Protein: MED15
Mediator of RNA polymerase II transcription subunit 15 (Autonomous replication regulatory protein 3) (Basal expression activator protein 1) (Defective silencing suppressor protein 4) (Mediator complex subunit 15) (Transcription regulatory protein GAL11) (Ty insertion suppressor protein 13)

Gene: MED15, GAL11
Organism: Saccharomyces cerevisiae S288C
Interactions: 125
UniProt ID: P19659

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001095 - TFIIE-class transcription factor complex binding
GO:0001097 - TFIIH-class transcription factor complex binding
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

381525

GAL4
Regulatory protein GAL4

13

1

Small-scale

0.762

High

586275

MED18
Mediator of RNA polymerase II transcription subunit 18

15

0

Small-scale

0.727

High

368717

GCN4
General control transcription factor GCN4

7

0

Small-scale

0.719

High

581330

MED14
Mediator of RNA polymerase II transcription subunit 14

10

0

Small-scale

0.717

High

586273

MED17
Mediator of RNA polymerase II transcription subunit 17

10

0

Small-scale

0.717

High

586269

MED16
Mediator of RNA polymerase II transcription subunit 16

9

0

Small-scale

0.716

High

586342

MED7
Mediator of RNA polymerase II transcription subunit 7

8

0

Small-scale

0.714

High

586312

MED3
Mediator of RNA polymerase II transcription subunit 3

8

0

Small-scale

0.714

High

586298

MED8
Mediator of RNA polymerase II transcription subunit 8

8

0

Small-scale

0.711

High

586343

MED2
Mediator of RNA polymerase II transcription subunit 2

8

0

Small-scale

0.711

High

586274

MED22
Mediator of RNA polymerase II transcription subunit 22

6

0

Small-scale

0.697

High

586285

MED20
Mediator of RNA polymerase II transcription subunit 20

6

0

Small-scale

0.696

High

586262

MED19
Mediator of RNA polymerase II transcription subunit 19

6

0

Small-scale

0.695

High

586347

MED1
Mediator of RNA polymerase II transcription subunit 1

5

0

Small-scale

0.676

High

586291

T2EA
Transcription initiation factor IIE subunit alpha

4

0

Small-scale

0.669

High

586325

MED5
Mediator of RNA polymerase II transcription subunit 5

4

0

Small-scale

0.661

High

586349

MED4
Mediator of RNA polymerase II transcription subunit 4

4

0

Small-scale

0.661

High

586292

T2EB
Transcription initiation factor IIE subunit beta

3

0

Small-scale

0.654

High

586281

MED9
Mediator of RNA polymerase II transcription subunit 9

4

0

Small-scale

0.653

High

586320

MED21
Mediator of RNA polymerase II transcription subunit 21

4

0

Small-scale

0.653

High

519491

PDR1
Transcription factor PDR1

2

1

Small-scale

0.650

High

586301

MED31
Mediator of RNA polymerase II transcription subunit 31

4

0

Small-scale

0.649

High

586302

MED6
Mediator of RNA polymerase II transcription subunit 6

4

0

Small-scale

0.649

High

375265

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

0

Small-scale

0.632

High

586339

MED10
Mediator of RNA polymerase II transcription subunit 10

3

0

Small-scale

0.625

High

490291

HSP71
Heat shock protein SSA1

3

1

High-throughput

0.624

High

586340

CDC73
Cell division control protein 73

3

0

Small-scale

0.614

High

586286

TAF14
Transcription initiation factor TFIID subunit 14

2

0

Small-scale

0.581

High

586329

GCN5
Histone acetyltransferase GCN5

2

0

High-throughput

0.576

High

586284

MSN2
Zinc finger protein MSN2

2

0

Small-scale

0.569

High

557861

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.561

High

586268

TF2B
Transcription initiation factor IIB

2

0

Small-scale

0.561

High

586330

TAF12
Transcription initiation factor TFIID subunit 12

2

0

Small-scale

0.561

High

586308

SSN3
Meiotic mRNA stability protein kinase SSN3

2

0

Small-scale

0.559

High

586345

RIO1
Serine/threonine-protein kinase RIO1

2

0

High-throughput

0.547

High

586323

MSN5
Protein MSN5

1

0

High-throughput

0.513

High

586351

SUS1
Transcription and mRNA export factor SUS1

1

0

High-throughput

0.513

High

392283

H2A2
Histone H2A.2

1

0

High-throughput

0.493

High

586328

IMA1
Importin subunit alpha

1

0

High-throughput

0.493

High

586337

IMB1
Importin subunit beta-1

1

0

High-throughput

0.493

High

586341

ESC8
Protein ESC8

1

0

Small-scale

0.486

High

586293

CCL1
Cyclin CCL1

1

1

Small-scale

0.481

High

436818

SWI5
Transcriptional factor SWI5

1

0

Small-scale

0.480

High

586270

BTAF1
TATA-binding protein-associated factor MOT1

1

1

Small-scale

0.479

High

586280

PDR3
Transcription factor PDR3

1

1

Small-scale

0.479

High

586319

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

1

High-throughput

0.479

High

515101

TAF13
Transcription initiation factor TFIID subunit 13

1

0

Small-scale

0.460

High

526944

TBP
TATA-box-binding protein

1

0

Small-scale

0.460

High

577124

SNF5
SWI/SNF chromatin-remodeling complex subunit SNF5

1

0

Small-scale

0.460

High

579766

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.460

High

586257

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

Small-scale

0.460

High

586258

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

Small-scale

0.460

High

586259

SNF2
Transcription regulatory protein SNF2

1

0

Small-scale

0.460

High

586265

MIG1
Regulatory protein MIG1

1

0

Small-scale

0.460

High

586266

RPB9
DNA-directed RNA polymerase II subunit RPB9

1

0

Small-scale

0.460

High

586276

T2AG
Transcription initiation factor IIA subunit 2

1

0

Small-scale

0.460

High

586277

TFB1
General transcription and DNA repair factor IIH subunit TFB1

1

0

Small-scale

0.460

High

586279

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

586305

SPT8
Transcription factor SPT8

1

0

Small-scale

0.460

High

586307

SNF11
Transcription regulatory protein SNF11

1

0

Small-scale

0.460

High

586313

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

Small-scale

0.460

High

586322

TAF4
Transcription initiation factor TFIID subunit 4

1

0

Small-scale

0.460

High

586332

SPC24
Kinetochore protein SPC24

1

0

High-throughput

0.460

High

586334

TAF7
Transcription initiation factor TFIID subunit 7

1

0

Small-scale

0.460

High

586335

TAF9
Transcription initiation factor TFIID subunit 9

1

0

Small-scale

0.460

High

586336

ARP9
Actin-like protein ARP9

1

0

Small-scale

0.460

High

586350

ARP7
Actin-related protein 7

1

0

Small-scale

0.460

High

406768

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

586260

AFT1
Iron-regulated transcriptional activator AFT1

1

0

Small-scale

0.458

High

586261

TAF2
Transcription initiation factor TFIID subunit 2

1

0

Small-scale

0.458

High

586271

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

586282

TKT2
Transketolase 2

1

0

High-throughput

0.458

High

586287

SPT10
Protein SPT10

1

0

High-throughput

0.458

High

586288

SPT21
Protein SPT21

1

0

High-throughput

0.458

High

586289

DEF1
RNA polymerase II degradation factor 1

1

0

High-throughput

0.458

High

586294

GBLP
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.458

High

586297

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.458

High

586299

PAF1
RNA polymerase II-associated protein 1

1

0

Small-scale

0.458

High

586300

RCK1
Serine/threonine-protein kinase RCK1

1

0

High-throughput

0.458

High

586304

TRA1
Transcription-associated protein 1

1

0

Small-scale

0.458

High

586306

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

High-throughput

0.458

High

586314

ULP2
Ubiquitin-like-specific protease 2

1

0

High-throughput

0.458

High

586315

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

586316

MGA2
Protein MGA2

1

0

Small-scale

0.458

High

586317

T2FB
Transcription initiation factor IIF subunit beta

1

0

Small-scale

0.458

High

586318

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.458

High

586324

TEL2
Telomere length regulation protein TEL2

1

0

Small-scale

0.458

High

586327

HAP5
Transcriptional activator HAP5

1

0

Small-scale

0.458

High

586331

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

586338

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

586344

SCC1
Sister chromatid cohesion protein 1

1

0

High-throughput

0.458

High

586346

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

586352

MED11
Mediator of RNA polymerase II transcription subunit 11

1

0

High-throughput

0.458

High

493163

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.445

High

510213

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

586311

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

586303

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

586264

INO2
Protein INO2

1

0

Small-scale

0.391

High

586272

MET4
Transcriptional activator of sulfur metabolism MET4

1

0

Small-scale

0.391

High

586333

SSL1
General transcription and DNA repair factor IIH subunit SSL1

1

0

Small-scale

0.251

Low

141143

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.249

Low

336197

CCPR
Cytochrome c peroxidase, mitochondrial

1

0

High-throughput

0.249

Low

357873

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

405419

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

407713

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

413295

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.249

Low

425753

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

470853

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.249

Low

472009

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

479912

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

480469

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

482072

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.249

Low

543166

HSC82
ATP-dependent molecular chaperone HSC82

1

0

High-throughput

0.249

Low

586263

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.249

Low

586267

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.249

Low

586278

SMY2
Protein SMY2

1

0

High-throughput

0.249

Low

586283

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.249

Low

586290

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

586295

PDX3
Pyridoxamine 5'-phosphate oxidase

1

0

High-throughput

0.249

Low

586296

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

0

High-throughput

0.249

Low

586309

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

586310

GDI1
Rab GDP-dissociation inhibitor

1

0

High-throughput

0.249

Low

586321

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.249

Low

586326

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.249

Low

586348

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024