Protein: METK2
S-adenosylmethionine synthase 2 (AdoMet synthase 2) (EC 2.5.1.6) (Methionine adenosyltransferase 2) (MAT 2)

Gene: METK2, SAM2
Organism: Saccharomyces cerevisiae S288C
Interactions: 105
UniProt ID: P19358

Gene Ontology (top 5):
GO:0004478 - methionine adenosyltransferase activity
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006555 - methionine metabolic process
GO:0006556 - S-adenosylmethionine biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

498431

METK1
S-adenosylmethionine synthase 1

6

16

Small-scale

0.944

High

583195

METK2
S-adenosylmethionine synthase 2

2

15

High-throughput

0.762

High

583242

ACS2
Acetyl-coenzyme A synthetase 2

2

2

Small-scale

0.611

High

340013

KPYK1
Pyruvate kinase 1

2

2

Small-scale

0.584

High

583237

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

583235

LCB2
Serine palmitoyltransferase 2

2

1

High-throughput

0.567

High

583230

SSB2
Ribosome-associated molecular chaperone SSB2

2

6

High-throughput

0.552

High

490287

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.536

High

583219

DBP8
ATP-dependent RNA helicase DBP8

1

1

High-throughput

0.536

High

583251

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

583261

IMB1
Importin subunit beta-1

1

1

High-throughput

0.536

High

583255

KA120
Importin beta-like protein KAP120

1

0

High-throughput

0.518

High

583220

YLF2
Obg-like ATPase homolog

1

2

High-throughput

0.515

High

583267

TFB4
General transcription and DNA repair factor IIH subunit TFB4

1

0

Small-scale

0.513

High

389625

DNLI1
DNA ligase 1

1

1

High-throughput

0.500

High

420467

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

High-throughput

0.500

High

526184

KIN2
Serine/threonine-protein kinase KIN2

1

1

High-throughput

0.500

High

539302

KSS1
Mitogen-activated protein kinase KSS1

1

4

High-throughput

0.500

High

583210

RAD24
Checkpoint protein RAD24

1

3

High-throughput

0.500

High

583216

ATG12
Ubiquitin-like protein ATG12

1

1

High-throughput

0.500

High

583231

RFC2
Replication factor C subunit 2

1

1

High-throughput

0.500

High

583250

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

5

High-throughput

0.500

High

583258

CTK1
CTD kinase subunit alpha

1

2

High-throughput

0.500

High

583259

MUS81
Crossover junction endonuclease MUS81

1

1

High-throughput

0.500

High

583196

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.479

High

583269

YP150
Putative serine/threonine-protein kinase YPL150W

1

0

High-throughput

0.479

High

141140

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

343528

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

410898

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.479

High

425750

RS19A
Small ribosomal subunit protein eS19A

1

1

High-throughput

0.479

High

537350

ALF
Fructose-bisphosphate aldolase

1

1

High-throughput

0.479

High

583198

SIS1
Protein SIS1

1

3

High-throughput

0.479

High

583199

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

583205

URK1
Uridine kinase

1

2

High-throughput

0.479

High

583206

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

583207

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

583211

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

583214

NOT4
General negative regulator of transcription subunit 4

1

1

Small-scale

0.479

High

583215

ARL1
ADP-ribosylation factor-like protein 1

1

2

High-throughput

0.479

High

583218

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

583223

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

583227

DHH1
ATP-dependent RNA helicase DHH1

1

2

High-throughput

0.479

High

583228

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

583244

GIS2
Zinc finger protein GIS2

1

2

High-throughput

0.479

High

583248

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

1

High-throughput

0.479

High

583252

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

583256

FDC1
Ferulic acid decarboxylase 1

1

1

High-throughput

0.479

High

583257

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.479

High

583270

SKS1
Serine/threonine-protein kinase SKS1

1

3

High-throughput

0.479

High

583271

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

342849

ENO2
Enolase 2

1

0

High-throughput

0.458

High

583265

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

583253

UBC7
Ubiquitin-conjugating enzyme E2 7

1

2

High-throughput

0.457

High

416279

SIR3
Regulatory protein SIR3

1

1

High-throughput

0.457

High

429622

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

1

High-throughput

0.457

High

583202

PWP2
Periodic tryptophan protein 2

1

2

High-throughput

0.457

High

583203

CDC20
APC/C activator protein CDC20

1

2

High-throughput

0.457

High

583204

RFA3
Replication factor A protein 3

1

1

High-throughput

0.457

High

583224

TEM1
Protein TEM1

1

2

High-throughput

0.457

High

583245

ELOA1
Elongin-A

1

1

High-throughput

0.457

High

583260

SEN15
tRNA-splicing endonuclease subunit SEN15

1

1

High-throughput

0.457

High

583264

RBX1
RING-box protein HRT1

1

1

High-throughput

0.457

High

583272

HSH49
Protein HSH49

1

1

High-throughput

0.457

High

365760

HSP82
ATP-dependent molecular chaperone HSP82

1

3

High-throughput

0.445

High

449900

HSP73
Heat shock protein SSA3

1

6

High-throughput

0.445

High

493158

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

510207

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.445

High

543162

HSC82
ATP-dependent molecular chaperone HSC82

1

3

High-throughput

0.445

High

583208

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

583209

HSP79
Heat shock protein homolog SSE2

1

11

High-throughput

0.445

High

583222

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.445

High

583225

TCPG
T-complex protein 1 subunit gamma

1

2

High-throughput

0.445

High

583226

TCPD
T-complex protein 1 subunit delta

1

2

High-throughput

0.445

High

583229

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.445

High

583254

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.439

High

524155

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

529991

STE12
Protein STE12

1

1

Small-scale

0.437

High

583200

GID7
Glucose-induced degradation protein 7

1

2

High-throughput

0.437

High

583217

ARPC1
Actin-related protein 2/3 complex subunit 1

1

2

High-throughput

0.437

High

583221

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.437

High

583233

ULP2
Ubiquitin-like-specific protease 2

1

1

Small-scale

0.437

High

583234

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

583236

MPG1
Mannose-1-phosphate guanyltransferase

1

2

High-throughput

0.437

High

583239

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

583240

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

583243

CAF40
Protein CAF40

1

1

Small-scale

0.437

High

583247

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

583266

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

583238

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.426

High

583273

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.279

Low

420431

RAD10
DNA repair protein RAD10

1

0

High-throughput

0.261

Low

527213

HAP3
Transcriptional activator HAP3

1

0

High-throughput

0.261

Low

583197

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.261

Low

583246

APP1
Phosphatidate phosphatase APP1

1

0

High-throughput

0.261

Low

583249

YE066
Putative uncharacterized protein YER066C-A

1

0

High-throughput

0.261

Low

583262

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.261

Low

583201

PER1
Protein PER1

1

0

High-throughput

0.249

Low

583212

IXR1
Intrastrand cross-link recognition protein

1

0

Small-scale

0.249

Low

583213

TOM6
Mitochondrial import receptor subunit TOM6

1

0

High-throughput

0.249

Low

583232

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

583241

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.249

Low

583263

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

583268

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

576209

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024