Protein: STAT3
Signal transducer and activator of transcription 3 (Acute-phase response factor)

Gene: STAT3
Organism: Mus musculus
Interactions: 119
UniProt ID: P42227

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

838263

STAT3
Signal transducer and activator of transcription 3

9

16

Small-scale

0.963

High

205458

SOCS3
Suppressor of cytokine signaling 3

7

20

Small-scale

0.951

High

838288

JAK2
Tyrosine-protein kinase JAK2

4

20

Small-scale

0.878

High

838289

JAK3
Tyrosine-protein kinase JAK3

2

20

Small-scale

0.776

High

838264

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.757

High

431331

SRC
Proto-oncogene tyrosine-protein kinase Src

2

16

Small-scale

0.754

High

591009

KPCE
Protein kinase C epsilon type

1

7

Small-scale

0.691

High

838272

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

20

Small-scale

0.691

High

838324

Q99K94
Signal transducer and activator of transcription

1

17

High-throughput

0.621

High

711216

PTN6
Tyrosine-protein phosphatase non-receptor type 6

1

13

Small-scale

0.618

High

777815

VGFR3
Vascular endothelial growth factor receptor 3

1

14

Small-scale

0.618

High

838273

FER
Tyrosine-protein kinase Fer

1

18

Small-scale

0.618

High

838277

TIE2
Angiopoietin-1 receptor

1

17

Small-scale

0.618

High

838282

CDON
Cell adhesion molecule-related/down-regulated by oncogenes

1

1

Small-scale

0.618

High

838296

BOC
Brother of CDO

1

1

Small-scale

0.618

High

838334

Q9QXJ2
Signal transducer and activator of transcription

1

16

Small-scale

0.618

High

838275

PRGR
Progesterone receptor

2

17

Small-scale

0.601

High

432068

JUN
Transcription factor Jun

2

7

Small-scale

0.586

High

370842

FOS
Protein c-Fos

2

12

Small-scale

0.584

High

838292

IL17
Interleukin-17A

2

3

Small-scale

0.584

High

838323

FOXP3
Forkhead box protein P3

2

2

Small-scale

0.584

High

663467

CRYAB
Alpha-crystallin B chain

2

4

Small-scale

0.576

High

778157

BTK
Tyrosine-protein kinase BTK

1

17

Small-scale

0.575

High

236405

DAPK3
Death-associated protein kinase 3

1

3

Small-scale

0.562

High

838294

MK03
Mitogen-activated protein kinase 3

2

5

Small-scale

0.552

High

838295

CDK6
Cyclin-dependent kinase 6

1

1

Small-scale

0.536

High

373667

MYC
Myc proto-oncogene protein

1

4

Small-scale

0.515

High

838268

CEBPG
CCAAT/enhancer-binding protein gamma

1

16

Small-scale

0.515

High

838293

IRAK1
Interleukin-1 receptor-associated kinase 1

1

2

Small-scale

0.515

High

838285

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

5

Small-scale

0.501

High

838279

PO6F1
POU domain, class 6, transcription factor 1

1

3

High-throughput

0.481

High

86317

TMF1
TATA element modulatory factor

1

3

Small-scale

0.479

High

98005

ARI1B
AT-rich interactive domain-containing protein 1B

1

1

Small-scale

0.479

High

147406

ANGP1
Angiopoietin-1

1

4

Small-scale

0.479

High

148217

NFIL3
Nuclear factor interleukin-3-regulated protein

1

8

Small-scale

0.479

High

148606

GATA2
Endothelial transcription factor GATA-2

1

3

Small-scale

0.479

High

236335

PIAS3
E3 SUMO-protein ligase PIAS3

1

5

Small-scale

0.479

High

313401

SP1
Transcription factor Sp1

1

4

Small-scale

0.479

High

405582

GRAB
Granzyme B(G,H)

1

2

Small-scale

0.479

High

478871

PAX1
Paired box protein Pax-1

1

2

Small-scale

0.479

High

482128

JUNB
Transcription factor JunB

1

9

Small-scale

0.479

High

582212

INGR1
Interferon gamma receptor 1

1

14

Small-scale

0.479

High

583133

IRF1
Interferon regulatory factor 1

1

20

Small-scale

0.479

High

594822

IL4RA
Interleukin-4 receptor subunit alpha

1

20

Small-scale

0.479

High

599253

GHR
Growth hormone receptor

1

20

Small-scale

0.479

High

630135

TBXT
T-box transcription factor T

1

6

Small-scale

0.479

High

644259

TAL1
T-cell acute lymphocytic leukemia protein 1 homolog

1

2

Small-scale

0.479

High

647872

GA45B
Growth arrest and DNA damage-inducible protein GADD45 beta

1

1

Small-scale

0.479

High

648020

HNF1A
Hepatocyte nuclear factor 1-alpha

1

3

Small-scale

0.479

High

669407

TNR1A
Tumor necrosis factor receptor superfamily member 1A

1

2

Small-scale

0.479

High

700389

CEBPB
CCAAT/enhancer-binding protein beta

1

13

Small-scale

0.479

High

713191

NOS2
Nitric oxide synthase, inducible

1

3

Small-scale

0.479

High

731963

SCP2
Sterol carrier protein 2

1

1

Small-scale

0.479

High

771398

HES1
Transcription factor HES-1

1

3

Small-scale

0.479

High

838265

RORG
Nuclear receptor ROR-gamma

1

14

Small-scale

0.479

High

838267

CEBPA
CCAAT/enhancer-binding protein alpha

1

8

Small-scale

0.479

High

838270

RACK1
Small ribosomal subunit protein RACK1

1

6

Small-scale

0.479

High

838271

NCOA1
Nuclear receptor coactivator 1

1

10

Small-scale

0.479

High

838274

LDB1
LIM domain-binding protein 1

1

1

Small-scale

0.479

High

838276

LYAM3
P-selectin

1

2

Small-scale

0.479

High

838278

ECT2
Protein ECT2

1

1

Small-scale

0.479

High

838280

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

4

Small-scale

0.479

High

838281

GSK3A
Glycogen synthase kinase-3 alpha

1

4

Small-scale

0.479

High

838283

STING
Stimulator of interferon genes protein

1

4

High-throughput

0.479

High

838287

I10R1
Interleukin-10 receptor subunit alpha

1

14

Small-scale

0.479

High

838290

SPTB2
Spectrin beta chain, non-erythrocytic 1

1

6

Small-scale

0.479

High

838297

HDAC4
Histone deacetylase 4

1

12

Small-scale

0.479

High

838298

PAXI1
PAX-interacting protein 1

1

4

Small-scale

0.479

High

838299

RIGI
Antiviral innate immune response receptor RIG-I

1

1

High-throughput

0.479

High

838302

SPOP
Speckle-type POZ protein

1

1

High-throughput

0.479

High

838303

ASAP2
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2

1

5

Small-scale

0.479

High

838305

IL17F
Interleukin-17F

1

3

Small-scale

0.479

High

838310

DZIP1
Cilium assembly protein DZIP1

1

3

Small-scale

0.479

High

838311

RFOX2
RNA binding protein fox-1 homolog 2

1

1

Small-scale

0.479

High

838312

GBP5
Guanylate-binding protein 5

1

2

Small-scale

0.479

High

838315

BAG4
BAG family molecular chaperone regulator 4

1

5

Small-scale

0.479

High

838316

ZN467
Zinc finger protein 467

1

2

Small-scale

0.479

High

838318

CADM4
Cell adhesion molecule 4

1

1

Small-scale

0.479

High

838320

ELP2
Elongator complex protein 2

1

8

Small-scale

0.479

High

838321

EED
Polycomb protein EED

1

4

High-throughput

0.479

High

838329

NDUAD
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13

1

1

Small-scale

0.479

High

838332

SMAD9
Mothers against decapentaplegic homolog 9

1

2

Small-scale

0.479

High

838336

GSK3B
Glycogen synthase kinase-3 beta

1

5

Small-scale

0.479

High

838337

BCL3
B-cell lymphoma 3 protein homolog

1

8

Small-scale

0.479

High

148420

RGS2
Regulator of G-protein signaling 2

1

0

Small-scale

0.458

High

377075

COLI
Pro-opiomelanocortin

1

0

Small-scale

0.458

High

616828

SDC1
Syndecan-1

1

0

Small-scale

0.458

High

838266

EFNB1
Ephrin-B1

1

0

Small-scale

0.458

High

838269

PCBP1
Poly(rC)-binding protein 1

1

0

Small-scale

0.458

High

838286

CTNA2
Catenin alpha-2

1

0

Small-scale

0.458

High

838307

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.458

High

838309

GBRA5
Gamma-aminobutyric acid receptor subunit alpha-5

1

0

Small-scale

0.458

High

838314

NAV1
Neuron navigator 1

1

0

Small-scale

0.458

High

838317

PDK1L
Serine/threonine-protein kinase PDIK1L

1

0

Small-scale

0.458

High

838319

ZNG1
Zinc-regulated GTPase metalloprotein activator 1

1

0

Small-scale

0.458

High

838322

STEA4
Metalloreductase STEAP4

1

0

Small-scale

0.458

High

838326

GGYF1
GRB10-interacting GYF protein 1

1

0

Small-scale

0.458

High

838327

QCR10
Cytochrome b-c1 complex subunit 10

1

0

Small-scale

0.458

High

838328

SRFB1
Serum response factor-binding protein 1

1

0

Small-scale

0.458

High

838330

S40A1
Ferroportin

1

0

Small-scale

0.458

High

838331

RT34
Small ribosomal subunit protein mS34

1

0

Small-scale

0.458

High

838333

PORCN
Protein-serine O-palmitoleoyltransferase porcupine

1

0

Small-scale

0.458

High

204770

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.457

High

266652

STMN3
Stathmin-3

1

2

Small-scale

0.457

High

403092

K2C1
Keratin, type II cytoskeletal 1

1

1

High-throughput

0.457

High

572874

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.457

High

838304

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

6

High-throughput

0.457

High

236814

LAT
Linker for activation of T-cells family member 1

1

1

High-throughput

0.445

High

838306

CP110
Centriolar coiled-coil protein of 110 kDa

1

0

High-throughput

0.438

High

838308

BANK1
B-cell scaffold protein with ankyrin repeats

1

0

High-throughput

0.438

High

838325

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.438

High

555568

FGL2
Fibroleukin

1

4

Small-scale

0.437

High

838284

SEM3G
Semaphorin-3G

1

1

Small-scale

0.437

High

838301

Q6ZPV5
MKIAA1235 protein

1

1

Small-scale

0.437

High

838313

INLR1
Interferon lambda receptor 1

1

14

Small-scale

0.437

High

838335

ANGL2
Angiopoietin-related protein 2

1

4

Small-scale

0.437

High

838291

TSN7
Tetraspanin-7

1

0

Small-scale

0.249

Low

838300

Q6YIY0
Gag protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025