Protein: RPB2
DNA-directed RNA polymerase II subunit RPB2 (RNA polymerase II subunit 2) (EC 2.7.7.6) (B150) (DNA-directed RNA polymerase II 140 kDa polypeptide)

Gene: RPB2
Organism: Saccharomyces cerevisiae S288C
Interactions: 208
UniProt ID: P08518

Gene Ontology (top 5):
GO:0001055 - RNA polymerase II activity
GO:0001172 - RNA-templated transcription
GO:0003677 - DNA binding
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439959

RPB3
DNA-directed RNA polymerase II subunit RPB3

26

16

Small-scale

0.991

High

375214

RPB1
DNA-directed RNA polymerase II subunit RPB1

19

20

Small-scale

0.987

High

440052

T2FB
Transcription initiation factor IIF subunit beta

8

2

Small-scale

0.969

High

439987

RPB9
DNA-directed RNA polymerase II subunit RPB9

8

12

Small-scale

0.969

High

440009

RPB7
DNA-directed RNA polymerase II subunit RPB7

9

11

Small-scale

0.967

High

439968

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

7

8

Small-scale

0.965

High

439986

SPT5
Transcription elongation factor SPT5

7

4

Small-scale

0.960

High

439971

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

5

9

Small-scale

0.924

High

440032

RPB11
DNA-directed RNA polymerase II subunit RPB11

5

9

Small-scale

0.919

High

440051

T2FA
Transcription initiation factor IIF subunit alpha

7

0

Small-scale

0.914

High

440024

PAF1
RNA polymerase II-associated protein 1

2

1

Small-scale

0.768

High

439989

TF2B
Transcription initiation factor IIB

2

5

Small-scale

0.754

High

440078

H3
Histone H3

2

4

Small-scale

0.754

High

439967

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

9

9

Small-scale

0.752

High

439966

RPB4
DNA-directed RNA polymerase II subunit RPB4

8

3

Small-scale

0.744

High

439969

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

7

6

Small-scale

0.742

High

440002

MCES
mRNA cap guanine-N7 methyltransferase

2

0

High-throughput

0.736

High

439980

RNA15
mRNA 3'-end-processing protein RNA15

1

1

Small-scale

0.724

High

440058

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

6

2

Small-scale

0.721

High

440083

NOP3
Serine/arginine

2

0

Small-scale

0.716

High

440041

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

5

3

Small-scale

0.709

High

440010

TAF14
Transcription initiation factor TFIID subunit 14

6

0

Small-scale

0.701

High

440106

CDC73
Cell division control protein 73

4

1

Small-scale

0.692

High

440039

RSP5
E3 ubiquitin-protein ligase RSP5

4

8

Small-scale

0.692

High

440072

NRD1
Protein NRD1

1

2

Small-scale

0.691

High

440005

SPT4
Transcription elongation factor SPT4

4

1

Small-scale

0.691

High

440110

IWR1
RNA polymerase II nuclear localization protein IWR1

4

1

Small-scale

0.691

High

440107

ASR1
Alcohol-sensitive RING finger protein 1

5

0

Small-scale

0.688

High

440104

IWS1
Transcription factor SPN1

4

1

High-throughput

0.688

High

440060

GPN1
GPN-loop GTPase 1

10

13

Small-scale

0.685

High

440044

RAD26
DNA repair and recombination protein RAD26

1

3

Small-scale

0.647

High

439997

SPT16
FACT complex subunit SPT16

3

1

Small-scale

0.640

High

439951

HSP71
Heat shock protein SSA1

3

6

High-throughput

0.634

High

439965

MED14
Mediator of RNA polymerase II transcription subunit 14

3

1

Small-scale

0.633

High

440035

PCF11
Protein PCF11

2

3

Small-scale

0.629

High

439982

RAD51
DNA repair protein RAD51

2

5

High-throughput

0.621

High

392019

H2A1
Histone H2A.1

1

3

High-throughput

0.618

High

406665

RS3
Small ribosomal subunit protein uS3

1

4

High-throughput

0.618

High

429583

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

16

Small-scale

0.618

High

439944

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

10

High-throughput

0.618

High

439973

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

10

High-throughput

0.618

High

440014

CENPA
Histone H3-like centromeric protein CSE4

1

4

High-throughput

0.618

High

440016

ELF1
Transcription elongation factor 1

1

1

High-throughput

0.618

High

440028

MIP6
RNA-binding protein MIP6

1

1

Small-scale

0.618

High

440045

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

6

High-throughput

0.618

High

440109

SUB2
ATP-dependent RNA helicase SUB2

1

1

High-throughput

0.618

High

440025

LEO1
RNA polymerase-associated protein LEO1

1

0

Small-scale

0.614

High

440082

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

1

Small-scale

0.601

High

440098

RT103
Regulator of Ty1 transposition protein 103

2

10

Small-scale

0.601

High

439978

SIS1
Protein SIS1

2

3

High-throughput

0.588

High

440115

TAF10
Transcription initiation factor TFIID subunit 10

2

1

High-throughput

0.588

High

440071

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

2

0

Small-scale

0.588

High

425569

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.586

High

440034

NAB3
Nuclear polyadenylated RNA-binding protein 3

1

0

High-throughput

0.586

High

440086

HAP5
Transcriptional activator HAP5

1

0

High-throughput

0.586

High

440117

YRA1
RNA annealing protein YRA1

1

0

High-throughput

0.586

High

439975

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

2

0

High-throughput

0.585

High

439977

SPT6
Transcription elongation factor SPT6

2

1

High-throughput

0.584

High

440043

ATAD2
ATPase histone chaperone YTA7

2

5

Small-scale

0.584

High

440057

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

5

High-throughput

0.584

High

440079

SEN1
Helicase SEN1

2

3

Small-scale

0.584

High

365601

HSP82
ATP-dependent molecular chaperone HSP82

2

4

High-throughput

0.571

High

439954

SSB1
Ribosome-associated molecular chaperone SSB1

2

6

High-throughput

0.571

High

439991

HS104
Heat shock protein 104

2

6

High-throughput

0.571

High

439988

URA7
CTP synthase 1

2

1

High-throughput

0.567

High

412436

KIN28
Serine/threonine-protein kinase KIN28

1

3

Small-scale

0.561

High

141065

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.553

High

405336

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.553

High

439952

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

440042

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

440000

MED18
Mediator of RNA polymerase II transcription subunit 18

2

0

Small-scale

0.547

High

440095

UFO1
Ubiquitin ligase complex F-box protein UFO1

1

0

Small-scale

0.537

High

389819

VDAC1
Mitochondrial outer membrane protein porin 1

1

3

High-throughput

0.536

High

412618

KAPA
cAMP-dependent protein kinase type 1

1

4

High-throughput

0.536

High

412930

KAPB
cAMP-dependent protein kinase type 2

1

4

High-throughput

0.536

High

439953

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

439990

XPO1
Exportin-1

1

3

High-throughput

0.536

High

440015

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.536

High

440020

TAF5
Transcription initiation factor TFIID subunit 5

1

2

High-throughput

0.536

High

440029

MED6
Mediator of RNA polymerase II transcription subunit 6

1

2

High-throughput

0.536

High

440054

ELP2
Elongator complex protein 2

1

2

Small-scale

0.536

High

440073

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

440090

GCN5
Histone acetyltransferase GCN5

1

8

High-throughput

0.536

High

440105

GPN3
GPN-loop GTPase 3

2

13

Small-scale

0.533

High

426495

GPT
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase

1

0

High-throughput

0.518

High

439999

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.515

High

440033

SPT8
Transcription factor SPT8

1

0

High-throughput

0.513

High

440061

YMR1
Phosphoinositide 3-phosphatase

1

0

High-throughput

0.513

High

440087

GIP3
GLC7-interacting protein 3

1

0

High-throughput

0.513

High

440097

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.513

High

439948

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

5

High-throughput

0.501

High

439962

FUS3
Mitogen-activated protein kinase FUS3

1

2

High-throughput

0.501

High

439979

RNA14
mRNA 3'-end-processing protein RNA14

1

1

Small-scale

0.501

High

440018

T2EB
Transcription initiation factor IIE subunit beta

1

1

Small-scale

0.501

High

339349

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.500

High

409589

KAPC
cAMP-dependent protein kinase type 3

1

4

High-throughput

0.500

High

439972

DBF2
Cell cycle protein kinase DBF2

1

5

High-throughput

0.500

High

439974

SAN1
Protein SAN1

1

1

High-throughput

0.500

High

439976

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

1

5

High-throughput

0.500

High

439994

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

4

High-throughput

0.500

High

440006

PRS6B
26S proteasome regulatory subunit 6B homolog

1

2

High-throughput

0.500

High

440013

KDX1
Serine/threonine-protein kinase KDX1

1

2

High-throughput

0.500

High

440021

CHK1
Serine/threonine-protein kinase CHK1

1

1

High-throughput

0.500

High

440074

CBK1
Serine/threonine-protein kinase CBK1

1

3

High-throughput

0.500

High

440094

KU80
ATP-dependent DNA helicase II subunit 2

1

2

High-throughput

0.500

High

440119

RAD59
DNA repair protein RAD59

1

1

High-throughput

0.500

High

439956

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

4

High-throughput

0.489

High

440022

GID4
Vacuolar import and degradation protein 24

1

1

High-throughput

0.489

High

440027

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.489

High

440055

GCN20
Protein GCN20

1

6

High-throughput

0.489

High

440121

HSP42
Heat shock protein 42

1

2

High-throughput

0.489

High

439957

UBC5
Ubiquitin-conjugating enzyme E2-16 kDa

1

0

Small-scale

0.480

High

440017

T2EA
Transcription initiation factor IIE subunit alpha

1

0

Small-scale

0.480

High

440068

RTF1
RNA polymerase-associated protein RTF1

1

0

Small-scale

0.480

High

440112

CLP1
mRNA cleavage and polyadenylation factor CLP1

1

0

Small-scale

0.480

High

439970

FAR1
Cyclin-dependent kinase inhibitor FAR1

1

0

High-throughput

0.479

High

439984

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.479

High

440001

RAD24
Checkpoint protein RAD24

1

0

High-throughput

0.479

High

440070

BUD32
EKC/KEOPS complex subunit BUD32

1

0

High-throughput

0.479

High

356175

H4
Histone H4

1

3

High-throughput

0.479

High

402842

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.479

High

413214

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.479

High

439950

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

439960

EF3A
Elongation factor 3A

1

7

High-throughput

0.479

High

439995

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

3

High-throughput

0.479

High

440003

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.479

High

440012

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

440019

GBLP
Small ribosomal subunit protein RACK1

1

3

High-throughput

0.479

High

440026

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.479

High

440037

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

2

High-throughput

0.479

High

440049

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

440065

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

2

High-throughput

0.479

High

440076

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

440077

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

440081

MCE1
mRNA-capping enzyme subunit alpha

1

1

High-throughput

0.479

High

440089

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.479

High

440092

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.479

High

440093

RBA50
RNA polymerase II-associated protein RBA50

1

3

High-throughput

0.479

High

440096

POB3
FACT complex subunit POB3

1

2

High-throughput

0.479

High

440099

RBS1
RNA-binding suppressor of PAS kinase protein 1

1

1

Small-scale

0.479

High

440101

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.479

High

440103

TFC6
Transcription factor tau 91 kDa subunit

1

2

High-throughput

0.479

High

440111

SGO1
Shugoshin

1

2

High-throughput

0.479

High

440116

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

5

High-throughput

0.479

High

440123

RUVB2
RuvB-like protein 2

1

8

High-throughput

0.479

High

439963

HPR1
THO complex subunit HPR1

1

0

Small-scale

0.458

High

440007

MED9
Mediator of RNA polymerase II transcription subunit 9

1

0

Small-scale

0.458

High

440031

PP2C7
Protein phosphatase 2C homolog 7, mitochondrial

1

0

High-throughput

0.458

High

440038

RS26B
Small ribosomal subunit protein eS26B

1

0

High-throughput

0.458

High

440075

CUZ1
CDC48-associated ubiquitin-like/zinc finger protein 1

1

0

Small-scale

0.458

High

440080

PRP38
Pre-mRNA-splicing factor 38

1

0

High-throughput

0.458

High

440088

ESP1
Separin

1

0

High-throughput

0.458

High

440100

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

440102

YL455
PWWP domain-containing protein YLR455W

1

0

Small-scale

0.458

High

440118

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

439993

DBF20
Serine/threonine-protein kinase DBF20

1

5

High-throughput

0.457

High

367627

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

427151

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.445

High

439958

VATB
V-type proton ATPase subunit B

1

2

High-throughput

0.445

High

439961

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.445

High

439983

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.445

High

440011

DEF1
RNA polymerase II degradation factor 1

1

1

High-throughput

0.445

High

440030

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

440046

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

440048

DJP1
DnaJ-like protein 1

1

4

High-throughput

0.445

High

440064

PHB2
Prohibitin-2

1

1

High-throughput

0.445

High

440066

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.445

High

440067

ACS2
Acetyl-coenzyme A synthetase 2

1

1

High-throughput

0.445

High

440085

ADA2
Transcriptional adapter 2

1

3

High-throughput

0.445

High

357789

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

382861

RL25
Large ribosomal subunit protein uL23

1

1

Small-scale

0.437

High

407629

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.437

High

425668

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.437

High

439945

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.437

High

439946

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

439947

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

439949

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

439955

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

439981

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.437

High

439985

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

440004

SMY2
Protein SMY2

1

2

High-throughput

0.437

High

440008

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

440036

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

440056

BUD27
Bud site selection protein 27

1

2

High-throughput

0.437

High

440062

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

440063

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

440084

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.437

High

440108

VAM6
Vacuolar morphogenesis protein 6

1

2

High-throughput

0.437

High

440113

GPN2
GPN-loop GTPase 2

1

13

High-throughput

0.437

High

440114

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.437

High

440124

RTP1
RNA polymerase II assembly factor RTP1

1

1

Small-scale

0.437

High

439992

MED16
Mediator of RNA polymerase II transcription subunit 16

1

0

High-throughput

0.426

High

439998

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

Small-scale

0.426

High

440120

MED1
Mediator of RNA polymerase II transcription subunit 1

1

0

High-throughput

0.426

High

343253

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

2

High-throughput

0.407

High

440047

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.282

High

440069

MON1
Vacuolar fusion protein MON1

1

0

High-throughput

0.269

Low

439964

CDC42
Cell division control protein 42

1

0

High-throughput

0.261

Low

439996

CDC11
Cell division control protein 11

1

0

High-throughput

0.261

Low

440023

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.261

Low

440050

COPB2
Coatomer subunit beta'

1

0

High-throughput

0.261

Low

440053

SKP2
F-box protein SKP2

1

0

High-throughput

0.261

Low

440122

HRT3
F-box protein HRT3

1

0

High-throughput

0.261

Low

140422

CET1
mRNA-capping enzyme subunit beta

1

0

High-throughput

0.249

Low

440040

BIM1
Protein BIM1

1

0

High-throughput

0.249

Low

440059

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.249

Low

440091

BUL2
Ubiquitin ligase-binding protein BUL2

1

0

Small-scale

0.249

Low


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Last updated: 15 Jul 2024