Protein: TOP1
DNA topoisomerase 1 (EC 5.6.2.1) (DNA topoisomerase I) (Omega-protein) (Relaxing enzyme) (Swivelase) (Untwisting enzyme)

Gene: TOP1, topA
Organism: Helicobacter pylori 26695
Interactions: 16
UniProt ID: P55991

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0003917 - DNA topoisomerase type I (single strand cut, ATP-independent) activity
GO:0005694 - chromosome
GO:0006265 - DNA topological change
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

202704

O25520
Restriction endonuclease subunit S

1

0

High-throughput

0.438

High

202832

O25604
Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta

1

0

High-throughput

0.438

High

201502

O24956
Cytochrome c oxidase, monoheme subunit, membrane-bound

1

0

High-throughput

0.238

Low

201769

O25061
Pimelyl-ACP methyl ester esterase BioV

1

0

High-throughput

0.238

Low

201895

HCPB
Beta-lactamase HcpB

1

0

High-throughput

0.238

Low

201921

O25106
Lysozyme

1

0

High-throughput

0.238

Low

202754

O25546
Uncharacterized protein

1

0

High-throughput

0.238

Low

202827

O25601
Outer membrane protein

1

0

High-throughput

0.238

Low

202837

O25605
DNA replication/recombination mediator RecO N-terminal domain-containing protein

1

0

High-throughput

0.238

Low

202891

O25638
Uncharacterized protein

1

0

High-throughput

0.238

Low

203377

O26026
Uncharacterized protein

1

0

High-throughput

0.238

Low

203386

O26047
DUF7149 domain-containing protein

1

0

High-throughput

0.238

Low

203423

O26081
Flagellar basal body rod protein FlgB

1

0

High-throughput

0.238

Low

489165

HPN
Histidine-rich metal-binding polypeptide

1

0

High-throughput

0.238

Low

939699

RP54
RNA polymerase sigma-54 factor

1

0

High-throughput

0.238

Low

939700

PYRF
Orotidine 5'-phosphate decarboxylase

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025