Protein: PRP8
Pre-mRNA-splicing factor 8

Gene: PRP8
Organism: Saccharomyces cerevisiae S288C
Interactions: 147
UniProt ID: P33334

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000350 - generation of catalytic spliceosome for second transesterification step
GO:0000387 - spliceosomal snRNP assembly
GO:0000389 - mRNA 3'-splice site recognition
GO:0000395 - mRNA 5'-splice site recognition

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

697193

BRR2
Pre-mRNA-splicing helicase BRR2

21

11

Small-scale

0.991

High

688715

AAR2
A1 cistron-splicing factor AAR2

10

2

Small-scale

0.983

High

704653

SN114
Pre-mRNA-splicing factor SNU114

10

5

Small-scale

0.976

High

704732

CWC2
Pre-mRNA-splicing factor CWC2

6

5

Small-scale

0.949

High

704680

SMD3
Small nuclear ribonucleoprotein Sm D3

6

7

Small-scale

0.943

High

704673

RSMB
Small nuclear ribonucleoprotein-associated protein B

5

2

High-throughput

0.922

High

704707

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

5

1

Small-scale

0.922

High

704683

LSM8
U6 snRNA-associated Sm-like protein LSm8

5

9

Small-scale

0.916

High

704686

PRP31
Pre-mRNA-processing factor 31

4

1

High-throughput

0.896

High

586387

PRP6
Pre-mRNA-splicing factor 6

4

10

Small-scale

0.892

High

589070

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

4

4

Small-scale

0.892

High

629366

BUD31
Pre-mRNA-splicing factor BUD31

4

3

Small-scale

0.892

High

704657

LSM2
U6 snRNA-associated Sm-like protein LSm2

4

7

Small-scale

0.892

High

704703

SMD1
Small nuclear ribonucleoprotein Sm D1

4

1

Small-scale

0.892

High

704699

LSM3
U6 snRNA-associated Sm-like protein LSm3

4

9

Small-scale

0.875

High

704689

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

3

7

High-throughput

0.867

High

704692

CWC22
Pre-mRNA-splicing factor CWC22

3

1

High-throughput

0.855

High

704720

LSM6
U6 snRNA-associated Sm-like protein LSm6

3

2

Small-scale

0.855

High

704675

LSM5
U6 snRNA-associated Sm-like protein LSm5

4

0

Small-scale

0.850

High

589422

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

3

8

High-throughput

0.839

High

704719

SMD2
Small nuclear ribonucleoprotein Sm D2

3

1

Small-scale

0.839

High

622305

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

3

8

Small-scale

0.834

High

704677

RUXG
Small nuclear ribonucleoprotein G

3

8

High-throughput

0.830

High

704698

RUXF
Small nuclear ribonucleoprotein F

3

2

High-throughput

0.830

High

704737

RUXE
Small nuclear ribonucleoprotein E

3

1

High-throughput

0.830

High

616107

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

3

5

Small-scale

0.827

High

704654

NTR2
Pre-mRNA-splicing factor NTR2

3

0

Small-scale

0.796

High

655691

PRP45
Pre-mRNA-processing protein 45

2

3

High-throughput

0.789

High

704674

LSM4
U6 snRNA-associated Sm-like protein LSm4

2

3

High-throughput

0.789

High

704696

LSM7
U6 snRNA-associated Sm-like protein LSm7

2

9

High-throughput

0.789

High

704739

PRP46
Pre-mRNA-splicing factor PRP46

2

6

High-throughput

0.789

High

657724

YJU2
Splicing factor YJU2

3

0

Small-scale

0.785

High

704694

CWC25
Pre-mRNA-splicing factor CWC25

2

0

High-throughput

0.748

High

704709

CEF1
Pre-mRNA-splicing factor CEF1

6

3

Small-scale

0.732

High

692278

PRP19
Pre-mRNA-processing factor 19

5

7

Small-scale

0.714

High

704713

SYF1
Pre-mRNA-splicing factor SYF1

5

11

Small-scale

0.714

High

704740

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

5

1

Small-scale

0.714

High

704731

RU2A
U2 small nuclear ribonucleoprotein A'

5

4

Small-scale

0.709

High

704665

LIN1
Protein LIN1

4

1

Small-scale

0.701

High

704735

CLF1
Pre-mRNA-splicing factor CLF1

4

11

Small-scale

0.691

High

704730

NCBP2
Nuclear cap-binding protein subunit 2

4

3

High-throughput

0.686

High

704702

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

3

4

Small-scale

0.680

High

704721

SP382
Pre-mRNA-splicing factor SPP382

4

0

Small-scale

0.667

High

586477

PRP9
Pre-mRNA-splicing factor PRP9

3

1

High-throughput

0.662

High

704688

CWC23
Pre-mRNA-splicing factor CWC23

3

5

High-throughput

0.662

High

704716

RSE1
Pre-mRNA-splicing factor RSE1

3

2

High-throughput

0.662

High

704651

NCBP1
Nuclear cap-binding protein complex subunit 1

3

1

High-throughput

0.656

High

477203

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

4

Small-scale

0.647

High

704708

CWC21
Pre-mRNA-splicing factor CWC21

3

0

Small-scale

0.633

High

554211

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

8

High-throughput

0.618

High

598619

ISY1
Pre-mRNA-splicing factor ISY1

1

3

High-throughput

0.618

High

704679

PRP17
Pre-mRNA-processing factor 17

1

9

High-throughput

0.618

High

704705

SLU7
Pre-mRNA-splicing factor SLU7

1

1

High-throughput

0.618

High

704724

DIB1
Spliceosomal protein DIB1

1

1

High-throughput

0.618

High

704742

HUB1
Ubiquitin-like modifier HUB1

1

1

Small-scale

0.618

High

692388

PRP21
Pre-mRNA-splicing factor PRP21

2

1

High-throughput

0.611

High

704658

SLT11
Pre-mRNA-splicing factor SLT11

2

3

High-throughput

0.611

High

704704

CUS1
Cold sensitive U2 snRNA suppressor 1

2

1

High-throughput

0.611

High

704670

PRP39
Pre-mRNA-processing factor 39

2

10

Small-scale

0.605

High

703186

PRP40
Pre-mRNA-processing protein PRP40

2

2

Small-scale

0.594

High

664736

BMH1
Protein BMH1

2

1

Small-scale

0.586

High

704681

CWC26
Pre-mRNA-splicing factor CWC26

1

0

High-throughput

0.586

High

704691

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.586

High

704701

PRP38
Pre-mRNA-splicing factor 38

1

0

High-throughput

0.586

High

704710

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.586

High

704660

SP381
Pre-mRNA-splicing factor SPP381

2

0

High-throughput

0.585

High

704717

SN309
Pre-mRNA-splicing factor SNT309

2

0

High-throughput

0.585

High

704678

DJP1
DnaJ-like protein 1

3

7

Small-scale

0.576

High

693976

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

2

4

High-throughput

0.571

High

700823

SMY2
Protein SMY2

2

0

Small-scale

0.559

High

493573

HSP72
Heat shock protein SSA2

2

4

High-throughput

0.552

High

704676

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

704734

UPC2
Sterol uptake control protein 2

2

0

Small-scale

0.551

High

376708

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

2

High-throughput

0.536

High

490774

HSP71
Heat shock protein SSA1

1

4

High-throughput

0.536

High

510771

SSB1
Ribosome-associated molecular chaperone SSB1

1

4

High-throughput

0.536

High

548523

GCN2
eIF-2-alpha kinase GCN2

1

2

High-throughput

0.536

High

704650

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.536

High

704723

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

3

High-throughput

0.536

High

704728

LUC7
Protein LUC7

1

2

High-throughput

0.536

High

704711

SNU56
56 kDa U1 small nuclear ribonucleoprotein component

1

0

High-throughput

0.513

High

704722

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.513

High

704652

MYO3
Myosin-3

1

1

High-throughput

0.501

High

704714

MYO5
Myosin-5

1

1

High-throughput

0.501

High

539891

RAD4
DNA repair protein RAD4

1

0

High-throughput

0.493

High

704741

YD85C
SERF-like protein YDL085C-A

1

0

High-throughput

0.493

High

704693

NOG2
Nucleolar GTP-binding protein 2

1

0

Small-scale

0.486

High

565188

KAR3
Kinesin-like protein KAR3

1

1

Small-scale

0.481

High

653113

MIG1
Regulatory protein MIG1

1

1

Small-scale

0.481

High

704671

RSP5
E3 ubiquitin-protein ligase RSP5

1

3

Small-scale

0.481

High

355427

H2B1
Histone H2B.1

1

6

High-throughput

0.479

High

355849

H2B2
Histone H2B.2

1

6

High-throughput

0.479

High

356371

H4
Histone H4

1

1

High-throughput

0.479

High

650262

SPT5
Transcription elongation factor SPT5

1

2

Small-scale

0.479

High

704687

SF3B1
U2 snRNP component HSH155

1

2

High-throughput

0.479

High

704700

NAM8
Protein NAM8

1

2

High-throughput

0.479

High

704726

PRP11
Pre-mRNA-splicing factor PRP11

1

1

High-throughput

0.479

High

704743

HSH49
Protein HSH49

1

3

High-throughput

0.479

High

452087

SWI1
SWI/SNF chromatin-remodeling complex subunit SWI1

1

0

Small-scale

0.460

High

594095

KICH
Choline kinase

1

0

Small-scale

0.460

High

704666

DNA2
DNA replication ATP-dependent helicase/nuclease DNA2 [Includes: DNA replication nuclease DNA2

1

0

Small-scale

0.460

High

704706

ECM5
Protein ECM5

1

0

Small-scale

0.460

High

661787

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

688179

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

691958

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

696627

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

704655

YK21
Uncharacterized protein YKR041W

1

0

High-throughput

0.458

High

704661

NTC20
Pre-mRNA-splicing factor NTC20

1

0

High-throughput

0.458

High

704662

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

704712

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

704718

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

704725

RDS3
Pre-mRNA-splicing factor RDS3

1

0

High-throughput

0.458

High

704727

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

704733

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.458

High

704738

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

366054

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

449991

HSP73
Heat shock protein SSA3

1

4

High-throughput

0.445

High

485487

SSBP1
Single-stranded nucleic acid-binding protein

1

3

High-throughput

0.445

High

498866

RL4A
Large ribosomal subunit protein uL4A

1

1

High-throughput

0.445

High

633088

MAS5
Mitochondrial protein import protein MAS5

1

6

High-throughput

0.445

High

680583

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

694394

HSP7F
Heat shock protein homolog SSE1

1

7

High-throughput

0.445

High

695931

HSP79
Heat shock protein homolog SSE2

1

7

High-throughput

0.445

High

704664

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

704669

CAJ1
Protein CAJ1

1

7

High-throughput

0.445

High

704672

HSP7E
Heat shock protein SSC3, mitochondrial

1

4

High-throughput

0.445

High

704697

APJ1
J domain-containing protein APJ1

1

6

High-throughput

0.445

High

704656

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

704663

IF5
Eukaryotic translation initiation factor 5

1

1

High-throughput

0.437

High

612220

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

704682

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

704684

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.426

High

704685

PFD3
Prefoldin subunit 3

1

0

High-throughput

0.426

High

704695

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.426

High

704715

PFD5
Prefoldin subunit 5

1

0

High-throughput

0.426

High

704736

HSP42
Heat shock protein 42

1

0

High-throughput

0.426

High

541660

SEC63
Protein translocation protein SEC63

1

5

High-throughput

0.407

High

691360

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

1

High-throughput

0.407

High

704667

TCPG
T-complex protein 1 subunit gamma

1

5

High-throughput

0.407

High

704668

TCPD
T-complex protein 1 subunit delta

1

6

High-throughput

0.407

High

381604

GAL80
Galactose/lactose metabolism regulatory protein GAL80

1

0

Small-scale

0.391

High

343576

PMG1
Phosphoglycerate mutase 1

2

0

Small-scale

0.300

High

704659

EXO84
Exocyst complex component EXO84

2

0

Small-scale

0.300

High

704690

YG1D
Probable transcriptional regulatory protein HAH1

2

0

Small-scale

0.300

High

140775

FOB1
DNA replication fork-blocking protein FOB1

1

0

Small-scale

0.251

Low

568936

GABAT
4-aminobutyrate aminotransferase

1

0

Small-scale

0.251

Low

704729

FMP45
SUR7 family protein FMP45

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024