Protein: NLRP1
NACHT, LRR and PYD domains-containing protein 1 (EC 3.4.-.-) (EC 3.6.4.-) (Caspase recruitment domain-containing protein 7) (Death effector filament-forming ced-4-like apoptosis protein) (Nucleotide-binding domain and caspase recruitment domain) [Cleaved into: NACHT, LRR and PYD domains-containing protein 1, C-terminus (NLRP1-CT); NACHT, LRR and PYD domains-containing protein 1, N-terminus (NLRP1-NT)]

Gene: NLRP1
Organism: Homo sapiens
Interactions: 33
UniProt ID: Q9C000

Gene Ontology (top 5):
GO:0002221 - pattern recognition receptor signaling pathway
GO:0003690 - double-stranded DNA binding
GO:0003725 - double-stranded RNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

667487

CASP1
Caspase-1

4

20

Small-scale

0.881

High

489455

BCL2
Apoptosis regulator Bcl-2

2

2

Small-scale

0.812

High

992126

B2CL1
Bcl-2-like protein 1

2

2

Small-scale

0.812

High

1318562

ASC
Apoptosis-associated speck-like protein containing a CARD

2

19

Small-scale

0.789

High

1318559

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

2

19

Small-scale

0.770

High

877001

CASP9
Caspase-9

2

20

Small-scale

0.754

High

1318560

NLRC4
NLR family CARD domain-containing protein 4

2

19

Small-scale

0.754

High

851673

NEK4
Serine/threonine-protein kinase Nek4

1

5

High-throughput

0.691

High

924403

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

4

High-throughput

0.665

High

152906

APAF
Apoptotic protease-activating factor 1

1

0

Small-scale

0.656

High

1082631

MK14
Mitogen-activated protein kinase 14

1

4

Small-scale

0.647

High

183335

MEFV
Pyrin

1

14

Small-scale

0.618

High

585550

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

8

Small-scale

0.618

High

788263

CASP2
Caspase-2

1

20

Small-scale

0.618

High

841873

CDK9
Cyclin-dependent kinase 9

1

3

High-throughput

0.618

High

851077

CASP5
Caspase-5

1

20

Small-scale

0.618

High

1315073

CARD6
Caspase recruitment domain-containing protein 6

1

8

Small-scale

0.618

High

1318558

NLRP1
NACHT, LRR and PYD domains-containing protein 1

1

18

Small-scale

0.618

High

1122745

PYDC2
Pyrin domain-containing protein 2

1

20

Small-scale

0.590

High

1235367

KCD17
BTB/POZ domain-containing protein KCTD17

1

1

High-throughput

0.536

High

361395

APOA1
Apolipoprotein A-I

1

0

High-throughput

0.513

High

125697

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

Small-scale

0.479

High

1042479

CUL3
Cullin-3

1

13

Small-scale

0.479

High

1043203

CUL4A
Cullin-4A

1

13

High-throughput

0.479

High

1043563

CUL4B
Cullin-4B

1

13

High-throughput

0.479

High

1052765

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

Small-scale

0.479

High

1103710

TR16L
Tripartite motif-containing protein 16-like protein

1

20

Small-scale

0.479

High

1149907

TRI68
E3 ubiquitin-protein ligase TRIM68

1

14

Small-scale

0.479

High

1162057

TRI65
E3 ubiquitin-protein ligase TRIM65

1

20

Small-scale

0.479

High

1318561

HERC5
E3 ISG15--protein ligase HERC5

1

4

Small-scale

0.479

High

1044431

PTC1
Protein patched homolog 1

1

2

Small-scale

0.437

High

1172827

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024