Protein: FOXO
Forkhead box protein O (dFOXO) (Protein FKHR)

Gene: FOXO
Organism: Drosophila melanogaster
Interactions: 211
UniProt ID: Q95V55

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

731981

CROC
Fork head domain-containing protein crocodile

1

19

High-throughput

0.698

High

731999

FD5
Fork head domain-containing protein FD5

1

18

High-throughput

0.698

High

709553

1433Z
14-3-3 protein zeta

2

20

High-throughput

0.611

High

1019882

1433E
14-3-3 protein epsilon

2

6

High-throughput

0.611

High

1378536

FOXO
Forkhead box protein O

1

17

Small-scale

0.575

High

119801

M9PBC6
Bub3 interacting GLEBS and zinc finger domain protein, isoform F

1

9

High-throughput

0.541

High

119930

M9PBR0
Blimp-1, isoform B

1

2

High-throughput

0.541

High

197695

PITX
Pituitary homeobox homolog Ptx1

1

20

High-throughput

0.541

High

234483

CTBP
C-terminal-binding protein

1

9

High-throughput

0.541

High

263797

CYCL
Protein cycle

1

14

High-throughput

0.541

High

393642

ANTP
Homeotic protein antennapedia

1

19

High-throughput

0.541

High

458829

SRYB
Serendipity locus protein beta

1

1

High-throughput

0.541

High

464739

SNAI
Protein snail

1

1

High-throughput

0.541

High

517359

HMH2
Homeobox protein H2.0

1

20

High-throughput

0.541

High

519302

ROUGH
Homeobox protein rough

1

20

High-throughput

0.541

High

542915

DA
Protein daughterless

1

1

High-throughput

0.541

High

653106

RUNT
Segmentation protein Runt

1

1

High-throughput

0.541

High

654054

DSX
Protein doublesex

1

8

High-throughput

0.541

High

662132

POXM
Paired box pox-meso protein

1

9

High-throughput

0.541

High

662185

POXN
Paired box pox-neuro protein

1

9

High-throughput

0.541

High

942228

COLL
Transcription factor collier

1

1

High-throughput

0.541

High

1042513

HMSH
Muscle segmentation homeobox

1

20

High-throughput

0.541

High

1064542

GAGA
Transcription activator GAGA

1

14

High-throughput

0.541

High

1196377

Q4V3F5
FI01110p

1

3

High-throughput

0.541

High

1264367

GLIS2
Zinc finger protein GLIS2 homolog

1

6

High-throughput

0.541

High

1267449

HEY
Hairy/enhancer-of-split related with YRPW motif protein

1

4

High-throughput

0.541

High

1305546

Q8IQJ5
Uncharacterized protein

1

20

High-throughput

0.541

High

1342978

PHO
Polycomb protein PHO

1

8

High-throughput

0.541

High

1378547

Q9VBN9
RE40275p

1

2

High-throughput

0.541

High

1378553

Q9VEF1
Uncharacterized protein

1

4

High-throughput

0.541

High

1378554

Q9VEF4
IP01257p

1

2

High-throughput

0.541

High

1378560

Q9VGL2
GM08392p

1

1

High-throughput

0.541

High

1378566

RN
Zinc finger protein rotund

1

2

High-throughput

0.541

High

1378580

Q9VQ77
LD29420p

1

3

High-throughput

0.541

High

1378582

BOWEL
Protein bowel

1

1

High-throughput

0.541

High

1378584

Q9VSC2
Extra-extra

1

20

High-throughput

0.541

High

1378591

CREBB
Cyclic AMP response element-binding protein B

1

5

High-throughput

0.541

High

1378595

Q9VYE0
Doublesex-Mab related 11E

1

8

High-throughput

0.541

High

1378610

Q9W423
LD18904p

1

1

High-throughput

0.541

High

1378616

R4GRV8
C2H2-type domain-containing protein

1

3

High-throughput

0.541

High

1378617

X2JDS9
Visual system homeobox 2

1

20

High-throughput

0.541

High

1302302

Q8I9J6
Histone deacetylase

1

17

Small-scale

0.536

High

1176445

E2F1
Transcription factor E2f1

1

0

High-throughput

0.518

High

1263579

Q7JZC5
Linking immunity and metabolism

1

0

High-throughput

0.518

High

1263629

Q7JZD5
Dorsal interacting protein 3

1

0

High-throughput

0.518

High

1344062

Q8SXZ6
RE39769p

1

0

High-throughput

0.518

High

1378538

SUZ12
Polycomb protein Su(z)12

1

0

High-throughput

0.518

High

1378564

Q9VHL0
Hinge2

1

0

High-throughput

0.518

High

1303699

AKT1
RAC serine/threonine-protein kinase

1

9

Small-scale

0.501

High

1378552

Q9VDJ9
non-specific serine/threonine protein kinase

1

1

Small-scale

0.501

High

1305103

Q8IQ04
GEO11681p1

1

1

High-throughput

0.494

High

1306399

INDRA
Zinc finger protein indra

1

0

High-throughput

0.486

High

84642

B7Z045
BTB-protein-VII, isoform G

1

12

High-throughput

0.481

High

713693

ABDA
Homeobox protein abdominal-A

1

20

High-throughput

0.481

High

1014348

UBX
Homeotic protein ultrabithorax

1

20

High-throughput

0.481

High

1174459

BUN2
Protein bunched, class 2/F/G isoform

1

2

High-throughput

0.481

High

1195847

Q4QPP9
GH02096p

1

3

High-throughput

0.481

High

1269824

Q7KUL4
Intermediate neuroblasts defective

1

20

High-throughput

0.481

High

1304931

Q8IPV7
Cabut, isoform B

1

12

High-throughput

0.481

High

1378550

Q9VCB2
LD04007p

1

14

High-throughput

0.481

High

1378557

Q9VEY3
48 related 2, isoform B

1

3

High-throughput

0.481

High

1378618

X2JIB5
Uncharacterized protein, isoform D

1

2

High-throughput

0.481

High

52477

A1Z6Z7
Uncharacterized protein, isoform A

1

11

High-throughput

0.479

High

54615

A1Z8U0
Pre-mRNA-processing-splicing factor 8

1

2

High-throughput

0.479

High

56733

A1ZAH8
40S ribosomal protein S15

1

1

High-throughput

0.479

High

57052

A1ZAN6
Rho guanine nucleotide exchange factor 2, isoform D

1

1

High-throughput

0.479

High

94915

E1JGL8
Uncharacterized protein, isoform C

1

13

High-throughput

0.479

High

197591

PAX6
Paired box protein Pax-6

1

17

Small-scale

0.479

High

232148

O44434
QKR58E-3

1

4

High-throughput

0.479

High

262630

RL10
Large ribosomal subunit protein uL16

1

1

High-throughput

0.479

High

263485

O61380
Eukaryotic translation initiation factor 4G1, isoform A

1

7

High-throughput

0.479

High

356810

CHDM
Chromodomain-helicase-DNA-binding protein Mi-2 homolog

1

20

High-throughput

0.479

High

462188

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

6

High-throughput

0.479

High

466818

KRH1
Krueppel homolog 1

1

1

Small-scale

0.479

High

534460

ACT1
Actin-5C

1

1

High-throughput

0.479

High

554094

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.479

High

616571

ARM
Armadillo segment polarity protein

1

14

Small-scale

0.479

High

618781

DDX17
ATP-dependent RNA helicase p62

1

3

High-throughput

0.479

High

628539

USP
Protein ultraspiracle

1

20

Small-scale

0.479

High

666617

MLE
Dosage compensation regulator mle

1

2

High-throughput

0.479

High

674033

BRM
ATP-dependent helicase brm

1

20

High-throughput

0.479

High

715126

CLH
Clathrin heavy chain

1

1

High-throughput

0.479

High

715366

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.479

High

760397

TTF2
Transcription termination factor 2

1

20

High-throughput

0.479

High

874990

PRS4
26S proteasome regulatory subunit 4

1

1

High-throughput

0.479

High

939570

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

1044928

NONA
Protein no-on-transient A

1

3

High-throughput

0.479

High

1052245

HMGD
High mobility group protein D

1

19

High-throughput

0.479

High

1064227

SQD
RNA-binding protein squid

1

6

High-throughput

0.479

High

1069814

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

9

High-throughput

0.479

High

1172897

RS5A
Small ribosomal subunit protein uS7A

1

2

High-throughput

0.479

High

1173924

ISWI
Chromatin-remodeling complex ATPase chain Iswi

1

20

High-throughput

0.479

High

1175600

CAF1
Chromatin assembly factor 1 p55 subunit

1

7

High-throughput

0.479

High

1234102

SARM1
NAD(+) hydrolase sarm1

1

8

High-throughput

0.479

High

1267356

Q7KLW9
Pre-mRNA-processing factor 19

1

11

High-throughput

0.479

High

1269965

Q7KV89
Mitogen-activated protein kinase kinase kinase kinase

1

3

High-throughput

0.479

High

1303216

PANG2
Protein pangolin, isoform J

1

20

Small-scale

0.479

High

1304044

SLE
Protein slender lobes

1

6

High-throughput

0.479

High

1306045

CLSPN
Claspin

1

4

High-throughput

0.479

High

1345659

RS23
Small ribosomal subunit protein uS12

1

1

High-throughput

0.479

High

1378540

EIF3H
Eukaryotic translation initiation factor 3 subunit H

1

5

High-throughput

0.479

High

1378541

Q9V3E7
LD24793p

1

3

High-throughput

0.479

High

1378542

Q9V426
LD07162p

1

3

High-throughput

0.479

High

1378544

Q9VA35
CIN85 and CD2AP related, isoform A

1

1

High-throughput

0.479

High

1378545

RS7
Small ribosomal subunit protein eS7

1

1

High-throughput

0.479

High

1378546

LARP
La-related protein 1

1

10

High-throughput

0.479

High

1378548

Q9VBX3
Vig2, isoform B

1

3

High-throughput

0.479

High

1378556

Q9VEV1
non-specific serine/threonine protein kinase

1

10

High-throughput

0.479

High

1378561

IPO9
Importin-9

1

11

High-throughput

0.479

High

1378562

Y6693
J domain-containing protein CG6693

1

7

High-throughput

0.479

High

1378563

Q9VHC7
FI21236p1

1

3

High-throughput

0.479

High

1378567

Q9VJ86
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.479

High

1378571

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

8

High-throughput

0.479

High

1378574

RHEB
GTP-binding protein Rheb homolog

1

1

High-throughput

0.479

High

1378576

Q9VP57
LD15904p

1

1

High-throughput

0.479

High

1378577

Q9VPL9
FI24801p1

1

20

High-throughput

0.479

High

1378586

Q9VTC1
ATP-dependent RNA helicase DDX42

1

4

High-throughput

0.479

High

1378588

Q9VV52
LD37257p

1

16

High-throughput

0.479

High

1378597

Q9VZF5
Kinesin-like protein

1

3

High-throughput

0.479

High

1378601

Q9W0R0
Cell division cycle 5, isoform A

1

1

High-throughput

0.479

High

1378602

Q9W1I0
TAR DNA-binding protein 43

1

9

High-throughput

0.479

High

1378604

Q9W254
Quaking related 58E-2, isoform A

1

4

High-throughput

0.479

High

1378609

Q9W414
Regulatory particle triple-A ATPase 4

1

1

High-throughput

0.479

High

1378613

Q9W4M7
Twenty-four, isoform B

1

5

High-throughput

0.479

High

1378614

DDB1
DNA damage-binding protein 1

1

1

High-throughput

0.479

High

57289

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

0

High-throughput

0.458

High

95045

E1JH23
Oxysterol-binding protein

1

0

High-throughput

0.458

High

122115

M9PHL6
Bifocal, isoform E

1

0

High-throughput

0.458

High

305435

EIF3E
Eukaryotic translation initiation factor 3 subunit E

1

0

High-throughput

0.458

High

822372

METK
S-adenosylmethionine synthase

1

0

High-throughput

0.458

High

836567

T2FB
General transcription factor IIF subunit 2

1

0

High-throughput

0.458

High

1051902

KPEL
Serine/threonine-protein kinase pelle

1

0

Small-scale

0.458

High

1070023

RS11
Small ribosomal subunit protein uS17

1

0

High-throughput

0.458

High

1377291

Q95RE4
LD37574p

1

0

High-throughput

0.458

High

1378549

Q9VC08
LD43724p

1

0

High-throughput

0.458

High

1378569

Q9VLC5
aldehyde dehydrogenase

1

0

High-throughput

0.458

High

1378587

AGO2
Protein argonaute-2

1

0

High-throughput

0.458

High

1378592

Q9VX08
LD10434p

1

0

High-throughput

0.458

High

1378594

RRP12
RRP12-like protein

1

0

High-throughput

0.458

High

1378605

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.458

High

2637

A0A0B4KHC8
Sp1-like factor for pairing sensitive-silencing, isoform B

1

14

High-throughput

0.457

High

2767

A0A0B4LH09
Maf-S, isoform B

1

3

High-throughput

0.457

High

2772

A0A0B4LH78
48 related 2, isoform D

1

4

High-throughput

0.457

High

355837

O96620
Intermediate neuroblasts defective protein

1

20

High-throughput

0.457

High

1174455

BUN1
Protein bunched, class 1/class 3/D/E isoforms

1

2

High-throughput

0.457

High

1378578

Q9VPQ5
Cabut, isoform A

1

12

High-throughput

0.457

High

1378579

ERM
Fez family zinc finger protein erm

1

2

High-throughput

0.457

High

1378598

Q9VZU5
BTB-protein-VII, isoform F

1

20

High-throughput

0.457

High

1378612

Q9W4F9
IP01388p

1

2

High-throughput

0.457

High

119941

M9PBS1
Earmuff, isoform B

1

2

High-throughput

0.439

High

1304484

Q8IPA6
RE15759p

1

1

High-throughput

0.439

High

1378539

Q9U4U5
LD16082p

1

1

High-throughput

0.439

High

58581

A1ZBW6
Uncharacterized protein, isoform A

1

4

High-throughput

0.437

High

98447

F0JAG2
MIP27703p

1

7

High-throughput

0.437

High

145783

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

4

High-throughput

0.437

High

264638

COPB2
Coatomer subunit beta'

1

6

High-throughput

0.437

High

471493

RLA1
Large ribosomal subunit protein P1

1

2

High-throughput

0.437

High

561586

SPTCA
Spectrin alpha chain

1

4

High-throughput

0.437

High

607492

RS17
Small ribosomal subunit protein eS17

1

1

High-throughput

0.437

High

856468

RL7A
Large ribosomal subunit protein eL8

1

3

High-throughput

0.437

High

938997

RL14
Large ribosomal subunit protein eL14

1

1

High-throughput

0.437

High

1193028

Q494K2
Chromosome transmission fidelity 4

1

10

High-throughput

0.437

High

1207936

Q5KTT4
Eukaryotic translation initiation factor 4 gamma 2

1

3

High-throughput

0.437

High

1269941

Q7KV70
Karst, isoform C

1

3

High-throughput

0.437

High

1378543

EPB41
Protein 4.1 homolog

1

1

High-throughput

0.437

High

1378551

DDX18
Probable ATP-dependent RNA helicase pitchoune

1

6

High-throughput

0.437

High

1378555

Q9VEH0
Aluminum tubes, isoform A

1

8

High-throughput

0.437

High

1378558

RRP15
RRP15-like protein

1

1

High-throughput

0.437

High

1378559

Q9VGH5
AT27789p

1

13

High-throughput

0.437

High

1378568

PESC
Pescadillo homolog

1

2

High-throughput

0.437

High

1378570

Y3096
Ribosomal L1 domain-containing protein CG13096

1

5

High-throughput

0.437

High

1378572

EI3F1
Eukaryotic translation initiation factor 3 subunit F-1

1

4

High-throughput

0.437

High

1378575

RL13A
Large ribosomal subunit protein uL13

1

1

High-throughput

0.437

High

1378581

Q9VQK7
LD45152p

1

1

High-throughput

0.437

High

1378583

RL18
Large ribosomal subunit protein eL18

1

1

High-throughput

0.437

High

1378585

Q9VT19
RRM domain-containing protein

1

8

High-throughput

0.437

High

1378589

LUC7L
Putative RNA-binding protein Alsin2

1

2

High-throughput

0.437

High

1378593

Q9VXQ5
Chaperonin containing TCP1 subunit 6

1

1

High-throughput

0.437

High

1378599

Q9W0A8
FI01658p

1

1

High-throughput

0.437

High

1378600

Q9W0B8
Coatomer subunit alpha

1

6

High-throughput

0.437

High

1378607

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.437

High

1378608

RL17
Large ribosomal subunit protein uL22

1

1

High-throughput

0.437

High

1304500

Q8IPA8
Uncharacterized protein, isoform E

1

2

High-throughput

0.417

High

1378537

Q9GR11
Ral guanine nucleotide dissociation stimulator-like protein

1

1

High-throughput

0.417

High

1304102

KTAP2
Protein KRTCAP2 homolog

1

0

High-throughput

0.282

High

1343123

Q8STG9
DSec61alpha

1

0

High-throughput

0.265

Low

196077

RL15
Large ribosomal subunit protein eL15

1

0

High-throughput

0.249

Low

231844

DKC1
H/ACA ribonucleoprotein complex subunit 4

1

0

High-throughput

0.249

Low

429098

RLA2
Large ribosomal subunit protein P2

1

0

High-throughput

0.249

Low

559163

RS26
Small ribosomal subunit protein eS26

1

0

High-throughput

0.249

Low

627446

RPA2
DNA-directed RNA polymerase I subunit RPA2

1

0

High-throughput

0.249

Low

710944

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.249

Low

782966

RL19
Large ribosomal subunit protein eL19

1

0

High-throughput

0.249

Low

832188

RL18A
Large ribosomal subunit protein eL20

1

0

High-throughput

0.249

Low

870610

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.249

Low

898292

RL9
Large ribosomal subunit protein uL6

1

0

High-throughput

0.249

Low

1019461

RPA1
DNA-directed RNA polymerase I subunit RPA1

1

0

High-throughput

0.249

Low

1268918

RS19B
Small ribosomal subunit protein eS19B

1

0

High-throughput

0.249

Low

1269238

Q7KTD0
ABC-type glutathione-S-conjugate transporter

1

0

High-throughput

0.249

Low

1269353

Q7KTL4
Septin interacting protein 2, isoform C

1

0

High-throughput

0.249

Low

1345578

Q8T3H9
AT04280p

1

0

High-throughput

0.249

Low

1378565

Q9VHV6
RE31520p

1

0

High-throughput

0.249

Low

1378573

Q9VNB9
Large ribosomal subunit protein eL33

1

0

High-throughput

0.249

Low

1378590

Q9VVU2
GEO07453p1

1

0

High-throughput

0.249

Low

1378596

Q9VZC8
GEO12024p1

1

0

High-throughput

0.249

Low

1378603

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

High-throughput

0.249

Low

1378606

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.249

Low

1378611

Q9W4C1
IP13321p

1

0

High-throughput

0.249

Low

1378615

Q9XZ31
Anastral spindle 2, isoform A

1

0

High-throughput

0.249

Low

1175020

NETB
Netrin-B

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025