Protein: E2F1
Transcription factor E2F1 (E2F-1) (PBR3) (Retinoblastoma-associated protein 1) (RBAP-1) (Retinoblastoma-binding protein 3) (RBBP-3) (pRB-binding protein E2F-1)

Gene: E2F1
Organism: Homo sapiens
Interactions: 232
UniProt ID: Q01094

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

414250

RB
Retinoblastoma-associated protein

71

20

Small-scale

0.998

High

963615

TFDP1
Transcription factor Dp-1

23

20

Small-scale

0.991

High

963616

TFDP2
Transcription factor Dp-2

9

20

Small-scale

0.972

High

660118

RBL1
Retinoblastoma-like protein 1

9

20

Small-scale

0.967

High

963655

TOPB1
DNA topoisomerase 2-binding protein 1

7

4

Small-scale

0.755

High

135241

E2F3
Transcription factor E2F3

2

14

High-throughput

0.754

High

963628

E2F4
Transcription factor E2F4

2

14

Small-scale

0.754

High

963606

SKP2
S-phase kinase-associated protein 2

7

4

Small-scale

0.743

High

963659

KAT2B
Histone acetyltransferase KAT2B

6

11

Small-scale

0.724

High

590166

CCNA2
Cyclin-A2

5

9

Small-scale

0.720

High

625370

CDK2
Cyclin-dependent kinase 2

5

16

Small-scale

0.717

High

435047

SP1
Transcription factor Sp1

4

10

Small-scale

0.705

High

963600

EP300
Histone acetyltransferase p300

5

12

Small-scale

0.704

High

963612

HDAC1
Histone deacetylase 1

5

6

Small-scale

0.702

High

963658

KAT2A
Histone acetyltransferase KAT2A

5

12

Small-scale

0.699

High

718765

PHB1
Prohibitin 1

5

0

Small-scale

0.694

High

963610

BIRC2
Baculoviral IAP repeat-containing protein 2

3

7

Small-scale

0.681

High

589831

TBP
TATA-box-binding protein

3

1

Small-scale

0.678

High

963648

MCPH1
Microcephalin

3

1

Small-scale

0.677

High

790751

CDN2A
Cyclin-dependent kinase inhibitor 2A

3

1

Small-scale

0.664

High

963711

TRRAP
Transformation/transcription domain-associated protein

3

4

Small-scale

0.650

High

963663

SIR1
NAD-dependent protein deacetylase sirtuin-1

3

0

Small-scale

0.649

High

963673

NECD
Necdin

2

6

Small-scale

0.649

High

130850

PSDE
26S proteasome non-ATPase regulatory subunit 14

3

3

Small-scale

0.640

High

624576

CCNE1
G1/S-specific cyclin-E1

3

11

Small-scale

0.640

High

963598

RBL2
Retinoblastoma-like protein 2

3

20

Small-scale

0.633

High

749384

BRCA1
Breast cancer type 1 susceptibility protein

3

5

Small-scale

0.631

High

943774

CCNA1
Cyclin-A1

2

9

Small-scale

0.629

High

963715

NCOA3
Nuclear receptor coactivator 3

2

3

Small-scale

0.629

High

963649

SETD7
Histone-lysine N-methyltransferase SETD7

3

0

Small-scale

0.627

High

131237

BIN1
Myc box-dependent-interacting protein 1

2

1

Small-scale

0.624

High

386542

P53
Cellular tumor antigen p53

2

3

Small-scale

0.624

High

962734

MDM2
E3 ubiquitin-protein ligase Mdm2

2

1

Small-scale

0.624

High

963702

FZR1
Fizzy-related protein homolog

2

4

Small-scale

0.624

High

779256

CCNF
Cyclin-F

2

16

Small-scale

0.620

High

848195

HCFC1
Host cell factor 1

2

3

Small-scale

0.620

High

265633

E2F6
Transcription factor E2F6

1

15

High-throughput

0.618

High

963619

E2F2
Transcription factor E2F2

1

14

High-throughput

0.618

High

963625

E2F5
Transcription factor E2F5

1

14

High-throughput

0.618

High

455330

PARP1
Poly [ADP-ribose] polymerase 1

2

5

Small-scale

0.611

High

963597

RING1
E3 ubiquitin-protein ligase RING1

2

17

Small-scale

0.611

High

697735

TF2H1
General transcription factor IIH subunit 1

2

0

Small-scale

0.603

High

232106

KDM1A
Lysine-specific histone demethylase 1A

2

7

Small-scale

0.602

High

960497

PURA
Transcriptional activator protein Pur-alpha

2

1

Small-scale

0.602

High

957685

XIAP
E3 ubiquitin-protein ligase XIAP

2

6

Small-scale

0.601

High

963668

LMBL3
Lethal(3)malignant brain tumor-like protein 3

2

13

Small-scale

0.601

High

819614

NRIP1
Nuclear receptor-interacting protein 1

2

0

Small-scale

0.598

High

963657

CBP
CREB-binding protein

2

11

Small-scale

0.594

High

587531

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

7

Small-scale

0.589

High

796264

MAGAB
Melanoma-associated antigen 11

2

6

Small-scale

0.584

High

841169

CDK7
Cyclin-dependent kinase 7

2

14

Small-scale

0.584

High

963601

CDC20
Cell division cycle protein 20 homolog

2

4

Small-scale

0.584

High

963605

TIF1B
Transcription intermediary factor 1-beta

2

6

Small-scale

0.584

High

963627

EZH2
Histone-lysine N-methyltransferase EZH2

2

6

Small-scale

0.584

High

963656

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

2

3

Small-scale

0.584

High

963705

PA2G4
Proliferation-associated protein 2G4

2

3

Small-scale

0.584

High

786313

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

High-throughput

0.578

High

963652

DDB2
DNA damage-binding protein 2

1

3

Small-scale

0.578

High

963712

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

3

Small-scale

0.578

High

963713

NCOR2
Nuclear receptor corepressor 2

1

7

High-throughput

0.578

High

646806

1433T
14-3-3 protein theta

1

6

Small-scale

0.573

High

963596

GABP1
GA-binding protein subunit beta-1

1

1

Small-scale

0.573

High

963623

NCOA6
Nuclear receptor coactivator 6

1

5

Small-scale

0.573

High

631401

BRD2
Bromodomain-containing protein 2

2

13

Small-scale

0.571

High

963622

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

2

Small-scale

0.570

High

487947

RARA
Retinoic acid receptor alpha

1

4

Small-scale

0.561

High

963589

SP2
Transcription factor Sp2

1

10

Small-scale

0.561

High

963590

SP4
Transcription factor Sp4

1

9

Small-scale

0.561

High

963591

SP3
Transcription factor Sp3

1

9

Small-scale

0.561

High

963594

UBE3A
Ubiquitin-protein ligase E3A

1

2

Small-scale

0.561

High

963602

TP53B
TP53-binding protein 1

1

3

Small-scale

0.561

High

963608

MTA1
Metastasis-associated protein MTA1

1

3

Small-scale

0.561

High

963613

CUL1
Cullin-1

1

2

Small-scale

0.561

High

963614

CUL2
Cullin-2

1

2

Small-scale

0.561

High

963626

CEBPE
CCAAT/enhancer-binding protein epsilon

1

6

Small-scale

0.561

High

963637

ATAD2
ATPase family AAA domain-containing protein 2

1

3

Small-scale

0.561

High

963669

NSE3
Non-structural maintenance of chromosomes element 3 homolog

1

6

Small-scale

0.561

High

963675

ARI3A
AT-rich interactive domain-containing protein 3A

1

9

Small-scale

0.561

High

963707

KDM2A
Lysine-specific demethylase 2A

1

9

Small-scale

0.561

High

246211

NBN
Nibrin

2

0

Small-scale

0.559

High

963698

APC5
Anaphase-promoting complex subunit 5

2

0

Small-scale

0.559

High

153644

ANM5
Protein arginine N-methyltransferase 5

1

4

Small-scale

0.554

High

963618

BTG3
Protein BTG3

1

0

Small-scale

0.554

High

771915

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.537

High

963677

RN126
E3 ubiquitin-protein ligase RNF126

1

0

Small-scale

0.537

High

963641

CARM1
Histone-arginine methyltransferase CARM1

1

4

Small-scale

0.536

High

963704

PHF8
Histone lysine demethylase PHF8

1

2

Small-scale

0.536

High

169278

MDM4
Protein Mdm4

1

1

Small-scale

0.527

High

311855

TRI16
Tripartite motif-containing protein 16

1

2

Small-scale

0.515

High

831879

CEBPD
CCAAT/enhancer-binding protein delta

1

6

Small-scale

0.515

High

878066

ANM2
Protein arginine N-methyltransferase 2

1

4

Small-scale

0.515

High

963609

BIRC3
Baculoviral IAP repeat-containing protein 3

1

2

Small-scale

0.515

High

963667

DCAF5
DDB1- and CUL4-associated factor 5

1

4

Small-scale

0.515

High

394550

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.515

High

963694

STML1
Stomatin-like protein 1

1

1

High-throughput

0.512

High

414867

CDK1
Cyclin-dependent kinase 1

1

14

Small-scale

0.501

High

584584

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

5

Small-scale

0.501

High

963607

ATM
Serine-protein kinase ATM

1

4

Small-scale

0.501

High

963611

ATR
Serine/threonine-protein kinase ATR

1

4

Small-scale

0.501

High

963706

FBW1A
F-box/WD repeat-containing protein 1A

1

6

Small-scale

0.501

High

963646

ARF
Tumor suppressor ARF

1

0

Small-scale

0.493

High

963666

PAWR
PRKC apoptosis WT1 regulator protein

1

0

Small-scale

0.493

High

486892

MYBB
Myb-related protein B

1

6

Small-scale

0.481

High

842109

R144A
E3 ubiquitin-protein ligase RNF144A

1

3

Small-scale

0.481

High

963588

SPIB
Transcription factor Spi-B

1

8

Small-scale

0.481

High

963617

FHL2
Four and a half LIM domains protein 2

1

5

Small-scale

0.481

High

963642

MGAP
MAX gene-associated protein

1

3

Small-scale

0.481

High

963672

TEAD3
Transcriptional enhancer factor TEF-5

1

2

Small-scale

0.481

High

963680

IPKB
cAMP-dependent protein kinase inhibitor beta

1

1

Small-scale

0.481

High

963603

PRDM2
PR domain zinc finger protein 2

1

0

Small-scale

0.480

High

165664

SET1A
Histone-lysine N-methyltransferase SETD1A

1

10

Small-scale

0.479

High

262255

ULK1
Serine/threonine-protein kinase ULK1

1

1

Small-scale

0.479

High

266339

TAD2A
Transcriptional adapter 2-alpha

1

9

High-throughput

0.479

High

312054

ZBT7A
Zinc finger and BTB domain-containing protein 7A

1

1

Small-scale

0.479

High

346546

MYC
Myc proto-oncogene protein

1

11

Small-scale

0.479

High

369422

ESR1
Estrogen receptor

1

6

Small-scale

0.479

High

487341

ANDR
Androgen receptor

1

5

Small-scale

0.479

High

672811

CDC27
Cell division cycle protein 27 homolog

1

1

Small-scale

0.479

High

728904

AHR
Aryl hydrocarbon receptor

1

3

Small-scale

0.479

High

740503

PPARG
Peroxisome proliferator-activated receptor gamma

1

5

Small-scale

0.479

High

826259

CDK8
Cyclin-dependent kinase 8

1

14

Small-scale

0.479

High

831228

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

Small-scale

0.479

High

835668

GSK3B
Glycogen synthase kinase-3 beta

1

10

Small-scale

0.479

High

836900

CDN1C
Cyclin-dependent kinase inhibitor 1C

1

4

Small-scale

0.479

High

846749

SMCA2
Probable global transcription activator SNF2L2

1

7

Small-scale

0.479

High

850000

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

4

Small-scale

0.479

High

933406

TBA4A
Tubulin alpha-4A chain

1

1

High-throughput

0.479

High

963592

TF65
Transcription factor p65

1

3

Small-scale

0.479

High

963593

UBXN1
UBX domain-containing protein 1

1

2

High-throughput

0.479

High

963599

RBBP4
Histone-binding protein RBBP4

1

6

Small-scale

0.479

High

963620

BECN1
Beclin-1

1

1

Small-scale

0.479

High

963624

SUZ12
Polycomb protein SUZ12

1

2

Small-scale

0.479

High

963629

DDB1
DNA damage-binding protein 1

1

4

Small-scale

0.479

High

963632

IF16
Gamma-interferon-inducible protein 16

1

1

Small-scale

0.479

High

963635

ARI4B
AT-rich interactive domain-containing protein 4B

1

10

High-throughput

0.479

High

963638

CWC27
Spliceosome-associated protein CWC27 homolog

1

3

High-throughput

0.479

High

963639

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

7

High-throughput

0.479

High

963645

DRAM1
DNA damage-regulated autophagy modulator protein 1

1

1

Small-scale

0.479

High

963654

SNX19
Sorting nexin-19

1

1

Small-scale

0.479

High

963660

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.479

High

963670

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

6

Small-scale

0.479

High

963671

PHF12
PHD finger protein 12

1

2

High-throughput

0.479

High

963674

KLF6
Krueppel-like factor 6

1

12

Small-scale

0.479

High

963679

PCGF6
Polycomb group RING finger protein 6

1

15

High-throughput

0.479

High

963681

EPC1
Enhancer of polycomb homolog 1

1

1

High-throughput

0.479

High

963682

CSR2B
Cysteine-rich protein 2-binding protein

1

2

High-throughput

0.479

High

963691

APC11
Anaphase-promoting complex subunit 11

1

1

Small-scale

0.479

High

963695

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

1

3

Small-scale

0.479

High

963696

LEF1
Lymphoid enhancer-binding factor 1

1

4

Small-scale

0.479

High

963697

APC7
Anaphase-promoting complex subunit 7

1

1

Small-scale

0.479

High

963701

YETS2
YEATS domain-containing protein 2

1

2

High-throughput

0.479

High

963710

LMBL1
Lethal(3)malignant brain tumor-like protein 1

1

10

Small-scale

0.479

High

318107

DIRA3
GTP-binding protein Di-Ras3

1

5

Small-scale

0.470

High

392956

IGF1
Insulin-like growth factor I

1

0

Small-scale

0.460

High

963683

BRMS1
Breast cancer metastasis-suppressor 1

1

0

Small-scale

0.460

High

206350

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.458

High

267644

TADA3
Transcriptional adapter 3

1

0

High-throughput

0.458

High

275343

ZMY10
Zinc finger MYND domain-containing protein 10

1

0

Small-scale

0.458

High

345399

FOS
Protein c-Fos

1

0

Small-scale

0.458

High

475640

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

521870

CADH1
Cadherin-1

1

0

Small-scale

0.458

High

571406

DDX5
Probable ATP-dependent RNA helicase DDX5

1

0

Small-scale

0.458

High

574196

BMP7
Bone morphogenetic protein 7

1

0

Small-scale

0.458

High

723967

CBS
Cystathionine beta-synthase

1

0

Small-scale

0.458

High

727131

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.458

High

821993

KC1A
Casein kinase I isoform alpha

1

0

Small-scale

0.458

High

825167

RL34
Large ribosomal subunit protein eL34

1

0

High-throughput

0.458

High

890612

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.458

High

963595

PTN11
Tyrosine-protein phosphatase non-receptor type 11

1

0

Small-scale

0.458

High

963644

ZZZ3
ZZ-type zinc finger-containing protein 3

1

0

High-throughput

0.458

High

963650

GATD1
GATA zinc finger domain-containing protein 1

1

0

High-throughput

0.458

High

963651

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

963664

SGF29
SAGA-associated factor 29

1

0

High-throughput

0.458

High

963686

NGRN
Neugrin

1

0

High-throughput

0.458

High

963689

RASF1
Ras association domain-containing protein 1

1

0

Small-scale

0.458

High

963690

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.458

High

963703

TIM
Protein timeless homolog

1

0

Small-scale

0.458

High

963708

NOP16
Nucleolar protein 16

1

0

High-throughput

0.458

High

124605

CLIC1
Chloride intracellular channel protein 1

1

1

High-throughput

0.445

High

128140

IF2B3
Insulin-like growth factor 2 mRNA-binding protein 3

1

2

High-throughput

0.445

High

153907

NHRF1
Na(+)/H(+) exchange regulatory cofactor NHE-RF1

1

2

High-throughput

0.445

High

165449

SR140
U2 snRNP-associated SURP motif-containing protein

1

1

High-throughput

0.445

High

244297

BRD4
Bromodomain-containing protein 4

1

9

High-throughput

0.445

High

272859

KS6A4
Ribosomal protein S6 kinase alpha-4

1

1

High-throughput

0.445

High

280382

GLRX3
Glutaredoxin-3

1

2

High-throughput

0.445

High

646387

KAD4
Adenylate kinase 4, mitochondrial

1

1

High-throughput

0.445

High

763330

AN32A
Acidic leucine-rich nuclear phosphoprotein 32 family member A

1

2

High-throughput

0.445

High

776651

STAT3
Signal transducer and activator of transcription 3

1

1

High-throughput

0.445

High

805639

RL27A
Large ribosomal subunit protein uL15

1

1

High-throughput

0.445

High

806286

RL21
Large ribosomal subunit protein eL21

1

1

High-throughput

0.445

High

846931

SMCA4
Transcription activator BRG1

1

8

High-throughput

0.445

High

963636

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.445

High

963643

SUGP1
SURP and G-patch domain-containing protein 1

1

1

High-throughput

0.445

High

963661

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.445

High

963662

MGN2
Protein mago nashi homolog 2

1

1

High-throughput

0.445

High

963665

SPF45
Splicing factor 45

1

3

High-throughput

0.445

High

963676

FERM1
Fermitin family homolog 1

1

1

High-throughput

0.445

High

963699

RALY
RNA-binding protein Raly

1

1

High-throughput

0.445

High

963700

MKLN1
Muskelin

1

4

High-throughput

0.445

High

963714

IF2B2
Insulin-like growth factor 2 mRNA-binding protein 2

1

2

High-throughput

0.445

High

434639

TSP1
Thrombospondin-1

1

2

Small-scale

0.437

High

321756

WIZ
Protein Wiz

1

0

High-throughput

0.426

High

430928

SYEP
Bifunctional glutamate/proline--tRNA ligase

1

0

High-throughput

0.426

High

527979

RINI
Ribonuclease inhibitor

1

0

High-throughput

0.426

High

679610

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

0

High-throughput

0.426

High

783015

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.426

High

799208

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.426

High

855620

KIF11
Kinesin-like protein KIF11

1

0

High-throughput

0.426

High

899715

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.426

High

907287

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.426

High

963604

RED
Protein Red

1

0

High-throughput

0.426

High

963621

PLSI
Plastin-1

1

0

High-throughput

0.426

High

963631

FSCN1
Fascin

1

0

High-throughput

0.426

High

963633

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.426

High

963653

H1X
Histone H1.10

1

0

High-throughput

0.426

High

963678

THIC
Acetyl-CoA acetyltransferase, cytosolic

1

0

High-throughput

0.426

High

963685

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

0

High-throughput

0.426

High

963692

F120A
Constitutive coactivator of PPAR-gamma-like protein 1

1

0

High-throughput

0.426

High

963709

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

0

High-throughput

0.426

High

949673

RL36A
Large ribosomal subunit protein eL42

1

1

High-throughput

0.407

High

963688

DBLOH
Diablo IAP-binding mitochondrial protein

1

0

Small-scale

0.391

High

963687

NPDC1
Neural proliferation differentiation and control protein 1

1

0

Small-scale

0.275

Low

131994

NCHL1
Neural cell adhesion molecule L1-like protein

1

0

High-throughput

0.249

Low

963630

PDK4
[Pyruvate dehydrogenase

1

0

Small-scale

0.249

Low

963640

LAP4B
Lysosomal-associated transmembrane protein 4B

1

0

Small-scale

0.249

Low

963693

ATS9
A disintegrin and metalloproteinase with thrombospondin motifs 9

1

0

Small-scale

0.249

Low

417709

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.232

Low

821109

GSHB
Glutathione synthetase

1

0

High-throughput

0.232

Low

822456

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.232

Low

963634

D19L1
Protein C-mannosyl-transferase DPY19L1

1

0

High-throughput

0.232

Low

963647

GPT11
G patch domain-containing protein 11

1

0

High-throughput

0.232

Low

963684

RM47
Large ribosomal subunit protein uL29m

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024