Protein: IDS
Iduronate 2-sulfatase (EC 3.1.6.13) (Alpha-L-iduronate sulfate sulfatase) (Idursulfase) [Cleaved into: Iduronate 2-sulfatase 42 kDa chain; Iduronate 2-sulfatase 14 kDa chain]

Gene: IDS
Organism: Homo sapiens
Interactions: 124
UniProt ID: P22304

Gene Ontology (top 5):
GO:0004423 - iduronate-2-sulfatase activity
GO:0005509 - calcium ion binding
GO:0005737 - cytoplasm
GO:0005764 - lysosome
GO:0006027 - glycosaminoglycan catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

606863

GALNS
N-acetylgalactosamine-6-sulfatase

3

7

High-throughput

0.861

High

606866

SPHM
N-sulphoglucosamine sulphohydrolase

1

7

High-throughput

0.691

High

437665

BGLR
Beta-glucuronidase

3

1

High-throughput

0.667

High

606882

CUL1
Cullin-1

3

2

High-throughput

0.667

High

606941

FKB14
Peptidyl-prolyl cis-trans isomerase FKBP14

3

3

High-throughput

0.667

High

606947

FBX3
F-box only protein 3

3

3

High-throughput

0.667

High

606892

ZNG1C
Zinc-regulated GTPase metalloprotein activator 1C

3

0

High-throughput

0.638

High

606948

PPT2
Lysosomal thioesterase PPT2

3

0

High-throughput

0.638

High

606914

SUMF1
Formylglycine-generating enzyme

4

13

Small-scale

0.630

High

501677

BIP
Endoplasmic reticulum chaperone BiP

2

6

High-throughput

0.611

High

606890

TBB8
Tubulin beta-8 chain

2

2

High-throughput

0.611

High

203022

COCH
Cochlin

3

1

High-throughput

0.609

High

301071

FBX21
F-box only protein 21

3

6

High-throughput

0.609

High

314540

ATS2
A disintegrin and metalloproteinase with thrombospondin motifs 2

3

3

High-throughput

0.609

High

606885

MESD
LRP chaperone MESD

3

4

High-throughput

0.609

High

606888

TAZ
Tafazzin

3

2

High-throughput

0.609

High

606897

GLT18
Polypeptide N-acetylgalactosaminyltransferase 18

3

1

High-throughput

0.609

High

606904

DYR2
Dihydrofolate reductase 2, mitochondrial

3

1

High-throughput

0.609

High

606905

P3H3
Prolyl 3-hydroxylase 3

3

2

High-throughput

0.609

High

606928

KLH15
Kelch-like protein 15

3

1

High-throughput

0.609

High

301470

WDR47
WD repeat-containing protein 47

2

0

High-throughput

0.585

High

580167

AMD
Peptidyl-glycine alpha-amidating monooxygenase

2

0

High-throughput

0.585

High

606951

AP3M1
AP-3 complex subunit mu-1

2

0

High-throughput

0.585

High

606952

LOXL2
Lysyl oxidase homolog 2

2

0

High-throughput

0.585

High

606868

NDST1
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1

2

1

High-throughput

0.558

High

606884

PDIA5
Protein disulfide-isomerase A5

2

4

High-throughput

0.558

High

606895

MANEL
Glycoprotein endo-alpha-1,2-mannosidase-like protein

2

1

High-throughput

0.558

High

606901

B3GLT
Beta-1,3-glucosyltransferase

2

1

High-throughput

0.558

High

606920

SC65
Endoplasmic reticulum protein SC65

2

2

High-throughput

0.558

High

129464

MANBA
Beta-mannosidase

1

1

High-throughput

0.536

High

327265

NOE2
Noelin-2

1

1

High-throughput

0.536

High

411294

INSR
Insulin receptor

1

1

High-throughput

0.536

High

538101

ENPL
Endoplasmin

1

2

High-throughput

0.536

High

606858

CALR
Calreticulin

1

8

High-throughput

0.536

High

606872

SKP1
S-phase kinase-associated protein 1

1

1

High-throughput

0.536

High

606874

PGBM
Basement membrane-specific heparan sulfate proteoglycan core protein

1

1

High-throughput

0.536

High

606877

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

6

High-throughput

0.536

High

606880

DNJC3
DnaJ homolog subfamily C member 3

1

5

High-throughput

0.536

High

606899

CSPG4
Chondroitin sulfate proteoglycan 4

1

5

High-throughput

0.536

High

606900

CREL2
Protein disulfide isomerase CRELD2

1

5

High-throughput

0.536

High

606903

PODN
Podocan

1

1

High-throughput

0.536

High

606916

PCSK9
Proprotein convertase subtilisin/kexin type 9

1

1

High-throughput

0.536

High

606931

LGMN
Legumain

1

1

High-throughput

0.536

High

327923

FTCD
Formimidoyltransferase-cyclodeaminase

1

0

High-throughput

0.518

High

606875

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.518

High

296359

AL1A2
Retinal dehydrogenase 2

1

0

High-throughput

0.513

High

536166

PERF
Perforin-1

1

0

High-throughput

0.513

High

606864

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.513

High

606870

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.513

High

606876

DIAC
Di-N-acetylchitobiase

1

0

High-throughput

0.513

High

606879

ASPH
Aspartyl/asparaginyl beta-hydroxylase

1

0

High-throughput

0.513

High

606924

TTC17
Tetratricopeptide repeat protein 17

1

0

High-throughput

0.513

High

606934

CHID1
Chitinase domain-containing protein 1

1

0

High-throughput

0.513

High

606939

DCP1A
mRNA-decapping enzyme 1A

1

0

High-throughput

0.513

High

606946

PCYOX
Prenylcysteine oxidase 1

1

0

High-throughput

0.513

High

606949

MA2B2
Epididymis-specific alpha-mannosidase

1

0

High-throughput

0.513

High

152078

TOR1B
Torsin-1B

1

1

High-throughput

0.489

High

182255

TPSN
Tapasin

1

1

High-throughput

0.489

High

257253

ATS4
A disintegrin and metalloproteinase with thrombospondin motifs 4

1

3

High-throughput

0.489

High

274404

CRTAP
Cartilage-associated protein

1

2

High-throughput

0.489

High

355015

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

2

High-throughput

0.489

High

435535

IGF1R
Insulin-like growth factor 1 receptor

1

1

High-throughput

0.489

High

531719

PDIA4
Protein disulfide-isomerase A4

1

2

High-throughput

0.489

High

606859

PCSK6
Proprotein convertase subtilisin/kexin type 6

1

3

High-throughput

0.489

High

606860

ERP29
Endoplasmic reticulum resident protein 29

1

4

High-throughput

0.489

High

606861

PDIA3
Protein disulfide-isomerase A3

1

2

High-throughput

0.489

High

606862

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.489

High

606867

PLXA3
Plexin-A3

1

1

High-throughput

0.489

High

606871

LAMB2
Laminin subunit beta-2

1

3

High-throughput

0.489

High

606881

OS9
Protein OS-9

1

2

High-throughput

0.489

High

606883

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

1

High-throughput

0.489

High

606893

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

1

1

High-throughput

0.489

High

606898

TXD11
Thioredoxin domain-containing protein 11

1

6

High-throughput

0.489

High

606907

GLT12
Polypeptide N-acetylgalactosaminyltransferase 12

1

1

High-throughput

0.489

High

606909

VWDE
von Willebrand factor D and EGF domain-containing protein

1

4

High-throughput

0.489

High

606915

TTC13
Tetratricopeptide repeat protein 13

1

4

High-throughput

0.489

High

606919

GPI8
GPI-anchor transamidase

1

1

High-throughput

0.489

High

606923

HMR1
Major histocompatibility complex class I-related gene protein

1

1

High-throughput

0.489

High

606927

NAR5
Ecto-ADP-ribosyltransferase 5

1

2

High-throughput

0.489

High

606933

CNPY3
Protein canopy homolog 3

1

2

High-throughput

0.489

High

606935

CNTP3
Contactin-associated protein-like 3

1

6

High-throughput

0.489

High

606942

UGGG2
UDP-glucose:glycoprotein glucosyltransferase 2

1

2

High-throughput

0.489

High

606943

CHPF2
Chondroitin sulfate glucuronyltransferase

1

2

High-throughput

0.489

High

606944

SE1L1
Protein sel-1 homolog 1

1

2

High-throughput

0.489

High

606950

PDIP2
Polymerase delta-interacting protein 2

1

3

High-throughput

0.489

High

434946

SP1
Transcription factor Sp1

1

0

High-throughput

0.458

High

575268

EGR1
Early growth response protein 1

1

0

High-throughput

0.458

High

606930

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

0

High-throughput

0.458

High

606913

SUMF2
Inactive C-alpha-formylglycine-generating enzyme 2

1

13

Small-scale

0.457

High

345328

FOS
Protein c-Fos

1

2

High-throughput

0.437

High

606869

NDST2
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 2

1

1

High-throughput

0.437

High

606912

PMGT2
Protein O-linked-mannose beta-1,4-N-acetylglucosaminyltransferase 2

1

1

High-throughput

0.437

High

606940

DISC1
Disrupted in schizophrenia 1 protein

1

2

High-throughput

0.417

High

606911

POC5
Centrosomal protein POC5

1

2

Small-scale

0.407

High

606929

CNT3B
Contactin-associated protein-like 3B

1

3

High-throughput

0.407

High

606878

SIA4C
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4

3

0

High-throughput

0.347

High

606889

TECT1
Tectonic-1

3

0

High-throughput

0.347

High

606894

GT253
Inactive glycosyltransferase 25 family member 3

3

0

High-throughput

0.347

High

606917

B3GL2
UDP-GalNAc:beta-1,3-N-acetylgalactosaminyltransferase 2

3

0

High-throughput

0.347

High

260275

ENTP5
Nucleoside diphosphate phosphatase ENTPD5

2

0

High-throughput

0.318

High

606922

EXT2
Exostosin-2

2

0

High-throughput

0.318

High

606937

XYLT2
Xylosyltransferase 2

2

0

High-throughput

0.318

High

606865

5HT6R
5-hydroxytryptamine receptor 6

1

0

High-throughput

0.282

High

606926

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.282

High

128705

RTCA
RNA 3'-terminal phosphate cyclase

1

0

High-throughput

0.279

Low

135985

ACACB
Acetyl-CoA carboxylase 2

1

0

High-throughput

0.279

Low

199580

B4GT5
Beta-1,4-galactosyltransferase 5

1

0

High-throughput

0.279

Low

606857

FGFR4
Fibroblast growth factor receptor 4

1

0

High-throughput

0.279

Low

606873

SC11A
Signal peptidase complex catalytic subunit SEC11A

1

0

High-throughput

0.279

Low

606886

GANAB
Neutral alpha-glucosidase AB

1

0

High-throughput

0.279

Low

606887

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.279

Low

606891

FUT11
Alpha-(1,3)-fucosyltransferase 11

1

0

High-throughput

0.279

Low

606896

METRL
Meteorin-like protein

1

0

High-throughput

0.279

Low

606906

FXRD2
FAD-dependent oxidoreductase domain-containing protein 2

1

0

High-throughput

0.279

Low

606908

TRM2A
tRNA

1

0

High-throughput

0.279

Low

606910

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

0

High-throughput

0.279

Low

606918

NLGN2
Neuroligin-2

1

0

High-throughput

0.279

Low

606921

CLP1
Polyribonucleotide 5'-hydroxyl-kinase Clp1

1

0

High-throughput

0.279

Low

606925

I17RA
Interleukin-17 receptor A

1

0

High-throughput

0.279

Low

606932

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

0

High-throughput

0.279

Low

606936

SIL1
Nucleotide exchange factor SIL1

1

0

High-throughput

0.279

Low

606945

SUN2
SUN domain-containing protein 2

1

0

High-throughput

0.279

Low

606902

TMPPE
Transmembrane protein with metallophosphoesterase domain

1

0

High-throughput

0.249

Low

606938

DEFM
Peptide deformylase, mitochondrial

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024