Protein: EIF3C
Eukaryotic translation initiation factor 3 subunit C (eIF3c) (Eukaryotic translation initiation factor 3 93 kDa subunit) (eIF3 p93) (Nuclear transport protein NIP1) (Translation initiation factor eIF3, p93 subunit)

Gene: EIF3C, NIP1
Organism: Saccharomyces cerevisiae S288C
Interactions: 156
UniProt ID: P32497

Gene Ontology (top 5):
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity
GO:0005737 - cytoplasm
GO:0005852 - eukaryotic translation initiation factor 3 complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

691516

SUI1
Eukaryotic translation initiation factor eIF-1

12

3

Small-scale

0.982

High

691536

IF5
Eukaryotic translation initiation factor 5

17

3

Small-scale

0.766

High

691533

EIF3A
Eukaryotic translation initiation factor 3 subunit A

16

6

Small-scale

0.764

High

410093

EIF3B
Eukaryotic translation initiation factor 3 subunit B

14

5

Small-scale

0.761

High

691549

EIF3I
Eukaryotic translation initiation factor 3 subunit I

10

3

Small-scale

0.756

High

691588

EIF3G
Eukaryotic translation initiation factor 3 subunit G

7

3

Small-scale

0.746

High

691592

EIF3J
Eukaryotic translation initiation factor 3 subunit J

6

0

Small-scale

0.699

High

690895

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

4

4

High-throughput

0.694

High

691547

IF2P
Eukaryotic translation initiation factor 5B

4

1

Small-scale

0.691

High

691528

GBLP
Small ribosomal subunit protein RACK1

4

2

Small-scale

0.681

High

691556

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

7

High-throughput

0.675

High

691513

EIF3C
Eukaryotic translation initiation factor 3 subunit C

1

1

High-throughput

0.665

High

691585

RLI1
Translation initiation factor RLI1

3

1

Small-scale

0.656

High

691515

RSSA1
Small ribosomal subunit protein uS2A

3

1

Small-scale

0.646

High

447169

IF2B
Eukaryotic translation initiation factor 2 subunit beta

3

3

Small-scale

0.642

High

691543

CSK2C
Casein kinase II subunit beta'

2

2

High-throughput

0.621

High

691575

BRE5
UBP3-associated protein BRE5

2

2

High-throughput

0.621

High

593045

RPB4
DNA-directed RNA polymerase II subunit RPB4

2

0

Small-scale

0.618

High

415919

DED1
ATP-dependent RNA helicase DED1

2

1

High-throughput

0.611

High

691519

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

2

0

High-throughput

0.602

High

691607

IF6
Eukaryotic translation initiation factor 6

2

1

High-throughput

0.601

High

691250

MYO4
Myosin-4

2

1

High-throughput

0.588

High

691531

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

2

3

High-throughput

0.588

High

691524

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.586

High

141221

RS9A
Small ribosomal subunit protein uS4A

2

0

High-throughput

0.585

High

691530

OLA1
Obg-like ATPase 1

2

1

High-throughput

0.571

High

406888

RS3
Small ribosomal subunit protein uS3

2

0

Small-scale

0.569

High

691605

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

High-throughput

0.563

High

510628

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.552

High

675891

XPO1
Exportin-1

1

3

High-throughput

0.536

High

691558

CSK2B
Casein kinase II subunit beta

1

2

High-throughput

0.536

High

691564

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.536

High

691580

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

4

High-throughput

0.536

High

691609

DUF1
DUB-associated factor 1

1

3

High-throughput

0.536

High

691594

BRE1
E3 ubiquitin-protein ligase BRE1

2

1

Small-scale

0.533

High

493466

HSP72
Heat shock protein SSA2

2

0

High-throughput

0.528

High

627822

SIS1
Protein SIS1

1

1

High-throughput

0.515

High

635697

TAH1
TPR repeat-containing protein associated with Hsp90

1

1

High-throughput

0.515

High

691573

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.515

High

691604

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

1

High-throughput

0.515

High

691522

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

Small-scale

0.513

High

691539

PIH1
Protein interacting with Hsp90 1

1

0

High-throughput

0.493

High

691551

YRB2
Ran-specific GTPase-activating protein 2

1

0

High-throughput

0.493

High

691595

TMC1
AN1-type zinc finger protein TMC1

1

0

High-throughput

0.493

High

613657

RS3A2
Small ribosomal subunit protein eS1B

1

1

High-throughput

0.489

High

691529

TAF5
Transcription initiation factor TFIID subunit 5

1

3

High-throughput

0.489

High

691535

ARPC1
Actin-related protein 2/3 complex subunit 1

1

4

High-throughput

0.489

High

691587

GCN5
Histone acetyltransferase GCN5

1

4

High-throughput

0.489

High

691601

HUA2
Protein HUA2

1

0

High-throughput

0.486

High

688864

SMY1
Kinesin-related protein SMY1

1

1

High-throughput

0.481

High

691544

END3
Actin cytoskeleton-regulatory complex protein END3

1

1

High-throughput

0.481

High

339517

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

408304

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

1

High-throughput

0.479

High

424832

IF4E
Eukaryotic translation initiation factor 4E

1

1

Small-scale

0.479

High

485678

IF4A
ATP-dependent RNA helicase eIF4A

1

4

Small-scale

0.479

High

543399

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

634112

SRO9
RNA-binding protein SRO9

1

1

High-throughput

0.479

High

680532

HS104
Heat shock protein 104

1

1

High-throughput

0.479

High

691520

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

691537

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

691571

CDH1
APC/C activator protein CDH1

1

4

Small-scale

0.479

High

691586

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

691560

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.460

High

407801

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

410338

SC160
Protein SCP160

1

0

High-throughput

0.458

High

413380

RS14A
Small ribosomal subunit protein uS11A

1

0

High-throughput

0.458

High

419833

SNF1
Carbon catabolite-derepressing protein kinase

1

0

Small-scale

0.458

High

482147

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

524224

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

593827

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.458

High

631742

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

644979

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

664703

BMH1
Protein BMH1

1

0

High-throughput

0.458

High

691517

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

691538

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

691550

TM108
Protein TMA108

1

0

High-throughput

0.458

High

691553

RLP7
Ribosome biogenesis protein RLP7

1

0

High-throughput

0.458

High

691562

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

691581

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

691598

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

691602

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

691603

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

High-throughput

0.458

High

549981

CSK21
Casein kinase II subunit alpha

1

8

Small-scale

0.457

High

365987

HSP82
ATP-dependent molecular chaperone HSP82

1

2

High-throughput

0.445

High

585276

MYO2
Myosin-2

1

1

High-throughput

0.445

High

691518

PRS7
26S proteasome regulatory subunit 7 homolog

1

1

High-throughput

0.445

High

691548

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

691523

CASP
Protein CASP

1

1

High-throughput

0.439

High

392083

H2A1
Histone H2A.1

1

1

High-throughput

0.437

High

392351

H2A2
Histone H2A.2

1

1

High-throughput

0.437

High

481485

RS11B
Small ribosomal subunit protein uS17B

1

1

High-throughput

0.437

High

638681

SPB4
ATP-dependent rRNA helicase SPB4

1

2

High-throughput

0.437

High

691521

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

691525

CENPA
Histone H3-like centromeric protein CSE4

1

1

High-throughput

0.437

High

691527

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.437

High

691566

UBC9
SUMO-conjugating enzyme UBC9

1

1

High-throughput

0.437

High

691574

COPA
Coatomer subunit alpha

1

1

High-throughput

0.437

High

691578

NUM1
Nuclear migration protein NUM1

1

1

High-throughput

0.437

High

691583

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.437

High

691591

HRQ1
ATP-dependent helicase HRQ1

1

2

Small-scale

0.437

High

340073

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

376687

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

0

Small-scale

0.426

High

424405

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

555900

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

633045

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

691540

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

691545

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

691554

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.426

High

691526

LHS1
Heat shock protein 70 homolog LHS1

1

1

High-throughput

0.407

High

691557

ERJ5
ER-localized J domain-containing protein 5

1

1

High-throughput

0.407

High

691559

RSSA2
Small ribosomal subunit protein uS2B

1

1

High-throughput

0.407

High

691565

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

1

High-throughput

0.407

High

691582

ADA2
Transcriptional adapter 2

1

1

High-throughput

0.407

High

661649

TF2B
Transcription initiation factor IIB

3

0

High-throughput

0.335

High

691579

MCE1
mRNA-capping enzyme subunit alpha

2

0

High-throughput

0.324

High

357950

RS17A
Small ribosomal subunit protein eS17A

2

0

High-throughput

0.318

High

470932

RS22A
Small ribosomal subunit protein uS8A

2

0

High-throughput

0.318

High

645324

RS7A
Small ribosomal subunit protein eS7A

2

0

High-throughput

0.318

High

480551

RS8A
Small ribosomal subunit protein eS8A

2

0

High-throughput

0.305

High

691569

YGI1
Uncharacterized protein YGL081W

1

0

High-throughput

0.279

Low

691570

SGF73
SAGA-associated factor 73

1

0

High-throughput

0.279

Low

691600

HFI1
Transcriptional coactivator HFI1/ADA1

1

0

High-throughput

0.279

Low

691532

SLT11
Pre-mRNA-splicing factor SLT11

1

0

High-throughput

0.269

Low

691568

MLC1
Myosin light chain 1

1

0

High-throughput

0.269

Low

691599

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.269

Low

691576

SLM2
Phosphatidylinositol 4,5-bisphosphate-binding protein SLM2

1

0

High-throughput

0.265

Low

691584

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.251

Low

356330

H4
Histone H4

1

0

High-throughput

0.249

Low

383017

RL25
Large ribosomal subunit protein uL23

1

0

High-throughput

0.249

Low

405501

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

425828

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

472083

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.249

Low

479988

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

619432

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

691514

SPT16
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

691534

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

691541

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

691546

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

691552

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

691555

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.249

Low

691561

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

691563

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

691577

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

691589

DHR1
Probable ATP-dependent RNA helicase DHR1

1

0

High-throughput

0.249

Low

691593

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

691596

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.249

Low

691597

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

691606

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.249

Low

691610

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

659137

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.232

Low

691542

SPT8
Transcription factor SPT8

1

0

High-throughput

0.232

Low

691567

SPT20
Transcription factor SPT20

1

0

High-throughput

0.232

Low

691572

YG1A
Uncharacterized membrane protein YGR016W

1

0

High-throughput

0.232

Low

691590

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.232

Low

691608

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024