Protein: EIF3A
Eukaryotic translation initiation factor 3 subunit A (eIF3a) (Eukaryotic translation initiation factor 3 110 kDa subunit homolog) (eIF3 p110) (Translation initiation factor eIF3, p110 subunit homolog)

Gene: EIF3A, RPG1
Organism: Saccharomyces cerevisiae S288C
Interactions: 168
UniProt ID: P38249

Gene Ontology (top 5):
GO:0000131 - incipient cellular bud site
GO:0001732 - formation of cytoplasmic translation initiation complex
GO:0002188 - translation reinitiation
GO:0003729 - mRNA binding
GO:0003743 - translation initiation factor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

410112

EIF3B
Eukaryotic translation initiation factor 3 subunit B

19

8

Small-scale

0.768

High

691533

EIF3C
Eukaryotic translation initiation factor 3 subunit C

16

6

Small-scale

0.764

High

746996

EIF3I
Eukaryotic translation initiation factor 3 subunit I

12

18

Small-scale

0.756

High

747036

EIF3G
Eukaryotic translation initiation factor 3 subunit G

12

11

Small-scale

0.756

High

746975

IF5
Eukaryotic translation initiation factor 5

7

6

Small-scale

0.746

High

701204

SUI1
Eukaryotic translation initiation factor eIF-1

7

2

Small-scale

0.744

High

747038

EIF3J
Eukaryotic translation initiation factor 3 subunit J

9

0

Small-scale

0.722

High

690914

IF2G
Eukaryotic translation initiation factor 2 subunit gamma

5

5

Small-scale

0.709

High

700370

RSSA1
Small ribosomal subunit protein uS2A

4

3

Small-scale

0.698

High

593842

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

4

2

Small-scale

0.694

High

491020

HSP71
Heat shock protein SSA1

4

13

High-throughput

0.666

High

447181

IF2B
Eukaryotic translation initiation factor 2 subunit beta

3

3

Small-scale

0.662

High

746983

CSK2C
Casein kinase II subunit beta'

3

3

Small-scale

0.662

High

747031

RLI1
Translation initiation factor RLI1

3

4

Small-scale

0.662

High

407003

RS3
Small ribosomal subunit protein uS3

3

1

Small-scale

0.646

High

543629

HSC82
ATP-dependent molecular chaperone HSC82

3

9

High-throughput

0.643

High

627963

SIS1
Protein SIS1

3

3

High-throughput

0.643

High

631837

RS2
Small ribosomal subunit protein uS5

3

1

Small-scale

0.640

High

746988

IF2P
Eukaryotic translation initiation factor 5B

3

8

Small-scale

0.640

High

141293

RS9A
Small ribosomal subunit protein uS4A

2

2

High-throughput

0.611

High

407875

RS13
Small ribosomal subunit protein uS15

2

2

High-throughput

0.611

High

747007

CSK2B
Casein kinase II subunit beta

2

3

Small-scale

0.611

High

747058

IF6
Eukaryotic translation initiation factor 6

2

2

High-throughput

0.601

High

662047

TF2B
Transcription initiation factor IIB

3

1

High-throughput

0.587

High

376765

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

2

7

Small-scale

0.584

High

742757

GBLP
Small ribosomal subunit protein RACK1

2

20

Small-scale

0.584

High

746977

OTU2
OTU domain-containing protein 2

2

2

Small-scale

0.584

High

704776

SLA2
Protein SLA2

1

20

Small-scale

0.573

High

366192

HSP82
ATP-dependent molecular chaperone HSP82

2

9

High-throughput

0.571

High

478135

HSP77
Import motor subunit, mitochondrial

2

18

High-throughput

0.571

High

680654

HS104
Heat shock protein 104

2

2

High-throughput

0.571

High

519584

ERF1
Eukaryotic peptide chain release factor subunit 1

2

0

High-throughput

0.563

High

747054

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

High-throughput

0.563

High

454298

TBA1
Tubulin alpha-1 chain

1

2

Small-scale

0.561

High

710007

RPB7
DNA-directed RNA polymerase II subunit RPB7

2

0

Small-scale

0.559

High

645404

RS7A
Small ribosomal subunit protein eS7A

2

2

High-throughput

0.558

High

511084

SSB1
Ribosome-associated molecular chaperone SSB1

2

13

High-throughput

0.552

High

584719

CSK22
Casein kinase II subunit alpha'

2

20

Small-scale

0.549

High

588052

HSP60
Heat shock protein 60, mitochondrial

2

9

High-throughput

0.537

High

509421

CDC24
Cell division control protein 24

1

18

High-throughput

0.536

High

675998

XPO1
Exportin-1

1

9

High-throughput

0.536

High

746999

MOB1
DBF2 kinase activator protein MOB1

1

6

High-throughput

0.536

High

747019

BRE5
UBP3-associated protein BRE5

1

5

High-throughput

0.536

High

747025

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

13

High-throughput

0.536

High

747060

DUF1
DUB-associated factor 1

1

20

High-throughput

0.536

High

746987

LAA1
AP-1 accessory protein LAA1

2

1

High-throughput

0.535

High

480632

RS8A
Small ribosomal subunit protein eS8A

2

2

High-throughput

0.533

High

425913

RS19A
Small ribosomal subunit protein eS19A

2

1

High-throughput

0.521

High

747008

RSSA2
Small ribosomal subunit protein uS2B

2

3

Small-scale

0.521

High

679959

2AAA
Protein phosphatase PP2A regulatory subunit A

1

5

High-throughput

0.515

High

593060

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

Small-scale

0.513

High

565560

PHO85
Cyclin-dependent protein kinase PHO85

1

17

Small-scale

0.501

High

747039

POC1
Proteasome chaperone 1

1

0

High-throughput

0.493

High

747045

TMC1
AN1-type zinc finger protein TMC1

1

0

High-throughput

0.493

High

746984

END3
Actin cytoskeleton-regulatory complex protein END3

1

16

High-throughput

0.481

High

746997

TBP6
Probable 26S proteasome subunit YTA6

1

6

High-throughput

0.481

High

747055

GYP5
GTPase-activating protein GYP5

1

3

High-throughput

0.481

High

624627

PCL1
PHO85 cyclin-1

1

0

Small-scale

0.480

High

339595

CDK1
Cyclin-dependent kinase 1

1

14

High-throughput

0.479

High

402937

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

3

Small-scale

0.479

High

408339

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

9

High-throughput

0.479

High

413469

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

415957

DED1
ATP-dependent RNA helicase DED1

1

6

High-throughput

0.479

High

434752

PBS2
MAP kinase kinase PBS2

1

20

High-throughput

0.479

High

479730

RS4A
Small ribosomal subunit protein eS4A

1

3

High-throughput

0.479

High

482230

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

536287

CPYI
Carboxypeptidase Y inhibitor

1

1

Small-scale

0.479

High

601753

RCC1
Guanine nucleotide exchange factor SRM1

1

6

High-throughput

0.479

High

605018

XRN1
5'-3' exoribonuclease 1

1

1

Small-scale

0.479

High

605988

RAD53
Serine/threonine-protein kinase RAD53

1

8

High-throughput

0.479

High

615259

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

Small-scale

0.479

High

645013

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

704328

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.479

High

729873

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

733654

LAS1
Protein LAS1

1

1

Small-scale

0.479

High

746562

OLA1
Obg-like ATPase 1

1

2

High-throughput

0.479

High

746976

RS20
Small ribosomal subunit protein uS10

1

2

High-throughput

0.479

High

746978

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

746982

IF1A
Eukaryotic translation initiation factor 1A

1

1

High-throughput

0.479

High

746986

DHH1
ATP-dependent RNA helicase DHH1

1

13

High-throughput

0.479

High

746989

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

13

Small-scale

0.479

High

746990

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

14

Small-scale

0.479

High

746993

ARB1
ABC transporter ATP-binding protein ARB1

1

3

Small-scale

0.479

High

747003

RLP7
Ribosome biogenesis protein RLP7

1

2

High-throughput

0.479

High

747011

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

747016

CDH1
APC/C activator protein CDH1

1

20

Small-scale

0.479

High

747017

EIF2A
Eukaryotic translation initiation factor 2A

1

8

High-throughput

0.479

High

747020

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

747026

RS15
Small ribosomal subunit protein uS19

1

1

High-throughput

0.479

High

747032

TOM1
E3 ubiquitin-protein ligase TOM1

1

8

High-throughput

0.479

High

747049

NEW1
[NU+] prion formation protein 1

1

4

High-throughput

0.479

High

747053

RIO1
Serine/threonine-protein kinase RIO1

1

4

High-throughput

0.479

High

700168

RT04
Small ribosomal subunit protein uS2m

1

3

High-throughput

0.470

High

728867

OSH1
Oxysterol-binding protein homolog 1

1

1

High-throughput

0.470

High

747015

MLC1
Myosin light chain 1

1

14

High-throughput

0.470

High

747057

OSH2
Oxysterol-binding protein homolog 2

1

1

High-throughput

0.470

High

746992

VAB2
Biogenesis of lysosome-related organelles complex 1 subunit VAB2

1

0

High-throughput

0.460

High

747009

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.460

High

747044

NDE1
Nuclear distribution protein nudE homolog 1

1

0

High-throughput

0.460

High

524272

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

700860

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

746973

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

746980

SDO1L
Restriction of telomere capping protein 3

1

0

Small-scale

0.458

High

746998

TM108
Protein TMA108

1

0

High-throughput

0.458

High

747000

CSN11
Cop9 signalosome complex subunit 11

1

0

Small-scale

0.458

High

747013

PSP2
Protein PSP2

1

0

High-throughput

0.458

High

747029

ESP1
Separin

1

0

High-throughput

0.458

High

747030

SVL3
Styryl dye vacuolar localization protein 3

1

0

High-throughput

0.458

High

747035

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

747046

SGO1
Shugoshin

1

0

High-throughput

0.458

High

747050

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

747056

CSN10
COP9 signalosome complex subunit 10

1

0

Small-scale

0.458

High

360853

TBB
Tubulin beta chain

1

2

High-throughput

0.445

High

424480

PYR1
Multifunctional protein URA2

1

2

High-throughput

0.445

High

450026

HSP73
Heat shock protein SSA3

1

13

High-throughput

0.445

High

493796

HSP72
Heat shock protein SSA2

1

13

High-throughput

0.445

High

633172

MAS5
Mitochondrial protein import protein MAS5

1

4

High-throughput

0.445

High

694573

HSP7F
Heat shock protein homolog SSE1

1

16

High-throughput

0.445

High

695952

HSP79
Heat shock protein homolog SSE2

1

16

High-throughput

0.445

High

715787

MDJ1
DnaJ homolog 1, mitochondrial

1

4

High-throughput

0.445

High

746979

SSZ1
Ribosome-associated complex subunit SSZ1

1

13

High-throughput

0.445

High

746991

HSP7E
Heat shock protein SSC3, mitochondrial

1

18

High-throughput

0.445

High

746994

SSB2
Ribosome-associated molecular chaperone SSB2

1

13

High-throughput

0.445

High

746995

RIO2
Serine/threonine-protein kinase RIO2

1

4

Small-scale

0.445

High

747021

JJJ1
J protein JJJ1

1

7

High-throughput

0.445

High

747051

NOP53
Ribosome biogenesis protein NOP53

1

1

High-throughput

0.439

High

358031

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.437

High

383102

RL25
Large ribosomal subunit protein uL23

1

2

High-throughput

0.437

High

405584

RL26A
Large ribosomal subunit protein uL24A

1

2

High-throughput

0.437

High

471018

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

472155

RL31A
Large ribosomal subunit protein eL31A

1

2

High-throughput

0.437

High

479337

RS23B
Small ribosomal subunit protein uS12B

1

1

Small-scale

0.437

High

480067

RS6A
Small ribosomal subunit protein eS6A

1

1

High-throughput

0.437

High

550016

CSK21
Casein kinase II subunit alpha

1

20

Small-scale

0.437

High

706233

RS3A1
Small ribosomal subunit protein eS1A

1

2

High-throughput

0.437

High

730783

CENPA
Histone H3-like centromeric protein CSE4

1

9

High-throughput

0.437

High

746985

TCPG
T-complex protein 1 subunit gamma

1

10

High-throughput

0.437

High

747001

ULP2
Ubiquitin-like-specific protease 2

1

2

High-throughput

0.437

High

747004

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

747005

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

14

High-throughput

0.437

High

747014

UBC9
SUMO-conjugating enzyme UBC9

1

3

High-throughput

0.437

High

747018

COPA
Coatomer subunit alpha

1

10

High-throughput

0.437

High

747023

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

747027

ULP1
Ubiquitin-like-specific protease 1

1

2

High-throughput

0.437

High

747033

GCN5
Histone acetyltransferase GCN5

1

18

High-throughput

0.437

High

747037

DHR1
Probable ATP-dependent RNA helicase DHR1

1

8

High-throughput

0.437

High

747047

RS10A
Small ribosomal subunit protein eS10A

1

9

High-throughput

0.437

High

747048

AP3D
AP-3 complex subunit delta

1

20

High-throughput

0.437

High

747059

SMC6
Structural maintenance of chromosomes protein 6

1

17

High-throughput

0.437

High

690805

GSH1
Glutamate--cysteine ligase

1

0

High-throughput

0.426

High

746974

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

9

High-throughput

0.407

High

747006

ERJ5
ER-localized J domain-containing protein 5

1

6

High-throughput

0.407

High

747024

MCE1
mRNA-capping enzyme subunit alpha

2

0

High-throughput

0.307

High

747052

MED2
Mediator of RNA polymerase II transcription subunit 2

2

0

High-throughput

0.307

High

732821

AUR1
Inositol phosphorylceramide synthase catalytic subunit AUR1

1

0

High-throughput

0.269

Low

747040

RRG8
Required for respiratory growth protein 8, mitochondrial

1

0

High-throughput

0.269

Low

747028

CENPP
Inner kinetochore subunit CTF19

1

0

High-throughput

0.251

Low

747034

RCF1
Respiratory supercomplex factor 1, mitochondrial

1

0

High-throughput

0.251

Low

746972

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

747002

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

747010

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

747012

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

747041

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

747042

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

747043

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.249

Low

747061

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

746981

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.232

Low

747022

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024