Protein: TOP1
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Maintenance of killer protein 1)

Gene: TOP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 81
UniProt ID: P04786

Gene Ontology (top 5):
GO:0000019 - regulation of mitotic recombination
GO:0000183 - rDNA heterochromatin formation
GO:0003677 - DNA binding
GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

388093

SPT16
FACT complex subunit SPT16

3

1

High-throughput

0.662

High

388086

NSR1
Nuclear localization sequence-binding protein

3

1

Small-scale

0.646

High

388094

RPD3
Histone deacetylase RPD3

2

2

High-throughput

0.621

High

388079

REB1
DNA-binding protein REB1

2

0

High-throughput

0.595

High

388130

TRI1
Protein TRI1

2

0

High-throughput

0.594

High

388117

TOF1
Topoisomerase 1-associated factor 1

2

0

Small-scale

0.593

High

355721

H2B2
Histone H2B.2

2

3

High-throughput

0.588

High

388090

RPC3
DNA-directed RNA polymerase III subunit RPC3

2

0

High-throughput

0.585

High

388089

MCM4
DNA replication licensing factor MCM4

2

6

Small-scale

0.584

High

388142

CMR1
DNA damage-binding protein CMR1

2

4

High-throughput

0.584

High

388118

APJ1
J domain-containing protein APJ1

2

1

High-throughput

0.571

High

388122

SLD5
DNA replication complex GINS protein SLD5

2

0

Small-scale

0.559

High

388074

HSP71
Heat shock protein SSA1

1

1

High-throughput

0.536

High

388075

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.536

High

388076

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.536

High

388084

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.536

High

388107

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.536

High

388121

ABF2
ARS-binding factor 2, mitochondrial

1

6

High-throughput

0.536

High

388120

TOF2
Topoisomerase 1-associated factor 2

1

0

Small-scale

0.529

High

388099

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

7

High-throughput

0.515

High

388100

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.515

High

388127

POB3
FACT complex subunit POB3

1

3

High-throughput

0.515

High

376565

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

High-throughput

0.500

High

140750

FOB1
DNA replication fork-blocking protein FOB1

1

0

Small-scale

0.493

High

388101

NCB5R
NADH-cytochrome b5 reductase 1

1

0

High-throughput

0.493

High

388129

SML1
Ribonucleotide reductase inhibitor protein SML1

1

0

High-throughput

0.493

High

388098

NNK1
Nitrogen network kinase 1

1

0

High-throughput

0.480

High

388103

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.480

High

356145

H4
Histone H4

1

1

High-throughput

0.479

High

388068

H2A1
Histone H2A.1

1

4

Small-scale

0.479

High

388069

H2A2
Histone H2A.2

1

4

Small-scale

0.479

High

388071

SIR2
NAD-dependent histone deacetylase SIR2

1

1

Small-scale

0.479

High

388077

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.479

High

388081

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

388088

BMH1
Protein BMH1

1

1

High-throughput

0.479

High

388108

ATAD2
ATPase histone chaperone YTA7

1

1

High-throughput

0.479

High

388109

MPH1
ATP-dependent DNA helicase MPH1

1

6

High-throughput

0.479

High

388119

H3
Histone H3

1

3

Small-scale

0.479

High

388125

SIZ1
E3 SUMO-protein ligase SIZ1

1

3

High-throughput

0.479

High

388140

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.479

High

388138

TIR4
Cell wall protein TIR4

1

1

High-throughput

0.470

High

388080

RE107
Recombination protein 107

1

0

High-throughput

0.460

High

388092

MEI5
Meiosis protein 5

1

0

High-throughput

0.460

High

388113

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

Small-scale

0.460

High

388135

NOP53
Ribosome biogenesis protein NOP53

1

0

High-throughput

0.460

High

388085

MRC1
Mediator of replication checkpoint protein 1

1

0

Small-scale

0.458

High

388087

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

388096

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

388111

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

388124

LRS4
Monopolin complex subunit LRS4

1

0

Small-scale

0.458

High

388128

CSM3
Chromosome segregation in meiosis protein 3

1

0

Small-scale

0.458

High

388131

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.458

High

388133

RLP24
Ribosome biogenesis protein RLP24

1

0

Small-scale

0.458

High

388134

SGO1
Shugoshin

1

0

High-throughput

0.458

High

388136

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

388137

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

388083

SIS1
Protein SIS1

1

1

High-throughput

0.445

High

388095

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.445

High

388104

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

388114

DPH4
Diphthamide biosynthesis protein 4

1

1

High-throughput

0.445

High

388091

SMY1
Kinesin-related protein SMY1

1

2

High-throughput

0.439

High

365515

HSP82
ATP-dependent molecular chaperone HSP82

1

0

High-throughput

0.426

High

388082

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

388102

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

388073

HSP77
Import motor subunit, mitochondrial

1

1

High-throughput

0.407

High

388106

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.407

High

388110

DJP1
DnaJ-like protein 1

1

2

High-throughput

0.407

High

388078

ACON
Aconitate hydratase, mitochondrial

1

0

High-throughput

0.279

Low

388112

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.279

Low

388123

CLU
Clustered mitochondria protein 1

1

0

High-throughput

0.279

Low

388105

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.269

Low

388116

MPS2
Monopolar spindle protein 2

1

0

High-throughput

0.251

Low

388139

NYV1
Vacuolar v-SNARE NYV1

1

0

High-throughput

0.251

Low

388143

ATG11
Autophagy-related protein 11

1

0

High-throughput

0.251

Low

388070

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.249

Low

388072

CBP1
Cytochrome B pre-mRNA-processing protein 1

1

0

High-throughput

0.249

Low

388115

TPN1
Vitamin B6 transporter TPN1

1

0

High-throughput

0.249

Low

388097

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.232

Low

388126

HSP31
Glutathione-independent glyoxalase HSP31

1

0

High-throughput

0.232

Low

388132

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

0

High-throughput

0.232

Low

388141

JID1
J domain-containing protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024