Protein: IF5A1
Eukaryotic translation initiation factor 5A-1 (eIF-5A-1) (Hypusine-containing protein HP2) (eIF-4D)

Gene: IF5A1, HYP2
Organism: Saccharomyces cerevisiae S288C
Interactions: 135
UniProt ID: P23301

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0003743 - translation initiation factor activity
GO:0003746 - translation elongation factor activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

615229

IF5A1
Eukaryotic translation initiation factor 5A-1

2

3

Small-scale

0.799

High

581092

IF5A2
Eukaryotic translation initiation factor 5A-2

2

3

High-throughput

0.776

High

615266

DHYS
Deoxyhypusine synthase

3

7

Small-scale

0.674

High

365824

HSP82
ATP-dependent molecular chaperone HSP82

3

2

High-throughput

0.640

High

615281

DOHH
Deoxyhypusine hydroxylase

2

2

Small-scale

0.633

High

615292

BRE5
UBP3-associated protein BRE5

2

0

High-throughput

0.595

High

399332

RLA0
Large ribosomal subunit protein uL10

2

0

Small-scale

0.585

High

410310

SC160
Protein SCP160

2

1

High-throughput

0.584

High

615245

ZUO1
Zuotin

2

1

Small-scale

0.584

High

615279

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

3

High-throughput

0.584

High

510309

SSB1
Ribosome-associated molecular chaperone SSB1

2

2

High-throughput

0.571

High

615271

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

Small-scale

0.571

High

447155

IF2B
Eukaryotic translation initiation factor 2 subunit beta

2

0

Small-scale

0.559

High

477135

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

4

High-throughput

0.543

High

614549

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.536

High

615252

PRS6B
26S proteasome regulatory subunit 6B homolog

1

1

High-throughput

0.536

High

615277

BUD27
Bud site selection protein 27

1

0

Small-scale

0.518

High

434734

PBS2
MAP kinase kinase PBS2

1

1

High-throughput

0.515

High

615230

EFGM
Elongation factor G, mitochondrial

1

3

High-throughput

0.515

High

615288

VPS4
Vacuolar protein sorting-associated protein 4

1

1

High-throughput

0.515

High

341646

ARGI
Arginase

1

0

High-throughput

0.513

High

519859

WHI2
Growth regulation protein

1

0

High-throughput

0.513

High

594108

CKS1
Cyclin-dependent kinases regulatory subunit

1

0

High-throughput

0.513

High

615238

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.513

High

615295

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

615305

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

615306

RBX1
RING-box protein HRT1

1

0

High-throughput

0.513

High

615246

KA122
Importin beta-like protein KAP122

1

0

Small-scale

0.504

High

521112

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.493

High

615243

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

0

High-throughput

0.493

High

615256

ANR2
Uncharacterized protein ANR2

1

0

High-throughput

0.493

High

615275

MKT1
Post-transcriptional regulator MKT1

1

0

High-throughput

0.493

High

615276

GPD2
Glycerol-3-phosphate dehydrogenase [NAD(+)] 2, mitochondrial

1

0

High-throughput

0.493

High

615283

GYP3
GTPase-activating protein GYP3

1

0

High-throughput

0.493

High

615286

LYS4
Homoaconitase, mitochondrial

1

0

High-throughput

0.493

High

615317

POC4
Proteasome chaperone 4

1

0

High-throughput

0.493

High

420232

CALM
Calmodulin

1

1

High-throughput

0.489

High

561109

CDC23
Anaphase-promoting complex subunit CDC23

1

1

High-throughput

0.489

High

367756

EF1A
Elongation factor 1-alpha

1

1

Small-scale

0.479

High

388944

SYTC
Threonine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

389052

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

408275

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

4

High-throughput

0.479

High

410075

EIF3B
Eukaryotic translation initiation factor 3 subunit B

1

2

Small-scale

0.479

High

425776

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

426260

RS19B
Small ribosomal subunit protein eS19B

1

2

Small-scale

0.479

High

477599

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

4

High-throughput

0.479

High

479682

RS4A
Small ribosomal subunit protein eS4A

1

1

Small-scale

0.479

High

498797

RL4A
Large ribosomal subunit protein uL4A

1

2

Small-scale

0.479

High

534886

RL3
Large ribosomal subunit protein uL3

1

1

Small-scale

0.479

High

543228

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

546142

SYKC
Lysine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

564225

RL8A
Large ribosomal subunit protein eL8A

1

1

Small-scale

0.479

High

593817

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

1

Small-scale

0.479

High

604917

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

615239

RL8B
Large ribosomal subunit protein eL8B

1

1

Small-scale

0.479

High

615241

EF2
Elongation factor 2

1

3

Small-scale

0.479

High

615244

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

1

1

Small-scale

0.479

High

615251

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

615257

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

615258

SYG
Glycine--tRNA ligase 1, mitochondrial

1

4

High-throughput

0.479

High

615259

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

1

Small-scale

0.479

High

615262

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

5

High-throughput

0.479

High

615263

YHI0
Putative proline--tRNA ligase YHR020W

1

2

High-throughput

0.479

High

615265

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.479

High

615268

MET30
F-box protein MET30

1

2

High-throughput

0.479

High

615269

RS14B
Small ribosomal subunit protein uS11B

1

1

Small-scale

0.479

High

615287

RL4B
Large ribosomal subunit protein uL4B

1

2

Small-scale

0.479

High

615289

MCM6
DNA replication licensing factor MCM6

1

1

High-throughput

0.479

High

615290

EIF2A
Eukaryotic translation initiation factor 2A

1

2

High-throughput

0.479

High

615298

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

141166

RS9A
Small ribosomal subunit protein uS4A

1

0

High-throughput

0.458

High

405441

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.458

High

406802

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

407738

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

481284

RL2A
Large ribosomal subunit protein uL2A

1

0

Small-scale

0.458

High

615233

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

615234

SYLC
Leucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

615235

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

615240

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

615242

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

615249

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

615250

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

Small-scale

0.458

High

615255

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

615261

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

615264

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

615273

TM108
Protein TMA108

1

0

High-throughput

0.458

High

615274

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

615284

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.458

High

615285

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

615291

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

615293

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

615296

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

615297

RL6A
Large ribosomal subunit protein eL6A

1

0

Small-scale

0.458

High

615300

CLU
Clustered mitochondria protein 1

1

0

Small-scale

0.458

High

615302

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

0

Small-scale

0.458

High

615303

MYO5
Myosin-5

1

0

High-throughput

0.458

High

615307

SGO1
Shugoshin

1

0

High-throughput

0.458

High

615309

TIM18
Mitochondrial import inner membrane translocase subunit TIM18

1

0

High-throughput

0.458

High

615311

TYW1
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase

1

0

Small-scale

0.458

High

615312

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

615314

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

0

Small-scale

0.458

High

615315

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.458

High

615318

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

615231

NAP1
Nucleosome assembly protein

1

0

High-throughput

0.438

High

615260

HSM3
DNA mismatch repair protein HSM3

1

0

High-throughput

0.438

High

413316

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

479934

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

613634

RS3A2
Small ribosomal subunit protein eS1B

1

2

Small-scale

0.437

High

615237

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

615248

RSSA1
Small ribosomal subunit protein uS2A

1

1

High-throughput

0.437

High

615253

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

615267

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

615270

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

615282

MOG1
Nuclear import protein MOG1

1

1

High-throughput

0.437

High

615313

TRMB
tRNA

1

1

High-throughput

0.437

High

615299

GCN5
Histone acetyltransferase GCN5

1

3

High-throughput

0.407

High

470874

RS22A
Small ribosomal subunit protein uS8A

2

0

Small-scale

0.305

High

615232

SIS1
Protein SIS1

2

0

High-throughput

0.305

High

615254

PXA2
Peroxisomal long-chain fatty acid import protein 1

1

0

High-throughput

0.282

High

586363

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.279

Low

615247

KU70
ATP-dependent DNA helicase II subunit 1

1

0

High-throughput

0.279

Low

615272

MED3
Mediator of RNA polymerase II transcription subunit 3

1

0

High-throughput

0.269

Low

615278

IES1
Ino eighty subunit 1

1

0

High-throughput

0.269

Low

615294

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.269

Low

615308

RPN8
26S proteasome regulatory subunit RPN8

1

0

High-throughput

0.269

Low

357893

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

472027

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

480495

RS8A
Small ribosomal subunit protein eS8A

1

0

High-throughput

0.249

Low

615236

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

615280

RL17B
Large ribosomal subunit protein uL22B

1

0

Small-scale

0.249

Low

615301

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.249

Low

615304

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

615310

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

615316

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024