Protein: O83531
Thiamine diphosphokinase (EC 2.7.6.2)

Gene: O83531, TP_0518
Organism: Treponema pallidum subsp. pallidum str. Nichols
Interactions: 70
UniProt ID: O83531

Gene Ontology (top 5):
GO:0004788 - thiamine diphosphokinase activity
GO:0005524 - ATP binding
GO:0006772 - thiamine metabolic process
GO:0009229 - thiamine diphosphate biosynthetic process
GO:0016301 - kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

309393

O83178
Thiamine ABC transporter, ATP-binding protein, putative

1

1

High-throughput

0.457

High

310836

O83851
ABC transporter, ATP-binding protein

1

1

High-throughput

0.457

High

309251

O83137
Uridylate kinase

1

0

High-throughput

0.438

High

310232

O83395
DNA 3'-5' helicase

1

0

High-throughput

0.438

High

310820

SYH
Histidine--tRNA ligase

1

0

High-throughput

0.438

High

310832

SYM
Methionine--tRNA ligase

1

0

High-throughput

0.438

High

310841

SYDND
Aspartate--tRNA(Asp/Asn) ligase

1

0

High-throughput

0.438

High

310824

O83666
Flagellar hook-associated protein 1

2

0

High-throughput

0.295

High

310844

FLAB3
Flagellin FlaB3

2

0

High-throughput

0.295

High

147323

RNZ
Ribonuclease Z

1

0

High-throughput

0.238

Low

308606

Y012
Uncharacterized protein TP_0012

1

0

High-throughput

0.238

Low

308680

Y031
Uncharacterized protein TP_0031

1

0

High-throughput

0.238

Low

308761

O83087
Polymer-forming cytoskeletal protein

1

0

High-throughput

0.238

Low

308794

O83089
Phosphoribosyltransferase domain-containing protein

1

0

High-throughput

0.238

Low

310819

O83630
Tetratricopeptide repeat protein

1

0

High-throughput

0.238

Low

310821

O83657
Conserved hypothetical integral membrane protein

1

0

High-throughput

0.238

Low

310822

Y656
Uncharacterized protein TP_0656

1

0

High-throughput

0.238

Low

310823

CSRA
Translational regulator CsrA

1

0

High-throughput

0.238

Low

310825

Y661
Uncharacterized protein TP_0661

1

0

High-throughput

0.238

Low

310826

DPO3A
DNA polymerase III subunit alpha

1

0

High-throughput

0.238

Low

310827

IOJAP
Ribosomal silencing factor RsfS

1

0

High-throughput

0.238

Low

310828

Y782
Uncharacterized protein TP_0782

1

0

High-throughput

0.238

Low

310829

O83764
Organic solvent tolerance-like N-terminal domain-containing protein

1

0

High-throughput

0.238

Low

310830

O83769
Antibiotic transport protein, putative

1

0

High-throughput

0.238

Low

310831

Y795
Uncharacterized protein TP_0795

1

0

High-throughput

0.238

Low

310833

Y802
Uncharacterized protein TP_0802

1

0

High-throughput

0.238

Low

310834

O83783
Exoribonuclease II

1

0

High-throughput

0.238

Low

310835

O83801
DUF2225 domain-containing protein

1

0

High-throughput

0.238

Low

310837

RS16
Small ribosomal subunit protein bS16

1

0

High-throughput

0.238

Low

310838

Y929
Uncharacterized protein TP_0929

1

0

High-throughput

0.238

Low

310839

O83909
Pyruvate oxidoreductase

1

0

High-throughput

0.238

Low

310840

Y969
Uncharacterized protein TP_0969

1

0

High-throughput

0.238

Low

310842

O83954
P26

1

0

High-throughput

0.238

Low

310843

RECX
Regulatory protein RecX

1

0

High-throughput

0.238

Low

310845

RL28
Large ribosomal subunit protein bL28

1

0

High-throughput

0.238

Low

310846

TP75
Protein Tp75

1

0

High-throughput

0.238

Low

310847

RFUA
ABC transporter riboflavin-binding protein RfuA

1

0

High-throughput

0.238

Low

308962

RS6
Small ribosomal subunit protein bS6

1

0

High-throughput

0.238

Low

309062

O83119
Quinoline 2-oxidoreductase

1

0

High-throughput

0.238

Low

309085

Y084
Uncharacterized protein TP_0084

1

0

High-throughput

0.238

Low

309101

O83123
PTS system, nitrogen regulatory IIA component

1

0

High-throughput

0.238

Low

309173

O83130
RNA polymerase sigma-24 factor

1

0

High-throughput

0.238

Low

309222

IF1
Translation initiation factor IF-1

1

0

High-throughput

0.238

Low

309271

5NTD
Probable 5'-nucleotidase

1

0

High-throughput

0.238

Low

309337

O83167
Uncharacterized protein

1

0

High-throughput

0.238

Low

309351

Y132
Uncharacterized protein TP_0132

1

0

High-throughput

0.238

Low

309406

Y150
Uncharacterized protein TP_0150

1

0

High-throughput

0.238

Low

309442

O83193
Pyrimidine 5'-nucleotidase

1

0

High-throughput

0.238

Low

309544

RL36
Large ribosomal subunit protein bL36

1

0

High-throughput

0.238

Low

309620

RL33
Large ribosomal subunit protein bL33

1

0

High-throughput

0.238

Low

309645

RL11
Large ribosomal subunit protein uL11

1

0

High-throughput

0.238

Low

309682

LNT1
Apolipoprotein N-acyltransferase 1

1

0

High-throughput

0.238

Low

310047

Y320
Uncharacterized protein TP_0320

1

0

High-throughput

0.238

Low

310075

O83353
Outer membrane lipoprotein carrier protein LolA

1

0

High-throughput

0.238

Low

310155

Y359
Uncharacterized protein TP_0359

1

0

High-throughput

0.238

Low

310182

Y368
Uncharacterized protein TP_0368

1

0

High-throughput

0.238

Low

310451

SECD
Protein translocase subunit SecD

1

0

High-throughput

0.238

Low

310459

O83427
DUF3276 family protein

1

0

High-throughput

0.238

Low

310503

O83449
SPOR domain-containing protein

1

0

High-throughput

0.238

Low

310599

O83468
GWxTD domain-containing protein

1

0

High-throughput

0.238

Low

310612

O83470
Uncharacterized protein

1

0

High-throughput

0.238

Low

310625

O83472
RNA-binding S4 domain-containing protein

1

0

High-throughput

0.238

Low

310640

Y462
Uncharacterized lipoprotein TP_0462/TP_0463

1

0

High-throughput

0.238

Low

310697

O83498
Adenylate cyclase

1

0

High-throughput

0.238

Low

310773

Y504
Uncharacterized protein TP_0504

1

0

High-throughput

0.238

Low

310801

RUVC
Crossover junction endodeoxyribonuclease RuvC

1

0

High-throughput

0.238

Low

310815

O83543
V-type ATPase, subunit F, putative

1

0

High-throughput

0.238

Low

310816

Y552
Uncharacterized protein TP_0552

1

0

High-throughput

0.238

Low

310817

O83574
J domain-containing protein

1

0

High-throughput

0.238

Low

310818

Y597
Uncharacterized protein TP_0597

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025