Protein: SIR2
NAD-dependent histone deacetylase SIR2 (EC 2.3.1.286) (Regulatory protein SIR2) (Silent information regulator 2)

Gene: SIR2
Organism: Saccharomyces cerevisiae S288C
Interactions: 103
UniProt ID: P06700

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin
GO:0003714 - transcription corepressor activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

416186

SIR4
Regulatory protein SIR4

30

1

Small-scale

0.993

High

416176

SIR2
NAD-dependent histone deacetylase SIR2

5

11

Small-scale

0.902

High

416231

NET1
Nucleolar protein NET1

20

1

Small-scale

0.766

High

416177

SIR3
Regulatory protein SIR3

8

1

Small-scale

0.749

High

416242

CDC14
Tyrosine-protein phosphatase CDC14

8

6

Small-scale

0.745

High

356160

H4
Histone H4

6

5

Small-scale

0.726

High

416241

H3
Histone H3

5

10

Small-scale

0.708

High

140753

FOB1
DNA replication fork-blocking protein FOB1

7

0

Small-scale

0.706

High

416244

TOF2
Topoisomerase 1-associated factor 2

3

1

Small-scale

0.667

High

334577

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

3

3

Small-scale

0.665

High

416204

MCM10
Minichromosome maintenance protein 10

3

0

Small-scale

0.636

High

355295

H2B1
Histone H2B.1

3

9

Small-scale

0.633

High

416253

ESC2
Protein ESC2

3

0

Small-scale

0.617

High

416191

CSK22
Casein kinase II subunit alpha'

2

11

Small-scale

0.611

High

365557

HSP82
ATP-dependent molecular chaperone HSP82

2

3

High-throughput

0.608

High

416255

ESC8
Protein ESC8

2

0

Small-scale

0.593

High

416184

RPA1
DNA-directed RNA polymerase I subunit RPA190

2

5

Small-scale

0.584

High

416193

RPA2
DNA-directed RNA polymerase I subunit RPA135

2

2

Small-scale

0.584

High

416259

NSI1
RNA polymerase I termination factor

1

1

Small-scale

0.561

High

416197

MCM3
DNA replication licensing factor MCM3

1

12

Small-scale

0.552

High

416182

HSP72
Heat shock protein SSA2

2

13

High-throughput

0.552

High

416185

SSB1
Ribosome-associated molecular chaperone SSB1

2

14

High-throughput

0.552

High

416209

HSP7F
Heat shock protein homolog SSE1

2

20

High-throughput

0.552

High

416257

RFM1
Repression factor of MSEs protein 1

2

1

Small-scale

0.549

High

416235

SGF73
SAGA-associated factor 73

1

0

Small-scale

0.537

High

416190

EF3A
Elongation factor 3A

2

5

High-throughput

0.537

High

416178

ADR1
Regulatory protein ADR1

1

6

High-throughput

0.536

High

416189

CSK21
Casein kinase II subunit alpha

1

13

High-throughput

0.536

High

416222

CHK1
Serine/threonine-protein kinase CHK1

1

3

High-throughput

0.536

High

416236

FMP48
Probable serine/threonine-protein kinase FMP48

1

3

High-throughput

0.536

High

416249

ERB1
Ribosome biogenesis protein ERB1

1

7

High-throughput

0.536

High

416195

GAS1
1,3-beta-glucanosyltransferase GAS1

1

0

Small-scale

0.529

High

375558

RPC1
DNA-directed RNA polymerase III subunit RPC1

1

5

High-throughput

0.515

High

416199

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

1

High-throughput

0.515

High

416251

IMB1
Importin subunit beta-1

1

7

Small-scale

0.515

High

340828

KTHY
Thymidylate kinase

1

0

High-throughput

0.513

High

416201

RIF1
Telomere length regulator protein RIF1

1

0

High-throughput

0.513

High

416247

VHS1
Serine/threonine-protein kinase VHS1

1

0

High-throughput

0.513

High

416239

ZDS2
Protein ZDS2

1

3

Small-scale

0.508

High

416212

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

Small-scale

0.504

High

416226

IFH1
Protein IFH1

1

7

Small-scale

0.501

High

416192

SIR1
Regulatory protein SIR1

1

0

Small-scale

0.493

High

416194

RPAB5
DNA-directed RNA polymerases I, II, and III subunit RPABC5

1

0

High-throughput

0.493

High

416224

SAK1
SNF1-activating kinase 1

1

1

High-throughput

0.489

High

416240

DNM1
Dynamin-related protein DNM1

1

2

High-throughput

0.489

High

416200

MCM5
Minichromosome maintenance protein 5

1

13

Small-scale

0.481

High

416213

MRE11
Double-strand break repair protein MRE11

1

2

Small-scale

0.481

High

416221

MCM7
DNA replication licensing factor MCM7

1

11

Small-scale

0.481

High

416233

ZDS1
Protein ZDS1

1

4

Small-scale

0.481

High

416234

MCM6
DNA replication licensing factor MCM6

1

14

Small-scale

0.481

High

355733

H2B2
Histone H2B.2

1

9

Small-scale

0.479

High

388071

TOP1
DNA topoisomerase 1

1

1

Small-scale

0.479

High

392014

H2A1
Histone H2A.1

1

10

Small-scale

0.479

High

416180

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.479

High

416196

RAD53
Serine/threonine-protein kinase RAD53

1

2

High-throughput

0.479

High

416198

HCM1
Forkhead transcription factor HCM1

1

2

Small-scale

0.479

High

416202

XPO1
Exportin-1

1

8

Small-scale

0.479

High

416206

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

416207

RPA12
DNA-directed RNA polymerase I subunit RPA12

1

1

High-throughput

0.479

High

416208

SRP40
Suppressor protein SRP40

1

7

High-throughput

0.479

High

416211

GLRX4
Monothiol glutaredoxin-4

1

3

Small-scale

0.479

High

416216

URB1
Nucleolar pre-ribosomal-associated protein 1

1

1

High-throughput

0.479

High

416217

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

416220

HMT1
Protein arginine N-methyltransferase 1

1

3

High-throughput

0.479

High

416230

SUM1
Suppressor of mar1-1 protein

1

1

Small-scale

0.479

High

416238

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

416243

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

2

High-throughput

0.479

High

416245

ADA2
Transcriptional adapter 2

1

5

Small-scale

0.479

High

416246

IMA1
Importin subunit alpha

1

7

Small-scale

0.479

High

416248

GLRX3
Monothiol glutaredoxin-3

1

2

Small-scale

0.479

High

416258

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

416261

SMC6
Structural maintenance of chromosomes protein 6

1

8

Small-scale

0.479

High

416232

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

416252

NEJ1
Non-homologous end-joining protein 1

1

0

Small-scale

0.458

High

416256

SGO1
Shugoshin

1

0

High-throughput

0.458

High

416237

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.457

High

392239

H2A2
Histone H2A.2

1

10

High-throughput

0.445

High

416179

PYR1
Multifunctional protein URA2

1

9

High-throughput

0.445

High

416181

HSP71
Heat shock protein SSA1

1

13

High-throughput

0.445

High

416210

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

416219

SET3
SET domain-containing protein 3

1

11

High-throughput

0.445

High

416225

CAJ1
Protein CAJ1

1

5

High-throughput

0.445

High

416228

SSB2
Ribosome-associated molecular chaperone SSB2

1

14

High-throughput

0.445

High

416260

RLF2
Chromatin assembly factor 1 subunit p90

1

2

High-throughput

0.445

High

416187

RL3
Large ribosomal subunit protein uL3

1

2

High-throughput

0.437

High

416223

ATG8
Autophagy-related protein 8

1

5

Small-scale

0.437

High

416227

BEM2
GTPase-activating protein BEM2/IPL2

1

2

High-throughput

0.437

High

416250

RTN1
Reticulon-like protein 1

1

1

Small-scale

0.437

High

416205

ASF1
Histone chaperone ASF1

1

0

High-throughput

0.426

High

416262

YN12B
Transposon Ty1-NL2 Gag-Pol polyprotein

1

0

High-throughput

0.426

High

367605

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.407

High

399261

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

416203

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

416214

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.407

High

416215

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.407

High

416229

STU2
Protein STU2

1

2

High-throughput

0.407

High

333658

ADH1
Alcohol dehydrogenase 1

2

0

High-throughput

0.307

High

416188

BGL2
Glucan 1,3-beta-glucosidase

2

0

High-throughput

0.307

High

416218

YKC3
Uncharacterized protein YKL023W

1

0

High-throughput

0.279

Low

416183

PCKA
Phosphoenolpyruvate carboxykinase

1

0

Small-scale

0.261

Low

416254

NCS1
Calcium-binding protein NCS-1

1

0

High-throughput

0.238

Low

339959

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024