Protein: MCPH1
Microcephalin

Gene: MCPH1
Organism: Homo sapiens
Interactions: 98
UniProt ID: Q8NEM0

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000132 - establishment of mitotic spindle orientation
GO:0000278 - mitotic cell cycle
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

963648

E2F1
Transcription factor E2F1

3

1

Small-scale

0.677

High

1243270

EFC4B
EF-hand calcium-binding domain-containing protein 4B

3

0

High-throughput

0.634

High

1243255

MCPH1
Microcephalin

1

0

Small-scale

0.619

High

749689

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.618

High

1243259

TOPB1
DNA topoisomerase 2-binding protein 1

1

1

Small-scale

0.618

High

988106

RAD51
DNA repair protein RAD51 homolog 1

2

1

Small-scale

0.595

High

555551

H2AX
Histone H2AX

2

0

Small-scale

0.569

High

1243257

SMRC2
SWI/SNF complex subunit SMARCC2

1

2

Small-scale

0.561

High

1243275

BIRC6
Baculoviral IAP repeat-containing protein 6

2

0

Small-scale

0.559

High

1074947

TERF2
Telomeric repeat-binding factor 2

1

0

Small-scale

0.557

High

266388

TAD2A
Transcriptional adapter 2-alpha

1

2

High-throughput

0.541

High

529434

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.541

High

1017174

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

Small-scale

0.537

High

1243282

FBW1B
F-box/WD repeat-containing protein 11

1

0

Small-scale

0.529

High

672863

CDC27
Cell division cycle protein 27 homolog

1

0

Small-scale

0.513

High

232338

KDM1A
Lysine-specific histone demethylase 1A

1

3

High-throughput

0.508

High

832588

MCM2
DNA replication licensing factor MCM2

1

1

Small-scale

0.501

High

1031568

ATM
Serine-protein kinase ATM

1

1

Small-scale

0.501

High

1038139

ATR
Serine/threonine-protein kinase ATR

1

1

Small-scale

0.501

High

661358

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

358538

CO1A1
Collagen alpha-1(I) chain

1

1

Small-scale

0.481

High

708706

MCM5
DNA replication licensing factor MCM5

1

1

Small-scale

0.481

High

1243276

SMOX
Spermine oxidase

1

1

Small-scale

0.481

High

154217

CHK1
Serine/threonine-protein kinase Chk1

1

0

Small-scale

0.480

High

1243277

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

Small-scale

0.479

High

846819

SMCA2
Probable global transcription activator SNF2L2

1

2

Small-scale

0.479

High

847019

SMCA4
Transcription activator BRG1

1

2

Small-scale

0.479

High

1051774

E2F2
Transcription factor E2F2

1

1

Small-scale

0.479

High

1243261

SMRC1
SWI/SNF complex subunit SMARCC1

1

2

Small-scale

0.479

High

135534

WN10B
Protein Wnt-10b

1

0

Small-scale

0.460

High

204503

ARK72
Aflatoxin B1 aldehyde reductase member 2

1

0

Small-scale

0.460

High

255930

OBSL1
Obscurin-like protein 1

1

0

Small-scale

0.460

High

365278

MT2
Metallothionein-2

1

0

Small-scale

0.460

High

417363

ENOA
Alpha-enolase

1

0

Small-scale

0.460

High

443668

VIME
Vimentin

1

0

Small-scale

0.460

High

490108

COT1
COUP transcription factor 1

1

0

Small-scale

0.460

High

499941

CH60
60 kDa heat shock protein, mitochondrial

1

0

Small-scale

0.460

High

532578

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.460

High

572411

LEG3
Galectin-3

1

0

Small-scale

0.460

High

598234

FLNA
Filamin-A

1

0

Small-scale

0.460

High

609959

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

0

Small-scale

0.460

High

658394

DPOD1
DNA polymerase delta catalytic subunit

1

0

Small-scale

0.460

High

821319

TCPE
T-complex protein 1 subunit epsilon

1

0

Small-scale

0.460

High

891229

GBRL2
Gamma-aminobutyric acid receptor-associated protein-like 2

1

0

Small-scale

0.460

High

913922

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

Small-scale

0.460

High

929571

RACK1
Small ribosomal subunit protein RACK1

1

0

Small-scale

0.460

High

929928

ACTG
Actin, cytoplasmic 2

1

0

Small-scale

0.460

High

1020492

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

0

Small-scale

0.460

High

1030680

NMI
N-myc-interactor

1

0

Small-scale

0.460

High

1054443

RBM39
RNA-binding protein 39

1

0

Small-scale

0.460

High

1069316

IPYR
Inorganic pyrophosphatase

1

0

Small-scale

0.460

High

1138791

PPRC1
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

1

0

Small-scale

0.460

High

1173080

FBX50
F-box only protein 50

1

0

Small-scale

0.460

High

1182930

SPT6H
Transcription elongation factor SPT6

1

0

Small-scale

0.460

High

1191924

SEN54
tRNA-splicing endonuclease subunit Sen54

1

0

Small-scale

0.460

High

1218359

WDR75
WD repeat-containing protein 75

1

0

Small-scale

0.460

High

1243256

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

0

Small-scale

0.460

High

1243262

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

Small-scale

0.460

High

1243263

KAT5
Histone acetyltransferase KAT5

1

0

Small-scale

0.460

High

1243265

THA11
THAP domain-containing protein 11

1

0

Small-scale

0.460

High

1243266

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

0

Small-scale

0.460

High

1243269

CCD77
Coiled-coil domain-containing protein 77

1

0

Small-scale

0.460

High

1243271

SKI8
Superkiller complex protein 8

1

0

Small-scale

0.460

High

1243272

RM46
Large ribosomal subunit protein mL46

1

0

Small-scale

0.460

High

1243273

TAF1D
TATA box-binding protein-associated factor RNA polymerase I subunit D

1

0

Small-scale

0.460

High

1243274

AKIP1
A-kinase-interacting protein 1

1

0

Small-scale

0.460

High

1243278

UXT
Protein UXT

1

0

Small-scale

0.460

High

1243280

RLP24
Probable ribosome biogenesis protein RLP24

1

0

Small-scale

0.460

High

1243281

PHF11
PHD finger protein 11

1

0

High-throughput

0.460

High

1243284

CSN3
COP9 signalosome complex subunit 3

1

0

Small-scale

0.460

High

1243285

RUVB2
RuvB-like 2

1

0

Small-scale

0.460

High

502335

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

777054

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

Small-scale

0.458

High

841273

CDK7
Cyclin-dependent kinase 7

1

0

High-throughput

0.458

High

847858

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.458

High

917618

H4
Histone H4

1

0

High-throughput

0.458

High

1059743

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

0

Small-scale

0.458

High

1140632

RN123
E3 ubiquitin-protein ligase RNF123

1

0

High-throughput

0.458

High

1243279

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1243283

FZR1
Fizzy-related protein homolog

1

0

Small-scale

0.458

High

1055540

DMC1
Meiotic recombination protein DMC1/LIM15 homolog

1

1

Small-scale

0.457

High

1191269

WDR53
WD repeat-containing protein 53

1

1

Small-scale

0.439

High

1224143

CORA1

1

1

Small-scale

0.439

High

1243267

S10AG
Protein S100-A16

1

1

Small-scale

0.439

High

1120400

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.426

High

124904

EIF3F
Eukaryotic translation initiation factor 3 subunit F

1

0

Small-scale

0.251

Low

206394

LTOR5
Ragulator complex protein LAMTOR5

1

0

Small-scale

0.251

Low

429918

CATL1
Procathepsin L

1

0

Small-scale

0.251

Low

612889

FBLN1
Fibulin-1

1

0

Small-scale

0.251

Low

725498

COPB2
Coatomer subunit beta'

1

0

Small-scale

0.251

Low

1051888

IF4A2
Eukaryotic initiation factor 4A-II

1

0

Small-scale

0.251

Low

1068408

PMVK
Phosphomevalonate kinase

1

0

Small-scale

0.251

Low

1159759

WDR73
WD repeat-containing protein 73

1

0

Small-scale

0.251

Low

1243258

MITD1
MIT domain-containing protein 1

1

0

Small-scale

0.251

Low

1243260

MRP2
ATP-binding cassette sub-family C member 2

1

0

High-throughput

0.251

Low

1243264

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

Small-scale

0.251

Low

1243268

B3GT6
Beta-1,3-galactosyltransferase 6

1

0

Small-scale

0.251

Low


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Last updated: 15 Jul 2024