Protein: IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial (EC 1.1.1.41) (Isocitric dehydrogenase) (NAD(+)-specific ICDH)

Gene: IDH2
Organism: Saccharomyces cerevisiae S288C
Interactions: 149
UniProt ID: P28241

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004449 - isocitrate dehydrogenase (NAD+) activity
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

657035

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

13

12

Small-scale

0.980

High

657076

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

12

High-throughput

0.691

High

477971

HSP77
Import motor subunit, mitochondrial

3

8

High-throughput

0.640

High

602427

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

High-throughput

0.618

High

657054

LONM
Lon protease homolog, mitochondrial

2

4

High-throughput

0.588

High

543320

HSC82
ATP-dependent molecular chaperone HSC82

2

6

High-throughput

0.584

High

657046

HSP78
Heat shock protein 78, mitochondrial

2

4

High-throughput

0.571

High

373217

COX4
Cytochrome c oxidase subunit 4, mitochondrial

2

0

High-throughput

0.559

High

637115

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

2

0

High-throughput

0.559

High

657113

RUVB2
RuvB-like protein 2

2

2

High-throughput

0.558

High

493366

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

367810

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.536

High

424379

PYR1
Multifunctional protein URA2

1

3

High-throughput

0.536

High

657049

GCN1
eIF-2-alpha kinase activator GCN1

1

3

High-throughput

0.536

High

657095

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

3

High-throughput

0.536

High

657097

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

657111

NEW1
[NU+] prion formation protein 1

1

2

High-throughput

0.536

High

365911

HSP82
ATP-dependent molecular chaperone HSP82

2

6

High-throughput

0.521

High

340051

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.513

High

657061

DBP8
ATP-dependent RNA helicase DBP8

1

0

High-throughput

0.513

High

360774

TBB
Tubulin beta chain

1

1

High-throughput

0.489

High

454216

TBA1
Tubulin alpha-1 chain

1

2

High-throughput

0.489

High

490532

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.489

High

657037

DBF20
Serine/threonine-protein kinase DBF20

1

3

High-throughput

0.489

High

657045

PRS6B
26S proteasome regulatory subunit 6B homolog

1

2

High-throughput

0.489

High

657050

SIP2
SNF1 protein kinase subunit beta-2

1

1

High-throughput

0.489

High

657059

RCK1
Serine/threonine-protein kinase RCK1

1

1

High-throughput

0.489

High

657069

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.489

High

657073

IMB4
Importin subunit beta-4

1

3

High-throughput

0.489

High

657084

RSSA2
Small ribosomal subunit protein uS2B

1

5

High-throughput

0.489

High

341953

ATPB
ATP synthase subunit beta, mitochondrial

1

3

High-throughput

0.479

High

343097

THDH
Threonine dehydratase, mitochondrial

1

3

High-throughput

0.479

High

382992

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.479

High

405479

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.479

High

406848

RS3
Small ribosomal subunit protein uS3

1

2

High-throughput

0.479

High

423584

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

1

High-throughput

0.479

High

423785

ATPA
ATP synthase subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

425528

PUT2
Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

425812

RS19A
Small ribosomal subunit protein eS19A

1

2

High-throughput

0.479

High

427198

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

2

High-throughput

0.479

High

482126

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

485666

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.479

High

558577

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

567939

MDHM
Malate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

584129

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.479

High

587972

HSP60
Heat shock protein 60, mitochondrial

1

5

High-throughput

0.479

High

596620

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

612928

AIM17
Probable oxidoreductase AIM17

1

1

High-throughput

0.479

High

630775

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

3

High-throughput

0.479

High

638658

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.479

High

641312

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

1

High-throughput

0.479

High

650208

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

1

High-throughput

0.479

High

657042

PREP
Presequence protease, mitochondrial

1

2

High-throughput

0.479

High

657051

MDJ1
DnaJ homolog 1, mitochondrial

1

1

High-throughput

0.479

High

657052

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

657053

MIC60
MICOS complex subunit MIC60

1

2

High-throughput

0.479

High

657063

TOM71
Protein TOM71

1

3

High-throughput

0.479

High

657070

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

1

High-throughput

0.479

High

657072

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

3

High-throughput

0.479

High

657081

ETFB
Probable electron transfer flavoprotein subunit beta

1

1

High-throughput

0.479

High

657083

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

3

High-throughput

0.479

High

657089

ALAM
Probable alanine aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

657094

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

657098

COX12
Cytochrome c oxidase subunit 12, mitochondrial

1

1

High-throughput

0.479

High

657099

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

657100

ABF2
ARS-binding factor 2, mitochondrial

1

3

Small-scale

0.479

High

657101

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

1

High-throughput

0.479

High

657102

RT10
Small ribosomal subunit protein uS10m

1

3

High-throughput

0.479

High

657105

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

2

High-throughput

0.479

High

657110

RS10A
Small ribosomal subunit protein eS10A

1

3

High-throughput

0.479

High

657114

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

410770

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

634984

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

635959

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.458

High

653054

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.458

High

657034

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.458

High

657041

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

657044

YPT7
Ypt/Rab-type GTPase YPT7

1

0

Small-scale

0.458

High

657058

GRPE
GrpE protein homolog, mitochondrial

1

0

High-throughput

0.458

High

657064

BCA1
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

High-throughput

0.458

High

657067

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

657077

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

657078

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.458

High

657082

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

0

High-throughput

0.458

High

657091

SUCA
Succinate--CoA ligase [ADP-forming] subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

657080

BNI1
Protein BNI1

1

1

High-throughput

0.457

High

565482

PHO85
Cyclin-dependent protein kinase PHO85

1

5

High-throughput

0.457

High

586367

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.457

High

632516

DMC1
Meiotic recombination protein DMC1

1

1

High-throughput

0.457

High

657066

TCPB
T-complex protein 1 subunit beta

1

2

High-throughput

0.457

High

657071

HAT2
Histone acetyltransferase type B subunit 2

1

6

High-throughput

0.457

High

657079

COPB2
Coatomer subunit beta'

1

6

High-throughput

0.457

High

657090

RPN14
26S proteasome regulatory subunit RPN14

1

8

High-throughput

0.457

High

657104

UTP5
U3 small nucleolar RNA-associated protein 5

1

3

High-throughput

0.457

High

541629

SEC63
Protein translocation protein SEC63

1

2

High-throughput

0.445

High

141200

RS9A
Small ribosomal subunit protein uS4A

1

2

High-throughput

0.437

High

339487

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.437

High

357930

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

407776

RS13
Small ribosomal subunit protein uS15

1

2

High-throughput

0.437

High

413351

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

470908

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

472059

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

479968

RS6A
Small ribosomal subunit protein eS6A

1

2

High-throughput

0.437

High

480530

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.437

High

524198

CAF20
Cap-associated protein CAF20

1

1

High-throughput

0.437

High

627760

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

631717

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.437

High

645300

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.437

High

657036

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

657038

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.437

High

657040

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.437

High

657043

RSSA1
Small ribosomal subunit protein uS2A

1

5

High-throughput

0.437

High

657048

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

657055

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.437

High

657060

RS20
Small ribosomal subunit protein uS10

1

3

High-throughput

0.437

High

657068

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

657086

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.437

High

657087

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.437

High

657088

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

657092

COPA
Coatomer subunit alpha

1

6

High-throughput

0.437

High

657096

H3
Histone H3

1

1

High-throughput

0.437

High

657103

RUVB1
RuvB-like protein 1

1

2

High-throughput

0.437

High

657106

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

657109

MCA1
Metacaspase-1

1

1

High-throughput

0.437

High

657112

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.437

High

372805

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

4

High-throughput

0.407

High

510490

SSB1
Ribosome-associated molecular chaperone SSB1

1

6

High-throughput

0.407

High

555862

VATB
V-type proton ATPase subunit B

1

3

High-throughput

0.407

High

657047

IXR1
Intrastrand cross-link recognition protein

1

3

High-throughput

0.407

High

657074

SCS2
Vesicle-associated membrane protein-associated protein SCS2

1

1

High-throughput

0.407

High

657075

SSB2
Ribosome-associated molecular chaperone SSB2

1

6

High-throughput

0.407

High

657085

NMD5
Nonsense-mediated mRNA decay protein 5

1

4

High-throughput

0.407

High

502960

SEC7
Protein transport protein SEC7

2

0

High-throughput

0.324

High

440864

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

2

0

High-throughput

0.313

High

420474

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.279

Low

429652

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.279

Low

619181

SPO13
Meiosis-specific protein SPO13

1

0

High-throughput

0.279

Low

541525

AMPL
Vacuolar aminopeptidase 1

1

0

High-throughput

0.265

Low

629538

CDC10
Cell division control protein 10

1

0

High-throughput

0.261

Low

657039

ARP2
Actin-related protein 2

1

0

High-throughput

0.261

Low

657108

SHS1
Seventh homolog of septin 1

1

0

High-throughput

0.261

Low

425507

PROF
Profilin

1

0

High-throughput

0.249

Low

633831

SGF29
SAGA-associated factor 29

1

0

Small-scale

0.249

Low

657056

GID4
Vacuolar import and degradation protein 24

1

0

High-throughput

0.249

Low

657057

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.249

Low

657062

GOSR1
Golgi SNAP receptor complex member 1

1

0

High-throughput

0.249

Low

657065

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

657093

NSG2
Protein NSG2

1

0

High-throughput

0.249

Low

657107

NCS1
Calcium-binding protein NCS-1

1

0

High-throughput

0.238

Low


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Last updated: 15 Jul 2024