High-throughput

0.249

Low

1182934

CEP76
Centrosomal protein of 76 kDa

1

0

High-throughput

0.249

Low

1182942

GCP3
Gamma-tubulin complex component 3

1

0

High-throughput

0.249

Low

1182964

HAUS2
HAUS augmin-like complex subunit 2

1

0

High-throughput

0.249

Low

1182966

S39A1
Zinc transporter ZIP1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024