Protein: PKP2
Plakophilin-2

Gene: PKP2
Organism: Homo sapiens
Interactions: 229
UniProt ID: Q99959

Gene Ontology (top 5):
GO:0001533 - cornified envelope
GO:0002159 - desmosome assembly
GO:0002934 - desmosome organization
GO:0005080 - protein kinase C binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

350487

RASK
GTPase KRas

3

20

High-throughput

0.827

High

717308

CTNB1
Catenin beta-1

3

18

Small-scale

0.827

High

1216819

ARMC8
Armadillo repeat-containing protein 8

2

11

Small-scale

0.775

High

915921

RHOB
Rho-related GTP-binding protein RhoB

2

20

High-throughput

0.754

High

1127139

MTUS2
Microtubule-associated tumor suppressor candidate 2

5

12

High-throughput

0.725

High

542428

PLAK
Junction plakoglobin

1

18

Small-scale

0.713

High

970835

DSG1
Desmoglein-1

1

20

Small-scale

0.713

High

905041

1433G
14-3-3 protein gamma

4

20

High-throughput

0.699

High

626239

APC
Adenomatous polyposis coli protein

1

20

High-throughput

0.691

High

683666

1433B
14-3-3 protein beta/alpha

4

20

High-throughput

0.691

High

982429

1433F
14-3-3 protein eta

4

20

High-throughput

0.690

High

793148

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

4

High-throughput

0.667

High

798452

LPAR6
Lysophosphatidic acid receptor 6

3

3

High-throughput

0.667

High

1044690

FHL3
Four and a half LIM domains protein 3

3

8

High-throughput

0.665

High

909960

1433E
14-3-3 protein epsilon

3

4

High-throughput

0.662

High

647224

1433T
14-3-3 protein theta

3

20

Small-scale

0.657

High

1071351

K1H1
Keratin, type I cuticular Ha1

3

16

High-throughput

0.654

High

927458

1433Z
14-3-3 protein zeta/delta

3

20

Small-scale

0.650

High

660683

GRN
Progranulin

3

0

High-throughput

0.638

High

626757

NK1R
Substance-P receptor

2

8

High-throughput

0.628

High

1117392

TM52B
Transmembrane protein 52B

2

1

High-throughput

0.628

High

1293231

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

1

High-throughput

0.628

High

1307372

NDEL1
Nuclear distribution protein nudE-like 1

3

14

High-throughput

0.625

High

971057

DSC2
Desmocollin-2

1

20

Small-scale

0.621

High

318215

DIRA3
GTP-binding protein Di-Ras3

1

11

High-throughput

0.618

High

320223

ERR2
Steroid hormone receptor ERR2

1

20

High-throughput

0.618

High

522153

CADH1
Cadherin-1

1

20

High-throughput

0.618

High

617363

SP100
Nuclear autoantigen Sp-100

1

17

High-throughput

0.618

High

845695

RAB9A
Ras-related protein Rab-9A

1

16

High-throughput

0.618

High

892562

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

894360

CDC42
Cell division control protein 42 homolog

1

20

High-throughput

0.618

High

895244

RAB2A
Ras-related protein Rab-2A

1

10

High-throughput

0.618

High

900842

RHOA
Transforming protein RhoA

1

20

High-throughput

0.618

High

914314

RB11A
Ras-related protein Rab-11A

1

5

High-throughput

0.618

High

925563

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1070365

RAB35
Ras-related protein Rab-35

1

12

High-throughput

0.618

High

1076726

RHOH
Rho-related GTP-binding protein RhoH

1

20

High-throughput

0.618

High

1307377

RHOJ
Rho-related GTP-binding protein RhoJ

1

20

High-throughput

0.618

High

684293

1433S
14-3-3 protein sigma

2

20

High-throughput

0.612

High

856568

EFNB2
Ephrin-B2

2

3

High-throughput

0.611

High

551819

DESP
Desmoplakin

2

15

Small-scale

0.608

High

360659

SPTA1
Spectrin alpha chain, erythrocytic 1

2

14

High-throughput

0.606

High

993285

ACTN3
Alpha-actinin-3

2

7

High-throughput

0.606

High

995177

GOGA2
Golgin subfamily A member 2

2

13

High-throughput

0.606

High

1118348

GRAP1
GRIP1-associated protein 1

2

9

High-throughput

0.606

High

1123312

PKHG4
Puratrophin-1

2

6

High-throughput

0.606

High

1254494

CCHCR
Coiled-coil alpha-helical rod protein 1

2

14

High-throughput

0.606

High

1283671

MGN2
Protein mago nashi homolog 2

2

1

High-throughput

0.606

High

1289539

HOOK2
Protein Hook homolog 2

2

17

High-throughput

0.606

High

1307375

CARD9
Caspase recruitment domain-containing protein 9

2

8

High-throughput

0.606

High

443757

VIME
Vimentin

2

10

Small-scale

0.586

High

647952

MARK3
MAP/microtubule affinity-regulating kinase 3

1

2

Small-scale

0.586

High

1307381

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

2

0

High-throughput

0.585

High

374764

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

13

High-throughput

0.584

High

507205

LAMP1
Lysosome-associated membrane glycoprotein 1

2

9

High-throughput

0.584

High

1307387

ANLN
Anillin

2

7

High-throughput

0.584

High

1206244

CC125
Coiled-coil domain-containing protein 125

2

0

High-throughput

0.580

High

1262188

TEKT4
Tektin-4

2

0

High-throughput

0.580

High

1307383

ROP1A
Ropporin-1A

2

0

High-throughput

0.580

High

1307396

SPN90
NCK-interacting protein with SH3 domain

2

0

High-throughput

0.580

High

1255258

HAVR2
Hepatitis A virus cellular receptor 2

2

1

High-throughput

0.574

High

338902

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.571

High

1024831

DUS4
Dual specificity protein phosphatase 4

2

2

High-throughput

0.571

High

1191875

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

2

13

High-throughput

0.571

High

156055

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

2

Small-scale

0.561

High

408912

K1C18
Keratin, type I cytoskeletal 18

1

18

Small-scale

0.561

High

531621

K2C5
Keratin, type II cytoskeletal 5

1

6

Small-scale

0.561

High

1297705

DMRTB
Doublesex- and mab-3-related transcription factor B1

2

0

High-throughput

0.559

High

1070159

RABE1
Rab GTPase-binding effector protein 1

2

14

High-throughput

0.553

High

1293347

CC120
Coiled-coil domain-containing protein 120

2

1

High-throughput

0.553

High

165025

SC16A
Protein transport protein Sec16A

1

11

High-throughput

0.536

High

230905

MAST3
Microtubule-associated serine/threonine-protein kinase 3

1

10

High-throughput

0.536

High

452475

PGFRB
Platelet-derived growth factor receptor beta

1

19

High-throughput

0.536

High

486316

CCL3
C-C motif chemokine 3

1

3

High-throughput

0.536

High

666345

NK3R
Neuromedin-K receptor

1

8

High-throughput

0.536

High

794098

MATR3
Matrin-3

1

6

High-throughput

0.536

High

798159

KI2L1
Killer cell immunoglobulin-like receptor 2DL1

1

4

High-throughput

0.536

High

801338

KI67
Proliferation marker protein Ki-67

1

8

High-throughput

0.536

High

813710

CAPZB
F-actin-capping protein subunit beta

1

2

High-throughput

0.536

High

833955

CLK2
Dual specificity protein kinase CLK2

1

14

High-throughput

0.536

High

1021083

FOXF2
Forkhead box protein F2

1

9

High-throughput

0.536

High

1033539

ILK
Integrin-linked protein kinase

1

8

High-throughput

0.536

High

1042384

CUL3
Cullin-3

1

17

High-throughput

0.536

High

1103169

KLH40
Kelch-like protein 40

1

2

High-throughput

0.536

High

1255906

TBCK
TBC domain-containing protein kinase-like protein

1

12

High-throughput

0.536

High

1260458

FBLI1
Filamin-binding LIM protein 1

1

8

High-throughput

0.536

High

1264757

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

2

High-throughput

0.536

High

1270553

CDKL2
Cyclin-dependent kinase-like 2

1

12

High-throughput

0.536

High

1305741

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

6

High-throughput

0.536

High

1307368

RBM4B
RNA-binding protein 4B

1

5

High-throughput

0.536

High

1307385

LRC4C
Leucine-rich repeat-containing protein 4C

1

2

High-throughput

0.536

High

1307392

TSAP1
tRNA selenocysteine 1-associated protein 1

1

4

High-throughput

0.536

High

1307393

GTSE1
G2 and S phase-expressed protein 1

1

2

High-throughput

0.536

High

1307395

GPC5B
G-protein coupled receptor family C group 5 member B

1

3

High-throughput

0.536

High

1307397

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

2

High-throughput

0.536

High

1307402

HSPB8
Heat shock protein beta-8

1

6

High-throughput

0.536

High

1307407

CLC11
C-type lectin domain family 11 member A

1

2

High-throughput

0.536

High

1307410

PCDGD
Protocadherin gamma-B1

1

1

High-throughput

0.536

High

1307411

PCDG7
Protocadherin gamma-A7

1

1

High-throughput

0.536

High

1307412

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

1

High-throughput

0.536

High

962570

ECT2L
Epithelial cell-transforming sequence 2 oncogene-like

2

13

High-throughput

0.521

High

1260767

DEP1B
DEP domain-containing protein 1B

2

5

High-throughput

0.521

High

1307401

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

1

High-throughput

0.515

High

515931

PRPS2
Ribose-phosphate pyrophosphokinase 2

1

0

High-throughput

0.513

High

968908

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.513

High

1307390

TNR19
Tumor necrosis factor receptor superfamily member 19

1

0

High-throughput

0.513

High

171440

SMAD9
Mothers against decapentaplegic homolog 9

1

7

High-throughput

0.508

High

1080891

HSPB2
Heat shock protein beta-2

1

6

High-throughput

0.508

High

1307399

GT2D1
General transcription factor II-I repeat domain-containing protein 1

1

4

Small-scale

0.508

High

1079715

UT2
Urea transporter 2

1

0

High-throughput

0.493

High

1307403

PNMA2
Paraneoplastic antigen Ma2

1

6

High-throughput

0.489

High

159257

CSKP
Peripheral plasma membrane protein CASK

1

17

High-throughput

0.481

High

314134

BAG4
BAG family molecular chaperone regulator 4

1

1

High-throughput

0.481

High

772134

VHL
von Hippel-Lindau disease tumor suppressor

1

2

Small-scale

0.481

High

856117

RBM5
RNA-binding protein 5

1

6

High-throughput

0.481

High

996005

DSC1
Desmocollin-1

1

20

Small-scale

0.481

High

1032580

CTBP1
C-terminal-binding protein 1

1

6

High-throughput

0.481

High

1264100

PIBF1
Progesterone-induced-blocking factor 1

1

1

High-throughput

0.481

High

1274210

RBPMS
RNA-binding protein with multiple splicing

1

2

High-throughput

0.481

High

1307367

AKAP9
A-kinase anchor protein 9

1

20

High-throughput

0.481

High

1307391

KLC4
Kinesin light chain 4

1

7

High-throughput

0.481

High

125679

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

7

High-throughput

0.479

High

149216

CTRO
Citron Rho-interacting kinase

1

10

High-throughput

0.479

High

164463

TRI66
Tripartite motif-containing protein 66

1

19

High-throughput

0.479

High

171328

EPHB6
Ephrin type-B receptor 6

1

20

High-throughput

0.479

High

178747

STX7
Syntaxin-7

1

6

High-throughput

0.479

High

210233

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

228490

PRKN
E3 ubiquitin-protein ligase parkin

1

13

High-throughput

0.479

High

268246

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

279689

FLOT1
Flotillin-1

1

5

High-throughput

0.479

High

305607

ZFPL1
Zinc finger protein-like 1

1

4

High-throughput

0.479

High

309006

KI20A
Kinesin-like protein KIF20A

1

20

High-throughput

0.479

High

318711

EYA4
Eyes absent homolog 4

1

2

High-throughput

0.479

High

345531

FOS
Protein c-Fos

1

6

High-throughput

0.479

High

959968

TF2B
Transcription initiation factor IIB

1

1

Small-scale

0.479

High

347714

MYC
Myc proto-oncogene protein

1

13

High-throughput

0.479

High

359402

K1C14
Keratin, type I cytoskeletal 14

1

16

Small-scale

0.479

High

409210

K2C8
Keratin, type II cytoskeletal 8

1

6

Small-scale

0.479

High

411837

LCK
Tyrosine-protein kinase Lck

1

17

High-throughput

0.479

High

433972

LYN
Tyrosine-protein kinase Lyn

1

17

High-throughput

0.479

High

442429

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

9

High-throughput

0.479

High

508168

FGFR1
Fibroblast growth factor receptor 1

1

20

High-throughput

0.479

High

527747

LAMP2
Lysosome-associated membrane glycoprotein 2

1

9

High-throughput

0.479

High

553544

RFA2
Replication protein A 32 kDa subunit

1

7

High-throughput

0.479

High

557234

PGFRA
Platelet-derived growth factor receptor alpha

1

20

High-throughput

0.479

High

567239

CXA1
Gap junction alpha-1 protein

1

13

High-throughput

0.479

High

591073

BTF3
Transcription factor BTF3

1

3

High-throughput

0.479

High

600215

TAF1
Transcription initiation factor TFIID subunit 1

1

20

High-throughput

0.479

High

652073

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

7

High-throughput

0.479

High

666640

LTK
Leukocyte tyrosine kinase receptor

1

20

High-throughput

0.479

High

668937

PML
Protein PML

1

20

High-throughput

0.479

High

670178

MARCS
Myristoylated alanine-rich C-kinase substrate

1

10

High-throughput

0.479

High

716759

CTNA1
Catenin alpha-1

1

20

High-throughput

0.479

High

718139

BMI1
Polycomb complex protein BMI-1

1

11

High-throughput

0.479

High

721270

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.479

High

738262

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

9

High-throughput

0.479

High

825522

LMAN1
Protein ERGIC-53

1

1

High-throughput

0.479

High

872479

EPHA5
Ephrin type-A receptor 5

1

20

High-throughput

0.479

High

872698

EPHA4
Ephrin type-A receptor 4

1

20

High-throughput

0.479

High

876488

AFAD
Afadin

1

20

High-throughput

0.479

High

877851

FOXA1
Hepatocyte nuclear factor 3-alpha

1

6

High-throughput

0.479

High

896809

ARP3
Actin-related protein 3

1

9

High-throughput

0.479

High

913072

ARF6
ADP-ribosylation factor 6

1

4

High-throughput

0.479

High

921699

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

8

High-throughput

0.479

High

940543

CXAR
Coxsackievirus and adenovirus receptor

1

2

High-throughput

0.479

High

968469

ROR2
Tyrosine-protein kinase transmembrane receptor ROR2

1

20

High-throughput

0.479

High

969944

KIF23
Kinesin-like protein KIF23

1

18

High-throughput

0.479

High

974994

CAV1
Caveolin-1

1

8

High-throughput

0.479

High

1030441

G3BP1
Ras GTPase-activating protein-binding protein 1

1

7

High-throughput

0.479

High

1048651

DSG2
Desmoglein-2

1

20

Small-scale

0.479

High

1064076

TNIP1
TNFAIP3-interacting protein 1

1

20

High-throughput

0.479

High

1066587

KIF14
Kinesin-like protein KIF14

1

18

High-throughput

0.479

High

1072582

EPHA7
Ephrin type-A receptor 7

1

20

High-throughput

0.479

High

1081581

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.479

High

1083884

NTRK2
BDNF/NT-3 growth factors receptor

1

20

High-throughput

0.479

High

1084158

OCLN
Occludin

1

5

High-throughput

0.479

High

1119607

MIDN
Midnolin

1

3

High-throughput

0.479

High

1147649

FTM
Protein fantom

1

20

High-throughput

0.479

High

1152064

LTOR1
Ragulator complex protein LAMTOR1

1

3

High-throughput

0.479

High

1168651

SYNE3
Nesprin-3

1

17

High-throughput

0.479

High

1188779

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

8

High-throughput

0.479

High

1230350

CXD3
Gap junction delta-3 protein

1

13

High-throughput

0.479

High

1236462

SIR6
NAD-dependent protein deacylase sirtuin-6

1

9

High-throughput

0.479

High

1256871

PARD3
Partitioning defective 3 homolog

1

20

High-throughput

0.479

High

1260888

DCAF4
DDB1- and CUL4-associated factor 4

1

3

High-throughput

0.479

High

1262807

PHIP
PH-interacting protein

1

16

High-throughput

0.479

High

1273828

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

12

Small-scale

0.479

High

1284030

LRC59
Leucine-rich repeat-containing protein 59

1

16

High-throughput

0.479

High

1304066

RING2
E3 ubiquitin-protein ligase RING2

1

13

High-throughput

0.479

High

1306938

ANM1
Protein arginine N-methyltransferase 1

1

4

Small-scale

0.479

High

1307370

CECR2
Chromatin remodeling regulator CECR2

1

13

High-throughput

0.479

High

1307371

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

14

High-throughput

0.479

High

1307373

BRD8
Bromodomain-containing protein 8

1

20

High-throughput

0.479

High

1307376

CHM4B
Charged multivesicular body protein 4b

1

6

High-throughput

0.479

High

1307378

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.479

High

1307379

EGLN3
Prolyl hydroxylase EGLN3

1

4

High-throughput

0.479

High

1307380

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

6

High-throughput

0.479

High

1307382

ECT2
Protein ECT2

1

15

High-throughput

0.479

High

1307384

RC3H2
Roquin-2

1

19

High-throughput

0.479

High

1307386

E41LA
Band 4.1-like protein 4A

1

14

High-throughput

0.479

High

1307389

RNC
Ribonuclease 3

1

3

High-throughput

0.479

High

1307398

ZRAN1
Ubiquitin thioesterase ZRANB1

1

20

High-throughput

0.479

High

1307404

CLC4E
C-type lectin domain family 4 member E

1

3

High-throughput

0.479

High

1307405

MYO6
Unconventional myosin-VI

1

11

High-throughput

0.479

High

1307406

LAMP3
Lysosome-associated membrane glycoprotein 3

1

9

High-throughput

0.479

High

1307409

FBW1A
F-box/WD repeat-containing protein 1A

1

20

High-throughput

0.479

High

1116727

Q4G0R1
PIBF1 protein

1

1

High-throughput

0.470

High

1284957

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.460

High

1307388

4ET
Eukaryotic translation initiation factor 4E transporter

1

0

High-throughput

0.460

High

328933

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.458

High

881671

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.458

High

1183674

TM10C
tRNA methyltransferase 10 homolog C

1

0

Small-scale

0.458

High

1268891

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1307394

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1307400

CTNA3
Catenin alpha-3

1

20

Small-scale

0.457

High

383951

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

High-throughput

0.445

High

529633

CFTR
Cystic fibrosis transmembrane conductance regulator

1

7

High-throughput

0.445

High

709024

MCM7
DNA replication licensing factor MCM7

1

17

Small-scale

0.445

High

1059353

CASP8
Caspase-8

1

4

High-throughput

0.445

High

1307408

ITM2B
Integral membrane protein 2B

1

4

High-throughput

0.445

High

1110069

AR13B
ADP-ribosylation factor-like protein 13B

1

12

High-throughput

0.437

High

1145904

CP135
Centrosomal protein of 135 kDa

1

15

High-throughput

0.437

High

1146780

A16L1
Autophagy-related protein 16-1

1

15

High-throughput

0.437

High

1203826

TMM17
Transmembrane protein 17

1

3

High-throughput

0.437

High

1283045

CK052
Uncharacterized protein C11orf52

1

5

High-throughput

0.437

High

1290036

RNF31
E3 ubiquitin-protein ligase RNF31

1

20

High-throughput

0.437

High

1307369

CP250
Centrosome-associated protein CEP250

1

12

High-throughput

0.437

High

1134755

LITD1
LINE-1 type transposase domain-containing protein 1

1

3

High-throughput

0.407

High

1307374

PED1A
PC-esterase domain-containing protein 1A

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024