Protein: SINA
E3 ubiquitin-protein ligase sina (EC 2.3.2.27) (RING-type E3 ubiquitin transferase sina) (Seven in absentia protein)

Gene: SINA
Organism: Drosophila melanogaster
Interactions: 137
UniProt ID: P21461

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

638277

SINA
E3 ubiquitin-protein ligase sina

3

16

Small-scale

0.871

High

638303

PHYL
Protein phyllopod

10

1

Small-scale

0.759

High

638287

TTKA
Protein tramtrack, alpha isoform

5

12

Small-scale

0.720

High

638344

Q9VFT4
AT27578p

3

4

High-throughput

0.653

High

638323

EBI
F-box-like/WD repeat-containing protein ebi

2

6

Small-scale

0.639

High

638379

Q9W3H5
GEO04367p1

4

1

High-throughput

0.628

High

638363

Q9VRY7
GH13213p

3

0

High-throughput

0.625

High

638328

Q9V3G9
AT18705p

3

1

High-throughput

0.596

High

54437

A1Z8K2
FI20150p1

2

1

High-throughput

0.596

High

264523

O62602
mitogen-activated protein kinase kinase

2

12

High-throughput

0.594

High

423566

HUNB
Protein hunchback

2

3

High-throughput

0.594

High

638279

DSX
Protein doublesex

2

1

High-throughput

0.594

High

638280

POXM
Paired box pox-meso protein

2

1

High-throughput

0.594

High

638281

POXN
Paired box pox-neuro protein

2

1

High-throughput

0.594

High

638284

UBE2N
Ubiquitin-conjugating enzyme E2 N

2

20

High-throughput

0.594

High

638286

ERKA
Mitogen-activated protein kinase ERK-A

2

8

High-throughput

0.594

High

638290

UBCD4
Ubiquitin-conjugating enzyme E2-22 kDa

2

20

High-throughput

0.594

High

638291

UBC84
Ubiquitin-conjugating enzyme E2-18 kDa

2

20

High-throughput

0.594

High

638295

ESMC
Enhancer of split mgamma protein

2

1

High-throughput

0.594

High

638296

RSMB
Small nuclear ribonucleoprotein-associated protein B

2

2

High-throughput

0.594

High

638302

TFDP
Transcription factor Dp

2

1

High-throughput

0.594

High

638308

Q4V6Y7
IP01295p

2

3

High-throughput

0.594

High

638315

Q8IHH3
AT01055p

2

2

High-throughput

0.594

High

638322

SH3G3
Endophilin-A

2

11

High-throughput

0.594

High

638324

Q961D1
Cyclin-K

2

2

High-throughput

0.594

High

638330

Q9V3M9
Tektin

2

3

High-throughput

0.594

High

638333

Q9VA79
FI06144p

2

1

High-throughput

0.594

High

638335

KL98A
Kinesin-like protein Klp98A

2

4

High-throughput

0.594

High

638338

Q9VBQ3
FI08017p

2

1

High-throughput

0.594

High

638347

Q9VIK7
LD18032p

2

1

High-throughput

0.594

High

638349

Q9VJS5
AT16033p

2

20

High-throughput

0.594

High

638352

Q9VL73
LP20791p

2

1

High-throughput

0.594

High

638353

Q9VLF2
CCR4-NOT transcription complex subunit 9

2

1

High-throughput

0.594

High

638360

BOWEL
Protein bowel

2

3

High-throughput

0.594

High

638362

LIN28
Protein lin-28 homolog

2

2

High-throughput

0.594

High

638370

Q9VWS0
Inhibitor of growth protein

2

1

High-throughput

0.594

High

638377

Q9W2P8
Homeobrain

2

1

High-throughput

0.594

High

638385

Q9XZ57
Eb1, isoform E

2

5

High-throughput

0.594

High

638386

MB21L
Protein mab-21-like

2

1

High-throughput

0.594

High

638278

SUS
Protein suppressor of sable

2

0

High-throughput

0.569

High

638282

DISC
Protein disconnected

2

0

High-throughput

0.569

High

638311

ADRM1
Proteasomal ubiquitin receptor ADRM1 homolog

2

0

High-throughput

0.569

High

638342

Q9VDP8
CG4973 protein

2

0

High-throughput

0.569

High

638346

MCM10
Protein MCM10 homolog

2

0

High-throughput

0.569

High

518453

AST5
Achaete-scute complex protein T5

1

1

Small-scale

0.552

High

638312

Q7KNM2
Dorsal interacting protein 4

1

20

Small-scale

0.552

High

638294

PROML
Prominin-like protein

2

1

High-throughput

0.542

High

638326

SPIN
Protein spinster

2

1

High-throughput

0.542

High

638327

Q9I7W2
COMM domain-containing protein 3

2

1

High-throughput

0.542

High

638356

POLZ2
DNA polymerase zeta subunit 2

2

1

High-throughput

0.542

High

638366

Q9VW77
IP19827p

2

2

High-throughput

0.542

High

638374

Q9W0B3
Vacuolar protein sorting-associated protein VTA1 homolog

2

2

High-throughput

0.542

High

602959

KINH
Kinesin heavy chain

1

2

High-throughput

0.508

High

638283

UBCD1
Ubiquitin-conjugating enzyme E2-17 kDa

1

20

Small-scale

0.508

High

638301

DIAP1
Death-associated inhibitor of apoptosis 1

1

12

High-throughput

0.508

High

638332

CSN7
COP9 signalosome complex subunit 7

1

2

High-throughput

0.508

High

638334

Q9VAA9
JIL-1 anchoring and stabilizing protein, isoform A

1

3

High-throughput

0.508

High

638372

Q9VZY2
Myocardin-related transcription factor, isoform D

1

4

High-throughput

0.508

High

54833

A1Z904
Dystrobrevin

1

4

High-throughput

0.494

High

91354

C6SV46
RE29848p

1

1

High-throughput

0.494

High

122018

M9PHB8
Sarcoplasmic calcium-binding protein, isoform C

1

1

High-throughput

0.494

High

608019

TTKB
Protein tramtrack, beta isoform

1

10

High-throughput

0.494

High

638297

Q058W3
IP14616p

1

1

High-throughput

0.494

High

638300

Q0IGU0
IP21556p

1

5

High-throughput

0.494

High

638305

Q29R02
LD04512p

1

4

High-throughput

0.494

High

638309

Q5BIB4
RE15812p

1

7

High-throughput

0.494

High

638361

Q9VRL1
GEO06356p1

1

20

High-throughput

0.494

High

638380

Q9W481
LD15807p

1

3

High-throughput

0.494

High

638382

Q9W4B3
Visual system homeobox 2

1

6

High-throughput

0.494

High

638306

Q29R10
LD24322p

1

0

High-throughput

0.486

High

638321

Q8SX78
LD05679p

1

0

High-throughput

0.486

High

638336

Q9VBJ6
Uncharacterized protein

1

0

High-throughput

0.486

High

638345

Q9VHL0
Hinge2

1

0

High-throughput

0.486

High

638355

Q9VMH2
Actin-related protein 2/3 complex subunit 4

1

0

High-throughput

0.486

High

638357

Q9VPD4
Vesicle transport protein

1

0

High-throughput

0.486

High

355866

O96676
BcDNA.GH12350

1

1

High-throughput

0.481

High

614868

EMS
Homeotic protein empty spiracles

1

6

High-throughput

0.481

High

638292

GSC
Homeobox protein goosecoid

1

13

High-throughput

0.481

High

638299

Q0E9B2
Dystrobrevin

1

4

High-throughput

0.481

High

638310

Q6NNF8
SD21550p

1

1

High-throughput

0.481

High

638318

Q8IQ53
GEO11416p1

1

20

High-throughput

0.481

High

638341

Q9VDN4
Uncharacterized protein, isoform A

1

3

High-throughput

0.481

High

638369

Q9VWP7
C2H2-type domain-containing protein

1

1

High-throughput

0.481

High

638388

X2JDS9
Visual system homeobox 2

1

7

High-throughput

0.481

High

518487

AST4
Achaete-scute complex protein T4

1

3

Small-scale

0.479

High

356194

O97059
Ccp84Ab

1

2

High-throughput

0.464

High

615048

PTC
Protein patched

1

2

High-throughput

0.464

High

638293

CNN
Centrosomin

1

5

High-throughput

0.464

High

638340

Q9VCT6
Uncharacterized protein

1

2

High-throughput

0.464

High

638348

Q9VJM1
GEO13348p1

1

1

High-throughput

0.464

High

638354

SDHF4
Succinate dehydrogenase assembly factor 4, mitochondrial

1

1

High-throughput

0.464

High

638364

Q9VT89
Insulin-like growth factor-binding protein complex acid labile subunit

1

6

High-throughput

0.464

High

638378

Q9W2X3
MIP13962p

1

1

High-throughput

0.464

High

638307

Q2PE13
Activating transcription factor-2

1

0

High-throughput

0.460

High

47022

A0A4D6K416
Transmembrane protein 198

1

1

High-throughput

0.451

High

54234

A1Z8D4
AT13868p

1

3

High-throughput

0.451

High

94115

D5A7J7
RH44958p

1

1

High-throughput

0.451

High

638304

Q29QK1
IP05464p

1

1

High-throughput

0.451

High

638313

Q8I942
IP11514p

1

1

High-throughput

0.451

High

638316

Q8INY5
RE08003p1

1

2

High-throughput

0.451

High

638317

Q8INY6
RH05790p

1

2

High-throughput

0.451

High

54246

A1Z8D5
FI20187p1

1

3

High-throughput

0.439

High

118120

M9MSK1
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

638319

Q8IR73
Uncharacterized protein

1

1

High-throughput

0.439

High

638320

Q8IRR4
GM27849p

1

3

High-throughput

0.439

High

638329

Q9V3L8
Ccp84Aa

1

2

High-throughput

0.439

High

638365

Q9VUE1
Histidine-rich glycoprotein

1

1

High-throughput

0.439

High

638367

Q9VWD2
Transmembrane protein 198

1

1

High-throughput

0.439

High

638387

X2JCJ0
Uncharacterized protein, isoform B

1

1

High-throughput

0.439

High

638389

X2JEH3
Uncharacterized protein, isoform E

1

2

High-throughput

0.439

High

638314

Q8IGE8
RH36596p

1

1

High-throughput

0.417

High

638383

Q9W4I6
Uncharacterized protein, isoform A

1

1

High-throughput

0.417

High

638381

Q9W483
GH18971p

3

0

High-throughput

0.340

High

91373

C6SV53
Bip1, isoform B

2

0

High-throughput

0.310

High

638298

Q058Z8
GEO11848p1

2

0

High-throughput

0.310

High

638325

Q961J0
GH21160p

2

0

High-throughput

0.310

High

638343

Q9VDX4
MIP05121p

2

0

High-throughput

0.310

High

638351

Q9VKU4
IP09348p

2

0

High-throughput

0.310

High

638358

Q9VPV6
AT13819p

2

0

High-throughput

0.310

High

638359

Q9VPZ1
GEO12410p1

2

0

High-throughput

0.310

High

638368

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3 homolog

2

0

High-throughput

0.310

High

638371

Q9VZJ1
Protein dpy-30 homolog

2

0

High-throughput

0.310

High

638373

Q9W0A2
MIP23106p

2

0

High-throughput

0.310

High

638376

Q9W2A3
IP10558p

2

0

High-throughput

0.310

High

638288

GRK
Protein gurken

1

0

High-throughput

0.282

High

54416

A1Z8J5
Shavenoid, isoform A

1

0

High-throughput

0.265

Low

197925

SURF4
Surfeit locus protein 4 homolog

1

0

High-throughput

0.265

Low

638285

HYI
Putative hydroxypyruvate isomerase

1

0

High-throughput

0.265

Low

638289

RL9
Large ribosomal subunit protein uL6

1

0

High-throughput

0.265

Low

638331

Q9V3P2
Nucleolar protein 10

1

0

High-throughput

0.265

Low

638337

Q9VBP2
GH01133p

1

0

High-throughput

0.265

Low

638339

Q9VC06
LD37516p

1

0

High-throughput

0.265

Low

638350

Q9VJX2
Uncharacterized protein

1

0

High-throughput

0.265

Low

638384

Q9XZ22
Uncharacterized protein, isoform A

1

0

High-throughput

0.265

Low

56566

A1ZAC0
Transferrin

1

0

High-throughput

0.238

Low

638375

Q9W0Z5
LP09747p

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025