Protein: I2BP2
Interferon regulatory factor 2-binding protein 2 (IRF-2-binding protein 2) (IRF-2BP2)

Gene: I2BP2, IRF2BP2
Organism: Homo sapiens
Interactions: 96
UniProt ID: Q7Z5L9

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0002327 - immature B cell differentiation
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

536533

IRF2
Interferon regulatory factor 2

5

3

Small-scale

0.728

High

1048840

VGLL4
Transcription cofactor vestigial-like protein 4

4

2

Small-scale

0.702

High

1191125

I2BP1
Interferon regulatory factor 2-binding protein 1

4

7

Small-scale

0.694

High

548312

FOSL2
Fos-related antigen 2

3

4

High-throughput

0.667

High

1191138

CCNL2
Cyclin-L2

3

1

High-throughput

0.667

High

1191146

I2BPL
Probable E3 ubiquitin-protein ligase IRF2BPL

3

7

Small-scale

0.640

High

1191136

UPP
Uracil phosphoribosyltransferase homolog

3

0

High-throughput

0.638

High

1035249

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

2

1

Small-scale

0.631

High

1191129

SIR6
NAD-dependent protein deacylase sirtuin-6

2

2

High-throughput

0.611

High

638325

RBTN2
Rhombotin-2

2

0

High-throughput

0.602

High

670887

GFRP
GTP cyclohydrolase 1 feedback regulatory protein

2

0

High-throughput

0.602

High

244614

BRD4
Bromodomain-containing protein 4

2

2

High-throughput

0.584

High

377435

GCR
Glucocorticoid receptor

2

10

Small-scale

0.584

High

487556

ANDR
Androgen receptor

2

12

Small-scale

0.584

High

782585

HNF4A
Hepatocyte nuclear factor 4-alpha

2

6

Small-scale

0.584

High

383866

ERBB2
Receptor tyrosine-protein kinase erbB-2

2

2

High-throughput

0.576

High

1070978

ERBB4
Receptor tyrosine-protein kinase erbB-4

2

2

High-throughput

0.576

High

871640

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.536

High

1049994

SCRIB
Protein scribble homolog

1

2

High-throughput

0.536

High

831463

CEBPA
CCAAT/enhancer-binding protein alpha

1

6

High-throughput

0.527

High

601944

ERBB3
Receptor tyrosine-protein kinase erbB-3

2

2

High-throughput

0.526

High

1191126

RBM45
RNA-binding protein 45

1

0

High-throughput

0.513

High

1191128

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1191142

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.513

High

323862

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.489

High

135126

NFIB
Nuclear factor 1 B-type

1

4

High-throughput

0.479

High

177333

HDAC3
Histone deacetylase 3

1

1

Small-scale

0.479

High

203455

MTG8R
Protein CBFA2T2

1

1

Small-scale

0.479

High

253989

MTG16
Protein CBFA2T3

1

1

Small-scale

0.479

High

261538

NCOR1
Nuclear receptor corepressor 1

1

3

Small-scale

0.479

High

301902

TRI37
E3 ubiquitin-protein ligase TRIM37

1

2

High-throughput

0.479

High

369907

ESR1
Estrogen receptor

1

8

High-throughput

0.479

High

551189

ITF2
Transcription factor 4

1

2

Small-scale

0.479

High

551548

TFE2
Transcription factor E2-alpha

1

2

Small-scale

0.479

High

641463

PAX6
Paired box protein Pax-6

1

2

High-throughput

0.479

High

658523

TEAD1
Transcriptional enhancer factor TEF-1

1

1

High-throughput

0.479

High

668792

PML
Protein PML

1

1

High-throughput

0.479

High

679128

TLX1
T-cell leukemia homeobox protein 1

1

1

High-throughput

0.479

High

727885

SOX6
Transcription factor SOX-6

1

9

High-throughput

0.479

High

751702

GRP75
Stress-70 protein, mitochondrial

1

2

High-throughput

0.479

High

785378

ELK3
ETS domain-containing protein Elk-3

1

1

High-throughput

0.479

High

799117

NKX21
Homeobox protein Nkx-2.1

1

5

High-throughput

0.479

High

818196

SOX2
Transcription factor SOX-2

1

9

Small-scale

0.479

High

884193

KLF3
Krueppel-like factor 3

1

4

High-throughput

0.479

High

1018236

NFIA
Nuclear factor 1 A-type

1

4

High-throughput

0.479

High

1021127

FOXC1
Forkhead box protein C1

1

2

High-throughput

0.479

High

1024867

KLF10
Krueppel-like factor 10

1

2

High-throughput

0.479

High

1041915

CUL3
Cullin-3

1

2

High-throughput

0.479

High

1054405

RBM39
RNA-binding protein 39

1

3

Small-scale

0.479

High

1060319

NFIX
Nuclear factor 1 X-type

1

4

High-throughput

0.479

High

1081300

E2F4
Transcription factor E2F4

1

3

High-throughput

0.479

High

1191122

I2BP2
Interferon regulatory factor 2-binding protein 2

1

7

Small-scale

0.479

High

1191127

SLX4
Structure-specific endonuclease subunit SLX4

1

2

High-throughput

0.479

High

1191131

NUP35
Nucleoporin NUP35

1

1

High-throughput

0.479

High

1191132

SP7
Transcription factor Sp7

1

4

High-throughput

0.479

High

1191134

HDAC2
Histone deacetylase 2

1

1

High-throughput

0.479

High

1191135

SH3K1
SH3 domain-containing kinase-binding protein 1

1

1

High-throughput

0.479

High

1191139

SIN3A
Paired amphipathic helix protein Sin3a

1

2

Small-scale

0.479

High

1191141

HTF4
Transcription factor 12

1

2

Small-scale

0.479

High

1191147

BACD3
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3

1

1

Small-scale

0.479

High

1191148

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1191149

HM20A
High mobility group protein 20A

1

5

Small-scale

0.479

High

1191152

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1191153

TES
Testin

1

2

High-throughput

0.479

High

1191155

TRRAP
Transformation/transcription domain-associated protein

1

1

Small-scale

0.479

High

1191156

NCOR2
Nuclear receptor corepressor 2

1

3

Small-scale

0.479

High

171045

TBXT
T-box transcription factor T

1

0

High-throughput

0.458

High

227909

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

347182

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

387005

P53
Cellular tumor antigen p53

1

0

Small-scale

0.458

High

455600

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

553065

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

568216

TAL1
T-cell acute lymphocytic leukemia protein 1

1

0

Small-scale

0.458

High

596779

CD11B
Cyclin-dependent kinase 11B

1

0

Small-scale

0.458

High

651568

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

720806

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

905988

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

High-throughput

0.458

High

932230

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

980798

TLE3
Transducin-like enhancer protein 3

1

0

High-throughput

0.458

High

1167254

BCOR
BCL-6 corepressor

1

0

Small-scale

0.458

High

1191123

LDB1
LIM domain-binding protein 1

1

0

Small-scale

0.458

High

1191124

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1191130

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1191133

SMG7
Nonsense-mediated mRNA decay factor SMG7

1

0

High-throughput

0.458

High

1191137

THOC1
THO complex subunit 1

1

0

High-throughput

0.458

High

1191140

MINT
Msx2-interacting protein

1

0

Small-scale

0.458

High

1191143

SSBP3
Single-stranded DNA-binding protein 3

1

0

Small-scale

0.458

High

1191144

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

1191151

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1191154

ASF1A
Histone chaperone ASF1A

1

0

High-throughput

0.458

High

385086

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

825717

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.282

High

1191145

ACH10
Neuronal acetylcholine receptor subunit alpha-10

1

0

High-throughput

0.279

Low

390984

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

1191150

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024